Result of FASTA (omim) for
pF1KB0459
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0459, 508 aa
1>>>pF1KB0459 508 - 508 aa - 508 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6757+/-0.000552; mu= -0.7126+/- 0.033
mean_var=748.1048+/-174.435, 0's: 0 Z-trim(118.1): 1191 B-trim: 0 in 0/52
Lambda= 0.046891
statistics sampled from 30337 (31940) to 30337 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.346), width: 16
Scan time: 5.440
The best scores are: opt bits E(92320)
NP_002369 (OMIM: 600038) megakaryocyte-associated ( 508) 3446 249.4 2e-65
XP_011526320 (OMIM: 600038) megakaryocyte-associat ( 507) 3268 237.4 8.2e-62
NP_647612 (OMIM: 600038) megakaryocyte-associated ( 507) 3268 237.4 8.2e-62
NP_647611 (OMIM: 600038) megakaryocyte-associated ( 466) 3138 228.5 3.5e-59
NP_001341917 (OMIM: 124095) tyrosine-protein kinas ( 450) 1621 125.9 2.7e-28
NP_001120662 (OMIM: 124095) tyrosine-protein kinas ( 450) 1621 125.9 2.7e-28
NP_004374 (OMIM: 124095) tyrosine-protein kinase C ( 450) 1621 125.9 2.7e-28
NP_001294957 (OMIM: 176942) tyrosine-protein kinas ( 647) 926 79.1 4.5e-14
XP_011541573 (OMIM: 176942) tyrosine-protein kinas ( 822) 926 79.3 5.1e-14
XP_016864720 (OMIM: 176942) tyrosine-protein kinas ( 822) 926 79.3 5.1e-14
XP_016864719 (OMIM: 176942) tyrosine-protein kinas ( 822) 926 79.3 5.1e-14
NP_005237 (OMIM: 176942) tyrosine-protein kinase F ( 822) 926 79.3 5.1e-14
NP_001294960 (OMIM: 176942) tyrosine-protein kinas ( 453) 916 78.2 6.2e-14
NP_005966 (OMIM: 602004) protein-tyrosine kinase 6 ( 451) 914 78.0 6.8e-14
NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 897 76.9 1.5e-13
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 898 77.1 1.5e-13
NP_543013 (OMIM: 617797) tyrosine-protein kinase S ( 488) 893 76.7 1.9e-13
XP_024302814 (OMIM: 153390,615758) tyrosine-protei ( 567) 881 76.0 3.5e-13
XP_024302815 (OMIM: 153390,615758) tyrosine-protei ( 567) 881 76.0 3.5e-13
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 875 75.5 4.4e-13
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 875 75.5 4.4e-13
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 853 74.0 1.2e-12
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 853 74.0 1.2e-12
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 853 74.0 1.2e-12
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 853 74.0 1.2e-12
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 853 74.0 1.3e-12
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 853 74.0 1.3e-12
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 834 72.8 3.1e-12
XP_024307014 (OMIM: 164880) tyrosine-protein kinas ( 543) 834 72.8 3.1e-12
XP_024307011 (OMIM: 164880) tyrosine-protein kinas ( 543) 834 72.8 3.1e-12
XP_024307012 (OMIM: 164880) tyrosine-protein kinas ( 543) 834 72.8 3.1e-12
XP_016881449 (OMIM: 164880) tyrosine-protein kinas ( 543) 834 72.8 3.1e-12
XP_024307013 (OMIM: 164880) tyrosine-protein kinas ( 543) 834 72.8 3.1e-12
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 829 72.4 3.9e-12
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 829 72.4 3.9e-12
XP_011527315 (OMIM: 114500,190090,616937) proto-on ( 536) 829 72.4 3.9e-12
XP_016883514 (OMIM: 114500,190090,616937) proto-on ( 542) 818 71.7 6.6e-12
XP_016883513 (OMIM: 114500,190090,616937) proto-on ( 542) 818 71.7 6.6e-12
XP_016883515 (OMIM: 114500,190090,616937) proto-on ( 542) 818 71.7 6.6e-12
XP_016883516 (OMIM: 114500,190090,616937) proto-on ( 542) 818 71.7 6.6e-12
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 814 71.4 7.9e-12
XP_016868905 (OMIM: 165120) tyrosine-protein kinas ( 491) 813 71.3 8e-12
NP_001104567 (OMIM: 165120) tyrosine-protein kinas ( 491) 813 71.3 8e-12
NP_002341 (OMIM: 165120) tyrosine-protein kinase L ( 512) 813 71.3 8.2e-12
XP_011515831 (OMIM: 165120) tyrosine-protein kinas ( 682) 813 71.5 9.3e-12
XP_016866139 (OMIM: 137025) tyrosine-protein kinas ( 537) 809 71.1 1e-11
XP_016866140 (OMIM: 137025) tyrosine-protein kinas ( 537) 809 71.1 1e-11
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 809 71.1 1e-11
NP_001357458 (OMIM: 137025) tyrosine-protein kinas ( 537) 809 71.1 1e-11
XP_016866142 (OMIM: 137025) tyrosine-protein kinas ( 537) 809 71.1 1e-11
>>NP_002369 (OMIM: 600038) megakaryocyte-associated tyro (508 aa)
initn: 3446 init1: 3446 opt: 3446 Z-score: 1296.4 bits: 249.4 E(92320): 2e-65
Smith-Waterman score: 3446; 100.0% identity (100.0% similar) in 508 aa overlap (1-508:1-508)
10 20 30 40 50 60
pF1KB0 MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA
430 440 450 460 470 480
490 500
pF1KB0 RELRSAGAPASVSGQDADGSTSPRSQEP
::::::::::::::::::::::::::::
NP_002 RELRSAGAPASVSGQDADGSTSPRSQEP
490 500
>>XP_011526320 (OMIM: 600038) megakaryocyte-associated t (507 aa)
initn: 3267 init1: 3267 opt: 3268 Z-score: 1231.3 bits: 237.4 E(92320): 8.2e-62
Smith-Waterman score: 3268; 97.8% identity (98.6% similar) in 497 aa overlap (13-508:11-507)
10 20 30 40 50
pF1KB0 MQGHFPAERREGRPRRGTRGQQQL-LVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCE
: .: . ..: ::::::::::::::::::::::::::::::::::
XP_011 MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCE
10 20 30 40 50
60 70 80 90 100 110
pF1KB0 HTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB0 LMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB0 TIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB0 AQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB0 GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNI
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB0 LVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVF
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB0 SYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL
420 430 440 450 460 470
480 490 500
pF1KB0 ARELRSAGAPASVSGQDADGSTSPRSQEP
:::::::::::::::::::::::::::::
XP_011 ARELRSAGAPASVSGQDADGSTSPRSQEP
480 490 500
>>NP_647612 (OMIM: 600038) megakaryocyte-associated tyro (507 aa)
initn: 3267 init1: 3267 opt: 3268 Z-score: 1231.3 bits: 237.4 E(92320): 8.2e-62
Smith-Waterman score: 3268; 97.8% identity (98.6% similar) in 497 aa overlap (13-508:11-507)
10 20 30 40 50
pF1KB0 MQGHFPAERREGRPRRGTRGQQQL-LVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCE
: .: . ..: ::::::::::::::::::::::::::::::::::
NP_647 MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCE
10 20 30 40 50
60 70 80 90 100 110
pF1KB0 HTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 HTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB0 LMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 LMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB0 TIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 TIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB0 AQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 AQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB0 GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNI
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB0 LVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 LVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVF
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB0 SYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 SYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL
420 430 440 450 460 470
480 490 500
pF1KB0 ARELRSAGAPASVSGQDADGSTSPRSQEP
:::::::::::::::::::::::::::::
NP_647 ARELRSAGAPASVSGQDADGSTSPRSQEP
480 490 500
>>NP_647611 (OMIM: 600038) megakaryocyte-associated tyro (466 aa)
initn: 3138 init1: 3138 opt: 3138 Z-score: 1184.1 bits: 228.5 E(92320): 3.5e-59
Smith-Waterman score: 3138; 100.0% identity (100.0% similar) in 466 aa overlap (43-508:1-466)
20 30 40 50 60 70
pF1KB0 RPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRK
::::::::::::::::::::::::::::::
NP_647 MPTRRWAPGTQCITKCEHTRPKPGELAFRK
10 20 30
80 90 100 110 120 130
pF1KB0 GDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 GDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 AVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 AVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMD
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 MVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 MVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 GEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 GEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGN
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 LVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 LVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDF
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 GLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 GLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLK
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB0 EVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_647 EVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASV
400 410 420 430 440 450
500
pF1KB0 SGQDADGSTSPRSQEP
::::::::::::::::
NP_647 SGQDADGSTSPRSQEP
460
>>NP_001341917 (OMIM: 124095) tyrosine-protein kinase CS (450 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 629.6 bits: 125.9 E(92320): 2.7e-28
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (48-479:8-440)
20 30 40 50 60 70
pF1KB0 TRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVT
: ::.::.: . .: : ::::.:
NP_001 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLT
10 20 30
80 90 100 110 120 130
pF1KB0 ILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
:. . .. .::..:... :.::.. :. ...::...: ::::::::::::. ..: . :
NP_001 IVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
::: ::::::::. .::::.:::: : :::.... ..:.::: :.: :::..::::
NP_001 YPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
..: ..::.:..:: .:: .:..:. :.:: ::...: : ::.:::: :. :.: :
NP_001 TSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 QKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVN
.::::: :: :.:::::: :..:::...: :::.:::::... ::::: :...::.::.
NP_001 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLA
.::.:::.... ::.::: : :.:::::....:::::::::.::::: :::::::::.
NP_001 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS
: . :...:::::::::::.. ::..::::::::.::::..:.::.:::.. ::.:
NP_001 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB0 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQ
:::::.:. :.::: :. .:..::. . : :: : .: :.:
NP_001 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
400 410 420 430 440 450
500
pF1KB0 DADGSTSPRSQEP
>>NP_001120662 (OMIM: 124095) tyrosine-protein kinase CS (450 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 629.6 bits: 125.9 E(92320): 2.7e-28
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (48-479:8-440)
20 30 40 50 60 70
pF1KB0 TRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVT
: ::.::.: . .: : ::::.:
NP_001 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLT
10 20 30
80 90 100 110 120 130
pF1KB0 ILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
:. . .. .::..:... :.::.. :. ...::...: ::::::::::::. ..: . :
NP_001 IVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
::: ::::::::. .::::.:::: : :::.... ..:.::: :.: :::..::::
NP_001 YPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
..: ..::.:..:: .:: .:..:. :.:: ::...: : ::.:::: :. :.: :
NP_001 TSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 QKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVN
.::::: :: :.:::::: :..:::...: :::.:::::... ::::: :...::.::.
NP_001 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLA
.::.:::.... ::.::: : :.:::::....:::::::::.::::: :::::::::.
NP_001 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS
: . :...:::::::::::.. ::..::::::::.::::..:.::.:::.. ::.:
NP_001 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB0 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQ
:::::.:. :.::: :. .:..::. . : :: : .: :.:
NP_001 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
400 410 420 430 440 450
500
pF1KB0 DADGSTSPRSQEP
>>NP_004374 (OMIM: 124095) tyrosine-protein kinase CSK [ (450 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 629.6 bits: 125.9 E(92320): 2.7e-28
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (48-479:8-440)
20 30 40 50 60 70
pF1KB0 TRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVT
: ::.::.: . .: : ::::.:
NP_004 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLT
10 20 30
80 90 100 110 120 130
pF1KB0 ILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
:. . .. .::..:... :.::.. :. ...::...: ::::::::::::. ..: . :
NP_004 IVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
::: ::::::::. .::::.:::: : :::.... ..:.::: :.: :::..::::
NP_004 YPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
..: ..::.:..:: .:: .:..:. :.:: ::...: : ::.:::: :. :.: :
NP_004 TSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 QKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVN
.::::: :: :.:::::: :..:::...: :::.:::::... ::::: :...::.::.
NP_004 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLA
.::.:::.... ::.::: : :.:::::....:::::::::.::::: :::::::::.
NP_004 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS
: . :...:::::::::::.. ::..::::::::.::::..:.::.:::.. ::.:
NP_004 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB0 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQ
:::::.:. :.::: :. .:..::. . : :: : .: :.:
NP_004 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
400 410 420 430 440 450
500
pF1KB0 DADGSTSPRSQEP
>>NP_001294957 (OMIM: 176942) tyrosine-protein kinase Fe (647 aa)
initn: 703 init1: 376 opt: 926 Z-score: 374.2 bits: 79.1 E(92320): 4.5e-14
Smith-Waterman score: 926; 37.4% identity (63.9% similar) in 441 aa overlap (53-479:211-639)
30 40 50 60 70 80
pF1KB0 QLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEAC
: . . . .: : . . :: .:
NP_001 QKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERK
190 200 210 220 230 240
90 100 110 120 130
pF1KB0 ENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
: : .. ..: .: .. :...:: . ..: : :. . :.:: : :: . :
NP_001 ERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPRIEAQELL
250 260 270 280 290
140 150 160 170 180 190
pF1KB0 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
. ..: :::::: .::.::: : . :. . . :. . :.. : :. ....:.
NP_001 K--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNIPQLIDHH
300 310 320 330 340 350
200 210 220 230 240 250
pF1KB0 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
: .: .: :. . :.:. . . :: .:.:.:: : .:
NP_001 YTTKQVI-------TKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKD
360 370 380 390 400
260 270 280 290 300 310
pF1KB0 Q-KVAVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGN
. .::::. : :. . ::.:. .. ...: :.:.:.:: . : .::.:: :: :.
NP_001 KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGD
410 420 430 440 450 460
320 330 340 350 360 370
pF1KB0 LVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDF
...::: : . .. ::..::: .: :: :::::. .:::::::: ::.:. : :.:::
NP_001 FLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDF
470 480 490 500 510 520
380 390 400 410 420
pF1KB0 GLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPK
:... : :. :: ..:.::::::::..:...:.:::::::.::::.:: : :::
NP_001 GMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG
530 540 550 560 570 580
430 440 450 460 470 480
pF1KB0 MSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGA
:. ... : ::.:::: :. :: . .: .::. .: :: : .: ..:
NP_001 MTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
590 600 610 620 630 640
490 500
pF1KB0 PASVSGQDADGSTSPRSQEP
>>XP_011541573 (OMIM: 176942) tyrosine-protein kinase Fe (822 aa)
initn: 703 init1: 376 opt: 926 Z-score: 373.3 bits: 79.3 E(92320): 5.1e-14
Smith-Waterman score: 926; 37.4% identity (63.9% similar) in 441 aa overlap (53-479:386-814)
30 40 50 60 70 80
pF1KB0 QLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEAC
: . . . .: : . . :: .:
XP_011 QKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERK
360 370 380 390 400 410
90 100 110 120 130
pF1KB0 ENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
: : .. ..: .: .. :...:: . ..: : :. . :.:: : :: . :
XP_011 ERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPRIEAQELL
420 430 440 450 460 470
140 150 160 170 180 190
pF1KB0 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
. ..: :::::: .::.::: : . :. . . :. . :.. : :. ....:.
XP_011 K--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNIPQLIDHH
480 490 500 510 520 530
200 210 220 230 240 250
pF1KB0 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
: .: .: :. . :.:. . . :: .:.:.:: : .:
XP_011 YTTKQVI-------TKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKD
540 550 560 570 580
260 270 280 290 300 310
pF1KB0 Q-KVAVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGN
. .::::. : :. . ::.:. .. ...: :.:.:.:: . : .::.:: :: :.
XP_011 KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGD
590 600 610 620 630 640
320 330 340 350 360 370
pF1KB0 LVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDF
...::: : . .. ::..::: .: :: :::::. .:::::::: ::.:. : :.:::
XP_011 FLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDF
650 660 670 680 690 700
380 390 400 410 420
pF1KB0 GLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPK
:... : :. :: ..:.::::::::..:...:.:::::::.::::.:: : :::
XP_011 GMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG
710 720 730 740 750 760
430 440 450 460 470 480
pF1KB0 MSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGA
:. ... : ::.:::: :. :: . .: .::. .: :: : .: ..:
XP_011 MTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
770 780 790 800 810 820
490 500
pF1KB0 PASVSGQDADGSTSPRSQEP
>>XP_016864720 (OMIM: 176942) tyrosine-protein kinase Fe (822 aa)
initn: 703 init1: 376 opt: 926 Z-score: 373.3 bits: 79.3 E(92320): 5.1e-14
Smith-Waterman score: 926; 37.4% identity (63.9% similar) in 441 aa overlap (53-479:386-814)
30 40 50 60 70 80
pF1KB0 QLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEAC
: . . . .: : . . :: .:
XP_016 QKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERK
360 370 380 390 400 410
90 100 110 120 130
pF1KB0 ENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
: : .. ..: .: .. :...:: . ..: : :. . :.:: : :: . :
XP_016 ERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPRIEAQELL
420 430 440 450 460 470
140 150 160 170 180 190
pF1KB0 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
. ..: :::::: .::.::: : . :. . . :. . :.. : :. ....:.
XP_016 K--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNIPQLIDHH
480 490 500 510 520 530
200 210 220 230 240 250
pF1KB0 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
: .: .: :. . :.:. . . :: .:.:.:: : .:
XP_016 YTTKQVI-------TKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKD
540 550 560 570 580
260 270 280 290 300 310
pF1KB0 Q-KVAVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGN
. .::::. : :. . ::.:. .. ...: :.:.:.:: . : .::.:: :: :.
XP_016 KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGD
590 600 610 620 630 640
320 330 340 350 360 370
pF1KB0 LVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDF
...::: : . .. ::..::: .: :: :::::. .:::::::: ::.:. : :.:::
XP_016 FLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDF
650 660 670 680 690 700
380 390 400 410 420
pF1KB0 GLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPK
:... : :. :: ..:.::::::::..:...:.:::::::.::::.:: : :::
XP_016 GMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG
710 720 730 740 750 760
430 440 450 460 470 480
pF1KB0 MSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGA
:. ... : ::.:::: :. :: . .: .::. .: :: : .: ..:
XP_016 MTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
770 780 790 800 810 820
490 500
pF1KB0 PASVSGQDADGSTSPRSQEP
508 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:48:13 2019 done: Thu Oct 24 21:48:14 2019
Total Scan time: 5.440 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]