FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB1290, 749 aa 1>>>pF1KB1290 749 - 749 aa - 749 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 15.2673+/-0.000482; mu= -23.4678+/- 0.030 mean_var=681.0966+/-138.354, 0's: 0 Z-trim(124.2): 75 B-trim: 0 in 0/62 Lambda= 0.049144 statistics sampled from 45193 (45331) to 45193 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.531), width: 16 Scan time: 16.580 The best scores are: opt bits E(85289) NP_003971 (OMIM: 604108) ensconsin isoform 3 [Homo ( 749) 4885 361.7 6.3e-99 XP_006715664 (OMIM: 604108) PREDICTED: ensconsin i ( 757) 4859 359.8 2.3e-98 XP_006715663 (OMIM: 604108) PREDICTED: ensconsin i ( 771) 4746 351.8 6e-96 NP_001185543 (OMIM: 604108) ensconsin isoform 1 [H ( 771) 4746 351.8 6e-96 NP_001185537 (OMIM: 604108) ensconsin isoform 1 [H ( 771) 4746 351.8 6e-96 NP_001185544 (OMIM: 604108) ensconsin isoform 5 [H ( 734) 4731 350.8 1.2e-95 XP_006715661 (OMIM: 604108) PREDICTED: ensconsin i ( 779) 4720 350.0 2.2e-95 XP_006715662 (OMIM: 604108) PREDICTED: ensconsin i ( 779) 4720 350.0 2.2e-95 NP_001185538 (OMIM: 604108) ensconsin isoform 2 [H ( 779) 4720 350.0 2.2e-95 XP_011534545 (OMIM: 604108) PREDICTED: ensconsin i ( 742) 4705 348.9 4.4e-95 NP_001185548 (OMIM: 604108) ensconsin isoform 8 [H ( 603) 3919 293.1 2.2e-78 NP_001185547 (OMIM: 604108) ensconsin isoform 8 [H ( 603) 3919 293.1 2.2e-78 NP_001185546 (OMIM: 604108) ensconsin isoform 7 [H ( 655) 3704 277.9 9.2e-74 NP_001185545 (OMIM: 604108) ensconsin isoform 6 [H ( 712) 3527 265.4 5.9e-70 NP_001185540 (OMIM: 604108) ensconsin isoform 4 [H ( 734) 3527 265.4 6e-70 XP_016866960 (OMIM: 604108) PREDICTED: ensconsin i ( 734) 3527 265.4 6e-70 XP_011534546 (OMIM: 604108) PREDICTED: ensconsin i ( 742) 3510 264.2 1.4e-69 XP_011534548 (OMIM: 604108) PREDICTED: ensconsin i ( 705) 3503 263.7 1.9e-69 XP_011534547 (OMIM: 604108) PREDICTED: ensconsin i ( 720) 3503 263.7 1.9e-69 >>NP_003971 (OMIM: 604108) ensconsin isoform 3 [Homo sap (749 aa) initn: 4885 init1: 4885 opt: 4885 Z-score: 1897.0 bits: 361.7 E(85289): 6.3e-99 Smith-Waterman score: 4885; 100.0% identity (100.0% similar) in 749 aa overlap (1-749:1-749) 10 20 30 40 50 60 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB1 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB1 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB1 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB1 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB1 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB1 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB1 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB1 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB1 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB1 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB1 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN 670 680 690 700 710 720 730 740 pF1KB1 PILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::: NP_003 PILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 >>XP_006715664 (OMIM: 604108) PREDICTED: ensconsin isofo (757 aa) initn: 3238 init1: 3238 opt: 4859 Z-score: 1887.0 bits: 359.8 E(85289): 2.3e-98 Smith-Waterman score: 4859; 98.9% identity (98.9% similar) in 757 aa overlap (1-749:1-757) 10 20 30 40 50 60 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB1 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB1 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB1 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 190 200 210 220 230 240 250 260 270 280 290 pF1KB1 KSTAALSGEA--------ASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTA :::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_006 KSTAALSGEAVIPICPRSASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB1 SYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB1 SVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATV 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB1 EERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAG 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB1 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB1 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB1 EQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB1 KPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNS 670 680 690 700 710 720 720 730 740 pF1KB1 ESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::: XP_006 ESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 >>XP_006715663 (OMIM: 604108) PREDICTED: ensconsin isofo (771 aa) initn: 4746 init1: 4746 opt: 4746 Z-score: 1843.6 bits: 351.8 E(85289): 6e-96 Smith-Waterman score: 4746; 99.2% identity (99.3% similar) in 735 aa overlap (15-749:37-771) 10 20 30 40 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS .: : :::::::::::::::::::::: XP_006 ALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPKAPDSYKVQDKKNASSRPASAIS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB1 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB1 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB1 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB1 VVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB1 RRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB1 PTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPL 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB1 VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNAS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB1 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB1 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB1 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPC 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB1 TTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKP 670 680 690 700 710 720 710 720 730 740 pF1KB1 SRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::::::::::: XP_006 SRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 760 770 >>NP_001185543 (OMIM: 604108) ensconsin isoform 1 [Homo (771 aa) initn: 4746 init1: 4746 opt: 4746 Z-score: 1843.6 bits: 351.8 E(85289): 6e-96 Smith-Waterman score: 4746; 99.2% identity (99.3% similar) in 735 aa overlap (15-749:37-771) 10 20 30 40 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS .: : :::::::::::::::::::::: NP_001 ALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPKAPDSYKVQDKKNASSRPASAIS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB1 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB1 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB1 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB1 VVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB1 RRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB1 PTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPL 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB1 VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNAS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB1 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB1 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB1 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPC 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB1 TTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKP 670 680 690 700 710 720 710 720 730 740 pF1KB1 SRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 760 770 >>NP_001185537 (OMIM: 604108) ensconsin isoform 1 [Homo (771 aa) initn: 4746 init1: 4746 opt: 4746 Z-score: 1843.6 bits: 351.8 E(85289): 6e-96 Smith-Waterman score: 4746; 99.2% identity (99.3% similar) in 735 aa overlap (15-749:37-771) 10 20 30 40 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS .: : :::::::::::::::::::::: NP_001 ALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPKAPDSYKVQDKKNASSRPASAIS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB1 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB1 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB1 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB1 VVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB1 RRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB1 PTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPL 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB1 VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNAS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB1 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB1 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB1 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPC 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB1 TTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKP 670 680 690 700 710 720 710 720 730 740 pF1KB1 SRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 760 770 >>NP_001185544 (OMIM: 604108) ensconsin isoform 5 [Homo (734 aa) initn: 4731 init1: 4731 opt: 4731 Z-score: 1838.1 bits: 350.8 E(85289): 1.2e-95 Smith-Waterman score: 4731; 99.9% identity (100.0% similar) in 727 aa overlap (23-749:8-734) 10 20 30 40 50 60 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV .::::::::::::::::::::::::::::::::::::: NP_001 MEDTKLYSPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 10 20 30 40 70 80 90 100 110 120 pF1KB1 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB1 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB1 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB1 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB1 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB1 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB1 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB1 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB1 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB1 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB1 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN 650 660 670 680 690 700 730 740 pF1KB1 PILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::: NP_001 PILAFDDEGTLGPLPQVDGVQTQQTAEVI 710 720 730 >>XP_006715661 (OMIM: 604108) PREDICTED: ensconsin isofo (779 aa) initn: 3238 init1: 3238 opt: 4720 Z-score: 1833.6 bits: 350.0 E(85289): 2.2e-95 Smith-Waterman score: 4720; 98.1% identity (98.3% similar) in 743 aa overlap (15-749:37-779) 10 20 30 40 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS .: : :::::::::::::::::::::: XP_006 ALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPKAPDSYKVQDKKNASSRPASAIS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB1 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB1 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB1 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS 190 200 210 220 230 240 230 240 250 260 270 pF1KB1 VVNRLLTPTHSFLARSKSTAALSGEA--------ASCSPIIMPYKAAHSRNSMDRPKLFV :::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_006 VVNRLLTPTHSFLARSKSTAALSGEAVIPICPRSASCSPIIMPYKAAHSRNSMDRPKLFV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB1 TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB1 PHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB1 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB1 PSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB1 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB1 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB1 TEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEII 670 680 690 700 710 720 700 710 720 730 740 pF1KB1 NLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 760 770 >>XP_006715662 (OMIM: 604108) PREDICTED: ensconsin isofo (779 aa) initn: 3238 init1: 3238 opt: 4720 Z-score: 1833.6 bits: 350.0 E(85289): 2.2e-95 Smith-Waterman score: 4720; 98.1% identity (98.3% similar) in 743 aa overlap (15-749:37-779) 10 20 30 40 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS .: : :::::::::::::::::::::: XP_006 ALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPKAPDSYKVQDKKNASSRPASAIS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB1 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB1 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB1 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS 190 200 210 220 230 240 230 240 250 260 270 pF1KB1 VVNRLLTPTHSFLARSKSTAALSGEA--------ASCSPIIMPYKAAHSRNSMDRPKLFV :::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_006 VVNRLLTPTHSFLARSKSTAALSGEAVIPICPRSASCSPIIMPYKAAHSRNSMDRPKLFV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB1 TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB1 PHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB1 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB1 PSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB1 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB1 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB1 TEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEII 670 680 690 700 710 720 700 710 720 730 740 pF1KB1 NLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 760 770 >>NP_001185538 (OMIM: 604108) ensconsin isoform 2 [Homo (779 aa) initn: 3238 init1: 3238 opt: 4720 Z-score: 1833.6 bits: 350.0 E(85289): 2.2e-95 Smith-Waterman score: 4720; 98.1% identity (98.3% similar) in 743 aa overlap (15-749:37-779) 10 20 30 40 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS .: : :::::::::::::::::::::: NP_001 ALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPKAPDSYKVQDKKNASSRPASAIS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB1 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB1 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB1 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESS 190 200 210 220 230 240 230 240 250 260 270 pF1KB1 VVNRLLTPTHSFLARSKSTAALSGEA--------ASCSPIIMPYKAAHSRNSMDRPKLFV :::::::::::::::::::::::::: :::::::::::::::::::::::::: NP_001 VVNRLLTPTHSFLARSKSTAALSGEAVIPICPRSASCSPIIMPYKAAHSRNSMDRPKLFV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB1 TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB1 PHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB1 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB1 PSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB1 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB1 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGG 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB1 TEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEII 670 680 690 700 710 720 700 710 720 730 740 pF1KB1 NLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 730 740 750 760 770 >>XP_011534545 (OMIM: 604108) PREDICTED: ensconsin isofo (742 aa) initn: 3238 init1: 3238 opt: 4705 Z-score: 1828.1 bits: 348.9 E(85289): 4.4e-95 Smith-Waterman score: 4705; 98.8% identity (98.9% similar) in 735 aa overlap (23-749:8-742) 10 20 30 40 50 60 pF1KB1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV .::::::::::::::::::::::::::::::::::::: XP_011 MEDTKLYSPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 10 20 30 40 70 80 90 100 110 120 pF1KB1 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB1 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB1 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 170 180 190 200 210 220 250 260 270 280 290 pF1KB1 KSTAALSGEA--------ASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTA :::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_011 KSTAALSGEAVIPICPRSASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB1 SYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPG 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB1 SVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATV 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB1 EERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAG 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB1 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR 470 480 490 500 510 520 540 550 560 570 580 590 pF1KB1 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 530 540 550 560 570 580 600 610 620 630 640 650 pF1KB1 EQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNG 590 600 610 620 630 640 660 670 680 690 700 710 pF1KB1 KPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNS 650 660 670 680 690 700 720 730 740 pF1KB1 ESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI ::::::::::::::::::::::::::::::::::::: XP_011 ESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTAEVI 710 720 730 740 749 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:49:10 2016 done: Thu Nov 3 11:49:12 2016 Total Scan time: 16.580 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]