Result of FASTA (omim) for
pF1KB0409
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0409, 466 aa
1>>>pF1KB0409 466 - 466 aa - 466 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3021+/-0.000483; mu= 12.7410+/- 0.029
mean_var=188.3443+/-37.135, 0's: 0 Z-trim(115.1): 449 B-trim: 77 in 1/54
Lambda= 0.093454
statistics sampled from 24765 (25377) to 24765 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.298), width: 16
Scan time: 9.060
The best scores are: opt bits E(85289)
NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 3294 457.5 3.6e-128
NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 2992 416.7 6.2e-116
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 2578 360.8 3.6e-99
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 2272 319.5 9.3e-87
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 2272 319.7 1e-86
XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 2272 319.7 1.1e-86
XP_006720026 (OMIM: 227500,608446,613878) PREDICTE ( 412) 1948 275.9 1.4e-73
NP_001299603 (OMIM: 227600,613872) coagulation fac ( 444) 784 119.0 2.6e-26
NP_001300842 (OMIM: 122700,300746,300807,306900) c ( 423) 689 106.2 1.8e-22
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 687 106.0 2.3e-22
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 687 106.0 2.3e-22
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 687 106.1 2.5e-22
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 635 99.0 3.1e-20
NP_001299604 (OMIM: 227600,613872) coagulation fac ( 332) 618 96.5 1.2e-19
NP_000495 (OMIM: 227600,613872) coagulation factor ( 488) 618 96.7 1.5e-19
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 621 97.4 1.5e-19
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 621 97.4 1.5e-19
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 600 94.2 7.5e-19
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 600 94.2 7.5e-19
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 600 94.5 9.4e-19
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 600 94.5 9.4e-19
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 600 94.5 9.4e-19
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 594 93.3 1.1e-18
NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 592 93.2 1.6e-18
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 590 93.1 2.4e-18
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 589 92.9 2.5e-18
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 582 91.9 4.5e-18
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 582 92.0 5e-18
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 567 90.3 2.7e-17
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 567 90.3 2.7e-17
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 567 90.3 2.7e-17
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 567 90.3 2.7e-17
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 567 90.3 2.8e-17
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 567 90.3 2.8e-17
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 567 90.3 2.8e-17
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 562 89.4 3.4e-17
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 557 88.8 6.2e-17
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 547 87.0 9.8e-17
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 553 88.4 1e-16
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 553 88.4 1e-16
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 547 87.1 1.1e-16
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 548 87.4 1.1e-16
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 547 87.2 1.1e-16
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 547 87.2 1.1e-16
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 544 86.5 1.2e-16
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 544 86.5 1.2e-16
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 547 87.2 1.2e-16
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 541 86.5 2.3e-16
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 541 86.5 2.3e-16
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 541 86.5 2.3e-16
>>NP_000122 (OMIM: 227500,608446,613878) coagulation fac (466 aa)
initn: 3294 init1: 3294 opt: 3294 Z-score: 2422.2 bits: 457.5 E(85289): 3.6e-128
Smith-Waterman score: 3294; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466)
10 20 30 40 50 60
pF1KB0 MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
370 380 390 400 410 420
430 440 450 460
pF1KB0 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
430 440 450 460
>>NP_062562 (OMIM: 227500,608446,613878) coagulation fac (444 aa)
initn: 3113 init1: 2992 opt: 2992 Z-score: 2202.3 bits: 416.7 E(85289): 6.2e-116
Smith-Waterman score: 3073; 95.3% identity (95.3% similar) in 466 aa overlap (1-466:1-444)
10 20 30 40 50 60
pF1KB0 MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
::::::::::::::::::::: :::::::::::::::::
NP_062 MVSQALRLLCLLLGLQGCLAA----------------------VFVTQEEAHGVLHRRRR
10 20 30
70 80 90 100 110 120
pF1KB0 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB0 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB0 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB0 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB0 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB0 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
340 350 360 370 380 390
430 440 450 460
pF1KB0 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
::::::::::::::::::::::::::::::::::::::::::::::
NP_062 IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
400 410 420 430 440
>>NP_001254483 (OMIM: 227500,608446,613878) coagulation (382 aa)
initn: 2578 init1: 2578 opt: 2578 Z-score: 1901.3 bits: 360.8 E(85289): 3.6e-99
Smith-Waterman score: 2578; 99.7% identity (100.0% similar) in 362 aa overlap (105-466:21-382)
80 90 100 110 120 130
pF1KB0 RECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLP
.:::::::::::::::::::::::::::::
NP_001 MVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLP
10 20 30 40 50
140 150 160 170 180 190
pF1KB0 AFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYP
60 70 80 90 100 110
200 210 220 230 240 250
pF1KB0 CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHC
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB0 FDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVL
180 190 200 210 220 230
320 330 340 350 360 370
pF1KB0 TDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQS
240 250 260 270 280 290
380 390 400 410 420 430
pF1KB0 RKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHF
300 310 320 330 340 350
440 450 460
pF1KB0 GVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
::::::::::::::::::::::::::::::::
NP_001 GVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
360 370 380
>>XP_011535778 (OMIM: 227500,608446,613878) PREDICTED: c (364 aa)
initn: 2272 init1: 2272 opt: 2272 Z-score: 1678.6 bits: 319.5 E(85289): 9.3e-87
Smith-Waterman score: 2272; 100.0% identity (100.0% similar) in 322 aa overlap (145-466:43-364)
120 130 140 150 160 170
pF1KB0 CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRC
::::::::::::::::::::::::::::::
XP_011 RRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQLICVNENGGCEQYCSDHTGTKRSCRC
20 30 40 50 60 70
180 190 200 210 220 230
pF1KB0 HEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNG
80 90 100 110 120 130
240 250 260 270 280 290
pF1KB0 AQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTY
140 150 160 170 180 190
300 310 320 330 340 350
pF1KB0 VPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATA
200 210 220 230 240 250
360 370 380 390 400 410
pF1KB0 LELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRG
260 270 280 290 300 310
420 430 440 450 460
pF1KB0 TWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
320 330 340 350 360
>>XP_011535777 (OMIM: 227500,608446,613878) PREDICTED: c (433 aa)
initn: 2685 init1: 2272 opt: 2272 Z-score: 1677.8 bits: 319.7 E(85289): 1e-86
Smith-Waterman score: 2487; 90.5% identity (91.0% similar) in 398 aa overlap (105-466:36-433)
80 90 100 110 120 130
pF1KB0 RECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLP
.:::::::::::::::::::::::::::::
XP_011 RQGQHCRDFIMVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLP
10 20 30 40 50 60
140 150
pF1KB0 AFEGRNCETH------------------------------------KDDQLICVNENGGC
:::::::::. ::::::::::::::
XP_011 AFEGRNCETQESPASWRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQLICVNENGGC
70 80 90 100 110 120
160 170 180 190 200 210
pF1KB0 EQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKV
130 140 150 160 170 180
220 230 240 250 260 270
pF1KB0 CPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDG
190 200 210 220 230 240
280 290 300 310 320 330
pF1KB0 DEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRF
250 260 270 280 290 300
340 350 360 370 380 390
pF1KB0 SLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKD
310 320 330 340 350 360
400 410 420 430 440 450
pF1KB0 SCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPG
370 380 390 400 410 420
460
pF1KB0 VLLRAPFP
::::::::
XP_011 VLLRAPFP
430
>>XP_011535776 (OMIM: 227500,608446,613878) PREDICTED: c (495 aa)
initn: 3091 init1: 2272 opt: 2272 Z-score: 1677.2 bits: 319.7 E(85289): 1.1e-86
Smith-Waterman score: 2982; 88.2% identity (88.4% similar) in 502 aa overlap (1-466:16-495)
10 20 30 40
pF1KB0 MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVF
::::::::::::::::::::: ::
XP_011 MGNVNRQGQHCRDFIMVSQALRLLCLLLGLQGCLAA----------------------VF
10 20 30
50 60 70 80 90 100
pF1KB0 VTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYS
40 50 60 70 80 90
110 120 130 140
pF1KB0 DGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETH---------------------
::::::::::::::::::::::::::::::::::::::.
XP_011 DGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETQESPASWRRLKREASCWSSGSR
100 110 120 130 140 150
150 160 170 180
pF1KB0 ---------------KDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTP
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGDLCSALVPSSPDKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTP
160 170 180 190 200 210
190 200 210 220 230 240
pF1KB0 TVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVV
220 230 240 250 260 270
250 260 270 280 290 300
pF1KB0 SAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLH
280 290 300 310 320 330
310 320 330 340 350 360
pF1KB0 QPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQD
340 350 360 370 380 390
370 380 390 400 410 420
pF1KB0 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA
400 410 420 430 440 450
430 440 450 460
pF1KB0 TVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
:::::::::::::::::::::::::::::::::::::
XP_011 TVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
460 470 480 490
>>XP_006720026 (OMIM: 227500,608446,613878) PREDICTED: c (412 aa)
initn: 2051 init1: 1930 opt: 1948 Z-score: 1441.9 bits: 275.9 E(85289): 1.4e-73
Smith-Waterman score: 2612; 85.0% identity (85.2% similar) in 466 aa overlap (1-466:16-412)
10 20 30 40
pF1KB0 MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVF
::::::::::::::::::::: ::
XP_006 MGNVNRQGQHCRDFIMVSQALRLLCLLLGLQGCLAA----------------------VF
10 20 30
50 60 70 80 90 100
pF1KB0 VTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYS
40 50 60 70 80 90
110 120 130 140 150 160
pF1KB0 DGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDH
::::::::::::::::::::::::::::::::::::::
XP_006 DGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCET----------------------
100 110 120 130
170 180 190 200 210 220
pF1KB0 TGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECP
.::::::::::::::::::::::::::::::::::
XP_006 -------------------------LEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECP
140 150 160 170
230 240 250 260 270 280
pF1KB0 WQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRV
180 190 200 210 220 230
290 300 310 320 330 340
pF1KB0 AQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWG
240 250 260 270 280 290
350 360 370 380 390 400
pF1KB0 QLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSG
300 310 320 330 340 350
410 420 430 440 450 460
pF1KB0 GPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPF
360 370 380 390 400 410
pF1KB0 P
:
XP_006 P
>>NP_001299603 (OMIM: 227600,613872) coagulation factor (444 aa)
initn: 1176 init1: 455 opt: 784 Z-score: 593.4 bits: 119.0 E(85289): 2.6e-26
Smith-Waterman score: 1099; 39.1% identity (68.8% similar) in 430 aa overlap (44-464:24-435)
20 30 40 50 60 70
pF1KB0 GLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSL
.:. .:.:...: : :::.::::.. : :
NP_001 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHL
10 20 30 40 50
80 90 100 110 120 130
pF1KB0 ERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCL
:::: :: ::.:::::.:.:...:. :: .:.::::: .::::: :.::: : : : ::
NP_001 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL
60 70 80 90 100 110
140 150 160 170 180 190
pF1KB0 PAFEGRNCET--HKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTV
.:::.::: . . .. . : :. .: . . : :... ::
NP_001 EGFEGKNCELWPYPCGKQTLERRKRSVAQATSS-SGEAPDSITWKPY----DAADLDPT-
120 130 140 150 160
200 210 220 230 240
pF1KB0 EYPCGKIPILEKRNASKPQ-G-----RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLIN
: : . . : ..:. : :::::. : ::::::.::. . . .::::...
NP_001 ENPFDLLDF----NQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILS
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB0 TIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIA
.....::::. . : .. . .:... ...: : ..: :: . .. : . :::
NP_001 EFYILTAAHCLYQAKRFK---VRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB0 LLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPR
.:::. :... .:.: ::::: ..: :: . ..:::.:. ..: . .: .:.::
NP_001 VLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB0 LMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSW
. ..: :...: ::. ::::::. ..:.:.:::::::.:... :...::::::
NP_001 VDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSW
350 360 370 380 390
430 440 450 460
pF1KB0 GQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
:.::: :..:.::.:. ...:... :... : . .::
NP_001 GEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
400 410 420 430 440
>>NP_001300842 (OMIM: 122700,300746,300807,306900) coagu (423 aa)
initn: 1021 init1: 310 opt: 689 Z-score: 524.4 bits: 106.2 E(85289): 1.8e-22
Smith-Waterman score: 932; 36.0% identity (60.1% similar) in 444 aa overlap (44-449:30-418)
20 30 40 50 60 70
pF1KB0 GLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAF-LEELRPGS
::. .:.:. .:.: .: :. :::. :.
NP_001 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGN
10 20 30 40 50
80 90 100 110 120 130
pF1KB0 LERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFC
::::: ::.::::::::.:...::: :: .: :
NP_001 LERECMEEKCSFEEAREVFENTERTTEFWKQYVD--------------------------
60 70 80 90
140 150 160 170 180 190
pF1KB0 LPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVE
. : .:: :::.:.. . .: : : ::: : . :: :.:
NP_001 ----------------VTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVP
100 110 120 130
200 210 220
pF1KB0 YPCGKI---------------PILEKRNASKPQG----------------RIVGGKVCPK
.:::.. : .. :... . :.:::.
NP_001 FPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKP
140 150 160 170 180 190
230 240 250 260 270
pF1KB0 GECPWQVLLLVNGA--QLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGD
:. ::::.: :: .:::...: :.:.:::: ... .. .: :::.. : .
NP_001 GQFPWQVVL--NGKVDAFCGGSIVNEKWIVTAAHC---VETGVKITVVAGEHNIEETEHT
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB0 EQSRRVAQVIIPSTYVPGTT--NHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVR
::.: : ..: .: . . :::::::.: .:.::...:.:.:. .. : : :..
NP_001 EQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADK---EYTNIFLK
260 270 280 290 300
340 350 360 370 380 390
pF1KB0 FS--LVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDG
:. :::::... .: .:: :. : :: . ::.... . : . :::::. .:
NP_001 FGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFT-----IYNNMFCAGFHEG
310 320 330 340 350 360
400 410 420 430 440 450
pF1KB0 SKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEP
..:::.:::::::.:. .:: .::::.:::. :: :..:.::.::.:..:...
NP_001 GRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
370 380 390 400 410 420
460
pF1KB0 RPGVLLRAPFP
>>NP_000303 (OMIM: 176860,612283,612304) vitamin K-depen (461 aa)
initn: 920 init1: 290 opt: 687 Z-score: 522.6 bits: 106.0 E(85289): 2.3e-22
Smith-Waterman score: 1110; 40.0% identity (67.6% similar) in 447 aa overlap (39-457:20-455)
10 20 30 40 50 60
pF1KB0 LCLLLGLQGCLAAGGVAKASGGETRDMPWKPGP-HRVFVTQEEAHGVLHRRRRANAFLEE
:.: :: ..:.:: ::. :.:::.::::
NP_000 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEE
10 20 30 40
70 80 90 100 110
pF1KB0 LRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSP--------CQNGG
:: .:::::: :: :.::::.:::.... : :: .. ::::: : : . :
NP_000 LRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHG
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB0 SCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYS
.: : . :. : : ..::: :. .. . : : .:::: .:: ...: .: : : ::.
NP_000 TCIDGIGSFSCDCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYK
110 120 130 140 150 160
180 190 200 210 220
pF1KB0 LLADGVSCTPTVEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQ
: : ..: :.:..:::. : .::. . .. : :.. ::. .:. :::
NP_000 LGDDLLQCHPAVKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQ
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB0 VLLLVNGAQL-CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVA
:.:: . .: ::..::. ::..::::.:. :. :.. :::.:: . . : . .
NP_000 VVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIK
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB0 QVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWG
.:.. .: .::..:::::.: ::..:.. .::.:::. ..:: : . . .::.:::
NP_000 EVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB0 QLLDRGATALE--LMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSC
.: : . .::: .: . ..: . : ..: :.::: .:.:
NP_000 YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDAC
350 360 370 380 390
410 420 430 440 450 460
pF1KB0 KGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVL
.:::::: .. ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. :
NP_000 EGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKS
400 410 420 430 440 450
pF1KB0 LRAPFP
NP_000 WAP
460
466 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:02:39 2016 done: Sat Nov 5 18:02:40 2016
Total Scan time: 9.060 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]