FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0980, 450 aa 1>>>pF1KB0980 450 - 450 aa - 450 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6658+/-0.000359; mu= 2.0653+/- 0.022 mean_var=182.8825+/-38.682, 0's: 0 Z-trim(120.1): 71 B-trim: 1056 in 1/52 Lambda= 0.094839 statistics sampled from 34817 (34923) to 34817 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.409), width: 16 Scan time: 10.980 The best scores are: opt bits E(85289) NP_003457 (OMIM: 167415,218700) paired box protein ( 450) 3045 428.9 1.4e-119 XP_011510092 (OMIM: 167415,218700) PREDICTED: pair ( 507) 3033 427.2 4.8e-119 XP_011510093 (OMIM: 167415,218700) PREDICTED: pair ( 500) 2713 383.5 7.1e-106 XP_011510096 (OMIM: 167415,218700) PREDICTED: pair ( 387) 2058 293.8 5.5e-79 NP_039246 (OMIM: 167415,218700) paired box protein ( 398) 2050 292.7 1.2e-78 XP_016860368 (OMIM: 167415,218700) PREDICTED: pair ( 402) 2050 292.7 1.2e-78 XP_011510095 (OMIM: 167415,218700) PREDICTED: pair ( 444) 2046 292.2 1.9e-78 XP_011510094 (OMIM: 167415,218700) PREDICTED: pair ( 455) 2038 291.1 4.2e-78 XP_016860367 (OMIM: 167415,218700) PREDICTED: pair ( 459) 2038 291.1 4.2e-78 NP_039247 (OMIM: 167415,218700) paired box protein ( 321) 1780 255.7 1.3e-67 NP_054698 (OMIM: 167415,218700) paired box protein ( 287) 1777 255.2 1.6e-67 NP_003980 (OMIM: 120330,167409,191830,616002) pair ( 409) 1300 190.1 9.5e-48 XP_016871775 (OMIM: 120330,167409,191830,616002) P ( 440) 1300 190.1 1e-47 NP_000269 (OMIM: 120330,167409,191830,616002) pair ( 394) 1287 188.3 3.2e-47 NP_001291498 (OMIM: 120330,167409,191830,616002) p ( 425) 1287 188.3 3.4e-47 NP_003979 (OMIM: 120330,167409,191830,616002) pair ( 396) 1277 186.9 8.2e-47 XP_016871776 (OMIM: 120330,167409,191830,616002) P ( 427) 1277 186.9 8.8e-47 XP_016871777 (OMIM: 120330,167409,191830,616002) P ( 424) 1267 185.6 2.2e-46 NP_001267476 (OMIM: 167414,615545) paired box prot ( 357) 1151 169.6 1.2e-41 NP_001267481 (OMIM: 167414,615545) paired box prot ( 328) 1141 168.3 2.8e-41 NP_001267477 (OMIM: 167414,615545) paired box prot ( 362) 1141 168.3 3.1e-41 NP_057953 (OMIM: 167414,615545) paired box protein ( 391) 1138 167.9 4.3e-41 XP_005251538 (OMIM: 167414,615545) PREDICTED: pair ( 390) 1120 165.4 2.4e-40 NP_001267478 (OMIM: 167414,615545) paired box prot ( 324) 1108 163.7 6.4e-40 XP_011516198 (OMIM: 167414,615545) PREDICTED: pair ( 410) 1098 162.4 2e-39 XP_016871770 (OMIM: 120330,167409,191830,616002) P ( 496) 1089 161.2 5.5e-39 NP_001267479 (OMIM: 167414,615545) paired box prot ( 295) 1081 160.0 7.6e-39 XP_011516199 (OMIM: 167414,615545) PREDICTED: pair ( 409) 1080 160.0 1.1e-38 NP_003978 (OMIM: 120330,167409,191830,616002) pair ( 417) 1023 152.2 2.5e-36 NP_003981 (OMIM: 120330,167409,191830,616002) pair ( 432) 1023 152.2 2.6e-36 XP_016871774 (OMIM: 120330,167409,191830,616002) P ( 448) 1023 152.2 2.6e-36 XP_016871773 (OMIM: 120330,167409,191830,616002) P ( 463) 1023 152.2 2.7e-36 XP_016871772 (OMIM: 120330,167409,191830,616002) P ( 483) 963 144.0 8.3e-34 XP_016871771 (OMIM: 120330,167409,191830,616002) P ( 483) 963 144.0 8.3e-34 NP_001267482 (OMIM: 167414,615545) paired box prot ( 319) 876 132.0 2.3e-30 NP_001267483 (OMIM: 167414,615545) paired box prot ( 348) 876 132.0 2.4e-30 XP_016871778 (OMIM: 120330,167409,191830,616002) P ( 374) 822 124.6 4.3e-28 NP_000271 (OMIM: 106210,120430,136520,148190,16555 ( 422) 791 120.4 9e-27 NP_001121084 (OMIM: 106210,120430,136520,148190,16 ( 422) 791 120.4 9e-27 NP_001245394 (OMIM: 106210,120430,136520,148190,16 ( 422) 791 120.4 9e-27 NP_001245393 (OMIM: 106210,120430,136520,148190,16 ( 422) 791 120.4 9e-27 NP_001297088 (OMIM: 106210,120430,136520,148190,16 ( 401) 775 118.2 3.9e-26 NP_001120838 (OMIM: 122880,148820,193500,268220,60 ( 483) 680 105.3 3.8e-22 NP_001244025 (OMIM: 167411,615560) paired box prot ( 457) 668 103.6 1.1e-21 NP_852122 (OMIM: 122880,148820,193500,268220,60659 ( 479) 668 103.6 1.2e-21 NP_006185 (OMIM: 167416,604625) paired box protein ( 341) 665 103.1 1.2e-21 NP_852123 (OMIM: 122880,148820,193500,268220,60659 ( 484) 668 103.6 1.2e-21 NP_852124 (OMIM: 122880,148820,193500,268220,60659 ( 505) 668 103.7 1.2e-21 NP_006183 (OMIM: 167411,615560) paired box protein ( 534) 668 103.7 1.3e-21 NP_852126 (OMIM: 122880,148820,193500,268220,60659 ( 403) 642 100.0 1.2e-20 >>NP_003457 (OMIM: 167415,218700) paired box protein Pax (450 aa) initn: 3045 init1: 3045 opt: 3045 Z-score: 2267.9 bits: 428.9 E(85289): 1.4e-119 Smith-Waterman score: 3045; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450) 10 20 30 40 50 60 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP 370 380 390 400 410 420 430 440 450 pF1KB0 NSSLLSSPYYYSSTSRPSAPPTTATAFDHL :::::::::::::::::::::::::::::: NP_003 NSSLLSSPYYYSSTSRPSAPPTTATAFDHL 430 440 450 >>XP_011510092 (OMIM: 167415,218700) PREDICTED: paired b (507 aa) initn: 2606 init1: 2606 opt: 3033 Z-score: 2258.3 bits: 427.2 E(85289): 4.8e-119 Smith-Waterman score: 3033; 99.8% identity (99.8% similar) in 451 aa overlap (1-450:57-507) 10 20 30 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVV :::::::::::::::::::::::::::::: XP_011 QPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVV 30 40 50 60 70 80 40 50 60 70 80 pF1KB0 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG-RYYETGSIRPGVIGGSKPKVATPKVV ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRPGVIGGSKPKVATPKVV 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB0 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB0 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB0 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB0 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB0 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS 390 400 410 420 430 440 390 400 410 420 430 440 pF1KB0 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH 450 460 470 480 490 500 450 pF1KB0 L : XP_011 L >>XP_011510093 (OMIM: 167415,218700) PREDICTED: paired b (500 aa) initn: 2716 init1: 2259 opt: 2713 Z-score: 2021.8 bits: 383.5 E(85289): 7.1e-106 Smith-Waterman score: 2713; 92.0% identity (94.2% similar) in 448 aa overlap (1-444:57-499) 10 20 30 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVV :::::::::::::::::::::::::::::: XP_011 QPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVV 30 40 50 60 70 80 40 50 60 70 80 pF1KB0 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG-RYYETGSIRPGVIGGSKPKVATPKVV ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRPGVIGGSKPKVATPKVV 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB0 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB0 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB0 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB0 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB0 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS 390 400 410 420 430 440 390 400 410 420 430 440 pF1KB0 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSL---LSSPYYYSSTSRPSAPPTTATA ::::::::.: .: : : .: : ..: ...: :.::.: :: : XP_011 AIAGMVAGKERAGRK-GSTAKRKY---WSKEVNTLAMPMATPPT-PPTARPGASPTPAC 450 460 470 480 490 500 450 pF1KB0 FDHL >>XP_011510096 (OMIM: 167415,218700) PREDICTED: paired b (387 aa) initn: 2032 init1: 2032 opt: 2058 Z-score: 1539.1 bits: 293.8 E(85289): 5.5e-79 Smith-Waterman score: 2498; 86.0% identity (86.0% similar) in 450 aa overlap (1-450:1-387) 10 20 30 40 50 60 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVA- 250 260 270 280 290 310 320 330 340 350 360 pF1KB0 PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL XP_011 ------------------------------------------------------------ 370 380 390 400 410 420 pF1KB0 LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 --GREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP 300 310 320 330 340 350 430 440 450 pF1KB0 NSSLLSSPYYYSSTSRPSAPPTTATAFDHL :::::::::::::::::::::::::::::: XP_011 NSSLLSSPYYYSSTSRPSAPPTTATAFDHL 360 370 380 >>NP_039246 (OMIM: 167415,218700) paired box protein Pax (398 aa) initn: 2091 init1: 2040 opt: 2050 Z-score: 1533.0 bits: 292.7 E(85289): 1.2e-78 Smith-Waterman score: 2052; 82.6% identity (86.5% similar) in 385 aa overlap (1-385:1-359) 10 20 30 40 50 60 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL : :: : :.:.:.: : :: .: . :. .. NP_039 P--PFWI--------CSKSAPGSRPSM-------------PFPMLPPCT---GSSRARPS 310 320 330 370 380 390 400 410 420 pF1KB0 LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP .:.. :: : : : . ... NP_039 SQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASP 340 350 360 370 380 390 >>XP_016860368 (OMIM: 167415,218700) PREDICTED: paired b (402 aa) initn: 2062 init1: 2040 opt: 2050 Z-score: 1532.9 bits: 292.7 E(85289): 1.2e-78 Smith-Waterman score: 2052; 82.6% identity (86.5% similar) in 385 aa overlap (1-385:1-359) 10 20 30 40 50 60 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL : :: : :.:.:.: : :: .: . :. .. XP_016 P--PFWI--------CSKSAPGSRPSM-------------PFPMLPPCT---GSSRARPS 310 320 330 370 380 390 400 410 420 pF1KB0 LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP .:.. :: : : : . ... XP_016 SQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQVRRGPAGRGALQRGSIGARWDTRS 340 350 360 370 380 390 >>XP_011510095 (OMIM: 167415,218700) PREDICTED: paired b (444 aa) initn: 1593 init1: 1593 opt: 2046 Z-score: 1529.3 bits: 292.2 E(85289): 1.9e-78 Smith-Waterman score: 2486; 85.8% identity (85.8% similar) in 451 aa overlap (1-450:57-444) 10 20 30 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVV :::::::::::::::::::::::::::::: XP_011 QPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVV 30 40 50 60 70 80 40 50 60 70 80 pF1KB0 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG-RYYETGSIRPGVIGGSKPKVATPKVV ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRPGVIGGSKPKVATPKVV 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB0 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB0 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB0 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB0 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF :::::::::::::::::::::::::::::: XP_011 TLDDGKATLTPSNTPLGRNLSTHQTYPVVA------------------------------ 330 340 350 330 340 350 360 370 380 pF1KB0 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS ::::::::::::::::::::::::::: XP_011 ---------------------------------GREMVGPTLPGYPPHIPTSGQGSYASS 360 370 380 390 400 410 420 430 440 pF1KB0 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH 390 400 410 420 430 440 450 pF1KB0 L : XP_011 L >>XP_011510094 (OMIM: 167415,218700) PREDICTED: paired b (455 aa) initn: 2058 init1: 1601 opt: 2038 Z-score: 1523.2 bits: 291.1 E(85289): 4.2e-78 Smith-Waterman score: 2040; 82.4% identity (86.3% similar) in 386 aa overlap (1-385:57-416) 10 20 30 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVV :::::::::::::::::::::::::::::: XP_011 QPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVV 30 40 50 60 70 80 40 50 60 70 80 pF1KB0 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG-RYYETGSIRPGVIGGSKPKVATPKVV ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRPGVIGGSKPKVATPKVV 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB0 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB0 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB0 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB0 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF :::::::::::::::::::::::::::::: : :: : :.:.:.: : XP_011 TLDDGKATLTPSNTPLGRNLSTHQTYPVVAAP--PFWI--------CSKSAPGSRPSM-- 330 340 350 360 370 330 340 350 360 370 380 pF1KB0 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS :: .: . :. .. .:.. :: : : : . ... XP_011 -----------PFPMLPPCT---GSSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPL 380 390 400 410 420 390 400 410 420 430 440 pF1KB0 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH XP_011 PSQAWWQEVNTLAMPMATPPTPPTARPGASPTPAC 430 440 450 >>XP_016860367 (OMIM: 167415,218700) PREDICTED: paired b (459 aa) initn: 1601 init1: 1601 opt: 2038 Z-score: 1523.2 bits: 291.1 E(85289): 4.2e-78 Smith-Waterman score: 2040; 82.4% identity (86.3% similar) in 386 aa overlap (1-385:57-416) 10 20 30 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVV :::::::::::::::::::::::::::::: XP_016 QPAGQGSGRRGPDLREEAPSPRRAASDSPAMPHNSIRSGHGGLNQLGGAFVNGRPLPEVV 30 40 50 60 70 80 40 50 60 70 80 pF1KB0 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG-RYYETGSIRPGVIGGSKPKVATPKVV ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_016 RQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRPGVIGGSKPKVATPKVV 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB0 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVA 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB0 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLS 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB0 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNS 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB0 TLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAF :::::::::::::::::::::::::::::: : :: : :.:.:.: : XP_016 TLDDGKATLTPSNTPLGRNLSTHQTYPVVAAP--PFWI--------CSKSAPGSRPSM-- 330 340 350 360 370 330 340 350 360 370 380 pF1KB0 LDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASS :: .: . :. .. .:.. :: : : : . ... XP_016 -----------PFPMLPPCT---GSSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPL 380 390 400 410 420 390 400 410 420 430 440 pF1KB0 AIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH XP_016 PSQAWWQVRRGPAGRGALQRGSIGARWDTRSKRHTVPYS 430 440 450 >>NP_039247 (OMIM: 167415,218700) paired box protein Pax (321 aa) initn: 1829 init1: 1778 opt: 1780 Z-score: 1334.7 bits: 255.7 E(85289): 1.3e-67 Smith-Waterman score: 1780; 85.2% identity (89.6% similar) in 317 aa overlap (1-312:1-317) 10 20 30 40 50 60 pF1KB0 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_039 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF 190 200 210 220 230 240 250 260 270 280 290 pF1KB0 ERQHYPEAYASPSHTKGEQGLY---P-LPLLNSTLDDG-KATLTPSNTPLGRNLSTHQTY :::::::::::::::::::: : : . : . .:.. : . . . .. NP_039 ERQHYPEAYASPSHTKGEQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB0 PVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQF :... : : : .: NP_039 PMATPPTPPTARPGASPTPAC 310 320 450 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:39:55 2016 done: Sat Nov 5 17:39:56 2016 Total Scan time: 10.980 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]