FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0968, 431 aa 1>>>pF1KB0968 431 - 431 aa - 431 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4915+/-0.000384; mu= -2.1513+/- 0.024 mean_var=564.5640+/-128.424, 0's: 0 Z-trim(125.7): 785 B-trim: 2748 in 1/61 Lambda= 0.053978 statistics sampled from 48659 (50023) to 48659 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.843), E-opt: 0.2 (0.587), width: 16 Scan time: 11.020 The best scores are: opt bits E(85289) NP_690599 (OMIM: 606633,613849) transcription fact ( 431) 3097 255.5 1.9e-67 NP_001166938 (OMIM: 606633,613849) transcription f ( 431) 3097 255.5 1.9e-67 XP_011536202 (OMIM: 606633,613849) PREDICTED: tran ( 413) 2986 246.8 7.6e-65 NP_001287766 (OMIM: 606633,613849) transcription f ( 413) 2986 246.8 7.6e-65 NP_954871 (OMIM: 608613) transcription factor Sp6 ( 376) 813 77.5 6.3e-14 XP_006722178 (OMIM: 608613) PREDICTED: transcripti ( 376) 813 77.5 6.3e-14 NP_001245177 (OMIM: 608613) transcription factor S ( 376) 813 77.5 6.3e-14 NP_945194 (OMIM: 608306) transcription factor Sp8 ( 490) 808 77.3 9.6e-14 NP_874359 (OMIM: 608306) transcription factor Sp8 ( 508) 808 77.3 9.7e-14 NP_001313472 (OMIM: 600540) transcription factor S ( 471) 618 62.5 2.7e-09 NP_001313471 (OMIM: 600540) transcription factor S ( 767) 618 62.8 3.5e-09 XP_005249885 (OMIM: 600540) PREDICTED: transcripti ( 767) 618 62.8 3.5e-09 NP_003103 (OMIM: 600540) transcription factor Sp4 ( 784) 618 62.8 3.5e-09 NP_001003845 (OMIM: 609391) transcription factor S ( 398) 605 61.4 4.9e-09 XP_005246599 (OMIM: 609391) PREDICTED: transcripti ( 442) 605 61.4 5.2e-09 XP_011509461 (OMIM: 609391) PREDICTED: transcripti ( 454) 605 61.5 5.2e-09 NP_001238754 (OMIM: 189906) transcription factor S ( 737) 606 61.8 6.5e-09 NP_003100 (OMIM: 189906) transcription factor Sp1 ( 778) 606 61.9 6.7e-09 XP_011536998 (OMIM: 189906) PREDICTED: transcripti ( 778) 606 61.9 6.7e-09 NP_612482 (OMIM: 189906) transcription factor Sp1 ( 785) 606 61.9 6.8e-09 NP_001017371 (OMIM: 601804) transcription factor S ( 713) 590 60.6 1.5e-08 NP_001166183 (OMIM: 601804) transcription factor S ( 778) 590 60.6 1.6e-08 NP_003102 (OMIM: 601804) transcription factor Sp3 ( 781) 590 60.6 1.6e-08 NP_057079 (OMIM: 605328,612001) Krueppel-like fact ( 288) 515 54.2 5.2e-07 NP_003101 (OMIM: 601801) transcription factor Sp2 ( 613) 522 55.2 5.5e-07 XP_006722088 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_006722090 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_016880457 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_016880458 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_011523444 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_011523445 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_006722089 (OMIM: 601801) PREDICTED: transcripti ( 660) 522 55.2 5.7e-07 XP_006722086 (OMIM: 601801) PREDICTED: transcripti ( 667) 522 55.2 5.8e-07 XP_011523442 (OMIM: 601801) PREDICTED: transcripti ( 717) 522 55.3 6e-07 XP_011523441 (OMIM: 601801) PREDICTED: transcripti ( 727) 522 55.3 6e-07 XP_011523440 (OMIM: 601801) PREDICTED: transcripti ( 760) 522 55.3 6.2e-07 XP_011523439 (OMIM: 601801) PREDICTED: transcripti ( 768) 522 55.3 6.2e-07 XP_011523438 (OMIM: 601801) PREDICTED: transcripti ( 771) 522 55.3 6.3e-07 NP_114124 (OMIM: 606139) Krueppel-like factor 16 [ ( 252) 500 52.9 1.1e-06 NP_057354 (OMIM: 602016) Krueppel-like factor 2 [H ( 355) 499 53.1 1.4e-06 NP_619638 (OMIM: 609393) Krueppel-like factor 14 [ ( 323) 475 51.1 4.8e-06 XP_011513788 (OMIM: 600540) PREDICTED: transcripti ( 711) 481 52.1 5.5e-06 XP_005249886 (OMIM: 600540) PREDICTED: transcripti ( 706) 470 51.2 9.9e-06 XP_005247457 (OMIM: 606465) PREDICTED: Krueppel-li ( 416) 463 50.4 1.1e-05 NP_054798 (OMIM: 606465) Krueppel-like factor 15 [ ( 416) 463 50.4 1.1e-05 XP_011511045 (OMIM: 606465) PREDICTED: Krueppel-li ( 435) 463 50.4 1.1e-05 XP_011539002 (OMIM: 609602) PREDICTED: Krueppel-li ( 352) 452 49.4 1.8e-05 NP_775755 (OMIM: 609602) Krueppel-like factor 17 [ ( 389) 452 49.5 1.9e-05 NP_001197 (OMIM: 602902) Krueppel-like factor 9 [H ( 244) 446 48.7 2e-05 XP_011525944 (OMIM: 111150,600599,613566,613673) P ( 324) 440 48.4 3.2e-05 >>NP_690599 (OMIM: 606633,613849) transcription factor S (431 aa) initn: 3097 init1: 3097 opt: 3097 Z-score: 1331.7 bits: 255.5 E(85289): 1.9e-67 Smith-Waterman score: 3097; 100.0% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KB0 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG 370 380 390 400 410 420 430 pF1KB0 GSPEQSNLLEI ::::::::::: NP_690 GSPEQSNLLEI 430 >>NP_001166938 (OMIM: 606633,613849) transcription facto (431 aa) initn: 3097 init1: 3097 opt: 3097 Z-score: 1331.7 bits: 255.5 E(85289): 1.9e-67 Smith-Waterman score: 3097; 100.0% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KB0 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG 370 380 390 400 410 420 430 pF1KB0 GSPEQSNLLEI ::::::::::: NP_001 GSPEQSNLLEI 430 >>XP_011536202 (OMIM: 606633,613849) PREDICTED: transcri (413 aa) initn: 2986 init1: 2986 opt: 2986 Z-score: 1285.2 bits: 246.8 E(85289): 7.6e-65 Smith-Waterman score: 2986; 100.0% identity (100.0% similar) in 413 aa overlap (19-431:1-413) 10 20 30 40 50 60 pF1KB0 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM :::::::::::::::::::::::::::::::::::::::::: XP_011 MLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM 10 20 30 40 70 80 90 100 110 120 pF1KB0 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB0 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB0 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB0 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB0 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB0 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG 350 360 370 380 390 400 430 pF1KB0 GSPEQSNLLEI ::::::::::: XP_011 GSPEQSNLLEI 410 >>NP_001287766 (OMIM: 606633,613849) transcription facto (413 aa) initn: 2986 init1: 2986 opt: 2986 Z-score: 1285.2 bits: 246.8 E(85289): 7.6e-65 Smith-Waterman score: 2986; 100.0% identity (100.0% similar) in 413 aa overlap (19-431:1-413) 10 20 30 40 50 60 pF1KB0 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM :::::::::::::::::::::::::::::::::::::::::: NP_001 MLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTM 10 20 30 40 70 80 90 100 110 120 pF1KB0 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB0 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB0 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB0 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB0 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB0 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPG 350 360 370 380 390 400 430 pF1KB0 GSPEQSNLLEI ::::::::::: NP_001 GSPEQSNLLEI 410 >>NP_954871 (OMIM: 608613) transcription factor Sp6 [Hom (376 aa) initn: 700 init1: 526 opt: 813 Z-score: 371.0 bits: 77.5 E(85289): 6.3e-14 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (59-427:8-376) 30 40 50 60 70 80 pF1KB0 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS ..:. . :: .: : :.: . . :: NP_954 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS 10 20 30 90 100 110 120 pF1KB0 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- :.::: :.. .:.: :: . : .: . : : :. ...: NP_954 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB0 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. NP_954 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH 100 110 120 130 140 190 200 210 220 230 240 pF1KB0 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG : :. : : .: : :.: : : : : ::.: : : : :. .: :.. NP_954 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS 150 160 170 180 190 200 250 260 270 280 290 pF1KB0 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: NP_954 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP 210 220 230 240 250 300 310 320 330 340 350 pF1KB0 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: NP_954 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB0 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : NP_954 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- 320 330 340 350 360 420 430 pF1KB0 GGSPEQSNLLEI :: :: NP_954 -GSVAPSN 370 >>XP_006722178 (OMIM: 608613) PREDICTED: transcription f (376 aa) initn: 700 init1: 526 opt: 813 Z-score: 371.0 bits: 77.5 E(85289): 6.3e-14 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (59-427:8-376) 30 40 50 60 70 80 pF1KB0 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS ..:. . :: .: : :.: . . :: XP_006 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS 10 20 30 90 100 110 120 pF1KB0 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- :.::: :.. .:.: :: . : .: . : : :. ...: XP_006 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB0 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. XP_006 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH 100 110 120 130 140 190 200 210 220 230 240 pF1KB0 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG : :. : : .: : :.: : : : : ::.: : : : :. .: :.. XP_006 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS 150 160 170 180 190 200 250 260 270 280 290 pF1KB0 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: XP_006 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP 210 220 230 240 250 300 310 320 330 340 350 pF1KB0 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: XP_006 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB0 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : XP_006 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- 320 330 340 350 360 420 430 pF1KB0 GGSPEQSNLLEI :: :: XP_006 -GSVAPSN 370 >>NP_001245177 (OMIM: 608613) transcription factor Sp6 [ (376 aa) initn: 700 init1: 526 opt: 813 Z-score: 371.0 bits: 77.5 E(85289): 6.3e-14 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (59-427:8-376) 30 40 50 60 70 80 pF1KB0 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS ..:. . :: .: : :.: . . :: NP_001 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS 10 20 30 90 100 110 120 pF1KB0 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- :.::: :.. .:.: :: . : .: . : : :. ...: NP_001 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB0 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. NP_001 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH 100 110 120 130 140 190 200 210 220 230 240 pF1KB0 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG : :. : : .: : :.: : : : : ::.: : : : :. .: :.. NP_001 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS 150 160 170 180 190 200 250 260 270 280 290 pF1KB0 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: NP_001 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP 210 220 230 240 250 300 310 320 330 340 350 pF1KB0 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: NP_001 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB0 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : NP_001 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- 320 330 340 350 360 420 430 pF1KB0 GGSPEQSNLLEI :: :: NP_001 -GSVAPSN 370 >>NP_945194 (OMIM: 608306) transcription factor Sp8 isof (490 aa) initn: 702 init1: 702 opt: 808 Z-score: 367.8 bits: 77.3 E(85289): 9.6e-14 Smith-Waterman score: 993; 40.2% identity (64.3% similar) in 440 aa overlap (13-430:63-490) 10 20 30 40 pF1KB0 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKA :.: : .:: . .... . :: . : . NP_945 WKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGS 40 50 60 70 80 90 50 60 70 80 90 pF1KB0 GTKKPYSVGSDLSASKTMGDAYPA---PFTSTNGLL-SPAGSPPAPTSGYANDYPPFSHS .. .:. :. .:. . . : : ::.. ... .:. : . .: .. .:: NP_945 PGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHS 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB0 FPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGP--GNT-P :...: ... : :.: : : ..: . :.::: ::.: . : :.. . :.. NP_945 ---QDGSHQP-VFISKVHTSVDGLQGIYPRVGMAHPYESWFKPS-HPGLGAAGEVGSAGA 160 170 180 190 200 160 170 180 190 200 210 pF1KB0 TPWWDMHPGGNWLG-GGQGQGDGLQGTL-PT-GPAQPPLNPQLPTYPSDFAPLNPAPYPA . :::. :..:. . ... .: :.: :. : : :. : : ::.. :. . . . NP_945 SSWWDV--GAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSS 210 220 230 240 250 260 220 230 240 250 260 pF1KB0 ---PHLLQPGPQHVLPQDVYKPKAVGN-----SGQLEGSGGAKPPRGASTGGSGGYGGSG :::.:. ::.. : .:: :. . : :.::. : :. .:. .:. NP_945 GASSHLLSPAGQHLM--DGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGGSPRSSA 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB0 ---AGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGE .::..:::::::: :::: :.:.::.: .::::::::::::::.::::::::::::: NP_945 RRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGE 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB0 RPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGP ::::::::::::::::::::.::.:::: ::.:.: .:.::: :::::::: .::. : NP_945 RPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGGG 390 400 410 420 430 440 390 400 410 420 430 pF1KB0 GPPPSGPKELGEGRSTGEEEASQTPRPSASPA-TPEKAPGGSPEQSNLLEI : .: : : . : . :. .. : .:: : . : :: NP_945 GGGSAGS---GSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE 450 460 470 480 490 >>NP_874359 (OMIM: 608306) transcription factor Sp8 isof (508 aa) initn: 850 init1: 702 opt: 808 Z-score: 367.6 bits: 77.3 E(85289): 9.7e-14 Smith-Waterman score: 993; 40.2% identity (64.3% similar) in 440 aa overlap (13-430:81-508) 10 20 30 40 pF1KB0 MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKA :.: : .:: . .... . :: . : . NP_874 WKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGS 60 70 80 90 100 110 50 60 70 80 90 pF1KB0 GTKKPYSVGSDLSASKTMGDAYPA---PFTSTNGLL-SPAGSPPAPTSGYANDYPPFSHS .. .:. :. .:. . . : : ::.. ... .:. : . .: .. .:: NP_874 PGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHS 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB0 FPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGP--GNT-P :...: ... : :.: : : ..: . :.::: ::.: . : :.. . :.. NP_874 ---QDGSHQP-VFISKVHTSVDGLQGIYPRVGMAHPYESWFKPS-HPGLGAAGEVGSAGA 180 190 200 210 220 160 170 180 190 200 210 pF1KB0 TPWWDMHPGGNWLG-GGQGQGDGLQGTL-PT-GPAQPPLNPQLPTYPSDFAPLNPAPYPA . :::. :..:. . ... .: :.: :. : : :. : : ::.. :. . . . NP_874 SSWWDV--GAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSS 230 240 250 260 270 280 220 230 240 250 260 pF1KB0 ---PHLLQPGPQHVLPQDVYKPKAVGN-----SGQLEGSGGAKPPRGASTGGSGGYGGSG :::.:. ::.. : .:: :. . : :.::. : :. .:. .:. NP_874 GASSHLLSPAGQHLM--DGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGGSPRSSA 290 300 310 320 330 340 270 280 290 300 310 320 pF1KB0 ---AGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGE .::..:::::::: :::: :.:.::.: .::::::::::::::.::::::::::::: NP_874 RRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGE 350 360 370 380 390 400 330 340 350 360 370 380 pF1KB0 RPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGP ::::::::::::::::::::.::.:::: ::.:.: .:.::: :::::::: .::. : NP_874 RPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGGG 410 420 430 440 450 460 390 400 410 420 430 pF1KB0 GPPPSGPKELGEGRSTGEEEASQTPRPSASPA-TPEKAPGGSPEQSNLLEI : .: : : . : . :. .. : .:: : . : :: NP_874 GGGSAGS---GSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE 470 480 490 500 >>NP_001313472 (OMIM: 600540) transcription factor Sp4 i (471 aa) initn: 567 init1: 529 opt: 618 Z-score: 288.0 bits: 62.5 E(85289): 2.7e-09 Smith-Waterman score: 618; 46.0% identity (62.9% similar) in 224 aa overlap (217-430:249-469) 190 200 210 220 230 240 pF1KB0 AQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHV-LPQDVYKPKAVGNSGQLEGSGG : : . : . : . : .:. .: ... : NP_001 NLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIG 220 230 240 250 260 270 250 260 270 280 290 pF1KB0 AKPP---------RGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSC : : .: .:. . :. : .:.::::.: : :. : :: : : NP_001 AVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPG--KKKQHIC 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB0 HIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTC :: ::::::::.:::.::::::::::::.:::.::::::::::::.:: :::: ::.: : NP_001 HIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFEC 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB0 LLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPE ::::: :::::::: .:: . : . :: :. :. .:: . : . NP_001 PECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSS-VTEVLGSPRIVTVAAISQ 400 410 420 430 440 450 420 430 pF1KB0 KAPGGSPEQSNLLEI . ..:. :. .: NP_001 DSNPATPNVSTNMEEF 460 470 431 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:33:20 2016 done: Sat Nov 5 17:33:22 2016 Total Scan time: 11.020 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]