FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0470, 991 aa 1>>>pF1KB0470 991 - 991 aa - 991 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.7610+/-0.000374; mu= -2.9722+/- 0.023 mean_var=325.1885+/-67.673, 0's: 0 Z-trim(122.9): 127 B-trim: 0 in 0/60 Lambda= 0.071122 statistics sampled from 41546 (41717) to 41546 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.489), width: 16 Scan time: 14.830 The best scores are: opt bits E(85289) NP_056216 (OMIM: 606542) histone deacetylase 7 iso ( 991) 6783 710.4 1.1e-203 XP_011536781 (OMIM: 606542) PREDICTED: histone dea ( 998) 6742 706.2 2.1e-202 XP_011536780 (OMIM: 606542) PREDICTED: histone dea (1035) 6739 705.9 2.7e-202 NP_001295019 (OMIM: 606542) histone deacetylase 7 ( 974) 6629 694.6 6.4e-199 XP_016874944 (OMIM: 606542) PREDICTED: histone dea (1018) 6626 694.3 8.2e-199 XP_011536783 (OMIM: 606542) PREDICTED: histone dea ( 952) 6472 678.5 4.5e-194 XP_011536784 (OMIM: 606542) PREDICTED: histone dea ( 952) 6472 678.5 4.5e-194 NP_001091886 (OMIM: 606542) histone deacetylase 7 ( 954) 4732 500.0 2.5e-140 XP_011536782 (OMIM: 606542) PREDICTED: histone dea ( 998) 4732 500.0 2.6e-140 XP_016874945 (OMIM: 606542) PREDICTED: histone dea ( 691) 4373 463.0 2.4e-129 XP_011536785 (OMIM: 606542) PREDICTED: histone dea ( 606) 3789 403.1 2.4e-111 XP_016860883 (OMIM: 605314) PREDICTED: histone dea (1069) 2423 263.1 5.7e-69 XP_016860884 (OMIM: 605314) PREDICTED: histone dea ( 917) 2279 248.3 1.4e-64 XP_011510529 (OMIM: 605314) PREDICTED: histone dea (1041) 2279 248.3 1.6e-64 XP_006712943 (OMIM: 605314) PREDICTED: histone dea (1062) 2279 248.3 1.6e-64 XP_006712942 (OMIM: 605314) PREDICTED: histone dea (1062) 2279 248.3 1.6e-64 XP_011510528 (OMIM: 605314) PREDICTED: histone dea (1065) 2279 248.3 1.6e-64 XP_011510526 (OMIM: 605314) PREDICTED: histone dea (1084) 2279 248.3 1.6e-64 XP_011510524 (OMIM: 605314) PREDICTED: histone dea (1089) 2279 248.3 1.6e-64 XP_006712941 (OMIM: 605314) PREDICTED: histone dea (1089) 2279 248.3 1.6e-64 XP_011510523 (OMIM: 605314) PREDICTED: histone dea (1089) 2279 248.3 1.6e-64 XP_011510525 (OMIM: 605314) PREDICTED: histone dea (1089) 2279 248.3 1.6e-64 XP_011510522 (OMIM: 605314) PREDICTED: histone dea (1090) 2279 248.3 1.6e-64 XP_011510519 (OMIM: 605314) PREDICTED: histone dea (1113) 2279 248.3 1.6e-64 XP_011510527 (OMIM: 605314) PREDICTED: histone dea (1079) 2278 248.2 1.7e-64 NP_006028 (OMIM: 605314) histone deacetylase 4 [Ho (1084) 2278 248.2 1.7e-64 XP_006712940 (OMIM: 605314) PREDICTED: histone dea (1108) 2278 248.2 1.8e-64 XP_011510532 (OMIM: 605314) PREDICTED: histone dea ( 673) 2265 246.7 3e-64 XP_011510521 (OMIM: 605314) PREDICTED: histone dea (1103) 2175 237.7 2.7e-61 XP_011510520 (OMIM: 605314) PREDICTED: histone dea (1108) 2175 237.7 2.7e-61 XP_016879485 (OMIM: 605315) PREDICTED: histone dea (1081) 2042 224.0 3.4e-57 XP_011522452 (OMIM: 605315) PREDICTED: histone dea (1113) 2042 224.0 3.4e-57 XP_016879484 (OMIM: 605315) PREDICTED: histone dea (1113) 2042 224.0 3.4e-57 XP_011522451 (OMIM: 605315) PREDICTED: histone dea (1114) 2042 224.0 3.4e-57 XP_005256963 (OMIM: 605315) PREDICTED: histone dea (1122) 2042 224.0 3.5e-57 NP_005465 (OMIM: 605315) histone deacetylase 5 iso (1122) 2042 224.0 3.5e-57 XP_005256962 (OMIM: 605315) PREDICTED: histone dea (1122) 2042 224.0 3.5e-57 NP_001015053 (OMIM: 605315) histone deacetylase 5 (1123) 2042 224.0 3.5e-57 XP_016879482 (OMIM: 605315) PREDICTED: histone dea (1152) 2042 224.0 3.5e-57 XP_016879481 (OMIM: 605315) PREDICTED: histone dea (1156) 2042 224.0 3.5e-57 XP_016879480 (OMIM: 605315) PREDICTED: histone dea (1160) 2042 224.0 3.5e-57 XP_016879479 (OMIM: 605315) PREDICTED: histone dea (1160) 2042 224.0 3.5e-57 XP_016879477 (OMIM: 605315) PREDICTED: histone dea (1161) 2042 224.0 3.5e-57 XP_016879478 (OMIM: 605315) PREDICTED: histone dea (1161) 2042 224.0 3.5e-57 XP_016879483 (OMIM: 605315) PREDICTED: histone dea (1120) 2039 223.7 4.3e-57 XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 1937 213.2 5.6e-54 NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 1937 213.2 5.6e-54 NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 1937 213.2 5.6e-54 NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 1937 213.2 5.7e-54 XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 1937 213.2 5.7e-54 >>NP_056216 (OMIM: 606542) histone deacetylase 7 isoform (991 aa) initn: 6783 init1: 6783 opt: 6783 Z-score: 3777.5 bits: 710.4 E(85289): 1.1e-203 Smith-Waterman score: 6783; 100.0% identity (100.0% similar) in 991 aa overlap (1-991:1-991) 10 20 30 40 50 60 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB0 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB0 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB0 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 910 920 930 940 950 960 970 980 990 pF1KB0 AVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::: NP_056 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 970 980 990 >>XP_011536781 (OMIM: 606542) PREDICTED: histone deacety (998 aa) initn: 6739 init1: 6739 opt: 6742 Z-score: 3754.7 bits: 706.2 E(85289): 2.1e-202 Smith-Waterman score: 6742; 99.6% identity (99.7% similar) in 991 aa overlap (1-991:9-998) 10 20 30 40 50 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEP . :: :::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEDGSLLPLSSP-KDGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEP 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 PPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 KSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB0 LPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAET 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB0 LGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB0 ITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB0 PSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB0 MQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQ 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB0 PEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPAS 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB0 LSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWS 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB0 RLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMF 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB0 VMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADH 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB0 STAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHD 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB0 DGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDL 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB0 VLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASE 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB0 ACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVP 900 910 920 930 940 950 960 970 980 990 pF1KB0 GADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::::::::::: XP_011 GADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL 960 970 980 990 >>XP_011536780 (OMIM: 606542) PREDICTED: histone deacety (1035 aa) initn: 6739 init1: 6739 opt: 6739 Z-score: 3752.8 bits: 705.9 E(85289): 2.7e-202 Smith-Waterman score: 6739; 99.7% identity (99.8% similar) in 989 aa overlap (3-991:47-1035) 10 20 30 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADT : .:::::::::::::::::::::::::: XP_011 SHGGDAEEVLAQHPTPTGRGAERRPRPPDSSAEGDGTQVSPGAHYCSPTGAGCPRPCADT 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB0 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KB0 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG 440 450 460 470 480 490 460 470 480 490 500 510 pF1KB0 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL 500 510 520 530 540 550 520 530 540 550 560 570 pF1KB0 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC 560 570 580 590 600 610 580 590 600 610 620 630 pF1KB0 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP 620 630 640 650 660 670 640 650 660 670 680 690 pF1KB0 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA 680 690 700 710 720 730 700 710 720 730 740 750 pF1KB0 SRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNG 740 750 760 770 780 790 760 770 780 790 800 810 pF1KB0 TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPE 800 810 820 830 840 850 820 830 840 850 860 870 pF1KB0 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 860 870 880 890 900 910 880 890 900 910 920 930 pF1KB0 AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSK 920 930 940 950 960 970 940 950 960 970 980 990 pF1KB0 YWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL 980 990 1000 1010 1020 1030 >>NP_001295019 (OMIM: 606542) histone deacetylase 7 isof (974 aa) initn: 6626 init1: 6626 opt: 6629 Z-score: 3692.2 bits: 694.6 E(85289): 6.4e-199 Smith-Waterman score: 6629; 99.9% identity (99.9% similar) in 973 aa overlap (19-991:3-974) 10 20 30 40 50 60 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA :: ::::::::::::::::::::::::::::::::::::::: NP_001 MHSP-GAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 10 20 30 40 70 80 90 100 110 120 pF1KB0 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB0 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB0 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB0 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB0 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB0 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB0 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB0 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB0 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB0 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB0 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB0 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB0 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB0 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB0 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 890 900 910 920 930 940 970 980 990 pF1KB0 AVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::: NP_001 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 950 960 970 >>XP_016874944 (OMIM: 606542) PREDICTED: histone deacety (1018 aa) initn: 6614 init1: 6614 opt: 6626 Z-score: 3690.3 bits: 694.3 E(85289): 8.2e-199 Smith-Waterman score: 6626; 98.4% identity (98.8% similar) in 989 aa overlap (3-991:31-1018) 10 20 30 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADT .: . :.. : : : ::::::::: XP_016 MFARSAGLCFPWVPGVSHGGDAEEVLAQHPTPTGRGAERRPRPPDSSAEG-GCPRPCADT 10 20 30 40 50 40 50 60 70 80 90 pF1KB0 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB0 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB0 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB0 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB0 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB0 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB0 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG 420 430 440 450 460 470 460 470 480 490 500 510 pF1KB0 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL 480 490 500 510 520 530 520 530 540 550 560 570 pF1KB0 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC 540 550 560 570 580 590 580 590 600 610 620 630 pF1KB0 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP 600 610 620 630 640 650 640 650 660 670 680 690 pF1KB0 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA 660 670 680 690 700 710 700 710 720 730 740 750 pF1KB0 SRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNG 720 730 740 750 760 770 760 770 780 790 800 810 pF1KB0 TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPE 780 790 800 810 820 830 820 830 840 850 860 870 pF1KB0 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 840 850 860 870 880 890 880 890 900 910 920 930 pF1KB0 AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSK 900 910 920 930 940 950 940 950 960 970 980 990 pF1KB0 YWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL 960 970 980 990 1000 1010 >>XP_011536783 (OMIM: 606542) PREDICTED: histone deacety (952 aa) initn: 6472 init1: 6472 opt: 6472 Z-score: 3605.3 bits: 678.5 E(85289): 4.5e-194 Smith-Waterman score: 6472; 100.0% identity (100.0% similar) in 952 aa overlap (40-991:1-952) 10 20 30 40 50 60 pF1KB0 QVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHH :::::::::::::::::::::::::::::: XP_011 MDLRVGQRPPVEPPPEPTLLALQRPQRLHH 10 20 30 70 80 90 100 110 120 pF1KB0 HLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB0 EVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB0 RKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB0 SPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB0 HPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB0 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKR 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB0 SAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB0 WEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSE 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB0 TPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGR 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB0 KASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWN 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB0 ELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACR 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB0 QLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAG 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB0 SGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPL 760 770 780 790 800 810 850 860 870 880 890 900 pF1KB0 GGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEE 820 830 840 850 860 870 910 920 930 940 950 960 pF1KB0 GWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLS 880 890 900 910 920 930 970 980 990 pF1KB0 VGILAEDRPSEQLVEEEEPMNL :::::::::::::::::::::: XP_011 VGILAEDRPSEQLVEEEEPMNL 940 950 >>XP_011536784 (OMIM: 606542) PREDICTED: histone deacety (952 aa) initn: 6472 init1: 6472 opt: 6472 Z-score: 3605.3 bits: 678.5 E(85289): 4.5e-194 Smith-Waterman score: 6472; 100.0% identity (100.0% similar) in 952 aa overlap (40-991:1-952) 10 20 30 40 50 60 pF1KB0 QVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHH :::::::::::::::::::::::::::::: XP_011 MDLRVGQRPPVEPPPEPTLLALQRPQRLHH 10 20 30 70 80 90 100 110 120 pF1KB0 HLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB0 EVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB0 RKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB0 SPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB0 HPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB0 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKR 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB0 SAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB0 WEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSE 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB0 TPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGR 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB0 KASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWN 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB0 ELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACR 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB0 QLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAG 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB0 SGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPL 760 770 780 790 800 810 850 860 870 880 890 900 pF1KB0 GGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEE 820 830 840 850 860 870 910 920 930 940 950 960 pF1KB0 GWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLS 880 890 900 910 920 930 970 980 990 pF1KB0 VGILAEDRPSEQLVEEEEPMNL :::::::::::::::::::::: XP_011 VGILAEDRPSEQLVEEEEPMNL 940 950 >>NP_001091886 (OMIM: 606542) histone deacetylase 7 isof (954 aa) initn: 4729 init1: 4729 opt: 4732 Z-score: 2640.4 bits: 500.0 E(85289): 2.5e-140 Smith-Waterman score: 6469; 96.3% identity (96.3% similar) in 991 aa overlap (1-991:1-954) 10 20 30 40 50 60 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP :::::::::::::::::::::::::: NP_001 SSTPASGCSSPNDSEHGPNPILGSEA---------------------------------- 250 260 310 320 330 340 350 360 pF1KB0 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---DSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB0 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB0 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 390 400 410 420 430 440 490 500 510 520 530 540 pF1KB0 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 450 460 470 480 490 500 550 560 570 580 590 600 pF1KB0 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 510 520 530 540 550 560 610 620 630 640 650 660 pF1KB0 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 570 580 590 600 610 620 670 680 690 700 710 720 pF1KB0 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 630 640 650 660 670 680 730 740 750 760 770 780 pF1KB0 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 690 700 710 720 730 740 790 800 810 820 830 840 pF1KB0 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 750 760 770 780 790 800 850 860 870 880 890 900 pF1KB0 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 810 820 830 840 850 860 910 920 930 940 950 960 pF1KB0 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 870 880 890 900 910 920 970 980 990 pF1KB0 AVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::: NP_001 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 930 940 950 >>XP_011536782 (OMIM: 606542) PREDICTED: histone deacety (998 aa) initn: 4769 init1: 4729 opt: 4732 Z-score: 2640.1 bits: 500.0 E(85289): 2.6e-140 Smith-Waterman score: 6425; 96.0% identity (96.1% similar) in 989 aa overlap (3-991:47-998) 10 20 30 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADT : .:::::::::::::::::::::::::: XP_011 SHGGDAEEVLAQHPTPTGRGAERRPRPPDSSAEGDGTQVSPGAHYCSPTGAGCPRPCADT 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEA------ 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG ::::::::::::::::::::::::::::: XP_011 -------------------------------DSDRRTHPTLGPRGPILGSPHTPLFLPHG 320 330 340 350 360 370 380 390 pF1KB0 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL 340 350 360 370 380 390 400 410 420 430 440 450 pF1KB0 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG 400 410 420 430 440 450 460 470 480 490 500 510 pF1KB0 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL 460 470 480 490 500 510 520 530 540 550 560 570 pF1KB0 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC 520 530 540 550 560 570 580 590 600 610 620 630 pF1KB0 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP 580 590 600 610 620 630 640 650 660 670 680 690 pF1KB0 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA 640 650 660 670 680 690 700 710 720 730 740 750 pF1KB0 SRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNG 700 710 720 730 740 750 760 770 780 790 800 810 pF1KB0 TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPE 760 770 780 790 800 810 820 830 840 850 860 870 pF1KB0 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 820 830 840 850 860 870 880 890 900 910 920 930 pF1KB0 AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSK 880 890 900 910 920 930 940 950 960 970 980 990 pF1KB0 YWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL 940 950 960 970 980 990 >>XP_016874945 (OMIM: 606542) PREDICTED: histone deacety (691 aa) initn: 4373 init1: 4373 opt: 4373 Z-score: 2443.2 bits: 463.0 E(85289): 2.4e-129 Smith-Waterman score: 4373; 99.5% identity (99.7% similar) in 643 aa overlap (3-645:47-689) 10 20 30 pF1KB0 MHSPGADGTQVSPGAHYCSPTGAGCPRPCADT : .:::::::::::::::::::::::::: XP_016 SHGGDAEEVLAQHPTPTGRGAERRPRPPDSSAEGDGTQVSPGAHYCSPTGAGCPRPCADT 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIP 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHG 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB0 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KB0 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG 440 450 460 470 480 490 460 470 480 490 500 510 pF1KB0 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPL 500 510 520 530 540 550 520 530 540 550 560 570 pF1KB0 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQC 560 570 580 590 600 610 580 590 600 610 620 630 pF1KB0 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP 620 630 640 650 660 670 640 650 660 670 680 690 pF1KB0 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVA ::::::::::::: XP_016 LSRLKLDNGKLAGGH 680 690 991 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:47:17 2016 done: Sat Nov 5 01:47:19 2016 Total Scan time: 14.830 Total Display time: 0.420 Function used was FASTA [36.3.4 Apr, 2011]