Result of FASTA (omim) for pF1KB0417
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB0417, 471 aa
  1>>>pF1KB0417 471 - 471 aa - 471 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.4215+/-0.000614; mu= 4.2204+/- 0.037
 mean_var=393.8643+/-93.097, 0's: 0 Z-trim(113.9): 756  B-trim: 1041 in 1/50
 Lambda= 0.064625
 statistics sampled from 22595 (23528) to 22595 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.276), width:  16
 Scan time:  8.850

The best scores are:                                      opt bits E(85289)
NP_689862 (OMIM: 615153) mixed lineage kinase doma ( 471) 3083 302.7 1.5e-81
XP_005255891 (OMIM: 615153) PREDICTED: mixed linea ( 471) 3083 302.7 1.5e-81
XP_011521238 (OMIM: 615153) PREDICTED: mixed linea ( 293) 1789 181.7 2.4e-45
NP_001135969 (OMIM: 615153) mixed lineage kinase d ( 263) 1187 125.5 1.7e-28
NP_002410 (OMIM: 600050) mitogen-activated protein ( 847)  355 48.7 7.4e-05
XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081)  345 47.9 0.00016
NP_001271159 (OMIM: 600136) mitogen-activated prot (1104)  345 47.9 0.00016
NP_149132 (OMIM: 600136) mitogen-activated protein (1118)  345 48.0 0.00016
XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166)  345 48.0 0.00017
NP_002437 (OMIM: 600137) mitogen-activated protein ( 954)  339 47.3 0.00022
NP_057062 (OMIM: 613932,616117) serine/threonine-p ( 835)  326 46.0 0.00048
NP_055030 (OMIM: 147671) insulin receptor-related  (1297)  326 46.3 0.00061
XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860)  313 44.8  0.0011
XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962)  313 44.9  0.0012
XP_011510844 (OMIM: 600600) PREDICTED: ephrin type ( 394)  302 43.3  0.0015
NP_009101 (OMIM: 604746) dual specificity testis-s ( 571)  299 43.2  0.0022
XP_006710350 (OMIM: 604746) PREDICTED: dual specif ( 571)  299 43.2  0.0022
XP_011538799 (OMIM: 604746) PREDICTED: dual specif ( 571)  299 43.2  0.0022
NP_001307729 (OMIM: 604746) dual specificity testi ( 488)  297 42.9  0.0023
NP_004432 (OMIM: 600600) ephrin type-B receptor 1  ( 984)  302 43.9  0.0025
XP_016861357 (OMIM: 600600) PREDICTED: ephrin type (1016)  302 43.9  0.0025
XP_016861356 (OMIM: 600600) PREDICTED: ephrin type (1032)  302 43.9  0.0025
XP_005264773 (OMIM: 179611) PREDICTED: ephrin type ( 918)  301 43.7  0.0025
XP_016861355 (OMIM: 600600) PREDICTED: ephrin type (1038)  302 43.9  0.0025
NP_690620 (OMIM: 601890) inactive tyrosine-protein ( 940)  301 43.7  0.0026
XP_011513068 (OMIM: 601890) PREDICTED: inactive ty ( 948)  301 43.7  0.0026
XP_005264772 (OMIM: 179611) PREDICTED: ephrin type ( 982)  301 43.8  0.0026
NP_005224 (OMIM: 179611) ephrin type-A receptor 3  ( 983)  301 43.8  0.0026
NP_690621 (OMIM: 601890) inactive tyrosine-protein (1014)  301 43.8  0.0027
NP_690619 (OMIM: 601890) inactive tyrosine-protein (1030)  301 43.8  0.0027
XP_011513067 (OMIM: 601890) PREDICTED: inactive ty (1038)  301 43.8  0.0027
NP_002812 (OMIM: 601890) inactive tyrosine-protein (1070)  301 43.8  0.0028
NP_001257327 (OMIM: 601890) inactive tyrosine-prot (1078)  301 43.8  0.0028
NP_065690 (OMIM: 263650,605706) receptor-interacti ( 784)  294 43.0  0.0037
XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387)  288 41.9  0.0037
XP_016870237 (OMIM: 108961,602875,615923,616255) P ( 579)  290 42.4   0.004
XP_016870239 (OMIM: 108961,602875,615923,616255) P ( 579)  290 42.4   0.004
XP_016870238 (OMIM: 108961,602875,615923,616255) P ( 579)  290 42.4   0.004
XP_011516197 (OMIM: 108961,602875,615923,616255) P ( 582)  290 42.4   0.004
XP_011541578 (OMIM: 176942) PREDICTED: tyrosine-pr ( 468)  287 42.0  0.0043
XP_016870235 (OMIM: 108961,602875,615923,616255) P ( 718)  290 42.5  0.0045
XP_016870236 (OMIM: 108961,602875,615923,616255) P ( 718)  290 42.5  0.0045
XP_011516193 (OMIM: 108961,602875,615923,616255) P ( 721)  290 42.5  0.0045
XP_016870234 (OMIM: 108961,602875,615923,616255) P ( 721)  290 42.5  0.0045
XP_005251536 (OMIM: 108961,602875,615923,616255) P ( 721)  290 42.5  0.0045
XP_011516194 (OMIM: 108961,602875,615923,616255) P ( 721)  290 42.5  0.0045
XP_011516195 (OMIM: 108961,602875,615923,616255) P ( 721)  290 42.5  0.0045
XP_011516192 (OMIM: 108961,602875,615923,616255) P ( 721)  290 42.5  0.0045
XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606)  288 42.2  0.0047
NP_001645 (OMIM: 311010) serine/threonine-protein  ( 606)  288 42.2  0.0047


>>NP_689862 (OMIM: 615153) mixed lineage kinase domain-l  (471 aa)
 initn: 3083 init1: 3083 opt: 3083  Z-score: 1585.3  bits: 302.7 E(85289): 1.5e-81
Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)

               10        20        30        40        50        60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB0 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
              370       380       390       400       410       420

              430       440       450       460       470 
pF1KB0 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
              430       440       450       460       470 

>>XP_005255891 (OMIM: 615153) PREDICTED: mixed lineage k  (471 aa)
 initn: 3083 init1: 3083 opt: 3083  Z-score: 1585.3  bits: 302.7 E(85289): 1.5e-81
Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)

               10        20        30        40        50        60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB0 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
              370       380       390       400       410       420

              430       440       450       460       470 
pF1KB0 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
              430       440       450       460       470 

>>XP_011521238 (OMIM: 615153) PREDICTED: mixed lineage k  (293 aa)
 initn: 1789 init1: 1789 opt: 1789  Z-score: 935.3  bits: 181.7 E(85289): 2.4e-45
Smith-Waterman score: 1789; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:1-273)

               10        20        30        40        50        60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
       :::::::::::::::::::::::::::::::::                           
XP_011 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETGYTIQKHLNSTEKSEAQTSW       
              250       260       270       280       290          

              310       320       330       340       350       360
pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS

>>NP_001135969 (OMIM: 615153) mixed lineage kinase domai  (263 aa)
 initn: 1568 init1: 1168 opt: 1187  Z-score: 632.4  bits: 125.5 E(85289): 1.7e-28
Smith-Waterman score: 1187; 90.3% identity (93.2% similar) in 206 aa overlap (1-203:1-206)

               10        20        30        40        50        60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL
              130       140       150       160       170       180

                 190       200       210       220       230       
pF1KB0 PP---KCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQA
            :   :: . ..:..:  . ::                                  
NP_001 ESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC
              190       200       210       220       230       240

>--
 initn: 381 init1: 381 opt: 381  Z-score: 226.2  bits: 50.4 E(85289): 7.3e-06
Smith-Waterman score: 381; 100.0% identity (100.0% similar) in 57 aa overlap (415-471:207-263)

          390       400       410       420       430       440    
pF1KB0 VFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREI
                                     ::::::::::::::::::::::::::::::
NP_001 RQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREI
        180       190       200       210       220       230      

          450       460       470 
pF1KB0 IDECRAHDPSVRPSVDEILKKLSTFSK
       :::::::::::::::::::::::::::
NP_001 IDECRAHDPSVRPSVDEILKKLSTFSK
        240       250       260   

>>NP_002410 (OMIM: 600050) mitogen-activated protein kin  (847 aa)
 initn: 193 init1: 193 opt: 355  Z-score: 208.2  bits: 48.7 E(85289): 7.4e-05
Smith-Waterman score: 362; 27.2% identity (58.4% similar) in 298 aa overlap (181-466:106-376)

              160       170       180       190       200       210
pF1KB0 LRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLR
                                     :: :  :. . :  :.. :.. :       
NP_002 AISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPC--EVASFQ--ELRLEEVIGI------
          80        90       100         110         120           

              220       230       240       250       260       270
pF1KB0 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI
        .  . .:.: ..   ::.:. ..    .:... ..  .: . .  .  :::. . ..:.
NP_002 -GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCL
          130       140       150       160       170       180    

              280       290       300          310          320    
pF1KB0 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLH-HS
       .:    :.. .::::   : : . :        :.:.   :::  :   :::.. :: ..
NP_002 EE----PNLCLVMEYAAGGPLSRALA-------GRRVPPHVLVNWAVQIARGMHYLHCEA
              190       200              210       220       230   

           330       340       350       360         370           
pF1KB0 EAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTRE--KTDRVKST---AYLS
        .: .:  ..:.:.:. :   ..   .: .::    ..: .::  :: .....   :...
NP_002 LVPVIHRDLKSNNILLLQ--PIESDDME-HKTLKITDFGLAREWHKTTQMSAAGTYAWMA
           240       250          260       270       280       290

      380       390       400       410       420       430        
pF1KB0 PQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCP
       :. ..   ..    :...:::..:::. ::..:..: .   .   :::..   :.   ::
NP_002 PEVIKASTFSKG--SDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP
              300         310       320       330       340        

      440       450       460       470                            
pF1KB0 SELREIIDECRAHDPSVRPSVDEILKKLSTFSK                           
         . ... .: :.::  ::.   ::..:                                
NP_002 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFD
      350       360       370       380       390       400        

>>XP_005267740 (OMIM: 600136) PREDICTED: mitogen-activat  (1081 aa)
 initn: 202 init1: 174 opt: 345  Z-score: 202.1  bits: 47.9 E(85289): 0.00016
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)

             160       170       180       190       200       210 
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
                                     :.:.   :  :. ::   .:.    : .  
XP_005 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
       100       110       120       130          140       150    

             220       230       240       250       260       270 
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
       .  . .:.. .    ::.:. ..    .:. . ..  .: : .  .. :::. . :.:. 
XP_005 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
            160       170       180       190       200       210  

             280       290       300          310          320     
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
       :    :.. .:::. . : : ..:.       :::.   .::  :   :::.  :: .::
XP_005 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
                220       230              240       250        260

           330       340       350       360          370          
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
         : .:  ..:::.:. :    :. . .: .   ... .: .::  .: .....   :..
XP_005 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
              270           280       290       300       310      

       380       390       400       410       420       430       
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
       .:. ..  ...    :...:.:..:::. ::..::.: ..  .   ::...   :.   :
XP_005 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
        320         330       340       350       360       370    

       440       450       460       470                           
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK                          
       :  . .....:   ::  :::  .:: .:.:                             
XP_005 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
          380       390       400       410       420       430    

XP_005 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
          440       450       460       470       480       490    

>>NP_001271159 (OMIM: 600136) mitogen-activated protein   (1104 aa)
 initn: 202 init1: 174 opt: 345  Z-score: 202.0  bits: 47.9 E(85289): 0.00016
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)

             160       170       180       190       200       210 
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
                                     :.:.   :  :. ::   .:.    : .  
NP_001 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
       100       110       120       130          140       150    

             220       230       240       250       260       270 
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
       .  . .:.. .    ::.:. ..    .:. . ..  .: : .  .. :::. . :.:. 
NP_001 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
            160       170       180       190       200       210  

             280       290       300          310          320     
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
       :    :.. .:::. . : : ..:.       :::.   .::  :   :::.  :: .::
NP_001 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
                220       230              240       250        260

           330       340       350       360          370          
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
         : .:  ..:::.:. :    :. . .: .   ... .: .::  .: .....   :..
NP_001 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
              270           280       290       300       310      

       380       390       400       410       420       430       
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
       .:. ..  ...    :...:.:..:::. ::..::.: ..  .   ::...   :.   :
NP_001 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
        320         330       340       350       360       370    

       440       450       460       470                           
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK                          
       :  . .....:   ::  :::  .:: .:.:                             
NP_001 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
          380       390       400       410       420       430    

NP_001 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
          440       450       460       470       480       490    

>>NP_149132 (OMIM: 600136) mitogen-activated protein kin  (1118 aa)
 initn: 202 init1: 174 opt: 345  Z-score: 202.0  bits: 48.0 E(85289): 0.00016
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)

             160       170       180       190       200       210 
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
                                     :.:.   :  :. ::   .:.    : .  
NP_149 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
       100       110       120       130          140       150    

             220       230       240       250       260       270 
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
       .  . .:.. .    ::.:. ..    .:. . ..  .: : .  .. :::. . :.:. 
NP_149 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
            160       170       180       190       200       210  

             280       290       300          310          320     
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
       :    :.. .:::. . : : ..:.       :::.   .::  :   :::.  :: .::
NP_149 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
                220       230              240       250        260

           330       340       350       360          370          
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
         : .:  ..:::.:. :    :. . .: .   ... .: .::  .: .....   :..
NP_149 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
              270           280       290       300       310      

       380       390       400       410       420       430       
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
       .:. ..  ...    :...:.:..:::. ::..::.: ..  .   ::...   :.   :
NP_149 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
        320         330       340       350       360       370    

       440       450       460       470                           
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK                          
       :  . .....:   ::  :::  .:: .:.:                             
NP_149 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
          380       390       400       410       420       430    

NP_149 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
          440       450       460       470       480       490    

>>XP_011535090 (OMIM: 600136) PREDICTED: mitogen-activat  (1166 aa)
 initn: 202 init1: 174 opt: 345  Z-score: 201.8  bits: 48.0 E(85289): 0.00017
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)

             160       170       180       190       200       210 
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
                                     :.:.   :  :. ::   .:.    : .  
XP_011 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
       100       110       120       130          140       150    

             220       230       240       250       260       270 
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
       .  . .:.. .    ::.:. ..    .:. . ..  .: : .  .. :::. . :.:. 
XP_011 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
            160       170       180       190       200       210  

             280       290       300          310          320     
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
       :    :.. .:::. . : : ..:.       :::.   .::  :   :::.  :: .::
XP_011 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
                220       230              240       250        260

           330       340       350       360          370          
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
         : .:  ..:::.:. :    :. . .: .   ... .: .::  .: .....   :..
XP_011 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
              270           280       290       300       310      

       380       390       400       410       420       430       
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
       .:. ..  ...    :...:.:..:::. ::..::.: ..  .   ::...   :.   :
XP_011 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
        320         330       340       350       360       370    

       440       450       460       470                           
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK                          
       :  . .....:   ::  :::  .:: .:.:                             
XP_011 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
          380       390       400       410       420       430    

XP_011 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
          440       450       460       470       480       490    

>>NP_002437 (OMIM: 600137) mitogen-activated protein kin  (954 aa)
 initn: 217 init1: 181 opt: 339  Z-score: 199.6  bits: 47.3 E(85289): 0.00022
Smith-Waterman score: 346; 26.4% identity (59.2% similar) in 299 aa overlap (182-466:84-357)

             160       170       180       190        200       210
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQE-QIKEIKKEQLSGSPWILLR
                                     :  .: .:::  ..:.. :.. :       
NP_002 GDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQ-LPQEIPFHELQLEEIIGV------
            60        70        80         90       100            

              220       230       240       250       260       270
pF1KB0 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI
        .  . .:.. ..   ::.:. .     . :.. .   .: . .  .. :::. . : :.
NP_002 -GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACL
         110       120       130       140       150       160     

              280       290       300          310          320    
pF1KB0 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLV---LGAARGLYRLHH-S
       .    ::.. .:::: . :.: ..:        :.:.   :::   . .:::.  ::. .
NP_002 N----PPHLCLVMEYARGGALSRVLA-------GRRVPPHVLVNWAVQVARGMNYLHNDA
             170       180              190       200       210    

           330       340        350       360         370          
pF1KB0 EAPELHGKIRSSNFLVTQGYQVK-LAGFELRKTQTSMSLGTTRE--KTDRVKST---AYL
        .: .:  ..: :.:. .. . . ::   :. :.    .: .::  :: .....   :..
NP_002 PVPIIHRDLKSINILILEAIENHNLADTVLKITD----FGLAREWHKTTKMSAAGTYAWM
          220       230       240           250       260       270

       380       390       400       410       420       430       
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
       .:. ..  .  .. .:...:::..:::. ::..:..  ..  .   ::...   :.   :
NP_002 APEVIR--LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTC
                280       290       300       310       320        

       440       450       460       470                           
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK                          
       :  . ....::   ::  ::.   :::.:                               
NP_002 PEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMF
      330       340       350       360       370       380        




471 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 18:45:36 2016 done: Sat Nov  5 18:45:38 2016
 Total Scan time:  8.850 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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