FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0407, 465 aa 1>>>pF1KB0407 465 - 465 aa - 465 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3893+/-0.000321; mu= 19.1189+/- 0.020 mean_var=102.0434+/-20.737, 0's: 0 Z-trim(118.4): 126 B-trim: 41 in 1/53 Lambda= 0.126964 statistics sampled from 31230 (31363) to 31230 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.368), width: 16 Scan time: 9.440 The best scores are: opt bits E(85289) NP_004553 (OMIM: 167000,211980,600116,602544,60757 ( 465) 3379 629.4 6.4e-180 XP_016866397 (OMIM: 167000,211980,600116,602544,60 ( 503) 3368 627.4 2.7e-179 XP_011534165 (OMIM: 167000,211980,600116,602544,60 ( 464) 3362 626.3 5.5e-179 XP_016866398 (OMIM: 167000,211980,600116,602544,60 ( 385) 2825 527.8 2e-149 NP_054642 (OMIM: 167000,211980,600116,602544,60757 ( 437) 1945 366.7 7.2e-101 NP_054643 (OMIM: 167000,211980,600116,602544,60757 ( 316) 1940 365.6 1.1e-100 XP_011515258 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 249 56.3 3.6e-07 XP_016868793 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 249 56.3 3.6e-07 XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 249 56.3 3.7e-07 XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 249 56.3 3.7e-07 XP_016868791 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 249 56.3 3.7e-07 NP_904355 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 249 56.3 3.7e-07 NP_056250 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 249 56.3 3.7e-07 NP_001267468 (OMIM: 607119) E3 ubiquitin-protein l ( 838) 249 56.3 3.7e-07 NP_001120833 (OMIM: 610872) E3 ubiquitin-protein l ( 587) 224 51.6 7e-06 NP_001287755 (OMIM: 610872) E3 ubiquitin-protein l ( 731) 224 51.7 8.1e-06 XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 588) 221 51.0 1e-05 XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 688) 221 51.1 1.1e-05 XP_011512731 (OMIM: 607489) PREDICTED: cullin-9 is (1834) 226 52.5 1.2e-05 NP_699172 (OMIM: 610872) E3 ubiquitin-protein liga ( 732) 221 51.1 1.2e-05 XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 732) 221 51.1 1.2e-05 XP_016866079 (OMIM: 607489) PREDICTED: cullin-9 is (1909) 226 52.5 1.2e-05 XP_011512729 (OMIM: 607489) PREDICTED: cullin-9 is (2095) 226 52.5 1.3e-05 XP_011512728 (OMIM: 607489) PREDICTED: cullin-9 is (2339) 226 52.6 1.4e-05 XP_011512727 (OMIM: 607489) PREDICTED: cullin-9 is (2456) 226 52.6 1.4e-05 NP_055904 (OMIM: 607489) cullin-9 [Homo sapiens] (2517) 226 52.6 1.5e-05 XP_011512726 (OMIM: 607489) PREDICTED: cullin-9 is (2539) 226 52.6 1.5e-05 XP_011512725 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 226 52.6 1.5e-05 XP_011512724 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 226 52.6 1.5e-05 XP_016866078 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 226 52.6 1.5e-05 XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 465) 210 48.9 3.5e-05 XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 498) 210 48.9 3.7e-05 NP_005735 (OMIM: 605624) E3 ubiquitin-protein liga ( 557) 210 49.0 4e-05 XP_005268596 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 348) 205 47.9 5.4e-05 XP_005268597 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 348) 205 47.9 5.4e-05 XP_016865560 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 348) 205 47.9 5.4e-05 XP_016865561 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 348) 205 47.9 5.4e-05 NP_899645 (OMIM: 605675) E3 ubiquitin-protein liga ( 348) 205 47.9 5.4e-05 XP_005268598 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 348) 205 47.9 5.4e-05 NP_001304263 (OMIM: 605615) E3 ubiquitin-protein l ( 351) 204 47.7 6.2e-05 XP_005268594 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 474) 205 48.0 6.7e-05 NP_899646 (OMIM: 605675) E3 ubiquitin-protein liga ( 474) 205 48.0 6.7e-05 XP_011536016 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 474) 205 48.0 6.7e-05 XP_016865559 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 474) 205 48.0 6.7e-05 NP_001188294 (OMIM: 605675) E3 ubiquitin-protein l ( 474) 205 48.0 6.7e-05 NP_899648 (OMIM: 605675) E3 ubiquitin-protein liga ( 474) 205 48.0 6.7e-05 NP_004281 (OMIM: 605675) E3 ubiquitin-protein liga ( 474) 205 48.0 6.7e-05 NP_899647 (OMIM: 605675) E3 ubiquitin-protein liga ( 474) 205 48.0 6.7e-05 XP_005268593 (OMIM: 605675) PREDICTED: E3 ubiquiti ( 474) 205 48.0 6.7e-05 XP_016861029 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 409) 204 47.7 6.9e-05 >>NP_004553 (OMIM: 167000,211980,600116,602544,607572) E (465 aa) initn: 3379 init1: 3379 opt: 3379 Z-score: 3351.1 bits: 629.4 E(85289): 6.4e-180 Smith-Waterman score: 3379; 100.0% identity (100.0% similar) in 465 aa overlap (1-465:1-465) 10 20 30 40 50 60 pF1KB0 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR 370 380 390 400 410 420 430 440 450 460 pF1KB0 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV ::::::::::::::::::::::::::::::::::::::::::::: NP_004 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 430 440 450 460 >>XP_016866397 (OMIM: 167000,211980,600116,602544,607572 (503 aa) initn: 3368 init1: 3368 opt: 3368 Z-score: 3339.8 bits: 627.4 E(85289): 2.7e-179 Smith-Waterman score: 3368; 99.6% identity (99.8% similar) in 465 aa overlap (1-465:39-503) 10 20 30 pF1KB0 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVV . :::::::::::::::::::::::::::: XP_016 NSDNCTYSLKNSEPQPESGRLYTRPEREYPITVFVRFNSSHGFPVEVDSDTSIFQLKEVV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB0 AKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRN 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB0 AAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYC 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB0 KGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFF 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB0 KCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB0 RLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGV 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB0 LCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQA 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB0 YRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCG 430 440 450 460 470 480 460 pF1KB0 CEWNRVCMGDHWFDV ::::::::::::::: XP_016 CEWNRVCMGDHWFDV 490 500 >>XP_011534165 (OMIM: 167000,211980,600116,602544,607572 (464 aa) initn: 2454 init1: 2454 opt: 3362 Z-score: 3334.3 bits: 626.3 E(85289): 5.5e-179 Smith-Waterman score: 3362; 99.8% identity (99.8% similar) in 465 aa overlap (1-465:1-464) 10 20 30 40 50 60 pF1KB0 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_011 VILHTDSRKDSPPAGSP-GRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP 130 140 150 160 170 190 200 210 220 230 240 pF1KB0 SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB0 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB0 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB0 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR 360 370 380 390 400 410 430 440 450 460 pF1KB0 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV ::::::::::::::::::::::::::::::::::::::::::::: XP_011 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 420 430 440 450 460 >>XP_016866398 (OMIM: 167000,211980,600116,602544,607572 (385 aa) initn: 2454 init1: 2454 opt: 2825 Z-score: 2803.7 bits: 527.8 E(85289): 2e-149 Smith-Waterman score: 2825; 99.7% identity (99.7% similar) in 386 aa overlap (80-465:1-385) 50 60 70 80 90 100 pF1KB0 LRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSS :::::::::::::::::::::::::::::: XP_016 MNATGGDDPRNAAGGCEREPQSLTRVDLSS 10 20 30 110 120 130 140 150 160 pF1KB0 SVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTC :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_016 SVLPGDSVGLAVILHTDSRKDSPPAGSP-GRSIYNSFYVYCKGPCQRVQPGKLRVQCSTC 40 50 60 70 80 170 180 190 200 210 220 pF1KB0 RQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLI 90 100 110 120 130 140 230 240 250 260 270 280 pF1KB0 ATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPC 150 160 170 180 190 200 290 300 310 320 330 340 pF1KB0 VAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRK 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB0 VTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKE 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB0 TIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 330 340 350 360 370 380 >>NP_054642 (OMIM: 167000,211980,600116,602544,607572) E (437 aa) initn: 1939 init1: 1939 opt: 1945 Z-score: 1931.9 bits: 366.7 E(85289): 7.2e-101 Smith-Waterman score: 3090; 94.0% identity (94.0% similar) in 465 aa overlap (1-465:1-437) 10 20 30 40 50 60 pF1KB0 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQ-- 130 140 150 160 170 190 200 210 220 230 240 pF1KB0 SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT :::::::::::::::::::::::::::::::::: NP_054 --------------------------EFFFKCGAHPTSDKETSVALHLIATNSRNITCIT 180 190 200 210 250 260 270 280 290 300 pF1KB0 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB0 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB0 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR 340 350 360 370 380 390 430 440 450 460 pF1KB0 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV ::::::::::::::::::::::::::::::::::::::::::::: NP_054 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 400 410 420 430 >>NP_054643 (OMIM: 167000,211980,600116,602544,607572) E (316 aa) initn: 1940 init1: 1940 opt: 1940 Z-score: 1928.6 bits: 365.6 E(85289): 1.1e-100 Smith-Waterman score: 2004; 68.0% identity (68.0% similar) in 465 aa overlap (1-465:1-316) 10 20 30 40 50 60 pF1KB0 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQ--- 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA NP_054 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KB0 VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP NP_054 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KB0 SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT :::::::::::::::::::::::::::::::::: NP_054 --------------------------EFFFKCGAHPTSDKETSVALHLIATNSRNITCIT 60 70 80 90 250 260 270 280 290 300 pF1KB0 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KB0 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB0 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR 220 230 240 250 260 270 430 440 450 460 pF1KB0 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV ::::::::::::::::::::::::::::::::::::::::::::: NP_054 CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV 280 290 300 310 >>XP_011515258 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (784 aa) initn: 192 init1: 89 opt: 249 Z-score: 249.8 bits: 56.3 E(85289): 3.6e-07 Smith-Waterman score: 249; 26.4% identity (54.6% similar) in 216 aa overlap (244-449:130-332) 220 230 240 250 260 270 pF1KB0 AHPTSDKETSVALHLIATNSRNITCITCTDVRSPV-LVFQCNSRHVICLDCFHLYCVTRL .. :. :. . ..: . : : :: : XP_011 EMCTDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCL 100 110 120 130 140 150 280 290 300 310 320 pF1KB0 NDRQFVHDPQLGYSLPCVAGCPNSLIK-ELHHFR-ILGEE-QYNRYQQYGAEE-CVLQMG ::... ... : .. ::. . . : .: ::... ...:... .. : . XP_011 --RQYLR-IEISESRVNIS-CPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPD 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB0 GVLCPRPGCGAGLLPE--PDQRKVTCEGGNGLGCGFAFCRECKEAYHEGE-CSAVFEASG :: : :: ... . :.:: : . ::: :: .::. .: .. :.:. . . XP_011 CRWCPAPDCGYAVIAFGCASCPKLTC-GRE--GCGTEFCYHCKQIWHPNQTCDAARQERA 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB0 TTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEK--NGGCMHMKCPQPQCRL . . . . .. .:. . :: ::::: . . : .:.: :: : : XP_011 QSLRLRTIRSSSISYSQESGAAADDIK----PCPRCAAYIIKMNDGSCNHMTCA--VCGC 280 290 300 310 320 450 460 pF1KB0 EWCWNCGCEWNRVCMGDHWFDV :.:: : XP_011 EFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAM 330 340 350 360 370 380 >>XP_016868793 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (784 aa) initn: 192 init1: 89 opt: 249 Z-score: 249.8 bits: 56.3 E(85289): 3.6e-07 Smith-Waterman score: 249; 26.4% identity (54.6% similar) in 216 aa overlap (244-449:130-332) 220 230 240 250 260 270 pF1KB0 AHPTSDKETSVALHLIATNSRNITCITCTDVRSPV-LVFQCNSRHVICLDCFHLYCVTRL .. :. :. . ..: . : : :: : XP_016 EMCTDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCL 100 110 120 130 140 150 280 290 300 310 320 pF1KB0 NDRQFVHDPQLGYSLPCVAGCPNSLIK-ELHHFR-ILGEE-QYNRYQQYGAEE-CVLQMG ::... ... : .. ::. . . : .: ::... ...:... .. : . XP_016 --RQYLR-IEISESRVNIS-CPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPD 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB0 GVLCPRPGCGAGLLPE--PDQRKVTCEGGNGLGCGFAFCRECKEAYHEGE-CSAVFEASG :: : :: ... . :.:: : . ::: :: .::. .: .. :.:. . . XP_016 CRWCPAPDCGYAVIAFGCASCPKLTC-GRE--GCGTEFCYHCKQIWHPNQTCDAARQERA 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB0 TTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEK--NGGCMHMKCPQPQCRL . . . . .. .:. . :: ::::: . . : .:.: :: : : XP_016 QSLRLRTIRSSSISYSQESGAAADDIK----PCPRCAAYIIKMNDGSCNHMTCA--VCGC 280 290 300 310 320 450 460 pF1KB0 EWCWNCGCEWNRVCMGDHWFDV :.:: : XP_016 EFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAM 330 340 350 360 370 380 >>XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (838 aa) initn: 192 init1: 89 opt: 249 Z-score: 249.5 bits: 56.3 E(85289): 3.7e-07 Smith-Waterman score: 249; 26.4% identity (54.6% similar) in 216 aa overlap (244-449:130-332) 220 230 240 250 260 270 pF1KB0 AHPTSDKETSVALHLIATNSRNITCITCTDVRSPV-LVFQCNSRHVICLDCFHLYCVTRL .. :. :. . ..: . : : :: : XP_016 EMCTDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCL 100 110 120 130 140 150 280 290 300 310 320 pF1KB0 NDRQFVHDPQLGYSLPCVAGCPNSLIK-ELHHFR-ILGEE-QYNRYQQYGAEE-CVLQMG ::... ... : .. ::. . . : .: ::... ...:... .. : . XP_016 --RQYLR-IEISESRVNIS-CPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPD 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB0 GVLCPRPGCGAGLLPE--PDQRKVTCEGGNGLGCGFAFCRECKEAYHEGE-CSAVFEASG :: : :: ... . :.:: : . ::: :: .::. .: .. :.:. . . XP_016 CRWCPAPDCGYAVIAFGCASCPKLTC-GRE--GCGTEFCYHCKQIWHPNQTCDAARQERA 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB0 TTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEK--NGGCMHMKCPQPQCRL . . . . .. .:. . :: ::::: . . : .:.: :: : : XP_016 QSLRLRTIRSSSISYSQESGAAADDIK----PCPRCAAYIIKMNDGSCNHMTCA--VCGC 280 290 300 310 320 450 460 pF1KB0 EWCWNCGCEWNRVCMGDHWFDV :.:: : XP_016 EFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAM 330 340 350 360 370 380 >>XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (838 aa) initn: 192 init1: 89 opt: 249 Z-score: 249.5 bits: 56.3 E(85289): 3.7e-07 Smith-Waterman score: 249; 26.4% identity (54.6% similar) in 216 aa overlap (244-449:130-332) 220 230 240 250 260 270 pF1KB0 AHPTSDKETSVALHLIATNSRNITCITCTDVRSPV-LVFQCNSRHVICLDCFHLYCVTRL .. :. :. . ..: . : : :: : XP_005 EMCTDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCL 100 110 120 130 140 150 280 290 300 310 320 pF1KB0 NDRQFVHDPQLGYSLPCVAGCPNSLIK-ELHHFR-ILGEE-QYNRYQQYGAEE-CVLQMG ::... ... : .. ::. . . : .: ::... ...:... .. : . XP_005 --RQYLR-IEISESRVNIS-CPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPD 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB0 GVLCPRPGCGAGLLPE--PDQRKVTCEGGNGLGCGFAFCRECKEAYHEGE-CSAVFEASG :: : :: ... . :.:: : . ::: :: .::. .: .. :.:. . . XP_005 CRWCPAPDCGYAVIAFGCASCPKLTC-GRE--GCGTEFCYHCKQIWHPNQTCDAARQERA 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB0 TTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEK--NGGCMHMKCPQPQCRL . . . . .. .:. . :: ::::: . . : .:.: :: : : XP_005 QSLRLRTIRSSSISYSQESGAAADDIK----PCPRCAAYIIKMNDGSCNHMTCA--VCGC 280 290 300 310 320 450 460 pF1KB0 EWCWNCGCEWNRVCMGDHWFDV :.:: : XP_005 EFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAM 330 340 350 360 370 380 465 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:51:27 2016 done: Sat Nov 5 17:51:28 2016 Total Scan time: 9.440 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]