FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0951, 183 aa 1>>>pF1KB0951 183 - 183 aa - 183 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1579+/-0.00105; mu= 13.1882+/- 0.064 mean_var=68.6200+/-13.710, 0's: 0 Z-trim(103.9): 191 B-trim: 451 in 2/49 Lambda= 0.154828 statistics sampled from 7430 (7645) to 7430 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.235), width: 16 Scan time: 1.520 The best scores are: opt bits E(32554) CCDS8778.1 RHEBL1 gene_id:121268|Hs108|chr12 ( 183) 1194 275.7 1.1e-74 CCDS5927.1 RHEB gene_id:6009|Hs108|chr7 ( 184) 657 155.8 1.4e-38 CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX ( 183) 433 105.7 1.6e-23 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 424 103.7 6.5e-23 CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 ( 183) 422 103.3 8.9e-23 CCDS6687.1 DIRAS2 gene_id:54769|Hs108|chr9 ( 199) 391 96.4 1.2e-20 CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 ( 184) 389 95.9 1.5e-20 CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 ( 184) 387 95.5 2e-20 CCDS5460.1 RALA gene_id:5898|Hs108|chr7 ( 206) 355 88.3 3.1e-18 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 353 87.9 4e-18 CCDS7814.1 RRAS2 gene_id:22800|Hs108|chr11 ( 204) 353 87.9 4.2e-18 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 352 87.6 4.6e-18 CCDS2520.1 RAB17 gene_id:64284|Hs108|chr2 ( 212) 352 87.7 5.1e-18 CCDS2131.1 RALB gene_id:5899|Hs108|chr2 ( 206) 347 86.6 1.1e-17 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 347 86.6 1.1e-17 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 346 86.3 1.2e-17 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 347 86.6 1.2e-17 CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 ( 217) 346 86.3 1.3e-17 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 343 85.6 1.9e-17 CCDS12092.1 DIRAS1 gene_id:148252|Hs108|chr19 ( 198) 339 84.8 3.6e-17 CCDS12774.1 RRAS gene_id:6237|Hs108|chr19 ( 218) 335 83.9 7.3e-17 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 325 81.6 2.8e-16 CCDS9321.1 RASL11A gene_id:387496|Hs108|chr13 ( 242) 325 81.7 3.7e-16 CCDS641.1 DIRAS3 gene_id:9077|Hs108|chr1 ( 229) 318 80.1 1.1e-15 CCDS8673.1 RERG gene_id:85004|Hs108|chr12 ( 199) 310 78.3 3.2e-15 CCDS41413.1 RAB25 gene_id:57111|Hs108|chr1 ( 213) 306 77.4 6.4e-15 CCDS9003.1 RAB21 gene_id:23011|Hs108|chr12 ( 225) 304 77.0 9.1e-15 CCDS3100.1 MRAS gene_id:22808|Hs108|chr3 ( 208) 303 76.7 9.9e-15 CCDS45826.1 RAB31 gene_id:11031|Hs108|chr18 ( 195) 301 76.3 1.3e-14 CCDS58036.1 RIT1 gene_id:6016|Hs108|chr1 ( 183) 299 75.8 1.7e-14 CCDS53603.1 RRAS2 gene_id:22800|Hs108|chr11 ( 169) 295 74.9 2.9e-14 CCDS11703.1 RAB37 gene_id:326624|Hs108|chr17 ( 216) 296 75.2 3e-14 CCDS8223.1 RAB6A gene_id:5870|Hs108|chr11 ( 208) 292 74.3 5.4e-14 CCDS3082.1 RAB6B gene_id:51560|Hs108|chr3 ( 208) 288 73.4 1e-13 CCDS62431.1 RIT2 gene_id:6014|Hs108|chr18 ( 153) 286 72.8 1.1e-13 CCDS82198.1 RAB37 gene_id:326624|Hs108|chr17 ( 196) 287 73.1 1.1e-13 CCDS8224.1 RAB6A gene_id:5870|Hs108|chr11 ( 208) 287 73.2 1.2e-13 CCDS32722.1 RAB37 gene_id:326624|Hs108|chr17 ( 223) 287 73.2 1.2e-13 CCDS54161.1 RAB37 gene_id:326624|Hs108|chr17 ( 228) 287 73.2 1.3e-13 CCDS12257.1 RAB3D gene_id:9545|Hs108|chr19 ( 219) 286 72.9 1.4e-13 CCDS560.1 RAB3B gene_id:5865|Hs108|chr1 ( 219) 284 72.5 2e-13 CCDS6175.1 RAB2A gene_id:5862|Hs108|chr8 ( 212) 283 72.3 2.2e-13 CCDS33497.1 RAB22A gene_id:57403|Hs108|chr20 ( 194) 282 72.0 2.4e-13 CCDS12372.1 RAB3A gene_id:5864|Hs108|chr19 ( 220) 281 71.8 3.1e-13 CCDS3976.1 RAB3C gene_id:115827|Hs108|chr5 ( 227) 281 71.8 3.2e-13 CCDS9570.1 RAB2B gene_id:84932|Hs108|chr14 ( 216) 280 71.6 3.6e-13 CCDS10200.1 RASL12 gene_id:51285|Hs108|chr15 ( 266) 281 71.9 3.6e-13 CCDS10460.1 RAB26 gene_id:25837|Hs108|chr16 ( 256) 280 71.6 4.1e-13 CCDS14766.1 RAB39B gene_id:116442|Hs108|chrX ( 213) 279 71.4 4.2e-13 CCDS33030.1 RAB4B gene_id:53916|Hs108|chr19 ( 213) 278 71.1 4.9e-13 >>CCDS8778.1 RHEBL1 gene_id:121268|Hs108|chr12 (183 aa) initn: 1194 init1: 1194 opt: 1194 Z-score: 1454.3 bits: 275.7 E(32554): 1.1e-74 Smith-Waterman score: 1194; 100.0% identity (100.0% similar) in 183 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS87 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC 130 140 150 160 170 180 pF1KB0 HLM ::: CCDS87 HLM >>CCDS5927.1 RHEB gene_id:6009|Hs108|chr7 (184 aa) initn: 618 init1: 618 opt: 657 Z-score: 806.0 bits: 155.8 E(32554): 1.4e-38 Smith-Waterman score: 657; 52.2% identity (81.5% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD :: . ::..::::: :::.::. :::::.: ..::::.:::..:..:.. .:.::.::: CCDS59 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK :::::::::.: .. : ..::.:::::::..::.::. .. :: . ::...:..::::: CCDS59 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERR- :: :: .. ::: :::::.:.:.::::.::: . .: ..: : ..... .: . CCDS59 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSS 130 140 150 160 170 180 180 pF1KB0 CHLM : .: CCDS59 CSVM >>CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX (183 aa) initn: 423 init1: 423 opt: 433 Z-score: 535.7 bits: 105.7 E(32554): 1.6e-23 Smith-Waterman score: 433; 37.3% identity (71.2% similar) in 177 aa overlap (4-180:1-177) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD .: :::.:: :::..:. ::: : : : ::::.:. : : . . .. :...: CCDS14 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK ::: .... . .: . .:..::::... .::: :. . ... . . .::..::::: CCDS14 TAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB0 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC .:: :::::.. ::. ::. :: :::.::. ..... .:....... :.. : CCDS14 VDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCC 120 130 140 150 160 170 pF1KB0 HLM CCDS14 TTCVVQ 180 >>CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 (183 aa) initn: 434 init1: 419 opt: 424 Z-score: 524.8 bits: 103.7 E(32554): 6.5e-23 Smith-Waterman score: 424; 39.6% identity (73.2% similar) in 164 aa overlap (4-167:1-164) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD .: :::.:: :::..:. ::: : : : ::::.:. : : . . .. :...: CCDS94 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK ::: .... . .: . .:..::::... .::: :. . ... . . .:::.::::: CCDS94 TAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB0 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC .:: ::::.. ::. ::: :: :::.::. . ... .:....... CCDS94 VDLESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCC 120 130 140 150 160 170 pF1KB0 HLM CCDS94 SACNIQ 180 >>CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 (183 aa) initn: 386 init1: 386 opt: 422 Z-score: 522.4 bits: 103.3 E(32554): 8.9e-23 Smith-Waterman score: 422; 38.4% identity (70.6% similar) in 177 aa overlap (4-180:1-177) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD .: :::.:: :::..:. ::: : : : ::::.:. : : . . .. :...: CCDS31 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK ::: .... . .: . .:..::::... .::: :. . ... . . :::..::::: CCDS31 TAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB0 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC .:: ::::. ::: ::: :. :::.::... .. .:....... . . :.: : CCDS31 VDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCC 120 130 140 150 160 170 pF1KB0 HLM CCDS31 SACVIL 180 >>CCDS6687.1 DIRAS2 gene_id:54769|Hs108|chr9 (199 aa) initn: 381 init1: 220 opt: 391 Z-score: 484.4 bits: 96.4 E(32554): 1.2e-20 Smith-Waterman score: 391; 38.0% identity (74.1% similar) in 158 aa overlap (8-164:9-166) 10 20 30 40 50 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLV .:...: :::.::. .::.: : :.: ::::.:: .... :. :... CCDS66 MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQIT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 DTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTR-VPVVLVG ::.:. .. . : :...::::.:: .:.. .. .:... : .: .. .:..::: CCDS66 DTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 NKADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQER :: : :: ::::. :.. ::..: .:::.::. :. .. .: ... CCDS66 NKCDESPSREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDG 130 140 150 160 170 180 180 pF1KB0 RCHLM CCDS66 KKSKQQKRKEKLKGKCVIM 190 >>CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 (184 aa) initn: 342 init1: 314 opt: 389 Z-score: 482.5 bits: 95.9 E(32554): 1.5e-20 Smith-Waterman score: 389; 35.3% identity (68.5% similar) in 184 aa overlap (4-183:1-184) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD .: :.:.:: :::..:. :::.: : : ::::.:..: : : . .. :...: CCDS89 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK ::: .... . .. . .:..::::.:. .:. ...: ... . . ::..::::: CCDS89 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB0 ADLSPEREVQAVEGKKLAESWGA-TFMESSARENQLTQGIFTKVIQEIARVENSYGQERR :: :: : .:..::..:. .:.::::. . .. :: ....: : :. :. CCDS89 CDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARK 120 130 140 150 160 170 180 pF1KB0 ---CHLM :.:. CCDS89 KSSCQLL 180 >>CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 (184 aa) initn: 340 init1: 312 opt: 387 Z-score: 480.1 bits: 95.5 E(32554): 2e-20 Smith-Waterman score: 387; 35.3% identity (69.6% similar) in 184 aa overlap (4-183:1-184) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD .: :.:.:: :::..:. :::.: : : ::::.:..: : : . .. :...: CCDS84 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK ::: .... . .. . .:..::::.:. .:. ...: ... . . ::..::::: CCDS84 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB0 ADLSPEREVQAVEGKKLAESW-GATFMESSARENQLTQGIFTKVIQEIAR---VENSYGQ :: :: : .:..::..: . .:.::::. . .. :: ....: : ::.. . CCDS84 CDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPK 120 130 140 150 160 170 180 pF1KB0 ERRCHLM .. : :. CCDS84 KKSCLLL 180 >>CCDS5460.1 RALA gene_id:5898|Hs108|chr7 (206 aa) initn: 349 init1: 349 opt: 355 Z-score: 440.8 bits: 88.3 E(32554): 3.1e-18 Smith-Waterman score: 355; 33.9% identity (70.6% similar) in 180 aa overlap (8-182:16-195) 10 20 30 40 50 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKD ::...: :::..:. ::. :: : :.:: ..: : :.: . CCDS54 MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 EFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRV : .. ..:::::..:. . ... . .:.. :.:.: ..:: . .. ... . . : CCDS54 EVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 PVVLVGNKADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEI-AR-V : .:::::.:: .:.:.. :.:. ::.:.....:.::. .. .: ...:: :: . CCDS54 PFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIRARKM 130 140 150 160 170 180 180 pF1KB0 ENSY---GQERRCHLM :.: :...: : CCDS54 EDSKEKNGKKKRKSLAKRIRERCCIL 190 200 >>CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 (189 aa) initn: 334 init1: 250 opt: 353 Z-score: 438.9 bits: 87.9 E(32554): 4e-18 Smith-Waterman score: 353; 35.0% identity (71.9% similar) in 160 aa overlap (8-167:5-163) 10 20 30 40 50 60 pF1KB0 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD :.:..: :::..:. :.....: . ::::.:..: : :.. . : ..: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK ::::.::: . ... .:.. :..... .::. :. ..... . . ::.:::::: CCDS87 TAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB0 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRC :: : : :.. ... ::.:.: :.:.::. : .. : ...:: CCDS87 CDL-PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEK 120 130 140 150 160 170 pF1KB0 HLM CCDS87 TPGCVKIKKCIIM 180 183 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:26:12 2016 done: Sat Nov 5 17:26:13 2016 Total Scan time: 1.520 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]