Result of FASTA (omim) for
pF1KB0475
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0475, 517 aa
1>>>pF1KB0475 517 - 517 aa - 517 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4670+/-0.000403; mu= 14.9462+/- 0.025
mean_var=172.5963+/-36.130, 0's: 0 Z-trim(117.4): 226 B-trim: 7 in 2/53
Lambda= 0.097624
statistics sampled from 29108 (29402) to 29108 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.345), width: 16
Scan time: 9.170
The best scores are: opt bits E(85289)
NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 ( 517) 3505 506.3 9.1e-143
NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 ( 458) 2272 332.5 1.6e-90
NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 ( 352) 2249 329.2 1.3e-89
XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 is ( 510) 748 117.9 7e-26
NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Ho ( 487) 747 117.8 7.5e-26
XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 is ( 541) 747 117.8 8.1e-26
NP_056295 (OMIM: 607147) nectin-3 isoform 1 precur ( 549) 718 113.8 1.4e-24
XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 is ( 526) 717 113.6 1.5e-24
XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 is ( 534) 717 113.6 1.5e-24
XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 is ( 580) 717 113.6 1.6e-24
NP_001230215 (OMIM: 607147) nectin-3 isoform 2 pre ( 366) 709 112.3 2.6e-24
NP_001129242 (OMIM: 173850) poliovirus receptor is ( 392) 650 104.0 8.5e-22
NP_006496 (OMIM: 173850) poliovirus receptor isofo ( 417) 650 104.0 8.9e-22
NP_001129240 (OMIM: 173850) poliovirus receptor is ( 372) 633 101.6 4.3e-21
NP_001129241 (OMIM: 173850) poliovirus receptor is ( 364) 615 99.0 2.5e-20
NP_002847 (OMIM: 600798) nectin-2 isoform alpha pr ( 479) 614 99.0 3.2e-20
NP_001036189 (OMIM: 600798) nectin-2 isoform delta ( 538) 569 92.8 2.8e-18
XP_011508324 (OMIM: 609607,613573) PREDICTED: nect ( 486) 555 90.7 1e-17
XP_011508325 (OMIM: 609607,613573) PREDICTED: nect ( 460) 552 90.3 1.3e-17
XP_011508323 (OMIM: 609607,613573) PREDICTED: nect ( 511) 552 90.3 1.4e-17
XP_005245565 (OMIM: 609607,613573) PREDICTED: nect ( 485) 545 89.3 2.8e-17
NP_112178 (OMIM: 609607,613573) nectin-4 precursor ( 510) 542 88.9 3.8e-17
XP_011525494 (OMIM: 600798) PREDICTED: nectin-2 is ( 369) 530 87.1 1e-16
XP_016861616 (OMIM: 607147) PREDICTED: nectin-3 is ( 337) 421 71.7 4e-12
XP_005271551 (OMIM: 605686) PREDICTED: cell adhesi ( 425) 347 61.4 6.3e-09
NP_001091987 (OMIM: 605686) cell adhesion molecule ( 414) 323 58.0 6.4e-08
NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398) 318 57.3 1e-07
NP_067012 (OMIM: 609743) cell adhesion molecule 3 ( 432) 318 57.3 1.1e-07
XP_016872947 (OMIM: 605686) PREDICTED: cell adhesi ( 402) 310 56.1 2.3e-07
NP_055148 (OMIM: 605686) cell adhesion molecule 1 ( 442) 310 56.2 2.4e-07
NP_001287973 (OMIM: 605686) cell adhesion molecule ( 453) 303 55.2 4.8e-07
NP_001287972 (OMIM: 605686) cell adhesion molecule ( 471) 303 55.2 4.9e-07
XP_016872946 (OMIM: 605686) PREDICTED: cell adhesi ( 477) 303 55.2 5e-07
XP_016881941 (OMIM: 609744) PREDICTED: cell adhesi ( 369) 300 54.7 5.7e-07
NP_001287974 (OMIM: 605686) cell adhesion molecule ( 443) 301 54.9 5.8e-07
NP_660339 (OMIM: 609744) cell adhesion molecule 4 ( 388) 300 54.7 5.8e-07
XP_005258677 (OMIM: 609744) PREDICTED: cell adhesi ( 345) 256 48.4 4e-05
XP_006713145 (OMIM: 609938) PREDICTED: cell adhesi ( 395) 253 48.1 5.8e-05
XP_016861552 (OMIM: 609938) PREDICTED: cell adhesi ( 397) 253 48.1 5.8e-05
NP_001161147 (OMIM: 609938) cell adhesion molecule ( 404) 253 48.1 5.9e-05
NP_001161146 (OMIM: 609938) cell adhesion molecule ( 435) 244 46.9 0.00015
XP_006713144 (OMIM: 609938) PREDICTED: cell adhesi ( 435) 244 46.9 0.00015
NP_694854 (OMIM: 609938) cell adhesion molecule 2 ( 437) 244 46.9 0.00015
XP_016861551 (OMIM: 609938) PREDICTED: cell adhesi ( 449) 244 46.9 0.00015
XP_016872950 (OMIM: 605686) PREDICTED: cell adhesi ( 267) 240 46.1 0.00016
XP_016872949 (OMIM: 605686) PREDICTED: cell adhesi ( 295) 227 44.3 0.00061
XP_016872948 (OMIM: 605686) PREDICTED: cell adhesi ( 324) 220 43.3 0.0013
>>NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 pre (517 aa)
initn: 3505 init1: 3505 opt: 3505 Z-score: 2684.1 bits: 506.3 E(85289): 9.1e-143
Smith-Waterman score: 3505; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517)
10 20 30 40 50 60
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 DSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDG
430 440 450 460 470 480
490 500 510
pF1KB0 YGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
:::::::::::::::::::::::::::::::::::::
NP_002 YGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
490 500 510
>>NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 pre (458 aa)
initn: 2276 init1: 2250 opt: 2272 Z-score: 1746.2 bits: 332.5 E(85289): 1.6e-90
Smith-Waterman score: 2279; 76.4% identity (83.7% similar) in 479 aa overlap (1-477:1-454)
10 20 30 40 50 60
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
::::::::::::::::::::::::::::::::::: : :..: : . . : :
NP_976 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEKPR----PQRG--LGSAARLLAGTV
310 320 330 340 350
370 380 390 400 410
pF1KB0 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHP-PMAQNLQYP
: ..:.:..: . :.... .. : : .. . .: : :. :
NP_976 A--VFLILVAVLTVFFLYNRQQKS-------PPETDGAGTDQPLSQKPEPSPSRQSSLVP
360 370 380 390 400
420 430 440 450 460 470
pF1KB0 DDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYF-TVDEAEARQ
.: . . : : . ..:::. . :.. : :: .. : .: .: :
NP_976 EDIQ-VVHLDP--GRQQQQEEEDLQ-------KLSLQPPYYDLGVSPSYHPSVRTTEPRG
410 420 430 440 450
480 490 500 510
pF1KB0 DGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
NP_976 ECP
>>NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 pre (352 aa)
initn: 2249 init1: 2249 opt: 2249 Z-score: 1729.9 bits: 329.2 E(85289): 1.3e-89
Smith-Waterman score: 2249; 96.8% identity (97.1% similar) in 349 aa overlap (1-349:1-349)
10 20 30 40 50 60
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 KITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 VYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 SVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_976 LNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGV
:::::::::::::::::::::::::::::::::: : : . ::
NP_976 FFKGPINYSLAGTYICEATNPIGTRSGQVEVNITAFCQLIYPGKGRTRARMF
310 320 330 340 350
370 380 390 400 410 420
pF1KB0 AGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPD
>>XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 isofor (510 aa)
initn: 658 init1: 308 opt: 748 Z-score: 585.6 bits: 117.9 E(85289): 7e-26
Smith-Waterman score: 756; 32.4% identity (61.6% similar) in 438 aa overlap (25-448:52-471)
10 20 30 40 50
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFA
: :. . . :. . . : .: :.: .
XP_016 ASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIE
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB0 NPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRL
. :::..:.: . :.:.::...:..: :: . :. :: : :..:.:: : .
XP_016 V---NETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNI
90 100 110 120 130
120 130 140 150 160 170
pF1KB0 ELEDEGVYICEFATFPTGNRESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCT
. : : :::. .::: :: .:. ..::...:: . :.: .... : .. : .: :
XP_016 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICI
140 150 160 170 180 190
180 190 200 210 220 230
pF1KB0 SANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-M
.:.::: . ..:: : :: : :: :.:.::.:.: :.: :. . ..:.:.. .
XP_016 AATGKPVAHIDWEGDL-GEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPAL
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB0 DR-FKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPK
.. .. :. :..:: :::.. :.::::.. : :.: :.:::::: . :. :.:. :
XP_016 EKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPD
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB0 GVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGP
:. :.. :: : :.... .:.:::..:: .: :: : . :.. :. .
XP_016 GLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDVPFKQTSS--------
320 330 340 350 360
360 370 380 390 400
pF1KB0 VPTAIIGGVAGSILLVLIVVGGIVVAL--RRRRHTF--KGDYSTKKHVYGNGYSKAGIPQ
:. :.: :..: ..:.. ..: : :..: .. : : : . . :
XP_016 --IAVAGAVIGAVLALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPL
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 HHPPMAQNLQYPDDSD-DEKKAGPLGGS------SYEEEEEEEEGGGGGERKVGGPHPKY
. . : . : ... :...: : : :.. :.:. : :
XP_016 PQKDLFQPEHLPLQTQFKEREVGNLQHSNGLNSRSFDYEDENPVGEDGIQQMYPLYNQMC
430 440 450 460 470 480
470 480 490 500 510
pF1KB0 DEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
XP_016 YQDRSPGKHHQNNDPKRVYIDPREHYV
490 500 510
>>NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Homo s (487 aa)
initn: 658 init1: 308 opt: 747 Z-score: 585.1 bits: 117.8 E(85289): 7.5e-26
Smith-Waterman score: 755; 33.2% identity (63.2% similar) in 419 aa overlap (44-448:48-448)
20 30 40 50 60 70
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
: .: :.: . . :::..:.: .
NP_001 RGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLIEV---NETITQISWEKIHGK
20 30 40 50 60 70
80 90 100 110 120 130
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
:.:.::...:..: :: . :. :: : :..:.:: : . . : : :::. .::: ::
NP_001 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
80 90 100 110 120 130
140 150 160 170 180 190
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
.:. ..::...:: . :.: .... : .. : .: : .:.::: . ..:: : ::
NP_001 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
140 150 160 170 180
200 210 220 230 240 250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
: :: :.:.::.:.: :.: :. . ..:.:.. ... .. :. :..:: :::.
NP_001 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
. :.::::.. : :.: :.:::::: . :. :.:. : :. :.. :: : :....
NP_001 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
250 260 270 280 290 300
320 330 340 350 360 370
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIV
.:.:::..:: .: :: : . :.. :. .... . :. :.: :..: ..:.
NP_001 SGVYICKVTNSLGQRSDQKVIYISDVPF--------KQTSSI--AVAGAVIGAVLALFII
310 320 330 340 350
380 390 400 410 420
pF1KB0 VGGIVVAL--RRRRHTF--KGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSD-DE
. ..: : :..: .. : : : . . : . . : . : ... :
NP_001 AIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEHLPLQTQFKE
360 370 380 390 400 410
430 440 450 460 470
pF1KB0 KKAGPLGGS------SYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQD
...: : : :.. :.:. : :
NP_001 REVGNLQHSNGLNSRSFDYEDENPVGEDGIQQMYPLYNQMCYQDRSPGKHHQNNDPKRVY
420 430 440 450 460 470
>>XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 isofor (541 aa)
initn: 658 init1: 308 opt: 747 Z-score: 584.5 bits: 117.8 E(85289): 8.1e-26
Smith-Waterman score: 755; 33.2% identity (63.2% similar) in 419 aa overlap (44-448:102-502)
20 30 40 50 60 70
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
: .: :.: . . :::..:.: .
XP_016 ILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLIEV---NETITQISWEKIHGK
80 90 100 110 120
80 90 100 110 120 130
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
:.:.::...:..: :: . :. :: : :..:.:: : . . : : :::. .::: ::
XP_016 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
130 140 150 160 170 180
140 150 160 170 180 190
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
.:. ..::...:: . :.: .... : .. : .: : .:.::: . ..:: : ::
XP_016 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
190 200 210 220 230 240
200 210 220 230 240 250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
: :: :.:.::.:.: :.: :. . ..:.:.. ... .. :. :..:: :::.
XP_016 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
. :.::::.. : :.: :.:::::: . :. :.:. : :. :.. :: : :....
XP_016 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIV
.:.:::..:: .: :: : . :.. :. .... . :. :.: :..: ..:.
XP_016 SGVYICKVTNSLGQRSDQKVIYISDVPF--------KQTSSI--AVAGAVIGAVLALFII
370 380 390 400 410
380 390 400 410 420
pF1KB0 VGGIVVAL--RRRRHTF--KGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSD-DE
. ..: : :..: .. : : : . . : . . : . : ... :
XP_016 AIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEHLPLQTQFKE
420 430 440 450 460 470
430 440 450 460 470
pF1KB0 KKAGPLGGS------SYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQD
...: : : :.. :.:. : :
XP_016 REVGNLQHSNGLNSRSFDYEDENPVGEDGIQQMYPLYNQMCYQDRSPGKHHQNNDPKRVY
480 490 500 510 520 530
>>NP_056295 (OMIM: 607147) nectin-3 isoform 1 precursor (549 aa)
initn: 786 init1: 308 opt: 718 Z-score: 562.4 bits: 113.8 E(85289): 1.4e-24
Smith-Waterman score: 833; 32.8% identity (60.3% similar) in 527 aa overlap (25-517:52-549)
10 20 30 40 50
pF1KB0 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFA
: :. . . :. . . : .: :.: .
NP_056 ASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIE
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB0 NPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRL
. :::..:.: . :.:.::...:..: :: . :. :: : :..:.:: : .
NP_056 ---VNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNI
90 100 110 120 130
120 130 140 150 160 170
pF1KB0 ELEDEGVYICEFATFPTGNRESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCT
. : : :::. .::: :: .:. ..::...:: . :.: .... : .. : .: :
NP_056 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICI
140 150 160 170 180 190
180 190 200 210 220 230
pF1KB0 SANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-M
.:.::: . ..:: : :: : :: :.:.::.:.: :.: :. . ..:.:.. .
NP_056 AATGKPVAHIDWEGDL-GEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPAL
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB0 DR-FKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPK
.. .. :. :..:: :::.. :.::::.. : :.: :.:::::: . :. :.:. :
NP_056 EKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPD
260 270 280 290 300 310
300 310 320 330 340
pF1KB0 GVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGR
:. :.. :: : :.... .:.:::..:: .: :: : . :.. : : :. :
NP_056 GLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPS
320 330 340 350 360 370
350 360 370 380
pF1KB0 RAG-----------PVP-------------TAIIGGVAGSILLVLIVVGGIVVALRRRRH
: : : : : . :.:....::. : . . ::::
NP_056 TADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-
380 390 400 410 420 430
390 400 410 420 430 440
pF1KB0 TFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEE
::.::: .:... . ..: . : . ..:. :::. :.: .:... .. ::
NP_056 TFRGDYFAKNYIPPSDMQKES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEE
440 450 460 470 480
450 460 470 480 490 500
pF1KB0 EEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-
: :. . . . .::. : : : .:... . :. : :.
NP_056 PE-------KTQWNNVENLNRFERPM----------DYYEDLKMGMKFVSDEHYDENEDD
490 500 510 520 530
510
pF1KB0 MVSQNDGSFISKKEWYV
.::. ::: ::..::::
NP_056 LVSHVDGSVISRREWYV
540
>>XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 isofor (526 aa)
initn: 786 init1: 308 opt: 717 Z-score: 561.8 bits: 113.6 E(85289): 1.5e-24
Smith-Waterman score: 832; 33.5% identity (60.8% similar) in 508 aa overlap (44-517:48-526)
20 30 40 50 60 70
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
: .: :.: . . :::..:.: .
XP_016 RGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLIE---VNETITQISWEKIHGK
20 30 40 50 60 70
80 90 100 110 120 130
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
:.:.::...:..: :: . :. :: : :..:.:: : . . : : :::. .::: ::
XP_016 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
80 90 100 110 120 130
140 150 160 170 180 190
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
.:. ..::...:: . :.: .... : .. : .: : .:.::: . ..:: : ::
XP_016 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
140 150 160 170 180
200 210 220 230 240 250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
: :: :.:.::.:.: :.: :. . ..:.:.. ... .. :. :..:: :::.
XP_016 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
. :.::::.. : :.: :.:::::: . :. :.:. : :. :.. :: : :....
XP_016 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
250 260 270 280 290 300
320 330 340 350
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGRRAG-----------PVP--
.:.:::..:: .: :: : . :.. : : :. : : : :
XP_016 SGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
310 320 330 340 350 360
360 370 380 390 400
pF1KB0 -----------TAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK
: : . :.:....::. : . . :::: ::.::: .:... . ..:
XP_016 TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-TFRGDYFAKNYIPPSDMQK
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB0 AGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYD
. : . ..:. :::. :.: .:... .. :: : :. . .
XP_016 ES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEEPE-------KTQWNNVENL
430 440 450 460 470
470 480 490 500 510
pF1KB0 EDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-MVSQNDGSFISKKEWYV
. .::. : : : .:... . :. : :. .::. ::: ::..::::
XP_016 NRFERPM----------DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
480 490 500 510 520
>>XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 isofor (534 aa)
initn: 786 init1: 308 opt: 717 Z-score: 561.8 bits: 113.6 E(85289): 1.5e-24
Smith-Waterman score: 832; 33.5% identity (60.8% similar) in 508 aa overlap (44-517:56-534)
20 30 40 50 60 70
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
: .: :.: . . :::..:.: .
XP_016 ILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLIE---VNETITQISWEKIHGK
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
:.:.::...:..: :: . :. :: : :..:.:: : . . : : :::. .::: ::
XP_016 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
.:. ..::...:: . :.: .... : .. : .: : .:.::: . ..:: : ::
XP_016 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
150 160 170 180 190
200 210 220 230 240 250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
: :: :.:.::.:.: :.: :. . ..:.:.. ... .. :. :..:: :::.
XP_016 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
200 210 220 230 240 250
260 270 280 290 300 310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
. :.::::.. : :.: :.:::::: . :. :.:. : :. :.. :: : :....
XP_016 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
260 270 280 290 300 310
320 330 340 350
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGRRAG-----------PVP--
.:.:::..:: .: :: : . :.. : : :. : : : :
XP_016 SGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
320 330 340 350 360 370
360 370 380 390 400
pF1KB0 -----------TAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK
: : . :.:....::. : . . :::: ::.::: .:... . ..:
XP_016 TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-TFRGDYFAKNYIPPSDMQK
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB0 AGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYD
. : . ..:. :::. :.: .:... .. :: : :. . .
XP_016 ES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEEPE-------KTQWNNVENL
440 450 460 470 480
470 480 490 500 510
pF1KB0 EDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-MVSQNDGSFISKKEWYV
. .::. : : : .:... . :. : :. .::. ::: ::..::::
XP_016 NRFERPM----------DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
490 500 510 520 530
>>XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 isofor (580 aa)
initn: 786 init1: 308 opt: 717 Z-score: 561.4 bits: 113.6 E(85289): 1.6e-24
Smith-Waterman score: 832; 33.5% identity (60.8% similar) in 508 aa overlap (44-517:102-580)
20 30 40 50 60 70
pF1KB0 WGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNG
: .: :.: . . :::..:.: .
XP_011 ILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLIE---VNETITQISWEKIHGK
80 90 100 110 120
80 90 100 110 120 130
pF1KB0 SKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGN
:.:.::...:..: :: . :. :: : :..:.:: : . . : : :::. .::: ::
XP_011 SSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGN
130 140 150 160 170 180
140 150 160 170 180 190
pF1KB0 RESQLNLTVMAKPT-NWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGE
.:. ..::...:: . :.: .... : .. : .: : .:.::: . ..:: : ::
XP_011 AQSSTTVTVLVEPTVSLIKGPDSLI---DGGNETV-AAICIAATGKPVAHIDWEGDL-GE
190 200 210 220 230 240
200 210 220 230 240 250
pF1KB0 AEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH-MDR-FKESLTLNVQYEPEVT
: :: :.:.::.:.: :.: :. . ..:.:.. ... .. :. :..:: :::.
XP_011 MESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB0 IEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL
. :.::::.. : :.: :.:::::: . :. :.:. : :. :.. :: : :....
XP_011 VTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNY
310 320 330 340 350 360
320 330 340 350
pF1KB0 AGTYICEATNPIGTRSGQVEVNITEFPYT----PSPPEHGRRAG-----------PVP--
.:.:::..:: .: :: : . :.. : : :. : : : :
XP_011 SGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
370 380 390 400 410 420
360 370 380 390 400
pF1KB0 -----------TAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK
: : . :.:....::. : . . :::: ::.::: .:... . ..:
XP_011 TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRR-TFRGDYFAKNYIPPSDMQK
430 440 450 460 470 480
410 420 430 440 450 460
pF1KB0 AGIPQHHPPMAQNLQ-YPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYD
. : . ..:. :::. :.: .:... .. :: : :. . .
XP_011 ES--QIDVLQQDELDSYPDSVKKENK-NPVNNLIRKDYLEEPE-------KTQWNNVENL
490 500 510 520 530
470 480 490 500 510
pF1KB0 EDAKRPYFTVDEAEARQDGYGDRTLGYQY-DPEQLDLAEN-MVSQNDGSFISKKEWYV
. .::. : : : .:... . :. : :. .::. ::: ::..::::
XP_011 NRFERPM----------DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
540 550 560 570 580
517 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 17:03:32 2016 done: Sat Nov 5 17:03:33 2016
Total Scan time: 9.170 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]