FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0401, 171 aa 1>>>pF1KB0401 171 - 171 aa - 171 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8617+/-0.000407; mu= 16.0864+/- 0.025 mean_var=90.3794+/-17.919, 0's: 0 Z-trim(113.3): 136 B-trim: 30 in 1/54 Lambda= 0.134909 statistics sampled from 22416 (22567) to 22416 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.265), width: 16 Scan time: 5.230 The best scores are: opt bits E(85289) NP_001138416 (OMIM: 609211) myosin regulatory ligh ( 172) 1108 225.2 3.9e-59 NP_001138417 (OMIM: 609211) myosin regulatory ligh ( 172) 1108 225.2 3.9e-59 NP_291024 (OMIM: 609211) myosin regulatory light c ( 172) 1108 225.2 3.9e-59 NP_006088 (OMIM: 609905) myosin regulatory light p ( 172) 1072 218.2 5e-57 NP_000423 (OMIM: 160781,608758) myosin regulatory ( 166) 634 133.0 2.3e-31 XP_016863734 (OMIM: 160782) PREDICTED: myosin ligh ( 173) 615 129.3 3e-30 NP_002468 (OMIM: 160782) myosin light chain 5 [Hom ( 173) 615 129.3 3e-30 XP_016863735 (OMIM: 160782) PREDICTED: myosin ligh ( 173) 615 129.3 3e-30 XP_006713949 (OMIM: 160782) PREDICTED: myosin ligh ( 328) 608 128.2 1.2e-29 NP_067046 (OMIM: 613993) myosin regulatory light c ( 175) 559 118.4 5.8e-27 XP_011513766 (OMIM: 613993) PREDICTED: myosin regu ( 208) 492 105.4 5.5e-23 XP_016863737 (OMIM: 160782) PREDICTED: myosin ligh ( 132) 468 100.5 1e-21 XP_016863736 (OMIM: 160782) PREDICTED: myosin ligh ( 132) 468 100.5 1e-21 XP_016867967 (OMIM: 613993) PREDICTED: myosin regu ( 132) 444 95.9 2.6e-20 XP_011513767 (OMIM: 613993) PREDICTED: myosin regu ( 163) 444 96.0 3e-20 NP_001316851 (OMIM: 114183) calmodulin isoform 1 [ ( 149) 401 87.6 9.5e-18 NP_008819 (OMIM: 114180,614916,616247) calmodulin ( 149) 401 87.6 9.5e-18 NP_005175 (OMIM: 114183) calmodulin isoform 1 [Hom ( 149) 401 87.6 9.5e-18 NP_001734 (OMIM: 114182,616249) calmodulin isoform ( 149) 401 87.6 9.5e-18 XP_006720321 (OMIM: 114180,614916,616247) PREDICTE ( 150) 400 87.4 1.1e-17 NP_001292553 (OMIM: 114182,616249) calmodulin isof ( 197) 400 87.5 1.3e-17 NP_005176 (OMIM: 114184) calmodulin-like protein 3 ( 149) 378 83.1 2.1e-16 XP_011513765 (OMIM: 613993) PREDICTED: myosin regu ( 231) 365 80.8 1.6e-15 NP_852667 (OMIM: 609905) myosin regulatory light p ( 118) 360 79.5 2.1e-15 XP_016867968 (OMIM: 613993) PREDICTED: myosin regu ( 99) 320 71.6 4e-13 XP_005249874 (OMIM: 613993) PREDICTED: myosin regu ( 155) 317 71.2 8.1e-13 NP_001316850 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 313 70.3 1.1e-12 NP_001316852 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 313 70.3 1.1e-12 NP_001292554 (OMIM: 114182,616249) calmodulin isof ( 113) 313 70.3 1.1e-12 NP_001292555 (OMIM: 114182,616249) calmodulin isof ( 113) 313 70.3 1.1e-12 NP_001316855 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 313 70.3 1.1e-12 NP_001316854 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 313 70.3 1.1e-12 NP_001316853 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 313 70.3 1.1e-12 NP_004335 (OMIM: 300006) centrin-2 [Homo sapiens] ( 172) 291 66.2 2.9e-11 NP_004057 (OMIM: 603187) centrin-1 [Homo sapiens] ( 172) 282 64.5 9.8e-11 NP_059118 (OMIM: 605183) calmodulin-like protein 5 ( 146) 251 58.4 5.7e-09 NP_003270 (OMIM: 191039) troponin C, skeletal musc ( 160) 248 57.8 9.1e-09 XP_011527333 (OMIM: 191039) PREDICTED: troponin C, ( 145) 245 57.2 1.3e-08 NP_002466 (OMIM: 609930) myosin light chain 6B [Ho ( 208) 246 57.6 1.4e-08 NP_001186558 (OMIM: 609930) myosin light chain 6B ( 208) 246 57.6 1.4e-08 NP_057450 (OMIM: 607314,614899) calcium-binding pr ( 220) 238 56.0 4.3e-08 NP_003271 (OMIM: 191040,611879,613243) troponin C, ( 161) 235 55.3 5.3e-08 NP_524147 (OMIM: 609931) myosin light polypeptide ( 151) 233 54.9 6.7e-08 NP_001305425 (OMIM: 607314,614899) calcium-binding ( 226) 229 54.3 1.5e-07 NP_066299 (OMIM: 609931) myosin light polypeptide ( 151) 226 53.5 1.7e-07 NP_004356 (OMIM: 602907) centrin-3 isoform 2 [Homo ( 167) 222 52.8 3.1e-07 NP_524146 (OMIM: 160780) myosin light chain 1/3, s ( 150) 215 51.4 7.5e-07 NP_619650 (OMIM: 610171) calmodulin-like protein 6 ( 181) 215 51.5 8.5e-07 XP_005244786 (OMIM: 610171) PREDICTED: calmodulin- ( 203) 215 51.5 9.2e-07 NP_524144 (OMIM: 160780) myosin light chain 1/3, s ( 194) 211 50.7 1.5e-06 >>NP_001138416 (OMIM: 609211) myosin regulatory light ch (172 aa) initn: 1077 init1: 1077 opt: 1108 Z-score: 1182.6 bits: 225.2 E(85289): 3.9e-59 Smith-Waterman score: 1108; 97.7% identity (98.8% similar) in 172 aa overlap (1-171:1-172) 10 20 30 40 50 pF1KB0 MSSKRTKTKT-KKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS ::::..:::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 LGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD 130 140 150 160 170 >>NP_001138417 (OMIM: 609211) myosin regulatory light ch (172 aa) initn: 1077 init1: 1077 opt: 1108 Z-score: 1182.6 bits: 225.2 E(85289): 3.9e-59 Smith-Waterman score: 1108; 97.7% identity (98.8% similar) in 172 aa overlap (1-171:1-172) 10 20 30 40 50 pF1KB0 MSSKRTKTKT-KKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS ::::..:::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 LGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD 130 140 150 160 170 >>NP_291024 (OMIM: 609211) myosin regulatory light chain (172 aa) initn: 1077 init1: 1077 opt: 1108 Z-score: 1182.6 bits: 225.2 E(85289): 3.9e-59 Smith-Waterman score: 1108; 97.7% identity (98.8% similar) in 172 aa overlap (1-171:1-172) 10 20 30 40 50 pF1KB0 MSSKRTKTKT-KKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS ::::..:::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 LGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 LGKNPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD 130 140 150 160 170 >>NP_006088 (OMIM: 609905) myosin regulatory light polyp (172 aa) initn: 1042 init1: 1042 opt: 1072 Z-score: 1144.7 bits: 218.2 E(85289): 5e-57 Smith-Waterman score: 1072; 93.0% identity (98.8% similar) in 172 aa overlap (1-171:1-172) 10 20 30 40 50 pF1KB0 MSSKRTKTKT-KKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS :::::.:.:: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLAS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 LGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE ::::::::::..::.:::::::::::::::::::::::::::::::::::::::.: :.: NP_006 LGKNPTDEYLEGMMSEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD :.:::::::::::::::::::.::::::::::::::.::::::::::::::: NP_006 DHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD 130 140 150 160 170 >>NP_000423 (OMIM: 160781,608758) myosin regulatory ligh (166 aa) initn: 627 init1: 388 opt: 634 Z-score: 684.2 bits: 133.0 E(85289): 2.3e-31 Smith-Waterman score: 634; 57.7% identity (84.7% similar) in 163 aa overlap (9-170:5-166) 10 20 30 40 50 60 pF1KB0 MSSKRTKTKTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASL :.::: :.::::.::.:.:::::::::...::::::::::.::.: .:.: NP_000 MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAAL 10 20 30 40 50 70 80 90 100 110 pF1KB0 GK-NPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQE :. : .: .: :..:::::::::.:::::::::.:.:::..: ::: :: :. :... NP_000 GRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLKA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 DYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD ::.::.:::...::. ::::... : : ::..: ....:. :: ..:: NP_000 DYVREMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHG-EEKD 120 130 140 150 160 >>XP_016863734 (OMIM: 160782) PREDICTED: myosin light ch (173 aa) initn: 586 init1: 341 opt: 615 Z-score: 664.0 bits: 129.3 E(85289): 3e-30 Smith-Waterman score: 615; 53.8% identity (80.3% similar) in 173 aa overlap (1-170:1-173) 10 20 30 40 50 pF1KB0 MSSKRTKTKTKK--RPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLA :.:..:: : : :::.::::. :.:.:::::::::...:::::::::::::.: : XP_016 MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 SLGK-NPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTI :::: : :. ::::..:: :::::::::..:::::.::: :..: ::: .: .. : : XP_016 SLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAEETILNAFKMLDPDGKGKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 QEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD ...:...:: ...:..: ::::.... : :: ::..: .. .. :: . .. XP_016 NKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKALSYVITHGEEKEE 130 140 150 160 170 >>NP_002468 (OMIM: 160782) myosin light chain 5 [Homo sa (173 aa) initn: 586 init1: 341 opt: 615 Z-score: 664.0 bits: 129.3 E(85289): 3e-30 Smith-Waterman score: 615; 53.8% identity (80.3% similar) in 173 aa overlap (1-170:1-173) 10 20 30 40 50 pF1KB0 MSSKRTKTKTKK--RPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLA :.:..:: : : :::.::::. :.:.:::::::::...:::::::::::::.: : NP_002 MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 SLGK-NPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTI :::: : :. ::::..:: :::::::::..:::::.::: :..: ::: .: .. : : NP_002 SLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAEETILNAFKMLDPDGKGKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 QEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD ...:...:: ...:..: ::::.... : :: ::..: .. .. :: . .. NP_002 NKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKALSYVITHGEEKEE 130 140 150 160 170 >>XP_016863735 (OMIM: 160782) PREDICTED: myosin light ch (173 aa) initn: 586 init1: 341 opt: 615 Z-score: 664.0 bits: 129.3 E(85289): 3e-30 Smith-Waterman score: 615; 53.8% identity (80.3% similar) in 173 aa overlap (1-170:1-173) 10 20 30 40 50 pF1KB0 MSSKRTKTKTKK--RPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLA :.:..:: : : :::.::::. :.:.:::::::::...:::::::::::::.: : XP_016 MASRKTKKKEGGALRAQRASSNVFSNFEQTQIQEFKEAFTLMDQNRDGFIDKEDLKDTYA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 SLGK-NPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTI :::: : :. ::::..:: :::::::::..:::::.::: :..: ::: .: .. : : XP_016 SLGKTNVKDDELDAMLKEASGPINFTMFLNLFGEKLSGTDAEETILNAFKMLDPDGKGKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 QEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD ...:...:: ...:..: ::::.... : :: ::..: .. .. :: . .. XP_016 NKEYIKRLLMSQADKMTAEEVDQMFQFASIDVAGNLDYKALSYVITHGEEKEE 130 140 150 160 170 >>XP_006713949 (OMIM: 160782) PREDICTED: myosin light ch (328 aa) initn: 586 init1: 341 opt: 608 Z-score: 653.4 bits: 128.2 E(85289): 1.2e-29 Smith-Waterman score: 608; 53.5% identity (80.2% similar) in 172 aa overlap (2-170:157-328) 10 20 pF1KB0 MSSKRTKTKTKK--RPQRATSNVFAMFDQSQ .:..:: : : :::.::::. :.:.: XP_006 PPSASWPCVHTPDCGPGRTLSSCAERRRPEASRKTKKKEGGALRAQRASSNVFSNFEQTQ 130 140 150 160 170 180 30 40 50 60 70 80 pF1KB0 IQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGK-NPTDEYLDAMMNEAPGPINFTMFLTM ::::::::...:::::::::::::.: ::::: : :. ::::..:: :::::::::.. XP_006 IQEFKEAFTLMDQNRDGFIDKEDLKDTYASLGKTNVKDDELDAMLKEASGPINFTMFLNL 190 200 210 220 230 240 90 100 110 120 130 140 pF1KB0 FGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPID :::::.::: :..: ::: .: .. : :...:...:: ...:..: ::::.... : :: XP_006 FGEKLSGTDAEETILNAFKMLDPDGKGKINKEYIKRLLMSQADKMTAEEVDQMFQFASID 250 260 270 280 290 300 150 160 170 pF1KB0 KKGNFNYIEFTRILKHGAKDKDD ::..: .. .. :: . .. XP_006 VAGNLDYKALSYVITHGEEKEE 310 320 >>NP_067046 (OMIM: 613993) myosin regulatory light chain (175 aa) initn: 570 init1: 338 opt: 559 Z-score: 605.0 bits: 118.4 E(85289): 5.8e-27 Smith-Waterman score: 559; 48.6% identity (78.3% similar) in 175 aa overlap (1-170:1-175) 10 20 30 40 50 pF1KB0 MSSKRTKTKTK----KRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDM :.:... :. : :. ::..::::.::.:.:::::::::. :::::::.: : ::.. NP_067 MASRKAGTRGKVAATKQAQRGSSNVFSMFEQAQIQEFKEAFSCIDQNRDGIICKADLRET 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 LASLGK-NPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATG ..::: . .: ::::..:. ::::::.:::.:::::::::::..: .:: :: . : NP_067 YSQLGKVSVPEEELDAMLQEGKGPINFTVFLTLFGEKLNGTDPEEAILSAFRMFDPSGKG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 TIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD ....: ...:: :..:.:. ::.... .:.: ::..: . :. :: . .. NP_067 VVNKDEFKQLLLTQADKFSPAEVEQMFALTPMDLAGNIDYKSLCYIITHGDEKEE 130 140 150 160 170 171 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:49:41 2016 done: Sat Nov 5 11:49:42 2016 Total Scan time: 5.230 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]