FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0993, 278 aa 1>>>pF1KB0993 278 - 278 aa - 278 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7738+/-0.000298; mu= 14.1753+/- 0.019 mean_var=89.3091+/-17.859, 0's: 0 Z-trim(119.3): 12 B-trim: 1021 in 1/53 Lambda= 0.135715 statistics sampled from 33263 (33275) to 33263 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.39), width: 16 Scan time: 8.260 The best scores are: opt bits E(85289) NP_006577 (OMIM: 610774) protein canopy homolog 3 ( 278) 1836 368.8 6.4e-102 NP_001305774 (OMIM: 610774) protein canopy homolog ( 189) 1236 251.2 1.1e-66 NP_001305771 (OMIM: 610774) protein canopy homolog ( 311) 1234 250.9 2.1e-66 NP_001305777 (OMIM: 610774) protein canopy homolog ( 151) 806 166.9 2e-41 NP_689968 (OMIM: 610047) protein canopy homolog 4 ( 248) 665 139.5 6.1e-33 NP_001305776 (OMIM: 610774) protein canopy homolog ( 116) 602 126.9 1.7e-29 >>NP_006577 (OMIM: 610774) protein canopy homolog 3 isof (278 aa) initn: 1836 init1: 1836 opt: 1836 Z-score: 1950.7 bits: 368.8 E(85289): 6.4e-102 Smith-Waterman score: 1836; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278) 10 20 30 40 50 60 pF1KB0 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 YRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRS 190 200 210 220 230 240 250 260 270 pF1KB0 SSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL :::::::::::::::::::::::::::::::::::::: NP_006 SSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL 250 260 270 >>NP_001305774 (OMIM: 610774) protein canopy homolog 3 i (189 aa) initn: 1236 init1: 1236 opt: 1236 Z-score: 1318.2 bits: 251.2 E(85289): 1.1e-66 Smith-Waterman score: 1236; 98.9% identity (99.5% similar) in 188 aa overlap (91-278:2-189) 70 80 90 100 110 120 pF1KB0 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN . :::::::::::::::::::::::::::: NP_001 MRRDLRLIEVTETICKRLLDYSLHKERTGSN 10 20 30 130 140 150 160 170 180 pF1KB0 RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB0 YRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRS 100 110 120 130 140 150 250 260 270 pF1KB0 SSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL :::::::::::::::::::::::::::::::::::::: NP_001 SSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL 160 170 180 >>NP_001305771 (OMIM: 610774) protein canopy homolog 3 i (311 aa) initn: 1822 init1: 1234 opt: 1234 Z-score: 1313.0 bits: 250.9 E(85289): 2.1e-66 Smith-Waterman score: 1753; 89.4% identity (89.4% similar) in 310 aa overlap (2-278:2-311) 10 20 30 40 50 60 pF1KB0 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK 10 20 30 40 50 60 70 80 90 pF1KB0 SAFEETGKTKEVIGTGYGILDQKASGVKYTKS---------------------------- :::::::::::::::::::::::::::::::: NP_001 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSISDPPDQMTYLPSSSESLPIGGELSSSS 70 80 90 100 110 120 100 110 120 130 140 pF1KB0 -----DLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCLGRDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDI 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB0 PYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCL 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB0 AEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKA 250 260 270 280 290 300 270 pF1KB0 SPLTHSPPDEL ::::::::::: NP_001 SPLTHSPPDEL 310 >>NP_001305777 (OMIM: 610774) protein canopy homolog 3 i (151 aa) initn: 806 init1: 806 opt: 806 Z-score: 864.6 bits: 166.9 E(85289): 2e-41 Smith-Waterman score: 806; 100.0% identity (100.0% similar) in 124 aa overlap (1-124:1-124) 10 20 30 40 50 60 pF1KB0 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW :::: NP_001 RFAKVGFGIVLHPLWGQACMYLSVSAGVSVI 130 140 150 >>NP_689968 (OMIM: 610047) protein canopy homolog 4 prec (248 aa) initn: 639 init1: 489 opt: 665 Z-score: 712.3 bits: 139.5 E(85289): 6.1e-33 Smith-Waterman score: 665; 44.9% identity (74.4% similar) in 227 aa overlap (17-238:6-231) 10 20 30 40 50 60 pF1KB0 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK : .::.:.: . : .. :..: :::::::::: ...::. NP_689 MGPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLLSTELQ 10 20 30 40 70 80 90 100 110 pF1KB0 SAFEETGKTKEVIGTGYGILD--QKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTG . . .::...::. : .:: .. : :. :. :: :. :..:.:.::::.: :: : NP_689 AELSRTGRSREVLELGQ-VLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB0 SNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIE : :.:::.:.:. ::..::.::::: . :: :::.: :.::. :::::....::::... NP_689 SLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVG 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB0 DWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKK---GDTAALGGKKSKKKSSRAKA ::: .:::. : .::: .::: . .:.:: : :.::. :. . : ...... . . NP_689 DWYFHHQEQPLQNFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEEQEEEEEEEEE 170 180 190 200 210 220 240 250 260 270 pF1KB0 AGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL :: NP_689 EGGDKMTKTGSHPKLDREDL 230 240 >>NP_001305776 (OMIM: 610774) protein canopy homolog 3 i (116 aa) initn: 602 init1: 602 opt: 602 Z-score: 650.3 bits: 126.9 E(85289): 1.7e-29 Smith-Waterman score: 602; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB0 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN :::::::::::::::::::::::::::::::: NP_001 SAFEETGKTKEVIGTGYGILDQKASGVKYTKSISDPPDQMTYLPSSSESLPIGTCG 70 80 90 100 110 130 140 150 160 170 180 pF1KB0 RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW 278 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:42:56 2016 done: Sat Nov 5 17:42:57 2016 Total Scan time: 8.260 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]