FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0417, 471 aa 1>>>pF1KB0417 471 - 471 aa - 471 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4215+/-0.000614; mu= 4.2204+/- 0.037 mean_var=393.8643+/-93.097, 0's: 0 Z-trim(113.9): 756 B-trim: 1041 in 1/50 Lambda= 0.064625 statistics sampled from 22595 (23528) to 22595 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.276), width: 16 Scan time: 8.850 The best scores are: opt bits E(85289) NP_689862 (OMIM: 615153) mixed lineage kinase doma ( 471) 3083 302.7 1.5e-81 XP_005255891 (OMIM: 615153) PREDICTED: mixed linea ( 471) 3083 302.7 1.5e-81 XP_011521238 (OMIM: 615153) PREDICTED: mixed linea ( 293) 1789 181.7 2.4e-45 NP_001135969 (OMIM: 615153) mixed lineage kinase d ( 263) 1187 125.5 1.7e-28 NP_002410 (OMIM: 600050) mitogen-activated protein ( 847) 355 48.7 7.4e-05 XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081) 345 47.9 0.00016 NP_001271159 (OMIM: 600136) mitogen-activated prot (1104) 345 47.9 0.00016 NP_149132 (OMIM: 600136) mitogen-activated protein (1118) 345 48.0 0.00016 XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166) 345 48.0 0.00017 NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 339 47.3 0.00022 NP_057062 (OMIM: 613932,616117) serine/threonine-p ( 835) 326 46.0 0.00048 NP_055030 (OMIM: 147671) insulin receptor-related (1297) 326 46.3 0.00061 XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860) 313 44.8 0.0011 XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962) 313 44.9 0.0012 XP_011510844 (OMIM: 600600) PREDICTED: ephrin type ( 394) 302 43.3 0.0015 NP_009101 (OMIM: 604746) dual specificity testis-s ( 571) 299 43.2 0.0022 XP_006710350 (OMIM: 604746) PREDICTED: dual specif ( 571) 299 43.2 0.0022 XP_011538799 (OMIM: 604746) PREDICTED: dual specif ( 571) 299 43.2 0.0022 NP_001307729 (OMIM: 604746) dual specificity testi ( 488) 297 42.9 0.0023 NP_004432 (OMIM: 600600) ephrin type-B receptor 1 ( 984) 302 43.9 0.0025 XP_016861357 (OMIM: 600600) PREDICTED: ephrin type (1016) 302 43.9 0.0025 XP_016861356 (OMIM: 600600) PREDICTED: ephrin type (1032) 302 43.9 0.0025 XP_005264773 (OMIM: 179611) PREDICTED: ephrin type ( 918) 301 43.7 0.0025 XP_016861355 (OMIM: 600600) PREDICTED: ephrin type (1038) 302 43.9 0.0025 NP_690620 (OMIM: 601890) inactive tyrosine-protein ( 940) 301 43.7 0.0026 XP_011513068 (OMIM: 601890) PREDICTED: inactive ty ( 948) 301 43.7 0.0026 XP_005264772 (OMIM: 179611) PREDICTED: ephrin type ( 982) 301 43.8 0.0026 NP_005224 (OMIM: 179611) ephrin type-A receptor 3 ( 983) 301 43.8 0.0026 NP_690621 (OMIM: 601890) inactive tyrosine-protein (1014) 301 43.8 0.0027 NP_690619 (OMIM: 601890) inactive tyrosine-protein (1030) 301 43.8 0.0027 XP_011513067 (OMIM: 601890) PREDICTED: inactive ty (1038) 301 43.8 0.0027 NP_002812 (OMIM: 601890) inactive tyrosine-protein (1070) 301 43.8 0.0028 NP_001257327 (OMIM: 601890) inactive tyrosine-prot (1078) 301 43.8 0.0028 NP_065690 (OMIM: 263650,605706) receptor-interacti ( 784) 294 43.0 0.0037 XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387) 288 41.9 0.0037 XP_016870237 (OMIM: 108961,602875,615923,616255) P ( 579) 290 42.4 0.004 XP_016870239 (OMIM: 108961,602875,615923,616255) P ( 579) 290 42.4 0.004 XP_016870238 (OMIM: 108961,602875,615923,616255) P ( 579) 290 42.4 0.004 XP_011516197 (OMIM: 108961,602875,615923,616255) P ( 582) 290 42.4 0.004 XP_011541578 (OMIM: 176942) PREDICTED: tyrosine-pr ( 468) 287 42.0 0.0043 XP_016870235 (OMIM: 108961,602875,615923,616255) P ( 718) 290 42.5 0.0045 XP_016870236 (OMIM: 108961,602875,615923,616255) P ( 718) 290 42.5 0.0045 XP_011516193 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045 XP_016870234 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045 XP_005251536 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045 XP_011516194 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045 XP_011516195 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045 XP_011516192 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045 XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606) 288 42.2 0.0047 NP_001645 (OMIM: 311010) serine/threonine-protein ( 606) 288 42.2 0.0047 >>NP_689862 (OMIM: 615153) mixed lineage kinase domain-l (471 aa) initn: 3083 init1: 3083 opt: 3083 Z-score: 1585.3 bits: 302.7 E(85289): 1.5e-81 Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI 370 380 390 400 410 420 430 440 450 460 470 pF1KB0 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 430 440 450 460 470 >>XP_005255891 (OMIM: 615153) PREDICTED: mixed lineage k (471 aa) initn: 3083 init1: 3083 opt: 3083 Z-score: 1585.3 bits: 302.7 E(85289): 1.5e-81 Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI 370 380 390 400 410 420 430 440 450 460 470 pF1KB0 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 430 440 450 460 470 >>XP_011521238 (OMIM: 615153) PREDICTED: mixed lineage k (293 aa) initn: 1789 init1: 1789 opt: 1789 Z-score: 935.3 bits: 181.7 E(85289): 2.4e-45 Smith-Waterman score: 1789; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:1-273) 10 20 30 40 50 60 pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD ::::::::::::::::::::::::::::::::: XP_011 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETGYTIQKHLNSTEKSEAQTSW 250 260 270 280 290 310 320 330 340 350 360 pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS >>NP_001135969 (OMIM: 615153) mixed lineage kinase domai (263 aa) initn: 1568 init1: 1168 opt: 1187 Z-score: 632.4 bits: 125.5 E(85289): 1.7e-28 Smith-Waterman score: 1187; 90.3% identity (93.2% similar) in 206 aa overlap (1-203:1-206) 10 20 30 40 50 60 pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL 130 140 150 160 170 180 190 200 210 220 230 pF1KB0 PP---KCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQA : :: . ..:..: . :: NP_001 ESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC 190 200 210 220 230 240 >-- initn: 381 init1: 381 opt: 381 Z-score: 226.2 bits: 50.4 E(85289): 7.3e-06 Smith-Waterman score: 381; 100.0% identity (100.0% similar) in 57 aa overlap (415-471:207-263) 390 400 410 420 430 440 pF1KB0 VFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREI :::::::::::::::::::::::::::::: NP_001 RQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREI 180 190 200 210 220 230 450 460 470 pF1KB0 IDECRAHDPSVRPSVDEILKKLSTFSK ::::::::::::::::::::::::::: NP_001 IDECRAHDPSVRPSVDEILKKLSTFSK 240 250 260 >>NP_002410 (OMIM: 600050) mitogen-activated protein kin (847 aa) initn: 193 init1: 193 opt: 355 Z-score: 208.2 bits: 48.7 E(85289): 7.4e-05 Smith-Waterman score: 362; 27.2% identity (58.4% similar) in 298 aa overlap (181-466:106-376) 160 170 180 190 200 210 pF1KB0 LRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLR :: : :. . : :.. :.. : NP_002 AISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPC--EVASFQ--ELRLEEVIGI------ 80 90 100 110 120 220 230 240 250 260 270 pF1KB0 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI . . .:.: .. ::.:. .. .:... .. .: . . . :::. . ..:. NP_002 -GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCL 130 140 150 160 170 180 280 290 300 310 320 pF1KB0 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLH-HS .: :.. .:::: : : . : :.:. ::: : :::.. :: .. NP_002 EE----PNLCLVMEYAAGGPLSRALA-------GRRVPPHVLVNWAVQIARGMHYLHCEA 190 200 210 220 230 330 340 350 360 370 pF1KB0 EAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTRE--KTDRVKST---AYLS .: .: ..:.:.:. : .. .: .:: ..: .:: :: ..... :... NP_002 LVPVIHRDLKSNNILLLQ--PIESDDME-HKTLKITDFGLAREWHKTTQMSAAGTYAWMA 240 250 260 270 280 290 380 390 400 410 420 430 pF1KB0 PQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCP :. .. .. :...:::..:::. ::..:..: . . :::.. :. :: NP_002 PEVIKASTFSKG--SDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP 300 310 320 330 340 440 450 460 470 pF1KB0 SELREIIDECRAHDPSVRPSVDEILKKLSTFSK . ... .: :.:: ::. ::..: NP_002 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFD 350 360 370 380 390 400 >>XP_005267740 (OMIM: 600136) PREDICTED: mitogen-activat (1081 aa) initn: 202 init1: 174 opt: 345 Z-score: 202.1 bits: 47.9 E(85289): 0.00016 Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405) 160 170 180 190 200 210 pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE :.:. : :. :: .:. : . XP_005 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI-- 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID . . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:. XP_005 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK 160 170 180 190 200 210 280 290 300 310 320 pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA : :.. .:::. . : : ..:. :::. .:: : :::. :: .:: XP_005 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA 220 230 240 250 260 330 340 350 360 370 pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL : .: ..:::.:. : :. . .: . ... .: .:: .: ..... :.. XP_005 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM 270 280 290 300 310 380 390 400 410 420 430 pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC .:. .. ... :...:.:..:::. ::..::.: .. . ::... :. : XP_005 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 320 330 340 350 360 370 440 450 460 470 pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK : . .....: :: ::: .:: .:.: XP_005 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF 380 390 400 410 420 430 XP_005 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE 440 450 460 470 480 490 >>NP_001271159 (OMIM: 600136) mitogen-activated protein (1104 aa) initn: 202 init1: 174 opt: 345 Z-score: 202.0 bits: 47.9 E(85289): 0.00016 Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405) 160 170 180 190 200 210 pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE :.:. : :. :: .:. : . NP_001 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI-- 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID . . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:. NP_001 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK 160 170 180 190 200 210 280 290 300 310 320 pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA : :.. .:::. . : : ..:. :::. .:: : :::. :: .:: NP_001 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA 220 230 240 250 260 330 340 350 360 370 pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL : .: ..:::.:. : :. . .: . ... .: .:: .: ..... :.. NP_001 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM 270 280 290 300 310 380 390 400 410 420 430 pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC .:. .. ... :...:.:..:::. ::..::.: .. . ::... :. : NP_001 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 320 330 340 350 360 370 440 450 460 470 pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK : . .....: :: ::: .:: .:.: NP_001 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF 380 390 400 410 420 430 NP_001 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE 440 450 460 470 480 490 >>NP_149132 (OMIM: 600136) mitogen-activated protein kin (1118 aa) initn: 202 init1: 174 opt: 345 Z-score: 202.0 bits: 48.0 E(85289): 0.00016 Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405) 160 170 180 190 200 210 pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE :.:. : :. :: .:. : . NP_149 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI-- 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID . . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:. NP_149 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK 160 170 180 190 200 210 280 290 300 310 320 pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA : :.. .:::. . : : ..:. :::. .:: : :::. :: .:: NP_149 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA 220 230 240 250 260 330 340 350 360 370 pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL : .: ..:::.:. : :. . .: . ... .: .:: .: ..... :.. NP_149 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM 270 280 290 300 310 380 390 400 410 420 430 pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC .:. .. ... :...:.:..:::. ::..::.: .. . ::... :. : NP_149 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 320 330 340 350 360 370 440 450 460 470 pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK : . .....: :: ::: .:: .:.: NP_149 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF 380 390 400 410 420 430 NP_149 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE 440 450 460 470 480 490 >>XP_011535090 (OMIM: 600136) PREDICTED: mitogen-activat (1166 aa) initn: 202 init1: 174 opt: 345 Z-score: 201.8 bits: 48.0 E(85289): 0.00017 Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405) 160 170 180 190 200 210 pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE :.:. : :. :: .:. : . XP_011 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI-- 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID . . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:. XP_011 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK 160 170 180 190 200 210 280 290 300 310 320 pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA : :.. .:::. . : : ..:. :::. .:: : :::. :: .:: XP_011 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA 220 230 240 250 260 330 340 350 360 370 pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL : .: ..:::.:. : :. . .: . ... .: .:: .: ..... :.. XP_011 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM 270 280 290 300 310 380 390 400 410 420 430 pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC .:. .. ... :...:.:..:::. ::..::.: .. . ::... :. : XP_011 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 320 330 340 350 360 370 440 450 460 470 pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK : . .....: :: ::: .:: .:.: XP_011 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF 380 390 400 410 420 430 XP_011 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE 440 450 460 470 480 490 >>NP_002437 (OMIM: 600137) mitogen-activated protein kin (954 aa) initn: 217 init1: 181 opt: 339 Z-score: 199.6 bits: 47.3 E(85289): 0.00022 Smith-Waterman score: 346; 26.4% identity (59.2% similar) in 299 aa overlap (182-466:84-357) 160 170 180 190 200 210 pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQE-QIKEIKKEQLSGSPWILLR : .: .::: ..:.. :.. : NP_002 GDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQ-LPQEIPFHELQLEEIIGV------ 60 70 80 90 100 220 230 240 250 260 270 pF1KB0 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI . . .:.. .. ::.:. . . :.. . .: . . .. :::. . : :. NP_002 -GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACL 110 120 130 140 150 160 280 290 300 310 320 pF1KB0 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLV---LGAARGLYRLHH-S . ::.. .:::: . :.: ..: :.:. ::: . .:::. ::. . NP_002 N----PPHLCLVMEYARGGALSRVLA-------GRRVPPHVLVNWAVQVARGMNYLHNDA 170 180 190 200 210 330 340 350 360 370 pF1KB0 EAPELHGKIRSSNFLVTQGYQVK-LAGFELRKTQTSMSLGTTRE--KTDRVKST---AYL .: .: ..: :.:. .. . . :: :. :. .: .:: :: ..... :.. NP_002 PVPIIHRDLKSINILILEAIENHNLADTVLKITD----FGLAREWHKTTKMSAAGTYAWM 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC .:. .. . .. .:...:::..:::. ::..:.. .. . ::... :. : NP_002 APEVIR--LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTC 280 290 300 310 320 440 450 460 470 pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK : . ....:: :: ::. :::.: NP_002 PEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMF 330 340 350 360 370 380 471 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:45:36 2016 done: Sat Nov 5 18:45:38 2016 Total Scan time: 8.850 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]