FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0971, 209 aa 1>>>pF1KB0971 209 - 209 aa - 209 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0844+/-0.000273; mu= 16.0942+/- 0.017 mean_var=79.9029+/-15.625, 0's: 0 Z-trim(120.4): 21 B-trim: 0 in 0/54 Lambda= 0.143481 statistics sampled from 35482 (35511) to 35482 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.416), width: 16 Scan time: 6.820 The best scores are: opt bits E(85289) XP_011540450 (OMIM: 611043) PREDICTED: protein lin ( 209) 1462 311.2 7.8e-85 NP_078950 (OMIM: 611043) protein lin-28 homolog A ( 209) 1462 311.2 7.8e-85 NP_001004317 (OMIM: 611044) protein lin-28 homolog ( 250) 912 197.4 1.7e-50 XP_011534120 (OMIM: 611044) PREDICTED: protein lin ( 258) 912 197.4 1.7e-50 XP_006715540 (OMIM: 611044) PREDICTED: protein lin ( 269) 912 197.4 1.8e-50 NP_057066 (OMIM: 611447) Y-box-binding protein 2 [ ( 364) 229 56.2 8e-08 XP_016875611 (OMIM: 603437) PREDICTED: Y-box-bindi ( 369) 227 55.8 1.1e-07 NP_003642 (OMIM: 603437) Y-box-binding protein 3 i ( 372) 227 55.8 1.1e-07 XP_011519173 (OMIM: 603437) PREDICTED: Y-box-bindi ( 200) 222 54.5 1.4e-07 XP_016875612 (OMIM: 603437) PREDICTED: Y-box-bindi ( 300) 222 54.7 1.9e-07 NP_001138898 (OMIM: 603437) Y-box-binding protein ( 303) 222 54.7 1.9e-07 NP_004550 (OMIM: 154030) nuclease-sensitive elemen ( 324) 203 50.7 3.1e-06 >>XP_011540450 (OMIM: 611043) PREDICTED: protein lin-28 (209 aa) initn: 1462 init1: 1462 opt: 1462 Z-score: 1644.0 bits: 311.2 E(85289): 7.8e-85 Smith-Waterman score: 1462; 100.0% identity (100.0% similar) in 209 aa overlap (1-209:1-209) 10 20 30 40 50 60 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 RAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQ 130 140 150 160 170 180 190 200 pF1KB0 GPSAQGKPTYFREEEEEIHSPTLLPEAQN ::::::::::::::::::::::::::::: XP_011 GPSAQGKPTYFREEEEEIHSPTLLPEAQN 190 200 >>NP_078950 (OMIM: 611043) protein lin-28 homolog A [Hom (209 aa) initn: 1462 init1: 1462 opt: 1462 Z-score: 1644.0 bits: 311.2 E(85289): 7.8e-85 Smith-Waterman score: 1462; 100.0% identity (100.0% similar) in 209 aa overlap (1-209:1-209) 10 20 30 40 50 60 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 RAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQ 130 140 150 160 170 180 190 200 pF1KB0 GPSAQGKPTYFREEEEEIHSPTLLPEAQN ::::::::::::::::::::::::::::: NP_078 GPSAQGKPTYFREEEEEIHSPTLLPEAQN 190 200 >>NP_001004317 (OMIM: 611044) protein lin-28 homolog B [ (250 aa) initn: 915 init1: 861 opt: 912 Z-score: 1027.7 bits: 197.4 E(85289): 1.7e-50 Smith-Waterman score: 912; 68.5% identity (78.7% similar) in 197 aa overlap (11-205:4-192) 10 20 30 40 50 60 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTA :: .:.. : : . :: : .: :.:.:.: ::::::::::::.:: NP_001 MAEGGASKGGGEEPGKLPEPA---EEESQVLRGTGHCKWFNVRMGFGFISMIN 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 RAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGS : : :: ::::::::::: ::::::::::: ::::::::.::::::::::::: :.:: NP_001 REGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGS 60 70 80 90 100 110 130 140 150 160 170 pF1KB0 ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLK--A :::::::..:::. ::::::::::::::::::.:::::::::.:::: ::::.:: : : NP_001 ERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVA 120 130 140 150 160 170 180 190 200 pF1KB0 QQGPSAQGKPTYFREEEEEIHSPTLLPEAQN : :.:: :.: : . :: NP_001 QPPASSQG-----RQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEA 180 190 200 210 220 >>XP_011534120 (OMIM: 611044) PREDICTED: protein lin-28 (258 aa) initn: 915 init1: 861 opt: 912 Z-score: 1027.5 bits: 197.4 E(85289): 1.7e-50 Smith-Waterman score: 912; 68.5% identity (78.7% similar) in 197 aa overlap (11-205:12-200) 10 20 30 40 50 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMT :: .:.. : : . :: : .: :.:.:.: ::::::::::::.:: XP_011 MRSFNQVSSAPGGASKGGGEEPGKLPEPA---EEESQVLRGTGHCKWFNVRMGFGFISMI 10 20 30 40 50 60 70 80 90 100 110 pF1KB0 ARAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIG : : :: ::::::::::: ::::::::::: ::::::::.::::::::::::: :.: XP_011 NREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB0 SERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLK-- ::::::::..:::. ::::::::::::::::::.:::::::::.:::: ::::.:: : XP_011 SERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNV 120 130 140 150 160 170 180 190 200 pF1KB0 AQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN :: :.:: :.: : . :: XP_011 AQPPASSQG-----RQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQE 180 190 200 210 220 230 >>XP_006715540 (OMIM: 611044) PREDICTED: protein lin-28 (269 aa) initn: 915 init1: 861 opt: 912 Z-score: 1027.3 bits: 197.4 E(85289): 1.8e-50 Smith-Waterman score: 912; 68.5% identity (78.7% similar) in 197 aa overlap (11-205:23-211) 10 20 30 40 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFN :: .:.. : : . :: : .: :.:.:.: ::::: XP_006 MSHRRQVLQKRMRSFNQVSSAPGGASKGGGEEPGKLPEPA---EEESQVLRGTGHCKWFN 10 20 30 40 50 50 60 70 80 90 100 pF1KB0 VRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIR :::::::.:: : : :: ::::::::::: ::::::::::: ::::::::.::::::: XP_006 VRMGFGFISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIR 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB0 VTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSIS :::::: :.:::::::::..:::. ::::::::::::::::::.:::::::::.:::: XP_006 VTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIM 120 130 140 150 160 170 170 180 190 200 pF1KB0 HMVASCPLK--AQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN ::::.:: : :: :.:: :.: : . :: XP_006 HMVANCPHKNVAQPPASSQG-----RQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAE 180 190 200 210 220 230 XP_006 ISERSGRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT 240 250 260 >>NP_057066 (OMIM: 611447) Y-box-binding protein 2 [Homo (364 aa) initn: 271 init1: 121 opt: 229 Z-score: 261.5 bits: 56.2 E(85289): 8e-08 Smith-Waterman score: 229; 36.6% identity (60.4% similar) in 134 aa overlap (3-131:59-182) 10 20 30 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAA :. ... :. : :. .: :: : : NP_057 VVPVPAGEPQKGGGAGGGGGAASGPAAGTPSAPGSRTPGNPATAVSGTP--APP-ARSQA 30 40 50 60 70 80 40 50 60 70 80 pF1KB0 DEPQL-LHGAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEG----FRSL :.: : .. : :::::: :.::.. . : ::::::. .. .. .::. NP_057 DKPVLAIQVLGTVKWFNVRNGYGFINRN-------DTKEDVFVHQTAIKRNNPRKFLRSV 90 100 110 120 130 90 100 110 120 130 140 pF1KB0 KEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDH .::.::: .. :: :. ::::::: ::. :. .. .. NP_057 GDGETVEFDVVEGEKGAEATNVTGPGGVPVKGSRYAPNRRKSRRFIPRPPSVAPPPMVAE 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB0 HAKECKLPPQPKKCHFCQSISHMVASCPLKAQQGPSAQGKPTYFREEEEEIHSPTLLPEA NP_057 IPSAGTGPGSKGERAEDSGQRPRRWCPPPFFYRRRFVRGPRPPNQQQPIEGTDRVEPKET 200 210 220 230 240 250 >>XP_016875611 (OMIM: 603437) PREDICTED: Y-box-binding p (369 aa) initn: 222 init1: 103 opt: 227 Z-score: 259.2 bits: 55.8 E(85289): 1.1e-07 Smith-Waterman score: 227; 36.7% identity (54.7% similar) in 139 aa overlap (10-140:64-192) 10 20 30 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLH : : : :: : . ::: . . ..: XP_016 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVL- 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB0 GAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEG----FRSLKEGEAVEF : :::::: :.::.. . : ::::::. .. .. .::. .::.::: XP_016 --GTVKWFNVRNGYGFINRN-------DTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEF 100 110 120 130 140 100 110 120 130 140 150 pF1KB0 TFKKSAKGLESIRVTGPGGVFCIGS----ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKE .. :: :. :::: :: :: .:: ... :: : : XP_016 DVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNYAGEEEEEGSGS 150 160 170 180 190 200 160 170 180 190 200 pF1KB0 CKLPPQPKKCHFCQSISHMVASCPLKAQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN XP_016 SEGFDPPATDRQFSGARNQLRRPQYRPQYRQRRFPPYHVGQTFDRRSRVLPHPNRIQAGE 210 220 230 240 250 260 >>NP_003642 (OMIM: 603437) Y-box-binding protein 3 isofo (372 aa) initn: 222 init1: 103 opt: 227 Z-score: 259.1 bits: 55.8 E(85289): 1.1e-07 Smith-Waterman score: 227; 36.7% identity (54.7% similar) in 139 aa overlap (10-140:64-192) 10 20 30 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLH : : : :: : . ::: . . ..: NP_003 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVL- 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB0 GAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEG----FRSLKEGEAVEF : :::::: :.::.. . : ::::::. .. .. .::. .::.::: NP_003 --GTVKWFNVRNGYGFINRN-------DTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEF 100 110 120 130 140 100 110 120 130 140 150 pF1KB0 TFKKSAKGLESIRVTGPGGVFCIGS----ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKE .. :: :. :::: :: :: .:: ... :: : : NP_003 DVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNYAGEEEEEGSGS 150 160 170 180 190 200 160 170 180 190 200 pF1KB0 CKLPPQPKKCHFCQSISHMVASCPLKAQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN NP_003 SEGFDPPATDRQFSGARNQLRRPQYRPQYRQRRFPPYHVGQTFDRRSRVLPHPNRIQAGE 210 220 230 240 250 260 >>XP_011519173 (OMIM: 603437) PREDICTED: Y-box-binding p (200 aa) initn: 222 init1: 103 opt: 222 Z-score: 257.0 bits: 54.5 E(85289): 1.4e-07 Smith-Waterman score: 222; 36.8% identity (54.1% similar) in 133 aa overlap (10-138:64-185) 10 20 30 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLH : : : :: : . ::: . . ..: XP_011 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVL- 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB0 GAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEG----FRSLKEGEAVEF : :::::: :.::.. . : ::::::. .. .. .::. .::.::: XP_011 --GTVKWFNVRNGYGFINRN-------DTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEF 100 110 120 130 140 100 110 120 130 140 150 pF1KB0 TFKKSAKGLESIRVTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLP .. :: :. :::: :: :: : . .: : : XP_011 DVVEGEKGAEAANVTGPDGVPVEGS-RYAADRRRYRRGYYGRRRGPPRNISDVWFNRR 150 160 170 180 190 200 160 170 180 190 200 pF1KB0 PQPKKCHFCQSISHMVASCPLKAQQGPSAQGKPTYFREEEEEIHSPTLLPEAQN >>XP_016875612 (OMIM: 603437) PREDICTED: Y-box-binding p (300 aa) initn: 222 init1: 103 opt: 222 Z-score: 254.7 bits: 54.7 E(85289): 1.9e-07 Smith-Waterman score: 223; 33.3% identity (50.0% similar) in 186 aa overlap (10-190:64-218) 10 20 30 pF1KB0 MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLH : : : :: : . ::: . . ..: XP_016 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVL- 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB0 GAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEG----FRSLKEGEAVEF : :::::: :.::.. . : ::::::. .. .. .::. .::.::: XP_016 --GTVKWFNVRNGYGFINRN-------DTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEF 100 110 120 130 140 100 110 120 130 140 150 pF1KB0 TFKKSAKGLESIRVTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLP .. :: :. :::: :: :: : . .: : : . : XP_016 DVVEGEKGAEAANVTGPDGVPVEGS-RYAADRRRYRRGYYGRR--------------RGP 150 160 170 180 160 170 180 190 200 pF1KB0 PQPKKCHFCQSISHMVASCPLKAQ-QGPSAQGKPTYFREEEEEIHSPTLLPEAQN :. :..: . : :: ::: .. .::: XP_016 PRNAG-----EIGEMKDGVPEGAQLQGP-VHRNPTYRPSRGPPRPRPAPAVGEAEDKENQ 190 200 210 220 230 240 XP_016 QATSGPNQPSVRRGYRRPYNYRRRPRPPNAPSQDGKEAKAGEAPTENPAPPTQQSSAE 250 260 270 280 290 300 209 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:34:33 2016 done: Sat Nov 5 17:34:34 2016 Total Scan time: 6.820 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]