FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0435, 448 aa 1>>>pF1KB0435 448 - 448 aa - 448 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7380+/-0.000331; mu= 16.7891+/- 0.021 mean_var=103.5487+/-20.748, 0's: 0 Z-trim(118.6): 58 B-trim: 964 in 1/54 Lambda= 0.126038 statistics sampled from 31650 (31722) to 31650 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.372), width: 16 Scan time: 6.240 The best scores are: opt bits E(85289) NP_071731 (OMIM: 129490,224900,604095,612630) tumo ( 448) 3055 566.0 7.3e-161 XP_011508805 (OMIM: 129490,224900,604095,612630) P ( 496) 3055 566.0 7.9e-161 XP_006712267 (OMIM: 129490,224900,604095,612630) P ( 480) 1559 294.0 5.9e-79 XP_011508804 (OMIM: 129490,224900,604095,612630) P ( 528) 1559 294.0 6.3e-79 XP_016876141 (OMIM: 606122) PREDICTED: tumor necro ( 328) 262 58.0 4.4e-08 XP_005266503 (OMIM: 606122) PREDICTED: tumor necro ( 328) 262 58.0 4.4e-08 NP_001191387 (OMIM: 606122) tumor necrosis factor ( 417) 262 58.1 5.3e-08 NP_683760 (OMIM: 606122) tumor necrosis factor rec ( 417) 262 58.1 5.3e-08 XP_005266502 (OMIM: 606122) PREDICTED: tumor necro ( 423) 262 58.1 5.3e-08 XP_016876140 (OMIM: 606122) PREDICTED: tumor necro ( 423) 262 58.1 5.3e-08 XP_011533448 (OMIM: 606122) PREDICTED: tumor necro ( 423) 262 58.1 5.3e-08 NP_061117 (OMIM: 606122) tumor necrosis factor rec ( 423) 262 58.1 5.3e-08 XP_011529309 (OMIM: 300276) PREDICTED: tumor necro ( 144) 250 55.5 1.1e-07 XP_011529308 (OMIM: 300276) PREDICTED: tumor necro ( 170) 250 55.5 1.3e-07 XP_011529306 (OMIM: 300276) PREDICTED: tumor necro ( 191) 250 55.6 1.4e-07 XP_016885195 (OMIM: 300276) PREDICTED: tumor necro ( 198) 250 55.6 1.4e-07 XP_016885193 (OMIM: 300276) PREDICTED: tumor necro ( 231) 250 55.6 1.6e-07 XP_011529304 (OMIM: 300276) PREDICTED: tumor necro ( 252) 250 55.7 1.7e-07 XP_011529303 (OMIM: 300276) PREDICTED: tumor necro ( 318) 250 55.8 2e-07 XP_011529302 (OMIM: 300276) PREDICTED: tumor necro ( 318) 250 55.8 2e-07 NP_001186616 (OMIM: 300276) tumor necrosis factor ( 297) 249 55.6 2.1e-07 NP_068555 (OMIM: 300276) tumor necrosis factor rec ( 297) 249 55.6 2.1e-07 NP_001311135 (OMIM: 300276) tumor necrosis factor ( 299) 249 55.6 2.1e-07 NP_001229239 (OMIM: 300276) tumor necrosis factor ( 318) 249 55.6 2.2e-07 NP_689408 (OMIM: 611211) tumor necrosis factor rec ( 430) 226 51.5 5.1e-06 NP_116260 (OMIM: 611211) tumor necrosis factor rec ( 430) 226 51.5 5.1e-06 XP_011529305 (OMIM: 300276) PREDICTED: tumor necro ( 238) 213 48.9 1.7e-05 >>NP_071731 (OMIM: 129490,224900,604095,612630) tumor ne (448 aa) initn: 3055 init1: 3055 opt: 3055 Z-score: 3009.0 bits: 566.0 E(85289): 7.3e-161 Smith-Waterman score: 3055; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448) 10 20 30 40 50 60 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 GYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 GYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 YMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 YMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 QGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 QGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 EAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 EAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 CLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 CLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRML 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 SSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 SSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIER 370 380 390 400 410 420 430 440 pF1KB0 LDAVESLCADILEWAGVVPPASQPHAAS :::::::::::::::::::::::::::: NP_071 LDAVESLCADILEWAGVVPPASQPHAAS 430 440 >>XP_011508805 (OMIM: 129490,224900,604095,612630) PREDI (496 aa) initn: 3055 init1: 3055 opt: 3055 Z-score: 3008.4 bits: 566.0 E(85289): 7.9e-161 Smith-Waterman score: 3055; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:49-496) 10 20 30 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSN :::::::::::::::::::::::::::::: XP_011 GKVPSSPTAAVTQMRRKEAYRHPKVSPWERMAHVGDCTQTPWLPVLVVSLMCSARAEYSN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 CGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRH 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 KDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYI 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 LKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSEN 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 DASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKIL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB0 DVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGG 380 390 400 410 420 430 400 410 420 430 440 pF1KB0 MTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS 440 450 460 470 480 490 >>XP_006712267 (OMIM: 129490,224900,604095,612630) PREDI (480 aa) initn: 1559 init1: 1559 opt: 1559 Z-score: 1538.5 bits: 294.0 E(85289): 5.9e-79 Smith-Waterman score: 2981; 93.3% identity (93.3% similar) in 480 aa overlap (1-448:1-480) 10 20 30 40 50 60 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 GYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 YMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSG 130 140 150 160 170 180 190 200 210 pF1KB0 QGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAP---------------------- :::::::::::::::::::::::::::::::::::::: XP_006 QGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPGDGPHAPVPCFLDSPSTPPVGE 190 200 210 220 230 240 220 230 240 250 260 pF1KB0 ----------ACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKS :::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGCSLPPLSPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB0 ENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKK 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB0 ILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEI 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB0 GGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS 430 440 450 460 470 480 >>XP_011508804 (OMIM: 129490,224900,604095,612630) PREDI (528 aa) initn: 1559 init1: 1559 opt: 1559 Z-score: 1537.9 bits: 294.0 E(85289): 6.3e-79 Smith-Waterman score: 2981; 93.3% identity (93.3% similar) in 480 aa overlap (1-448:49-528) 10 20 30 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSN :::::::::::::::::::::::::::::: XP_011 GKVPSSPTAAVTQMRRKEAYRHPKVSPWERMAHVGDCTQTPWLPVLVVSLMCSARAEYSN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 CGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRH 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 KDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYI 200 210 220 230 240 250 220 230 pF1KB0 LKTKPSAP--------------------------------ACCTSHPGKSVEAQVSKDEE :::::::: :::::::::::::::::::: XP_011 LKTKPSAPGDGPHAPVPCFLDSPSTPPVGEPGCSLPPLSPACCTSHPGKSVEAQVSKDEE 260 270 280 290 300 310 240 250 260 270 280 290 pF1KB0 KKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSP 320 330 340 350 360 370 300 310 320 330 340 350 pF1KB0 ELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSR 380 390 400 410 420 430 360 370 380 390 400 410 pF1KB0 MLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQI 440 450 460 470 480 490 420 430 440 pF1KB0 ERLDAVESLCADILEWAGVVPPASQPHAAS :::::::::::::::::::::::::::::: XP_011 ERLDAVESLCADILEWAGVVPPASQPHAAS 500 510 520 >>XP_016876141 (OMIM: 606122) PREDICTED: tumor necrosis (328 aa) initn: 201 init1: 103 opt: 262 Z-score: 266.0 bits: 58.0 E(85289): 4.4e-08 Smith-Waterman score: 267; 28.9% identity (55.5% similar) in 211 aa overlap (13-216:16-203) 10 20 30 40 50 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPY : ::. : :.. : ..: ..:. ... : : : :::: : XP_016 MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRS-GNCVPCNQCGPGMELS 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 LSCGYGTKDEDYGCVPCPAEKFSKG-GYQICRRHKDC---EGFFRATVLTPGDMENDAEC ::.: :: :: : ..:.. :.: :. :: . : .:. . .:: : XP_016 KECGFGY-GEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANC----SATSDAIC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 GPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTK-ECVGATSGASANFPGTSGSSTLSPFQ : ::::.: ... .. : : : :: . .:.. .. .. .:.. :: . XP_016 GDCLPGFYR-KTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKI------ASTASSPRD 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 HAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMF--YILKTKPSAPACCTSHPGKSVE : ::... :..:. ..:. :. .:. ... ::: XP_016 TA---------LAAVICSALATV-LLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSE 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 AQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEP XP_016 LSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASL 220 230 240 250 260 270 >>XP_005266503 (OMIM: 606122) PREDICTED: tumor necrosis (328 aa) initn: 201 init1: 103 opt: 262 Z-score: 266.0 bits: 58.0 E(85289): 4.4e-08 Smith-Waterman score: 267; 28.9% identity (55.5% similar) in 211 aa overlap (13-216:16-203) 10 20 30 40 50 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPY : ::. : :.. : ..: ..:. ... : : : :::: : XP_005 MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRS-GNCVPCNQCGPGMELS 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 LSCGYGTKDEDYGCVPCPAEKFSKG-GYQICRRHKDC---EGFFRATVLTPGDMENDAEC ::.: :: :: : ..:.. :.: :. :: . : .:. . .:: : XP_005 KECGFGY-GEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANC----SATSDAIC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 GPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTK-ECVGATSGASANFPGTSGSSTLSPFQ : ::::.: ... .. : : : :: . .:.. .. .. .:.. :: . XP_005 GDCLPGFYR-KTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKI------ASTASSPRD 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 HAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMF--YILKTKPSAPACCTSHPGKSVE : ::... :..:. ..:. :. .:. ... ::: XP_005 TA---------LAAVICSALATV-LLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSE 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 AQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEP XP_005 LSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASL 220 230 240 250 260 270 >>NP_001191387 (OMIM: 606122) tumor necrosis factor rece (417 aa) initn: 201 init1: 103 opt: 262 Z-score: 264.7 bits: 58.1 E(85289): 5.3e-08 Smith-Waterman score: 267; 28.9% identity (55.5% similar) in 211 aa overlap (13-216:16-203) 10 20 30 40 50 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPY : ::. : :.. : ..: ..:. ... : : : :::: : NP_001 MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRS-GNCVPCNQCGPGMELS 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 LSCGYGTKDEDYGCVPCPAEKFSKG-GYQICRRHKDC---EGFFRATVLTPGDMENDAEC ::.: :: :: : ..:.. :.: :. :: . : .:. . .:: : NP_001 KECGFGY-GEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANC----SATSDAIC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 GPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTK-ECVGATSGASANFPGTSGSSTLSPFQ : ::::.: ... .. : : : :: . .:.. .. .. .:.. :: . NP_001 GDCLPGFYR-KTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKI------ASTASSPRD 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 HAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMF--YILKTKPSAPACCTSHPGKSVE : ::... :..:. ..:. :. .:. ... ::: NP_001 TA---------LAAVICSALATV-LLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSE 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 AQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEP NP_001 LSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASL 220 230 240 250 260 270 >>NP_683760 (OMIM: 606122) tumor necrosis factor recepto (417 aa) initn: 201 init1: 103 opt: 262 Z-score: 264.7 bits: 58.1 E(85289): 5.3e-08 Smith-Waterman score: 267; 28.9% identity (55.5% similar) in 211 aa overlap (13-216:16-203) 10 20 30 40 50 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPY : ::. : :.. : ..: ..:. ... : : : :::: : NP_683 MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRS-GNCVPCNQCGPGMELS 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 LSCGYGTKDEDYGCVPCPAEKFSKG-GYQICRRHKDC---EGFFRATVLTPGDMENDAEC ::.: :: :: : ..:.. :.: :. :: . : .:. . .:: : NP_683 KECGFGY-GEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANC----SATSDAIC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 GPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTK-ECVGATSGASANFPGTSGSSTLSPFQ : ::::.: ... .. : : : :: . .:.. .. .. .:.. :: . NP_683 GDCLPGFYR-KTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKI------ASTASSPRD 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 HAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMF--YILKTKPSAPACCTSHPGKSVE : ::... :..:. ..:. :. .:. ... ::: NP_683 TA---------LAAVICSALATV-LLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSE 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 AQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEP NP_683 LSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASL 220 230 240 250 260 270 >>XP_005266502 (OMIM: 606122) PREDICTED: tumor necrosis (423 aa) initn: 201 init1: 103 opt: 262 Z-score: 264.6 bits: 58.1 E(85289): 5.3e-08 Smith-Waterman score: 267; 28.9% identity (55.5% similar) in 211 aa overlap (13-216:16-203) 10 20 30 40 50 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPY : ::. : :.. : ..: ..:. ... : : : :::: : XP_005 MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRS-GNCVPCNQCGPGMELS 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 LSCGYGTKDEDYGCVPCPAEKFSKG-GYQICRRHKDC---EGFFRATVLTPGDMENDAEC ::.: :: :: : ..:.. :.: :. :: . : .:. . .:: : XP_005 KECGFGY-GEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANC----SATSDAIC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 GPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTK-ECVGATSGASANFPGTSGSSTLSPFQ : ::::.: ... .. : : : :: . .:.. .. .. .:.. :: . XP_005 GDCLPGFYR-KTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKI------ASTASSPRD 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 HAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMF--YILKTKPSAPACCTSHPGKSVE : ::... :..:. ..:. :. .:. ... ::: XP_005 TA---------LAAVICSALATV-LLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSE 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 AQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEP XP_005 LSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASL 220 230 240 250 260 270 >>XP_016876140 (OMIM: 606122) PREDICTED: tumor necrosis (423 aa) initn: 201 init1: 103 opt: 262 Z-score: 264.6 bits: 58.1 E(85289): 5.3e-08 Smith-Waterman score: 267; 28.9% identity (55.5% similar) in 211 aa overlap (13-216:16-203) 10 20 30 40 50 pF1KB0 MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPY : ::. : :.. : ..: ..:. ... : : : :::: : XP_016 MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRS-GNCVPCNQCGPGMELS 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 LSCGYGTKDEDYGCVPCPAEKFSKG-GYQICRRHKDC---EGFFRATVLTPGDMENDAEC ::.: :: :: : ..:.. :.: :. :: . : .:. . .:: : XP_016 KECGFGY-GEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANC----SATSDAIC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 GPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTK-ECVGATSGASANFPGTSGSSTLSPFQ : ::::.: ... .. : : : :: . .:.. .. .. .:.. :: . XP_016 GDCLPGFYR-KTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKI------ASTASSPRD 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 HAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMF--YILKTKPSAPACCTSHPGKSVE : ::... :..:. ..:. :. .:. ... ::: XP_016 TA---------LAAVICSALATV-LLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSE 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 AQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEP XP_016 LSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASL 220 230 240 250 260 270 448 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 16:51:25 2016 done: Sat Nov 5 16:51:26 2016 Total Scan time: 6.240 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]