FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0471, 515 aa 1>>>pF1KB0471 515 - 515 aa - 515 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6513+/-0.000365; mu= 12.0260+/- 0.023 mean_var=102.8953+/-20.076, 0's: 0 Z-trim(115.9): 20 B-trim: 34 in 1/51 Lambda= 0.126438 statistics sampled from 26613 (26633) to 26613 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.312), width: 16 Scan time: 10.110 The best scores are: opt bits E(85289) NP_997468 (OMIM: 602376,610424,616669) interferon ( 515) 3437 637.7 2.4e-182 NP_001276054 (OMIM: 602376,610424,616669) interfer ( 515) 3437 637.7 2.4e-182 NP_997467 (OMIM: 602376,610424,616669) interferon ( 331) 1833 345.0 2e-94 NP_000865 (OMIM: 602376,610424,616669) interferon ( 331) 1833 345.0 2e-94 NP_001276055 (OMIM: 602376,610424,616669) interfer ( 239) 1572 297.3 3.3e-80 NP_001276057 (OMIM: 602376,610424,616669) interfer ( 239) 1572 297.3 3.3e-80 >>NP_997468 (OMIM: 602376,610424,616669) interferon alph (515 aa) initn: 3437 init1: 3437 opt: 3437 Z-score: 3394.6 bits: 637.7 E(85289): 2.4e-182 Smith-Waterman score: 3437; 100.0% identity (100.0% similar) in 515 aa overlap (1-515:1-515) 10 20 30 40 50 60 pF1KB0 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT 430 440 450 460 470 480 490 500 510 pF1KB0 FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR ::::::::::::::::::::::::::::::::::: NP_997 FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR 490 500 510 >>NP_001276054 (OMIM: 602376,610424,616669) interferon a (515 aa) initn: 3437 init1: 3437 opt: 3437 Z-score: 3394.6 bits: 637.7 E(85289): 2.4e-182 Smith-Waterman score: 3437; 100.0% identity (100.0% similar) in 515 aa overlap (1-515:1-515) 10 20 30 40 50 60 pF1KB0 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT 430 440 450 460 470 480 490 500 510 pF1KB0 FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR ::::::::::::::::::::::::::::::::::: NP_001 FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR 490 500 510 >>NP_997467 (OMIM: 602376,610424,616669) interferon alph (331 aa) initn: 1855 init1: 1833 opt: 1833 Z-score: 1816.2 bits: 345.0 E(85289): 2e-94 Smith-Waterman score: 1833; 100.0% identity (100.0% similar) in 280 aa overlap (1-280:1-280) 10 20 30 40 50 60 pF1KB0 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD :::::::::::::::::::::::::::::::::::::::: NP_997 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLRQGLAKGWNAVAIHRCSHNA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI NP_997 LQSETPELKQSSCLSFPSSWDYKRASLCPSD 310 320 330 >>NP_000865 (OMIM: 602376,610424,616669) interferon alph (331 aa) initn: 1855 init1: 1833 opt: 1833 Z-score: 1816.2 bits: 345.0 E(85289): 2e-94 Smith-Waterman score: 1833; 100.0% identity (100.0% similar) in 280 aa overlap (1-280:1-280) 10 20 30 40 50 60 pF1KB0 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD :::::::::::::::::::::::::::::::::::::::: NP_000 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLRQGLAKGWNAVAIHRCSHNA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI NP_000 LQSETPELKQSSCLSFPSSWDYKRASLCPSD 310 320 330 >>NP_001276055 (OMIM: 602376,610424,616669) interferon a (239 aa) initn: 1572 init1: 1572 opt: 1572 Z-score: 1561.0 bits: 297.3 E(85289): 3.3e-80 Smith-Waterman score: 1572; 100.0% identity (100.0% similar) in 237 aa overlap (1-237:1-237) 10 20 30 40 50 60 pF1KB0 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESEFS 190 200 210 220 230 250 260 270 280 290 300 pF1KB0 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD >>NP_001276057 (OMIM: 602376,610424,616669) interferon a (239 aa) initn: 1572 init1: 1572 opt: 1572 Z-score: 1561.0 bits: 297.3 E(85289): 3.3e-80 Smith-Waterman score: 1572; 100.0% identity (100.0% similar) in 237 aa overlap (1-237:1-237) 10 20 30 40 50 60 pF1KB0 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESEFS 190 200 210 220 230 250 260 270 280 290 300 pF1KB0 SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD 515 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:51:12 2016 done: Sat Nov 5 18:51:13 2016 Total Scan time: 10.110 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]