FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0408, 803 aa 1>>>pF1KB0408 803 - 803 aa - 803 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1905+/-0.000499; mu= 11.6607+/- 0.032 mean_var=376.6105+/-79.204, 0's: 0 Z-trim(119.9): 2030 B-trim: 160 in 2/55 Lambda= 0.066089 statistics sampled from 32215 (34503) to 32215 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.405), width: 16 Scan time: 12.040 The best scores are: opt bits E(85289) NP_003434 (OMIM: 604084) zinc finger and BTB domai ( 803) 5473 536.9 1.3e-151 NP_001274532 (OMIM: 604084) zinc finger and BTB do ( 810) 5449 534.6 6.3e-151 NP_001311066 (OMIM: 604084) zinc finger and BTB do ( 727) 4955 487.5 9e-137 NP_001274533 (OMIM: 604084) zinc finger and BTB do ( 727) 4955 487.5 9e-137 XP_011540387 (OMIM: 604084) PREDICTED: zinc finger ( 734) 4931 485.2 4.4e-136 XP_005246044 (OMIM: 604084) PREDICTED: zinc finger ( 734) 4931 485.2 4.4e-136 XP_011540390 (OMIM: 604084) PREDICTED: zinc finger ( 721) 4614 455.0 5.5e-127 NP_001229813 (OMIM: 604084) zinc finger and BTB do ( 721) 4614 455.0 5.5e-127 NP_001311067 (OMIM: 604084) zinc finger and BTB do ( 740) 4613 454.9 5.9e-127 XP_011540388 (OMIM: 604084) PREDICTED: zinc finger ( 728) 4590 452.7 2.7e-126 XP_016857731 (OMIM: 604084) PREDICTED: zinc finger ( 728) 4590 452.7 2.7e-126 XP_011540389 (OMIM: 604084) PREDICTED: zinc finger ( 728) 4590 452.7 2.7e-126 XP_005246043 (OMIM: 604084) PREDICTED: zinc finger ( 747) 4589 452.6 2.9e-126 XP_016882723 (OMIM: 603899) PREDICTED: zinc finger ( 518) 1208 130.0 2.6e-29 NP_001243102 (OMIM: 603899) zinc finger protein 85 ( 531) 1208 130.0 2.7e-29 XP_011526566 (OMIM: 603899) PREDICTED: zinc finger ( 536) 1208 130.0 2.7e-29 NP_003420 (OMIM: 603899) zinc finger protein 85 is ( 595) 1208 130.1 2.8e-29 NP_001243100 (OMIM: 603899) zinc finger protein 85 ( 625) 1208 130.1 2.9e-29 XP_011526565 (OMIM: 603899) PREDICTED: zinc finger ( 640) 1208 130.1 2.9e-29 NP_112495 (OMIM: 603975) zinc finger protein 93 [H ( 620) 1201 129.4 4.6e-29 NP_001276331 (OMIM: 604077) zinc finger protein 13 ( 616) 1196 129.0 6.4e-29 XP_016882731 (OMIM: 604077) PREDICTED: zinc finger ( 621) 1196 129.0 6.4e-29 XP_016882730 (OMIM: 604077) PREDICTED: zinc finger ( 628) 1196 129.0 6.4e-29 NP_001276330 (OMIM: 604077) zinc finger protein 13 ( 658) 1196 129.0 6.6e-29 XP_016882729 (OMIM: 604077) PREDICTED: zinc finger ( 658) 1196 129.0 6.6e-29 XP_006723426 (OMIM: 604077) PREDICTED: zinc finger ( 670) 1196 129.0 6.7e-29 NP_003427 (OMIM: 604077) zinc finger protein 135 i ( 670) 1196 129.0 6.7e-29 XP_005259268 (OMIM: 604077) PREDICTED: zinc finger ( 670) 1196 129.0 6.7e-29 XP_006723425 (OMIM: 604077) PREDICTED: zinc finger ( 670) 1196 129.0 6.7e-29 NP_009065 (OMIM: 604077) zinc finger protein 135 i ( 682) 1196 129.0 6.7e-29 XP_011526007 (OMIM: 603980) PREDICTED: zinc finger ( 531) 1185 127.8 1.2e-28 NP_001092096 (OMIM: 603980) zinc finger protein 98 ( 572) 1185 127.9 1.3e-28 NP_001243580 (OMIM: 603972) zinc finger protein 43 ( 744) 1184 127.9 1.6e-28 NP_001243583 (OMIM: 603972) zinc finger protein 43 ( 744) 1184 127.9 1.6e-28 NP_001243577 (OMIM: 603972) zinc finger protein 43 ( 803) 1184 128.0 1.6e-28 XP_016882704 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882699 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882705 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 NP_001243579 (OMIM: 603972) zinc finger protein 43 ( 803) 1184 128.0 1.6e-28 XP_016882703 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 NP_001243578 (OMIM: 603972) zinc finger protein 43 ( 803) 1184 128.0 1.6e-28 XP_016882697 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_011526561 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882696 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_011526559 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882700 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882698 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882702 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 XP_016882701 (OMIM: 603972) PREDICTED: zinc finger ( 803) 1184 128.0 1.6e-28 NP_003414 (OMIM: 603972) zinc finger protein 43 is ( 809) 1184 128.0 1.6e-28 >>NP_003434 (OMIM: 604084) zinc finger and BTB domain-co (803 aa) initn: 5473 init1: 5473 opt: 5473 Z-score: 2843.0 bits: 536.9 E(85289): 1.3e-151 Smith-Waterman score: 5473; 100.0% identity (100.0% similar) in 803 aa overlap (1-803:1-803) 10 20 30 40 50 60 pF1KB0 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 HLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 PGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 EEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 DYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 KQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 LSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 DMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 SCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRD 730 740 750 760 770 780 790 800 pF1KB0 GAEGQPALAETSPTAPECPPPAE ::::::::::::::::::::::: NP_003 GAEGQPALAETSPTAPECPPPAE 790 800 >>NP_001274532 (OMIM: 604084) zinc finger and BTB domain (810 aa) initn: 5459 init1: 4631 opt: 5449 Z-score: 2830.6 bits: 534.6 E(85289): 6.3e-151 Smith-Waterman score: 5449; 99.1% identity (99.1% similar) in 810 aa overlap (1-803:1-810) 10 20 30 40 50 60 pF1KB0 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 HLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 PGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 EEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 DYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 KQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 LSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVD 610 620 630 640 650 660 670 680 690 700 710 pF1KB0 DMVTLATEALAATAVTQLT-------VVPVGAAVTADETEVLKAEISKAVKQVQEEDPNT ::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 DMVTLATEALAATAVTQLTGPATLPAVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNT 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB0 HILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGE 730 740 750 760 770 780 780 790 800 pF1KB0 LVFRPRDGAEGQPALAETSPTAPECPPPAE :::::::::::::::::::::::::::::: NP_001 LVFRPRDGAEGQPALAETSPTAPECPPPAE 790 800 810 >>NP_001311066 (OMIM: 604084) zinc finger and BTB domain (727 aa) initn: 4955 init1: 4955 opt: 4955 Z-score: 2576.5 bits: 487.5 E(85289): 9e-137 Smith-Waterman score: 4955; 100.0% identity (100.0% similar) in 727 aa overlap (77-803:1-727) 50 60 70 80 90 100 pF1KB0 EYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIIT :::::::::::::::::::::::::::::: NP_001 MYTAKLSLSPENVDDVLAVATFLQMQDIIT 10 20 30 110 120 130 140 150 160 pF1KB0 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB0 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB0 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB0 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB0 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB0 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB0 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB0 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB0 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB0 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQV 580 590 600 610 620 630 710 720 730 740 750 760 pF1KB0 QEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAG 640 650 660 670 680 690 770 780 790 800 pF1KB0 QVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE ::::::::::::::::::::::::::::::::::::: NP_001 QVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 700 710 720 >>NP_001274533 (OMIM: 604084) zinc finger and BTB domain (727 aa) initn: 4955 init1: 4955 opt: 4955 Z-score: 2576.5 bits: 487.5 E(85289): 9e-137 Smith-Waterman score: 4955; 100.0% identity (100.0% similar) in 727 aa overlap (77-803:1-727) 50 60 70 80 90 100 pF1KB0 EYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIIT :::::::::::::::::::::::::::::: NP_001 MYTAKLSLSPENVDDVLAVATFLQMQDIIT 10 20 30 110 120 130 140 150 160 pF1KB0 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB0 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB0 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB0 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB0 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB0 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB0 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB0 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB0 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB0 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQV 580 590 600 610 620 630 710 720 730 740 750 760 pF1KB0 QEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAG 640 650 660 670 680 690 770 780 790 800 pF1KB0 QVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE ::::::::::::::::::::::::::::::::::::: NP_001 QVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 700 710 720 >>XP_011540387 (OMIM: 604084) PREDICTED: zinc finger and (734 aa) initn: 4941 init1: 4113 opt: 4931 Z-score: 2564.1 bits: 485.2 E(85289): 4.4e-136 Smith-Waterman score: 4931; 99.0% identity (99.0% similar) in 734 aa overlap (77-803:1-734) 50 60 70 80 90 100 pF1KB0 EYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIIT :::::::::::::::::::::::::::::: XP_011 MYTAKLSLSPENVDDVLAVATFLQMQDIIT 10 20 30 110 120 130 140 150 160 pF1KB0 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB0 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB0 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB0 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB0 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB0 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB0 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB0 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB0 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL 520 530 540 550 560 570 650 660 670 680 690 pF1KB0 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLT-------VVPVGAAVTADETEVLKAEI ::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_011 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLTGPATLPAVVPVGAAVTADETEVLKAEI 580 590 600 610 620 630 700 710 720 730 740 750 pF1KB0 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP 640 650 660 670 680 690 760 770 780 790 800 pF1KB0 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE :::::::::::::::::::::::::::::::::::::::::::: XP_011 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 700 710 720 730 >>XP_005246044 (OMIM: 604084) PREDICTED: zinc finger and (734 aa) initn: 4941 init1: 4113 opt: 4931 Z-score: 2564.1 bits: 485.2 E(85289): 4.4e-136 Smith-Waterman score: 4931; 99.0% identity (99.0% similar) in 734 aa overlap (77-803:1-734) 50 60 70 80 90 100 pF1KB0 EYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIIT :::::::::::::::::::::::::::::: XP_005 MYTAKLSLSPENVDDVLAVATFLQMQDIIT 10 20 30 110 120 130 140 150 160 pF1KB0 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB0 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB0 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB0 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDP 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB0 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLK 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB0 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLK 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB0 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTG 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB0 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPH 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB0 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKIL 520 530 540 550 560 570 650 660 670 680 690 pF1KB0 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLT-------VVPVGAAVTADETEVLKAEI ::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_005 EPEEGSEVSVVTVDDMVTLATEALAATAVTQLTGPATLPAVVPVGAAVTADETEVLKAEI 580 590 600 610 620 630 700 710 720 730 740 750 pF1KB0 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP 640 650 660 670 680 690 760 770 780 790 800 pF1KB0 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE :::::::::::::::::::::::::::::::::::::::::::: XP_005 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 700 710 720 730 >>XP_011540390 (OMIM: 604084) PREDICTED: zinc finger and (721 aa) initn: 4614 init1: 4614 opt: 4614 Z-score: 2400.8 bits: 455.0 E(85289): 5.5e-127 Smith-Waterman score: 4614; 99.7% identity (99.9% similar) in 674 aa overlap (130-803:48-721) 100 110 120 130 140 150 pF1KB0 QMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPI . :::::::::::::::::::::::::::: XP_011 PAMPSSHLLSRLPALGEMRRPWPQKVCPVPSPGGDKRAKEEKVATSTLSRLEQAGRSTPI 20 30 40 50 60 70 160 170 180 190 200 210 pF1KB0 GPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSE 80 90 100 110 120 130 220 230 240 250 260 270 pF1KB0 QEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQE 140 150 160 170 180 190 280 290 300 310 320 330 pF1KB0 LGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC 200 210 220 230 240 250 340 350 360 370 380 390 pF1KB0 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLF 260 270 280 290 300 310 400 410 420 430 440 450 pF1KB0 TTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG 320 330 340 350 360 370 460 470 480 490 500 510 pF1KB0 NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQR 380 390 400 410 420 430 520 530 540 550 560 570 pF1KB0 HVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRH 440 450 460 470 480 490 580 590 600 610 620 630 pF1KB0 HDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQG 500 510 520 530 540 550 640 650 660 670 680 690 pF1KB0 KAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEI 560 570 580 590 600 610 700 710 720 730 740 750 pF1KB0 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP 620 630 640 650 660 670 760 770 780 790 800 pF1KB0 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE :::::::::::::::::::::::::::::::::::::::::::: XP_011 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 680 690 700 710 720 >>NP_001229813 (OMIM: 604084) zinc finger and BTB domain (721 aa) initn: 4614 init1: 4614 opt: 4614 Z-score: 2400.8 bits: 455.0 E(85289): 5.5e-127 Smith-Waterman score: 4614; 99.7% identity (99.9% similar) in 674 aa overlap (130-803:48-721) 100 110 120 130 140 150 pF1KB0 QMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPI . :::::::::::::::::::::::::::: NP_001 PAMPSSHLLSRLPALGEMRRPWPQKVCPVPSPGGDKRAKEEKVATSTLSRLEQAGRSTPI 20 30 40 50 60 70 160 170 180 190 200 210 pF1KB0 GPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSE 80 90 100 110 120 130 220 230 240 250 260 270 pF1KB0 QEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQE 140 150 160 170 180 190 280 290 300 310 320 330 pF1KB0 LGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC 200 210 220 230 240 250 340 350 360 370 380 390 pF1KB0 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLF 260 270 280 290 300 310 400 410 420 430 440 450 pF1KB0 TTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG 320 330 340 350 360 370 460 470 480 490 500 510 pF1KB0 NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQR 380 390 400 410 420 430 520 530 540 550 560 570 pF1KB0 HVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRH 440 450 460 470 480 490 580 590 600 610 620 630 pF1KB0 HDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQG 500 510 520 530 540 550 640 650 660 670 680 690 pF1KB0 KAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEI 560 570 580 590 600 610 700 710 720 730 740 750 pF1KB0 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGP 620 630 640 650 660 670 760 770 780 790 800 pF1KB0 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE :::::::::::::::::::::::::::::::::::::::::::: NP_001 GGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 680 690 700 710 720 >>NP_001311067 (OMIM: 604084) zinc finger and BTB domain (740 aa) initn: 4613 init1: 4613 opt: 4613 Z-score: 2400.2 bits: 454.9 E(85289): 5.9e-127 Smith-Waterman score: 4943; 92.2% identity (92.2% similar) in 803 aa overlap (1-803:1-740) 10 20 30 40 50 60 pF1KB0 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 HLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATS ::::::::: NP_001 HLDISNAAG--------------------------------------------------- 130 140 150 160 170 180 pF1KB0 PGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------------GDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA 70 80 90 100 110 190 200 210 220 230 240 pF1KB0 EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQ 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB0 EEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKA 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB0 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB0 PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQC 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB0 DYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECG 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB0 KQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT 420 430 440 450 460 470 550 560 570 580 590 600 pF1KB0 QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGD 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB0 LSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVD 540 550 560 570 580 590 670 680 690 700 710 720 pF1KB0 DMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACD 600 610 620 630 640 650 730 740 750 760 770 780 pF1KB0 SCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRD 660 670 680 690 700 710 790 800 pF1KB0 GAEGQPALAETSPTAPECPPPAE ::::::::::::::::::::::: NP_001 GAEGQPALAETSPTAPECPPPAE 720 730 740 >>XP_011540388 (OMIM: 604084) PREDICTED: zinc finger and (728 aa) initn: 4600 init1: 3772 opt: 4590 Z-score: 2388.4 bits: 452.7 E(85289): 2.7e-126 Smith-Waterman score: 4590; 98.7% identity (98.8% similar) in 681 aa overlap (130-803:48-728) 100 110 120 130 140 150 pF1KB0 QMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPI . :::::::::::::::::::::::::::: XP_011 PAMPSSHLLSRLPALGEMRRPWPQKVCPVPSPGGDKRAKEEKVATSTLSRLEQAGRSTPI 20 30 40 50 60 70 160 170 180 190 200 210 pF1KB0 GPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSE 80 90 100 110 120 130 220 230 240 250 260 270 pF1KB0 QEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQE 140 150 160 170 180 190 280 290 300 310 320 330 pF1KB0 LGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC 200 210 220 230 240 250 340 350 360 370 380 390 pF1KB0 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLF 260 270 280 290 300 310 400 410 420 430 440 450 pF1KB0 TTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVG 320 330 340 350 360 370 460 470 480 490 500 510 pF1KB0 NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQR 380 390 400 410 420 430 520 530 540 550 560 570 pF1KB0 HVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRH 440 450 460 470 480 490 580 590 600 610 620 630 pF1KB0 HDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQG 500 510 520 530 540 550 640 650 660 670 680 690 pF1KB0 KAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLT-------VVPVGAAVTADET :::::::::::::::::::::::::::::::::::::::: ::::::::::::: XP_011 KAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTGPATLPAVVPVGAAVTADET 560 570 580 590 600 610 700 710 720 730 740 750 pF1KB0 EVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDAD 620 630 640 650 660 670 760 770 780 790 800 pF1KB0 FYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE 680 690 700 710 720 803 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:51:21 2016 done: Sat Nov 5 11:51:23 2016 Total Scan time: 12.040 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]