FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0179, 1220 aa 1>>>pF1KB0179 1220 - 1220 aa - 1220 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5865+/-0.000585; mu= 18.3207+/- 0.036 mean_var=257.3644+/-54.997, 0's: 0 Z-trim(113.7): 281 B-trim: 1697 in 3/54 Lambda= 0.079947 statistics sampled from 22750 (23171) to 22750 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.619), E-opt: 0.2 (0.272), width: 16 Scan time: 16.630 The best scores are: opt bits E(85289) NP_004932 (OMIM: 600396) ATP-dependent RNA helicas (1220) 8040 943.0 0 NP_001309150 (OMIM: 600396) ATP-dependent RNA heli (1218) 8011 939.7 0 NP_001309148 (OMIM: 600396) ATP-dependent RNA heli (1169) 7562 887.9 0 NP_001309149 (OMIM: 600396) ATP-dependent RNA heli (1152) 7542 885.6 0 NP_001289552 (OMIM: 600396) ATP-dependent RNA heli (1181) 7542 885.6 0 NP_001309147 (OMIM: 600396) ATP-dependent RNA heli (1179) 7513 882.2 0 NP_001309146 (OMIM: 600396) ATP-dependent RNA heli (1129) 7485 879.0 0 NP_001309145 (OMIM: 600396) ATP-dependent RNA heli ( 945) 6234 734.6 7.4e-211 XP_011513241 (OMIM: 603405) PREDICTED: putative pr ( 742) 2590 314.1 2.2e-84 XP_011513240 (OMIM: 603405) PREDICTED: putative pr ( 742) 2590 314.1 2.2e-84 NP_001157711 (OMIM: 603405) putative pre-mRNA-spli ( 981) 2590 314.3 2.5e-84 NP_003578 (OMIM: 603405) putative pre-mRNA-splicin (1041) 2590 314.3 2.6e-84 NP_054722 (OMIM: 605584) pre-mRNA-splicing factor (1227) 2545 309.2 1e-82 XP_011521786 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1227) 2545 309.2 1e-82 XP_011521787 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1227) 2545 309.2 1e-82 XP_005256326 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1192) 2481 301.8 1.7e-80 XP_016879402 (OMIM: 605584) PREDICTED: pre-mRNA-sp (1192) 2481 301.8 1.7e-80 NP_001349 (OMIM: 603403) pre-mRNA-splicing factor ( 795) 2145 262.8 6.3e-69 XP_011513242 (OMIM: 603405) PREDICTED: putative pr ( 560) 2069 253.8 2.3e-66 XP_011513243 (OMIM: 603405) PREDICTED: putative pr ( 524) 2053 251.9 8e-66 NP_064547 (OMIM: 614405) putative ATP-dependent RN ( 707) 1880 232.2 9.5e-60 NP_001186628 (OMIM: 614405) putative ATP-dependent ( 534) 1518 190.2 3e-47 XP_011525853 (OMIM: 615475) PREDICTED: probable AT (1143) 1222 156.6 8.6e-37 XP_005259500 (OMIM: 615475) PREDICTED: probable AT (1143) 1222 156.6 8.6e-37 NP_055496 (OMIM: 615475) probable ATP-dependent RN (1143) 1222 156.6 8.6e-37 XP_011525852 (OMIM: 615475) PREDICTED: probable AT (1143) 1222 156.6 8.6e-37 XP_016871893 (OMIM: 607960) PREDICTED: putative pr ( 743) 1161 149.3 8.9e-35 XP_016871894 (OMIM: 607960) PREDICTED: putative pr ( 743) 1161 149.3 8.9e-35 NP_060650 (OMIM: 607960) putative pre-mRNA-splicin ( 743) 1161 149.3 8.9e-35 XP_016880571 (OMIM: 607570) PREDICTED: probable AT ( 640) 913 120.6 3.4e-26 XP_016880572 (OMIM: 607570) PREDICTED: probable AT ( 640) 913 120.6 3.4e-26 XP_011523556 (OMIM: 607570) PREDICTED: probable AT ( 680) 913 120.6 3.5e-26 NP_001159773 (OMIM: 607570) probable ATP-dependent ( 702) 913 120.6 3.5e-26 XP_016880569 (OMIM: 607570) PREDICTED: probable AT ( 723) 913 120.7 3.6e-26 NP_078888 (OMIM: 607570) probable ATP-dependent RN ( 779) 913 120.7 3.7e-26 XP_006722146 (OMIM: 607570) PREDICTED: probable AT ( 752) 812 109.0 1.2e-22 XP_011523555 (OMIM: 607570) PREDICTED: probable AT ( 718) 725 99.0 1.2e-19 XP_016880366 (OMIM: 614405) PREDICTED: putative AT ( 279) 702 95.7 4.6e-19 NP_065916 (OMIM: 612767) ATP-dependent RNA helicas (1008) 693 95.5 1.9e-18 XP_016880570 (OMIM: 607570) PREDICTED: probable AT ( 653) 617 86.4 6.5e-16 NP_001107869 (OMIM: 612767) ATP-dependent RNA heli ( 994) 595 84.2 4.7e-15 NP_055781 (OMIM: 616423) putative ATP-dependent RN (1155) 558 80.0 9.8e-14 XP_016861406 (OMIM: 616423) PREDICTED: putative AT (1155) 558 80.0 9.8e-14 XP_016861405 (OMIM: 616423) PREDICTED: putative AT (1157) 558 80.0 9.8e-14 XP_016861404 (OMIM: 616423) PREDICTED: putative AT (1162) 558 80.0 9.8e-14 XP_006713096 (OMIM: 616423) PREDICTED: putative AT (1162) 558 80.0 9.8e-14 XP_011531799 (OMIM: 616423) PREDICTED: putative AT (1166) 558 80.0 9.8e-14 XP_011531800 (OMIM: 616423) PREDICTED: putative AT (1166) 558 80.0 9.8e-14 XP_011531798 (OMIM: 616423) PREDICTED: putative AT (1166) 558 80.0 9.8e-14 NP_001317919 (OMIM: 616423) putative ATP-dependent (1166) 558 80.0 9.8e-14 >>NP_004932 (OMIM: 600396) ATP-dependent RNA helicase DH (1220 aa) initn: 8040 init1: 8040 opt: 8040 Z-score: 5031.2 bits: 943.0 E(85289): 0 Smith-Waterman score: 8040; 100.0% identity (100.0% similar) in 1220 aa overlap (1-1220:1-1220) 10 20 30 40 50 60 pF1KB0 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP 1150 1160 1170 1180 1190 1200 1210 1220 pF1KB0 LYNRYEEPNAWRISRAFRRR :::::::::::::::::::: NP_004 LYNRYEEPNAWRISRAFRRR 1210 1220 >>NP_001309150 (OMIM: 600396) ATP-dependent RNA helicase (1218 aa) initn: 6971 init1: 6971 opt: 8011 Z-score: 5013.2 bits: 939.7 E(85289): 0 Smith-Waterman score: 8011; 99.8% identity (99.8% similar) in 1220 aa overlap (1-1220:1-1218) 10 20 30 40 50 60 pF1KB0 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR :::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: NP_001 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHR--TKKKKRSRSR 130 140 150 160 170 190 200 210 220 230 240 pF1KB0 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB0 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB0 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB0 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB0 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB0 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB0 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB0 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB0 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB0 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB0 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB0 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB0 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB0 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB0 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB0 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB0 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP 1140 1150 1160 1170 1180 1190 1210 1220 pF1KB0 LYNRYEEPNAWRISRAFRRR :::::::::::::::::::: NP_001 LYNRYEEPNAWRISRAFRRR 1200 1210 >>NP_001309148 (OMIM: 600396) ATP-dependent RNA helicase (1169 aa) initn: 7798 init1: 7562 opt: 7562 Z-score: 4733.4 bits: 887.9 E(85289): 0 Smith-Waterman score: 7562; 99.8% identity (99.9% similar) in 1151 aa overlap (1-1151:1-1151) 10 20 30 40 50 60 pF1KB0 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP :::::::: .: NP_001 LFNRQPEWDLYSRFSEWKSGTNCSSLSGT 1150 1160 >>NP_001309149 (OMIM: 600396) ATP-dependent RNA helicase (1152 aa) initn: 7542 init1: 7542 opt: 7542 Z-score: 4721.0 bits: 885.6 E(85289): 0 Smith-Waterman score: 7542; 100.0% identity (100.0% similar) in 1147 aa overlap (1-1147:1-1147) 10 20 30 40 50 60 pF1KB0 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP ::::::: NP_001 LFNRQPECISQD 1150 >>NP_001289552 (OMIM: 600396) ATP-dependent RNA helicase (1181 aa) initn: 7542 init1: 7542 opt: 7542 Z-score: 4720.9 bits: 885.6 E(85289): 0 Smith-Waterman score: 7542; 100.0% identity (100.0% similar) in 1147 aa overlap (1-1147:1-1147) 10 20 30 40 50 60 pF1KB0 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB0 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB0 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB0 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB0 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP ::::::: NP_001 LFNRQPECPKHFLPVVAVAVSLEQCLSKFEDLNKELGLVTC 1150 1160 1170 1180 >>NP_001309147 (OMIM: 600396) ATP-dependent RNA helicase (1179 aa) initn: 6473 init1: 6473 opt: 7513 Z-score: 4702.9 bits: 882.2 E(85289): 0 Smith-Waterman score: 7513; 99.8% identity (99.8% similar) in 1147 aa overlap (1-1147:1-1145) 10 20 30 40 50 60 pF1KB0 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR ::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: NP_001 VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEH--RTKKKKRSRSR 130 140 150 160 170 190 200 210 220 230 240 pF1KB0 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB0 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB0 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB0 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB0 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB0 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB0 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB0 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB0 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB0 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB0 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB0 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB0 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB0 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB0 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB0 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB0 LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP ::::::: NP_001 LFNRQPECPKHFLPVVAVAVSLEQCLSKFEDLNKELGLVTC 1140 1150 1160 1170 >>NP_001309146 (OMIM: 600396) ATP-dependent RNA helicase (1129 aa) initn: 7485 init1: 7485 opt: 7485 Z-score: 4685.6 bits: 879.0 E(85289): 0 Smith-Waterman score: 7485; 100.0% identity (100.0% similar) in 1129 aa overlap (92-1220:1-1129) 70 80 90 100 110 120 pF1KB0 TFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPV :::::::::::::::::::::::::::::: NP_001 MRPPAKPSTSKDPVVKPKTEKEKLKELFPV 10 20 30 130 140 150 160 170 180 pF1KB0 LCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRD 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB0 RNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKY 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB0 GERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELR 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB0 REGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEE 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB0 TSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDE 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB0 ETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSA 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB0 LAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKH 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB0 AFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQY 460 470 480 490 500 510 610 620 630 640 650 660 pF1KB0 LAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYM 520 530 540 550 560 570 670 680 690 700 710 720 pF1KB0 TDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLD 580 590 600 610 620 630 730 740 750 760 770 780 pF1KB0 AVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLT 640 650 660 670 680 690 790 800 810 820 830 840 pF1KB0 GQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNI 700 710 720 730 740 750 850 860 870 880 890 900 pF1KB0 AETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYR 760 770 780 790 800 810 910 920 930 940 950 960 pF1KB0 LYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQL 820 830 840 850 860 870 970 980 990 1000 1010 1020 pF1KB0 YTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRP 880 890 900 910 920 930 1030 1040 1050 1060 1070 1080 pF1KB0 KDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQ 940 950 960 970 980 990 1090 1100 1110 1120 1130 1140 pF1KB0 MLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSAL 1000 1010 1020 1030 1040 1050 1150 1160 1170 1180 1190 1200 pF1KB0 FNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPL 1060 1070 1080 1090 1100 1110 1210 1220 pF1KB0 YNRYEEPNAWRISRAFRRR ::::::::::::::::::: NP_001 YNRYEEPNAWRISRAFRRR 1120 >>NP_001309145 (OMIM: 600396) ATP-dependent RNA helicase (945 aa) initn: 6234 init1: 6234 opt: 6234 Z-score: 3906.5 bits: 734.6 E(85289): 7.4e-211 Smith-Waterman score: 6234; 100.0% identity (100.0% similar) in 945 aa overlap (276-1220:1-945) 250 260 270 280 290 300 pF1KB0 LDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGR :::::::::::::::::::::::::::::: NP_001 MQFGCFVQLEGLRKRWEGLVHISELRREGR 10 20 30 310 320 330 340 350 360 pF1KB0 VANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMR 40 50 60 70 80 90 370 380 390 400 410 420 pF1KB0 NPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGI 100 110 120 130 140 150 430 440 450 460 470 480 pF1KB0 LPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKE 160 170 180 190 200 210 490 500 510 520 530 540 pF1KB0 RRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGG 220 230 240 250 260 270 550 560 570 580 590 600 pF1KB0 NKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEA 280 290 300 310 320 330 610 620 630 640 650 660 pF1KB0 GYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGM 340 350 360 370 380 390 670 680 690 700 710 720 pF1KB0 LLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKF 400 410 420 430 440 450 730 740 750 760 770 780 pF1KB0 SQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEE 460 470 480 490 500 510 790 800 810 820 830 840 pF1KB0 IDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETS 520 530 540 550 560 570 850 860 870 880 890 900 pF1KB0 LTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTE 580 590 600 610 620 630 910 920 930 940 950 960 pF1KB0 RAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLG 640 650 660 670 680 690 970 980 990 1000 1010 1020 pF1KB0 ALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQ 700 710 720 730 740 750 1030 1040 1050 1060 1070 1080 pF1KB0 ALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGI 760 770 780 790 800 810 1090 1100 1110 1120 1130 1140 pF1KB0 MDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQ 820 830 840 850 860 870 1150 1160 1170 1180 1190 1200 pF1KB0 PEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRY 880 890 900 910 920 930 1210 1220 pF1KB0 EEPNAWRISRAFRRR ::::::::::::::: NP_001 EEPNAWRISRAFRRR 940 >>XP_011513241 (OMIM: 603405) PREDICTED: putative pre-mR (742 aa) initn: 2546 init1: 1960 opt: 2590 Z-score: 1636.1 bits: 314.1 E(85289): 2.2e-84 Smith-Waterman score: 2590; 57.3% identity (84.3% similar) in 654 aa overlap (553-1199:88-740) 530 540 550 560 570 580 pF1KB0 ANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQ . . :: :.:::.. ..:.:. :. ..: XP_011 LEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQ 60 70 80 90 100 110 590 600 610 620 630 640 pF1KB0 ILIVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRRVAAMSVAKRVSEEFGCCLGQE .::. ::::::::::: ::: : :::..: ::.::::::::::::: ::..:.: ::.: XP_011 VLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNE 120 130 140 150 160 170 650 660 670 680 690 700 pF1KB0 VGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLL :::.:::::::: .::..:::::::::: : .:::..:...:.:::::::.:::.::::. XP_011 VGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLI 180 190 200 210 220 230 710 720 730 740 750 760 pF1KB0 KKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASL : ... : ..:..:.:::.:...:: .: .::.: :::: .::.:.::: ::.:::.: . XP_011 KDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACV 240 250 260 270 280 290 770 780 790 800 810 820 pF1KB0 ITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQ ..:.:::.:.:::::::::::::::..:::.: .: . :: . ::..::.:. :::.:: XP_011 VSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQ 300 310 320 330 340 350 830 840 850 860 870 880 pF1KB0 TRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQ .:::.:.:::.::::.:::::::::::.:: ::.:::: ::: :: .::...:.::: :. XP_011 ARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSK 360 370 380 390 400 410 890 900 910 920 930 940 pF1KB0 AQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLL :.:.::::::::.. :::.:::: ::. :. :.:::::::.:...:: ::..::.::. XP_011 ASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLM 420 430 440 450 460 470 950 960 970 980 990 1000 pF1KB0 SFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGC :::.: ::.:::. :.::::.::::. : :: ::.:::.:..::: ::.. : . .: XP_011 HFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSC 480 490 500 510 520 530 1010 1020 1030 1040 1050 1060 pF1KB0 SEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNP :::.::...::::.: .::::::: . ::. ...: ::::.:: ::..: .. .:. XP_011 SEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQ 540 550 560 570 580 590 1070 1080 1090 1100 1110 1120 pF1KB0 WCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDP ::::::.: ::.:::.:.:.:. :...: .. . :: . .::.::: .:.: ..:. XP_011 WCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLT- 600 610 620 630 640 650 1130 1140 1150 1160 1170 1180 pF1KB0 QEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAF . ::::. .::.:.:::.:.::..::.:..::::::::::.::.: :. ::.: :: . XP_011 RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHY 660 670 680 690 700 710 1190 1200 1210 1220 pF1KB0 FKVS---DP--TKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR .:.. :: :. :. . : : XP_011 YKAKELEDPHAKKMPKKIGKTREELG 720 730 740 >>XP_011513240 (OMIM: 603405) PREDICTED: putative pre-mR (742 aa) initn: 2546 init1: 1960 opt: 2590 Z-score: 1636.1 bits: 314.1 E(85289): 2.2e-84 Smith-Waterman score: 2590; 57.3% identity (84.3% similar) in 654 aa overlap (553-1199:88-740) 530 540 550 560 570 580 pF1KB0 ANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQ . . :: :.:::.. ..:.:. :. ..: XP_011 LEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQ 60 70 80 90 100 110 590 600 610 620 630 640 pF1KB0 ILIVIGETGSGKTTQITQYLAEAGYTSRG-KIGCTQPRRVAAMSVAKRVSEEFGCCLGQE .::. ::::::::::: ::: : :::..: ::.::::::::::::: ::..:.: ::.: XP_011 VLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNE 120 130 140 150 160 170 650 660 670 680 690 700 pF1KB0 VGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLL :::.:::::::: .::..:::::::::: : .:::..:...:.:::::::.:::.::::. XP_011 VGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLI 180 190 200 210 220 230 710 720 730 740 750 760 pF1KB0 KKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASL : ... : ..:..:.:::.:...:: .: .::.: :::: .::.:.::: ::.:::.: . XP_011 KDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACV 240 250 260 270 280 290 770 780 790 800 810 820 pF1KB0 ITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQ ..:.:::.:.:::::::::::::::..:::.: .: . :: . ::..::.:. :::.:: XP_011 VSVLQIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQ 300 310 320 330 340 350 830 840 850 860 870 880 pF1KB0 TRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQ .:::.:.:::.::::.:::::::::::.:: ::.:::: ::: :: .::...:.::: :. XP_011 ARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSK 360 370 380 390 400 410 890 900 910 920 930 940 pF1KB0 AQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLL :.:.::::::::.. :::.:::: ::. :. :.:::::::.:...:: ::..::.::. XP_011 ASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLM 420 430 440 450 460 470 950 960 970 980 990 1000 pF1KB0 SFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGC :::.: ::.:::. :.::::.::::. : :: ::.:::.:..::: ::.. : . .: XP_011 HFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSC 480 490 500 510 520 530 1010 1020 1030 1040 1050 1060 pF1KB0 SEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNP :::.::...::::.: .::::::: . ::. ...: ::::.:: ::..: .. .:. XP_011 SEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQ 540 550 560 570 580 590 1070 1080 1090 1100 1110 1120 pF1KB0 WCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDP ::::::.: ::.:::.:.:.:. :...: .. . :: . .::.::: .:.: ..:. XP_011 WCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLT- 600 610 620 630 640 650 1130 1140 1150 1160 1170 1180 pF1KB0 QEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAF . ::::. .::.:.:::.:.::..::.:..::::::::::.::.: :. ::.: :: . XP_011 RSGYRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHY 660 670 680 690 700 710 1190 1200 1210 1220 pF1KB0 FKVS---DP--TKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR .:.. :: :. :. . : : XP_011 YKAKELEDPHAKKMPKKIGKTREELG 720 730 740 1220 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:43:22 2016 done: Thu Nov 3 11:43:24 2016 Total Scan time: 16.630 Total Display time: 0.520 Function used was FASTA [36.3.4 Apr, 2011]