FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0942, 392 aa 1>>>pF1KB0942 392 - 392 aa - 392 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7762+/-0.000414; mu= 11.0795+/- 0.026 mean_var=166.4084+/-34.758, 0's: 0 Z-trim(115.5): 266 B-trim: 1159 in 1/55 Lambda= 0.099423 statistics sampled from 25611 (25956) to 25611 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.304), width: 16 Scan time: 8.940 The best scores are: opt bits E(85289) NP_060376 (OMIM: 607811) p21-activated protein kin ( 392) 2605 386.0 8.1e-107 XP_005249261 (OMIM: 607811) PREDICTED: p21-activat ( 393) 2593 384.3 2.7e-106 XP_011513022 (OMIM: 607811) PREDICTED: p21-activat ( 415) 2405 357.4 3.6e-98 XP_011513023 (OMIM: 607811) PREDICTED: p21-activat ( 414) 2401 356.8 5.4e-98 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 264 50.2 8.8e-06 XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 264 50.2 8.8e-06 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 264 50.2 8.8e-06 XP_011531865 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 232 45.4 0.00017 XP_011531866 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 232 45.4 0.00017 XP_011531867 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 232 45.4 0.00017 XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 ( 300) 230 45.3 0.00024 XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 230 45.3 0.00025 XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 ( 326) 230 45.3 0.00025 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 230 45.3 0.00027 NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 230 45.3 0.00028 XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 ( 374) 230 45.4 0.00028 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 230 45.4 0.00029 NP_001269467 (OMIM: 139380,613065,616973) guanine ( 240) 224 44.3 0.00037 XP_016856549 (OMIM: 139380,613065,616973) PREDICTE ( 340) 224 44.4 0.00047 NP_002065 (OMIM: 139380,613065,616973) guanine nuc ( 340) 224 44.4 0.00047 XP_016856548 (OMIM: 139380,613065,616973) PREDICTE ( 340) 224 44.4 0.00047 XP_016856550 (OMIM: 139380,613065,616973) PREDICTE ( 340) 224 44.4 0.00047 NP_001269468 (OMIM: 139380,613065,616973) guanine ( 340) 224 44.4 0.00047 XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 226 45.0 0.00053 NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 226 45.0 0.00056 NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 226 45.0 0.00059 XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 226 45.1 0.00062 XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 226 45.1 0.00062 XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 226 45.1 0.00064 XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 226 45.1 0.00064 NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 226 45.1 0.00064 XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 226 45.1 0.00064 XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 226 45.1 0.00064 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 222 44.5 0.0009 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 222 44.5 0.0009 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 222 44.5 0.0009 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 222 44.5 0.0009 XP_005255829 (OMIM: 602703,616212) PREDICTED: kata ( 672) 222 44.5 0.00091 XP_016878350 (OMIM: 602703,616212) PREDICTED: kata ( 672) 222 44.5 0.00091 XP_016878351 (OMIM: 602703,616212) PREDICTED: kata ( 672) 222 44.5 0.00091 XP_016878349 (OMIM: 602703,616212) PREDICTED: kata ( 675) 222 44.5 0.00092 XP_006721184 (OMIM: 602703,616212) PREDICTED: kata ( 675) 222 44.5 0.00092 XP_006721185 (OMIM: 602703,616212) PREDICTED: kata ( 675) 222 44.5 0.00092 XP_011521112 (OMIM: 602703,616212) PREDICTED: kata ( 675) 222 44.5 0.00092 NP_006373 (OMIM: 604596) CMT1A duplicated region t ( 752) 216 43.7 0.0018 NP_001246 (OMIM: 603618) cell division cycle prote ( 499) 213 43.1 0.0018 XP_011535412 (OMIM: 601686) PREDICTED: telomerase (2104) 220 44.7 0.0024 XP_016863001 (OMIM: 606990) PREDICTED: coatomer su ( 877) 213 43.3 0.0027 NP_001305964 (OMIM: 601686) telomerase protein com (2519) 220 44.8 0.0027 NP_004757 (OMIM: 606990) coatomer subunit beta' [H ( 906) 213 43.3 0.0027 >>NP_060376 (OMIM: 607811) p21-activated protein kinase- (392 aa) initn: 2605 init1: 2605 opt: 2605 Z-score: 2038.7 bits: 386.0 E(85289): 8.1e-107 Smith-Waterman score: 2605; 100.0% identity (100.0% similar) in 392 aa overlap (1-392:1-392) 10 20 30 40 50 60 pF1KB0 MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 AHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 AHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 VIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 VWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKK 310 320 330 340 350 360 370 380 390 pF1KB0 ATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ :::::::::::::::::::::::::::::::: NP_060 ATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ 370 380 390 >>XP_005249261 (OMIM: 607811) PREDICTED: p21-activated p (393 aa) initn: 2401 init1: 2401 opt: 2593 Z-score: 2029.4 bits: 384.3 E(85289): 2.7e-106 Smith-Waterman score: 2593; 99.7% identity (99.7% similar) in 393 aa overlap (1-392:1-393) 10 20 30 40 50 pF1KB0 MELVAGCYEQVLFGFAVHPEPEACGDHEQ-WTLVADFTHHAHTASLSAVAVNSRFVVTGS ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_005 MELVAGCYEQVLFGFAVHPEPEACGDHEQQWTLVADFTHHAHTASLSAVAVNSRFVVTGS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 KDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 KAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB0 VVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB0 EFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB0 GVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSK 310 320 330 340 350 360 360 370 380 390 pF1KB0 KATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ ::::::::::::::::::::::::::::::::: XP_005 KATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ 370 380 390 >>XP_011513022 (OMIM: 607811) PREDICTED: p21-activated p (415 aa) initn: 2402 init1: 2402 opt: 2405 Z-score: 1883.4 bits: 357.4 E(85289): 3.6e-98 Smith-Waterman score: 2405; 95.3% identity (96.9% similar) in 387 aa overlap (6-392:31-415) 10 20 30 pF1KB0 MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVAD : : .:: .: . . ..::::::: XP_011 MLSSNPVKQYLNCSRTSRRQNPSASEFKKEGLYSAGIFG-KTHVSNNQ-APQQQWTLVAD 10 20 30 40 50 40 50 60 70 80 90 pF1KB0 FTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB0 LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB0 RSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSE 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB0 SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWK 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB0 LKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB0 DTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ 360 370 380 390 400 410 >>XP_011513023 (OMIM: 607811) PREDICTED: p21-activated p (414 aa) initn: 2401 init1: 2401 opt: 2401 Z-score: 1880.3 bits: 356.8 E(85289): 5.4e-98 Smith-Waterman score: 2401; 99.7% identity (100.0% similar) in 365 aa overlap (28-392:50-414) 10 20 30 40 50 pF1KB0 MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVT .::::::::::::::::::::::::::::: XP_011 QNPSASEFKKEGLYSAGIFGKTHVSNNQAPQQWTLVADFTHHAHTASLSAVAVNSRFVVT 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB0 GSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLK 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB0 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGE 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB0 QYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVC 200 210 220 230 240 250 240 250 260 270 280 290 pF1KB0 LCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLT 260 270 280 290 300 310 300 310 320 330 340 350 pF1KB0 CLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGD 320 330 340 350 360 370 360 370 380 390 pF1KB0 SKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ ::::::::::::::::::::::::::::::::::: XP_011 SKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ 380 390 400 410 >>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 148 init1: 148 opt: 264 Z-score: 224.8 bits: 50.2 E(85289): 8.8e-06 Smith-Waterman score: 267; 26.1% identity (61.8% similar) in 249 aa overlap (41-275:86-331) 20 30 40 50 60 pF1KB0 VLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVA--VNSRFVVTGSKDETIHIYD : ..: :: .: ..:..: :.:..:.: NP_060 NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 60 70 80 90 100 110 70 80 90 100 110 120 pF1KB0 MKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVT ... .: ::. . : .: . .:: ::. : . :::.: .:::.. ::. :. NP_060 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 120 130 140 150 160 170 130 140 150 160 170 180 pF1KB0 FLSIHPSGKLALSVGTDKTLRTWNLVEGR--SAFIKNIKQNAHIVEWSPRGEQYVVI--I . .. .:.: .: . : : :. . :. ...: . . . .:..:: : .:.. . NP_060 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATL 180 190 200 210 220 230 190 200 210 220 230 pF1KB0 QNKIDIYQLDTASISGTITNEKRISSVKFLSESVLA----VAGDEE-VIRFFDCDSLVCL .: . ... . .. : :..: . : . :: . :.:.:. .. ... .. . NP_060 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB0 CEFKAHENRVKDMFSFEIPEHHVIVSAS--SDGFIKMWKLKQDKKVPPSLLCEINTNARL ....: . : . . : ...:.::. .: ::.:: NP_060 QKLQGHTDVV--ISTACHPTENIIASAALENDKTIKLWKSDC 300 310 320 330 300 310 320 330 340 350 pF1KB0 TCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTG >>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa) initn: 148 init1: 148 opt: 264 Z-score: 224.8 bits: 50.2 E(85289): 8.8e-06 Smith-Waterman score: 267; 26.1% identity (61.8% similar) in 249 aa overlap (41-275:86-331) 20 30 40 50 60 pF1KB0 VLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVA--VNSRFVVTGSKDETIHIYD : ..: :: .: ..:..: :.:..:.: XP_005 NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 60 70 80 90 100 110 70 80 90 100 110 120 pF1KB0 MKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVT ... .: ::. . : .: . .:: ::. : . :::.: .:::.. ::. :. XP_005 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 120 130 140 150 160 170 130 140 150 160 170 180 pF1KB0 FLSIHPSGKLALSVGTDKTLRTWNLVEGR--SAFIKNIKQNAHIVEWSPRGEQYVVI--I . .. .:.: .: . : : :. . :. ...: . . . .:..:: : .:.. . XP_005 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATL 180 190 200 210 220 230 190 200 210 220 230 pF1KB0 QNKIDIYQLDTASISGTITNEKRISSVKFLSESVLA----VAGDEE-VIRFFDCDSLVCL .: . ... . .. : :..: . : . :: . :.:.:. .. ... .. . XP_005 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB0 CEFKAHENRVKDMFSFEIPEHHVIVSAS--SDGFIKMWKLKQDKKVPPSLLCEINTNARL ....: . : . . : ...:.::. .: ::.:: XP_005 QKLQGHTDVV--ISTACHPTENIIASAALENDKTIKLWKSDC 300 310 320 330 300 310 320 330 340 350 pF1KB0 TCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTG >>NP_438172 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 148 init1: 148 opt: 264 Z-score: 224.8 bits: 50.2 E(85289): 8.8e-06 Smith-Waterman score: 267; 26.1% identity (61.8% similar) in 249 aa overlap (41-275:86-331) 20 30 40 50 60 pF1KB0 VLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVA--VNSRFVVTGSKDETIHIYD : ..: :: .: ..:..: :.:..:.: NP_438 NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 60 70 80 90 100 110 70 80 90 100 110 120 pF1KB0 MKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVT ... .: ::. . : .: . .:: ::. : . :::.: .:::.. ::. :. NP_438 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 120 130 140 150 160 170 130 140 150 160 170 180 pF1KB0 FLSIHPSGKLALSVGTDKTLRTWNLVEGR--SAFIKNIKQNAHIVEWSPRGEQYVVI--I . .. .:.: .: . : : :. . :. ...: . . . .:..:: : .:.. . NP_438 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATL 180 190 200 210 220 230 190 200 210 220 230 pF1KB0 QNKIDIYQLDTASISGTITNEKRISSVKFLSESVLA----VAGDEE-VIRFFDCDSLVCL .: . ... . .. : :..: . : . :: . :.:.:. .. ... .. . NP_438 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB0 CEFKAHENRVKDMFSFEIPEHHVIVSAS--SDGFIKMWKLKQDKKVPPSLLCEINTNARL ....: . : . . : ...:.::. .: ::.:: NP_438 QKLQGHTDVV--ISTACHPTENIIASAALENDKTIKLWKSDC 300 310 320 330 300 310 320 330 340 350 pF1KB0 TCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTG >>XP_011531865 (OMIM: 614783,614813) PREDICTED: POC1 cen (246 aa) initn: 239 init1: 125 opt: 232 Z-score: 201.6 bits: 45.4 E(85289): 0.00017 Smith-Waterman score: 232; 28.8% identity (65.2% similar) in 132 aa overlap (40-168:101-230) 10 20 30 40 50 60 pF1KB0 QVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNS--RFVVTGSKDETIHIY ::::.. .: : . ::.: :.:.... XP_011 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 80 90 100 110 120 130 70 80 90 100 110 120 pF1KB0 DMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWECLKSIKAHKGQV ... .: .: . . : :: . : ..:...: . .:: .. ::..: : : : XP_011 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 140 150 160 170 180 190 130 140 150 160 170 180 pF1KB0 TFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNK :....:::: ..: :.:...:.. : .... . ..: XP_011 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHR--LLQHYQWTSHHCCLFKNGGVFCFWRL 200 210 220 230 240 190 200 210 220 230 240 pF1KB0 IDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHEN >>XP_011531866 (OMIM: 614783,614813) PREDICTED: POC1 cen (246 aa) initn: 239 init1: 125 opt: 232 Z-score: 201.6 bits: 45.4 E(85289): 0.00017 Smith-Waterman score: 232; 28.8% identity (65.2% similar) in 132 aa overlap (40-168:101-230) 10 20 30 40 50 60 pF1KB0 QVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNS--RFVVTGSKDETIHIY ::::.. .: : . ::.: :.:.... XP_011 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 80 90 100 110 120 130 70 80 90 100 110 120 pF1KB0 DMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWECLKSIKAHKGQV ... .: .: . . : :: . : ..:...: . .:: .. ::..: : : : XP_011 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 140 150 160 170 180 190 130 140 150 160 170 180 pF1KB0 TFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNK :....:::: ..: :.:...:.. : .... . ..: XP_011 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHR--LLQHYQWTSHHCCLFKNGGVFCFWRL 200 210 220 230 240 190 200 210 220 230 240 pF1KB0 IDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHEN >>XP_011531867 (OMIM: 614783,614813) PREDICTED: POC1 cen (246 aa) initn: 239 init1: 125 opt: 232 Z-score: 201.6 bits: 45.4 E(85289): 0.00017 Smith-Waterman score: 232; 28.8% identity (65.2% similar) in 132 aa overlap (40-168:101-230) 10 20 30 40 50 60 pF1KB0 QVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNS--RFVVTGSKDETIHIY ::::.. .: : . ::.: :.:.... XP_011 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 80 90 100 110 120 130 70 80 90 100 110 120 pF1KB0 DMKKKIEHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWECLKSIKAHKGQV ... .: .: . . : :: . : ..:...: . .:: .. ::..: : : : XP_011 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 140 150 160 170 180 190 130 140 150 160 170 180 pF1KB0 TFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNK :....:::: ..: :.:...:.. : .... . ..: XP_011 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHR--LLQHYQWTSHHCCLFKNGGVFCFWRL 200 210 220 230 240 190 200 210 220 230 240 pF1KB0 IDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHEN 392 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:23:15 2016 done: Sat Nov 5 17:23:17 2016 Total Scan time: 8.940 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]