FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0485, 528 aa 1>>>pF1KB0485 528 - 528 aa - 528 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9809+/-0.000354; mu= 16.1146+/- 0.022 mean_var=101.5351+/-21.004, 0's: 0 Z-trim(115.9): 81 B-trim: 466 in 1/53 Lambda= 0.127282 statistics sampled from 26671 (26757) to 26671 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.314), width: 16 Scan time: 10.350 The best scores are: opt bits E(85289) NP_114427 (OMIM: 612583) protein spinster homolog ( 528) 3504 654.2 2.8e-187 NP_001135920 (OMIM: 612583) protein spinster homol ( 528) 3504 654.2 2.8e-187 XP_016879248 (OMIM: 612583) PREDICTED: protein spi ( 573) 3504 654.2 3e-187 XP_016879247 (OMIM: 612583) PREDICTED: protein spi ( 578) 3484 650.5 3.8e-186 NP_001135922 (OMIM: 612583) protein spinster homol ( 455) 3004 562.3 1.1e-159 XP_016879246 (OMIM: 612583) PREDICTED: protein spi ( 591) 2908 544.8 2.7e-154 NP_001135923 (OMIM: 612583) protein spinster homol ( 476) 1829 346.6 1e-94 XP_006721159 (OMIM: 612583) PREDICTED: protein spi ( 521) 1829 346.6 1.1e-94 NP_001118230 (OMIM: 612584) protein spinster homol ( 549) 1692 321.5 4.2e-87 NP_872344 (OMIM: 611701) protein spinster homolog ( 512) 1656 314.8 3.9e-85 NP_001135921 (OMIM: 612583) protein spinster homol ( 454) 1338 256.4 1.3e-67 XP_011522026 (OMIM: 611701) PREDICTED: protein spi ( 479) 1338 256.4 1.4e-67 XP_011522028 (OMIM: 611701) PREDICTED: protein spi ( 399) 1330 254.9 3.4e-67 NP_001307378 (OMIM: 611701) protein spinster homol ( 385) 1278 245.3 2.5e-64 XP_011522025 (OMIM: 611701) PREDICTED: protein spi ( 490) 1233 237.1 9.1e-62 XP_011522030 (OMIM: 611701) PREDICTED: protein spi ( 316) 1001 194.4 4.3e-49 XP_011522027 (OMIM: 611701) PREDICTED: protein spi ( 461) 851 167.0 1.1e-40 XP_016879834 (OMIM: 611701) PREDICTED: protein spi ( 270) 834 163.7 6.6e-40 NP_001132928 (OMIM: 611700) putative transporter S ( 492) 205 48.4 6.1e-05 XP_005250200 (OMIM: 611700) PREDICTED: putative tr ( 492) 205 48.4 6.1e-05 NP_001315604 (OMIM: 185860) synaptic vesicle glyco ( 742) 195 46.7 0.0003 NP_001315603 (OMIM: 185860) synaptic vesicle glyco ( 742) 195 46.7 0.0003 NP_055664 (OMIM: 185860) synaptic vesicle glycopro ( 742) 195 46.7 0.0003 >>NP_114427 (OMIM: 612583) protein spinster homolog 1 is (528 aa) initn: 3504 init1: 3504 opt: 3504 Z-score: 3483.2 bits: 654.2 E(85289): 2.8e-187 Smith-Waterman score: 3504; 100.0% identity (100.0% similar) in 528 aa overlap (1-528:1-528) 10 20 30 40 50 60 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 PPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 PPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 SRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 SRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG 430 440 450 460 470 480 490 500 510 520 pF1KB0 TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI :::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI 490 500 510 520 >>NP_001135920 (OMIM: 612583) protein spinster homolog 1 (528 aa) initn: 3504 init1: 3504 opt: 3504 Z-score: 3483.2 bits: 654.2 E(85289): 2.8e-187 Smith-Waterman score: 3504; 100.0% identity (100.0% similar) in 528 aa overlap (1-528:1-528) 10 20 30 40 50 60 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 PPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 SRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG 430 440 450 460 470 480 490 500 510 520 pF1KB0 TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI 490 500 510 520 >>XP_016879248 (OMIM: 612583) PREDICTED: protein spinste (573 aa) initn: 3504 init1: 3504 opt: 3504 Z-score: 3482.8 bits: 654.2 E(85289): 3e-187 Smith-Waterman score: 3504; 100.0% identity (100.0% similar) in 528 aa overlap (1-528:46-573) 10 20 30 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGS :::::::::::::::::::::::::::::: XP_016 GLSDSKCSGLLPRVGSSVGPERGRARPPGTMAGSDTAPFLSQADDPDDGPVPGTPGLPGS 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 DMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARN 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 PSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITC 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB0 LTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 380 390 400 410 420 430 400 410 420 430 440 450 pF1KB0 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWP 440 450 460 470 480 490 460 470 480 490 500 510 pF1KB0 PSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRI 500 510 520 530 540 550 520 pF1KB0 VVPQRGRSTRVPVASVLI :::::::::::::::::: XP_016 VVPQRGRSTRVPVASVLI 560 570 >>XP_016879247 (OMIM: 612583) PREDICTED: protein spinste (578 aa) initn: 2013 init1: 2013 opt: 3484 Z-score: 3462.9 bits: 650.5 E(85289): 3.8e-186 Smith-Waterman score: 3484; 99.1% identity (99.1% similar) in 533 aa overlap (1-528:46-578) 10 20 30 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGS :::::::::::::::::::::::::::::: XP_016 GLSDSKCSGLLPRVGSSVGPERGRARPPGTMAGSDTAPFLSQADDPDDGPVPGTPGLPGS 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK 200 210 220 230 240 250 220 230 240 250 260 pF1KB0 DMAGDWHWALR-----VTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLR ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_016 DMAGDWHWALRPSVSQVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLR 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB0 ALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIF 320 330 340 350 360 370 330 340 350 360 370 380 pF1KB0 GLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATY 380 390 400 410 420 430 390 400 410 420 430 440 pF1KB0 IFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRL 440 450 460 470 480 490 450 460 470 480 490 500 pF1KB0 RRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGS 500 510 520 530 540 550 510 520 pF1KB0 TDDRIVVPQRGRSTRVPVASVLI ::::::::::::::::::::::: XP_016 TDDRIVVPQRGRSTRVPVASVLI 560 570 >>NP_001135922 (OMIM: 612583) protein spinster homolog 1 (455 aa) initn: 3004 init1: 3004 opt: 3004 Z-score: 2987.9 bits: 562.3 E(85289): 1.1e-159 Smith-Waterman score: 3004; 100.0% identity (100.0% similar) in 455 aa overlap (74-528:1-455) 50 60 70 80 90 100 pF1KB0 QEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTV :::::::::::::::::::::::::::::: NP_001 MDRFTVAGVLPDIEQFFNIGDSSSGLIQTV 10 20 30 110 120 130 140 150 160 pF1KB0 FISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVG 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB0 EASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVT 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB0 PGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAV 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB0 AFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEI 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB0 SRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVA 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB0 DILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFS 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB0 LMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPV 400 410 420 430 440 450 pF1KB0 ASVLI ::::: NP_001 ASVLI >>XP_016879246 (OMIM: 612583) PREDICTED: protein spinste (591 aa) initn: 1553 init1: 1492 opt: 2908 Z-score: 2891.1 bits: 544.8 E(85289): 2.7e-154 Smith-Waterman score: 2908; 98.9% identity (98.9% similar) in 445 aa overlap (1-440:46-490) 10 20 30 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGS :::::::::::::::::::::::::::::: XP_016 GLSDSKCSGLLPRVGSSVGPERGRARPPGTMAGSDTAPFLSQADDPDDGPVPGTPGLPGS 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK 200 210 220 230 240 250 220 230 240 250 260 pF1KB0 DMAGDWHWALR-----VTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLR ::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_016 DMAGDWHWALRPSVSQVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLR 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB0 ALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIF 320 330 340 350 360 370 330 340 350 360 370 380 pF1KB0 GLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATY 380 390 400 410 420 430 390 400 410 420 430 440 pF1KB0 IFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLACCTK 440 450 460 470 480 490 450 460 470 480 490 500 pF1KB0 RRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGS XP_016 QGPQTTGLWCPSGAAPPACPWPVCSSERLPLTYLHICHSWPWAHPTKGLGLTPWPGPASR 500 510 520 530 540 550 >>NP_001135923 (OMIM: 612583) protein spinster homolog 1 (476 aa) initn: 1826 init1: 1826 opt: 1829 Z-score: 1821.6 bits: 346.6 E(85289): 1e-94 Smith-Waterman score: 3044; 90.2% identity (90.2% similar) in 528 aa overlap (1-528:1-476) 10 20 30 40 50 60 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 PPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLR :::::::::::::::::::::::::::::: NP_001 PPRGAVERHSDLPPLNPTSWWADLRALARN------------------------------ 250 260 270 310 320 330 340 350 360 pF1KB0 SRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA :::::::::::::::::::::::::::::::::::::: NP_001 ----------------------LIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA 280 290 300 370 380 390 400 410 420 pF1KB0 TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA 310 320 330 340 350 360 430 440 450 460 470 480 pF1KB0 FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG 370 380 390 400 410 420 490 500 510 520 pF1KB0 TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI 430 440 450 460 470 >>XP_006721159 (OMIM: 612583) PREDICTED: protein spinste (521 aa) initn: 1826 init1: 1826 opt: 1829 Z-score: 1821.0 bits: 346.6 E(85289): 1.1e-94 Smith-Waterman score: 3044; 90.2% identity (90.2% similar) in 528 aa overlap (1-528:46-521) 10 20 30 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGS :::::::::::::::::::::::::::::: XP_006 GLSDSKCSGLLPRVGSSVGPERGRARPPGTMAGSDTAPFLSQADDPDDGPVPGTPGLPGS 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB0 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 DMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARN 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 PSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITC :::::::: XP_006 ----------------------------------------------------LIFGLITC 320 340 350 360 370 380 390 pF1KB0 LTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFI 330 340 350 360 370 380 400 410 420 430 440 450 pF1KB0 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWP 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB0 PSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRI 450 460 470 480 490 500 520 pF1KB0 VVPQRGRSTRVPVASVLI :::::::::::::::::: XP_006 VVPQRGRSTRVPVASVLI 510 520 >>NP_001118230 (OMIM: 612584) protein spinster homolog 2 (549 aa) initn: 1681 init1: 805 opt: 1692 Z-score: 1684.8 bits: 321.5 E(85289): 4.2e-87 Smith-Waterman score: 1692; 54.0% identity (76.7% similar) in 498 aa overlap (2-499:53-540) 10 20 30 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGST ::... . ... :: ::::: :: . NP_001 RRRRRRGAQRGAGGSGCCGARGAGGAGVSAAGDEVQTLSGSVRRAPTGP-PGTPGTPGCA 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB0 GNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFN .. :. . : .: : ::.: .:.: :.:::.::.:::::: ::.: :. NP_001 ATAKGPGAQQPKPASLGR------GRGA-AAAILSLGNVLNYLDRYTVAGVLLDIQQHFG 90 100 110 120 130 100 110 120 130 140 150 pF1KB0 IGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFW . : ..::.:.::: :.:: ::.:::::::.::: .. :: ::: ::..::::: ..:: NP_001 VKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFW 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB0 LLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKD ::.:.:::::.:::::::::::.:.:::. . :. :::.::::::.:::::::.::.::. NP_001 LLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB0 MAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNP ::::::::::.: ::... :....: :: ... .: ::: :..:: :: NP_001 AAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGDQLKAR-TSWLRDMKALIRNR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB0 SFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCL :.:.:::. .::.:.::.:..: : .: :..:: . : . :...:::::: :::. NP_001 SYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETC-NSPPCGAKDSLIFGAITCF 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB0 TGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIG :: ::: :. .: : .. ::::::::.:.:::: :. : .. :..:::..:: ::.: NP_001 TGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVG 380 390 400 410 420 430 400 410 420 430 440 450 pF1KB0 ETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPP :::: ::::.::::.::::::::.:: :.: ::::::::::::::.::: .:.. NP_001 ETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKD 440 450 460 470 480 490 460 470 480 490 500 510 pF1KB0 SFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRIV : : :: .: ..:::: :: .::: ::.::.:. .:: ::. .:. : NP_001 SPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQLAMPPASVKV 500 510 520 530 540 520 pF1KB0 VPQRGRSTRVPVASVLI >>NP_872344 (OMIM: 611701) protein spinster homolog 3 is (512 aa) initn: 1398 init1: 1374 opt: 1656 Z-score: 1649.5 bits: 314.8 E(85289): 3.9e-85 Smith-Waterman score: 1656; 54.0% identity (77.7% similar) in 480 aa overlap (20-498:10-484) 10 20 30 40 50 60 pF1KB0 MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL : :: :: :.. .: . : : . .: : :. . NP_872 MAGGMSAECPEPGPGGLQGQSPGPGRQCP--PPITPTSW--SLPPWRAYV 10 20 30 40 70 80 90 100 110 120 pF1KB0 IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD .::::::::::::. : .:::: ::.. :.:.:. .::.::::.: .. ::::::::: NP_872 AAAVLCYINLLNYMNWFIIAGVLLDIQEVFQISDNHAGLLQTVFVSCLLLSAPVFGYLGD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB0 RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV :..:: : :: .:: . :.:::: .. ::..:.::.::.: :::::::::...:::: NP_872 RHSRKATMSFGILLWSGAGLSSSFISPRYSWLFFLSRGIVGTGSASYSTIAPTVLGDLFV 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB0 ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE :::.:.:..::. :::::::::. :: : ..:.:.::::: : : .::..::.:.: . NP_872 RDQRTRVLAVFYIFIPVGSGLGYVLGSAVTMLTGNWRWALRVMPCLEAVALILLILLVPD 170 180 190 200 210 220 250 260 270 280 290 pF1KB0 PPRGAVERHSDLPPLN-PTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLL :::::.: ... . .:: :.: :..: ::: :.:: ::.:::::.:..::: ::: NP_872 PPRGAAETQGEGAVGGFRSSWCEDVRYLGKNWSFVWSTLGVTAMAFVTGALGFWAPKFLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB0 RSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVC ..::: : :::. . ::. :::::: .: .:::.:: ::.: .:: .. : :.::.: NP_872 EARVVHGLQPPCFQ-EPCSNPDSLIFGALTIMTGVIGVILGAEAARRYKKVIPGAEPLIC 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB0 ATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAE :..::..:: :.:.:. : ...:.:.:. .:: ::: :::.:::::: ::.: :.::: NP_872 ASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAE 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB0 AFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFL :.::...:.::::::::: ::::. :: : :.:..::.:: :.. :::: ::::. :: NP_872 ALQITVGHILGDAGSPYLTGLISSVLRARRPDSYLQRFRSLQQSFLCCAFVIALGGGCFL 410 420 430 440 450 460 480 490 500 510 520 pF1KB0 GTAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI ::...: :. :: : : NP_872 LTALYLERDETRAWQPVTGTPDSNDVDSNDLERQGLLSGAGASTEEP 470 480 490 500 510 528 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:55:21 2016 done: Sat Nov 5 11:55:22 2016 Total Scan time: 10.350 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]