FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0413, 467 aa 1>>>pF1KB0413 467 - 467 aa - 467 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2544+/-0.000725; mu= 18.6898+/- 0.044 mean_var=82.1255+/-15.994, 0's: 0 Z-trim(111.3): 39 B-trim: 57 in 2/49 Lambda= 0.141526 statistics sampled from 12269 (12307) to 12269 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.378), width: 16 Scan time: 3.270 The best scores are: opt bits E(32554) CCDS343.1 TINAGL1 gene_id:64129|Hs108|chr1 ( 467) 3459 715.8 2.3e-206 CCDS72745.1 TINAGL1 gene_id:64129|Hs108|chr1 ( 362) 2638 548.1 5.6e-156 CCDS55586.1 TINAGL1 gene_id:64129|Hs108|chr1 ( 436) 2245 467.9 9.2e-132 CCDS4955.1 TINAG gene_id:27283|Hs108|chr6 ( 476) 1525 320.9 1.8e-87 CCDS5986.1 CTSB gene_id:1508|Hs108|chr8 ( 339) 412 93.6 3.5e-19 CCDS8282.1 CTSC gene_id:1075|Hs108|chr11 ( 463) 277 66.1 8.8e-11 >>CCDS343.1 TINAGL1 gene_id:64129|Hs108|chr1 (467 aa) initn: 3459 init1: 3459 opt: 3459 Z-score: 3818.2 bits: 715.8 E(32554): 2.3e-206 Smith-Waterman score: 3459; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467) 10 20 30 40 50 60 pF1KB0 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY 370 380 390 400 410 420 430 440 450 460 pF1KB0 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH ::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH 430 440 450 460 >>CCDS72745.1 TINAGL1 gene_id:64129|Hs108|chr1 (362 aa) initn: 2638 init1: 2638 opt: 2638 Z-score: 2913.8 bits: 548.1 E(32554): 5.6e-156 Smith-Waterman score: 2638; 100.0% identity (100.0% similar) in 362 aa overlap (106-467:1-362) 80 90 100 110 120 130 pF1KB0 FCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQC :::::::::::::::::::::::::::::: CCDS72 MHGGRIYPVLGTYWDNCNRCTCQENRQWQC 10 20 30 140 150 160 170 180 190 pF1KB0 DQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 DQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYT 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB0 VLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 VLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLS 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB0 PQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 PQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRA 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB0 MGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 MGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB0 YKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 YKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERG 280 290 300 310 320 330 440 450 460 pF1KB0 HFRIVRGVNECDIESFVLGVWGRVGMEDMGHH :::::::::::::::::::::::::::::::: CCDS72 HFRIVRGVNECDIESFVLGVWGRVGMEDMGHH 340 350 360 >>CCDS55586.1 TINAGL1 gene_id:64129|Hs108|chr1 (436 aa) initn: 2237 init1: 2237 opt: 2245 Z-score: 2479.0 bits: 467.9 E(32554): 9.2e-132 Smith-Waterman score: 3147; 93.4% identity (93.4% similar) in 467 aa overlap (1-467:1-436) 10 20 30 40 50 60 pF1KB0 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT ::::: :::::::::::::::::::::::: CCDS55 NCNRC-------------------------------WQAGNHSAFWGMTLDEGIRYRLGT 130 140 190 200 210 220 230 240 pF1KB0 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB0 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB0 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB0 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY 330 340 350 360 370 380 430 440 450 460 pF1KB0 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH ::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH 390 400 410 420 430 >>CCDS4955.1 TINAG gene_id:27283|Hs108|chr6 (476 aa) initn: 1451 init1: 664 opt: 1525 Z-score: 1684.0 bits: 320.9 E(32554): 1.8e-87 Smith-Waterman score: 1525; 49.4% identity (73.5% similar) in 427 aa overlap (45-463:54-474) 20 30 40 50 60 70 pF1KB0 AGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGA--ICY :.::.. ::. : : :. . .: .:: CCDS49 LSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFG-CCEDRDDGCVTEFYAANALCY 30 40 50 60 70 80 80 90 100 110 120 pF1KB0 CDLFCNRTVSDCCPDFWDFCLGV---PP---PFPPIQGCMHGGRIYPVLGTYWDNCNRCT :: ::.: ::::::. .:: :: :. : .::.. :. : .. .::: :: CCDS49 CDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYP-EGCFKDGQHYEEGSVIKENCNSCT 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB0 CQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS :. ..::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. :: CCDS49 CS-GQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPM 150 160 170 180 190 200 190 200 210 220 230 240 pF1KB0 VMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHS ...:.:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.: CCDS49 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS 210 220 230 240 250 260 250 260 270 280 290 300 pF1KB0 LGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPA :..: ::::::.:: .....:: .: .: :::.::.::.:: :::. .:. . CCDS49 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPL---FKDQNATN 270 280 290 300 310 310 320 330 340 350 360 pF1KB0 PPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQAL : : ::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::. CCDS49 NGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAI 320 330 340 350 360 370 370 380 390 400 410 420 pF1KB0 MEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANS :.:.:::: :: ::: :. . . :.::. ::.::.:::: .:. :.: :::: CCDS49 MQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANS 380 390 400 410 420 430 430 440 450 460 pF1KB0 WGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH :: .::: :.:::.::::: :::......::.. : CCDS49 WGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 440 450 460 470 >>CCDS5986.1 CTSB gene_id:1508|Hs108|chr8 (339 aa) initn: 510 init1: 144 opt: 412 Z-score: 457.8 bits: 93.6 E(32554): 3.5e-19 Smith-Waterman score: 583; 33.0% identity (59.3% similar) in 327 aa overlap (145-453:29-326) 120 130 140 150 160 170 pF1KB0 LGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGI .... .:. : ::::.. :... .. CCDS59 MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHN--FYNVDMSYLK 10 20 30 40 50 180 190 200 210 220 pF1KB0 RY---RLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPN--LIHEPLDQGNCAGS : :: .: . :: ... ::..:.: :.::. :.: :::.:.. CCDS59 RLCGTFLGGPKPPQRVMFTEDLK--------LPASFDAREQWPQCPTIKEIRDQGSCGSC 60 70 80 90 100 230 240 250 260 270 280 pF1KB0 WAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSC-DTHQQQGCRGGRLDGAWWFLRRRGVV :::... . :::. ::. .:.. .: ..::.: . .:: :: :: : :.:.: CCDS59 WAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLV 110 120 130 140 150 160 290 300 310 320 330 pF1KB0 S-----DH--CYPFS--GRERDEAGPAPPCMMHSRAMGRGKRQATAH-CPNSY--VNNND : .: : :.: :. : ::: :.: .. : .: . ..: CCDS59 SGGLYESHVGCRPYSIPPCEHHVNGSRPPCT------GEGDTPKCSKICEPGYSPTYKQD 170 180 190 200 210 220 340 350 360 370 380 390 pF1KB0 IYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRR . : .....:.:: :...::::.. . :. ::.:::.:.:.:. . CCDS59 KHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEM-------- 230 240 250 260 270 400 410 420 430 440 450 pF1KB0 HGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVW : :...: ::: : .: :: .::::. ::. : :.:.:: ..: ::: :. CCDS59 MGGHAIRILGWGVE---NGT--PYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGI 280 290 300 310 320 460 pF1KB0 GRVGMEDMGHH CCDS59 PRTDQYWEKI 330 >>CCDS8282.1 CTSC gene_id:1075|Hs108|chr11 (463 aa) initn: 395 init1: 161 opt: 277 Z-score: 307.0 bits: 66.1 E(32554): 8.8e-11 Smith-Waterman score: 460; 29.6% identity (58.2% similar) in 318 aa overlap (143-453:171-455) 120 130 140 150 160 170 pF1KB0 PVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDE : ...:::: . .: : .. . .:: . CCDS82 KVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGD 150 160 170 180 190 200 180 190 200 210 220 pF1KB0 GIRYRLG----TIRPSSSVMNMHEIYTVLNPGEVLPTAFEASE-KWPNLIHEPLDQGNCA :: : ::. . .. . .:. :::... . . :.. .:..:. CCDS82 MIRRSGGHSRKIPRPKPAPLTAEIQQKILH----LPTSWDWRNVHGINFVSPVRNQASCG 210 220 230 240 250 230 240 250 260 270 280 pF1KB0 GSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGR-LDGAWWFLRRRG . ..:.. .. :. : . . .::.::::...:: .. :::.:: : . . : CCDS82 SCYSFASMGMLEARIRILTNNSQTPILSPQEVVSC-SQYAQGCEGGFPYLIAGKYAQDFG 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB0 VVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRL .: . :.:..: . :: :. : : ... . : : CCDS82 LVEEACFPYTGTD-------SPCKMKE------------DCFRYY--SSEYHYVGGFY-- 320 330 340 350 350 360 370 380 390 400 pF1KB0 GSNDKEIMK-ELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKIT :. .. .:: ::...::. . .::..::. :: ::: :: .: : . .:.: .. CCDS82 GGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHT--GLRDPFNPFELTNHAVLLV 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB0 GWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMG :.: .. . . :: . :::: .::: :.::: ::..:: :::... CCDS82 GYGTDS---ASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL 420 430 440 450 460 pF1KB0 HH 467 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:52:01 2016 done: Sat Nov 5 11:52:02 2016 Total Scan time: 3.270 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]