FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB2260, 876 aa 1>>>pF1KB2260 876 - 876 aa - 876 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.0646+/-0.00108; mu= -10.5647+/- 0.064 mean_var=438.4538+/-96.326, 0's: 0 Z-trim(114.0): 216 B-trim: 0 in 0/53 Lambda= 0.061251 statistics sampled from 14349 (14567) to 14349 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.447), width: 16 Scan time: 5.180 The best scores are: opt bits E(32554) CCDS4690.1 DDR1 gene_id:780|Hs108|chr6 ( 876) 6105 554.7 2.6e-157 CCDS56411.1 DDR1 gene_id:780|Hs108|chr6 ( 894) 6105 554.7 2.6e-157 CCDS34385.1 DDR1 gene_id:780|Hs108|chr6 ( 913) 3568 330.6 8.1e-90 CCDS47396.1 DDR1 gene_id:780|Hs108|chr6 ( 919) 3568 330.6 8.1e-90 CCDS75419.1 DDR1 gene_id:780|Hs108|chr6 ( 767) 3142 292.8 1.5e-78 CCDS1241.1 DDR2 gene_id:4921|Hs108|chr1 ( 855) 1250 125.7 3.5e-28 CCDS35050.1 NTRK2 gene_id:4915|Hs108|chr9 ( 822) 831 88.7 4.8e-17 CCDS6671.1 NTRK2 gene_id:4915|Hs108|chr9 ( 838) 831 88.7 4.9e-17 CCDS58399.1 NTRK3 gene_id:4916|Hs108|chr15 ( 817) 803 86.2 2.6e-16 CCDS10340.1 NTRK3 gene_id:4916|Hs108|chr15 ( 825) 803 86.2 2.7e-16 CCDS30890.1 NTRK1 gene_id:4914|Hs108|chr1 ( 760) 796 85.5 3.9e-16 CCDS30891.1 NTRK1 gene_id:4914|Hs108|chr1 ( 790) 796 85.6 4e-16 CCDS1161.1 NTRK1 gene_id:4914|Hs108|chr1 ( 796) 796 85.6 4e-16 CCDS75874.1 MUSK gene_id:4593|Hs108|chr9 ( 783) 776 83.8 1.3e-15 CCDS48005.1 MUSK gene_id:4593|Hs108|chr9 ( 869) 776 83.8 1.4e-15 CCDS626.1 ROR1 gene_id:4919|Hs108|chr1 ( 937) 685 75.8 4e-13 CCDS53525.1 RET gene_id:5979|Hs108|chr10 (1072) 660 73.7 2.1e-12 CCDS7200.1 RET gene_id:5979|Hs108|chr10 (1114) 660 73.7 2.1e-12 CCDS6691.1 ROR2 gene_id:4920|Hs108|chr9 ( 943) 653 73.0 2.9e-12 CCDS5116.1 ROS1 gene_id:6098|Hs108|chr6 (2347) 628 71.1 2.6e-11 CCDS4410.1 FGFR4 gene_id:2264|Hs108|chr5 ( 802) 613 69.4 3e-11 CCDS4411.1 FGFR4 gene_id:2264|Hs108|chr5 ( 762) 612 69.3 3e-11 CCDS78096.1 FGFR4 gene_id:2264|Hs108|chr5 ( 734) 608 68.9 3.8e-11 >>CCDS4690.1 DDR1 gene_id:780|Hs108|chr6 (876 aa) initn: 6105 init1: 6105 opt: 6105 Z-score: 2937.8 bits: 554.7 E(32554): 2.6e-157 Smith-Waterman score: 6105; 100.0% identity (100.0% similar) in 876 aa overlap (1-876:1-876) 10 20 30 40 50 60 pF1KB2 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB2 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB2 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB2 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB2 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB2 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB2 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB2 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB2 PPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 PPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB2 QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB2 LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB2 CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB2 ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB2 GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP 790 800 810 820 830 840 850 860 870 pF1KB2 QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV :::::::::::::::::::::::::::::::::::: CCDS46 QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 850 860 870 >>CCDS56411.1 DDR1 gene_id:780|Hs108|chr6 (894 aa) initn: 6105 init1: 6105 opt: 6105 Z-score: 2937.7 bits: 554.7 E(32554): 2.6e-157 Smith-Waterman score: 6105; 100.0% identity (100.0% similar) in 876 aa overlap (1-876:19-894) 10 20 30 40 pF1KB2 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTI :::::::::::::::::::::::::::::::::::::::::: CCDS56 MSLPRCCPHPLRPEGSGAMGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB2 PDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB2 QGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVAR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB2 LVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB2 LQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB2 MQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRV 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB2 ARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 ARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEP 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB2 RGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 RGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVH 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB2 LSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLP 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB2 PPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEG 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB2 QFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB2 KDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 KDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTIS 670 680 690 700 710 720 710 720 730 740 750 760 pF1KB2 YPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 YPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB2 QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGE 790 800 810 820 830 840 830 840 850 860 870 pF1KB2 FFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 FFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 850 860 870 880 890 >>CCDS34385.1 DDR1 gene_id:780|Hs108|chr6 (913 aa) initn: 3545 init1: 3545 opt: 3568 Z-score: 1726.0 bits: 330.6 E(32554): 8.1e-90 Smith-Waterman score: 5994; 95.9% identity (95.9% similar) in 908 aa overlap (1-871:1-908) 10 20 30 40 50 60 pF1KB2 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB2 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB2 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB2 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB2 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB2 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB2 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB2 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 430 440 450 460 470 480 490 500 pF1KB2 PPPYQEPRPRGNPPHSAPCVPNGSA----------------------------------- ::::::::::::::::::::::::: CCDS34 PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB2 --YSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB2 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 610 620 630 640 650 660 630 640 650 660 670 680 pF1KB2 ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 670 680 690 700 710 720 690 700 710 720 730 740 pF1KB2 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 730 740 750 760 770 780 750 760 770 780 790 800 pF1KB2 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 790 800 810 820 830 840 810 820 830 840 850 860 pF1KB2 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 850 860 870 880 890 900 870 pF1KB2 LHRFLAEDALNTV :::::::: CCDS34 LHRFLAEDALNTV 910 >>CCDS47396.1 DDR1 gene_id:780|Hs108|chr6 (919 aa) initn: 5240 init1: 3545 opt: 3568 Z-score: 1726.0 bits: 330.6 E(32554): 8.1e-90 Smith-Waterman score: 5933; 95.3% identity (95.3% similar) in 908 aa overlap (1-865:1-908) 10 20 30 40 50 60 pF1KB2 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB2 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB2 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB2 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB2 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB2 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB2 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB2 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE 430 440 450 460 470 480 490 500 pF1KB2 PPPYQEPRPRGNPPHSAPCVPNGSA----------------------------------- ::::::::::::::::::::::::: CCDS47 PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB2 --YSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB2 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 610 620 630 640 650 660 630 640 650 660 670 pF1KB2 ATKNA------RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLS ::::: ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KB2 AHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 AHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV 730 740 750 760 770 780 740 750 760 770 780 790 pF1KB2 GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW 790 800 810 820 830 840 800 810 820 830 840 850 pF1KB2 EVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQ 850 860 870 880 890 900 860 870 pF1KB2 RPPFSQLHRFLAEDALNTV :::::::: CCDS47 RPPFSQLHRFLAEDALNTV 910 >>CCDS75419.1 DDR1 gene_id:780|Hs108|chr6 (767 aa) initn: 5112 init1: 3138 opt: 3142 Z-score: 1523.6 bits: 292.8 E(32554): 1.5e-78 Smith-Waterman score: 4940; 85.8% identity (86.6% similar) in 876 aa overlap (1-876:1-767) 10 20 30 40 50 60 pF1KB2 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB2 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB2 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB2 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB2 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB2 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB2 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB2 GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE ::::::::::::::::::::::::::::: ::: CCDS75 GCLVAIILLLLLIIALMLWRLHWRRLLSK----VLE------------------------ 430 440 450 490 500 510 520 530 540 pF1KB2 PPPYQEPRPRGNPPHSAPCVPNGSAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTL ..:: :. CCDS75 ----SHPRTRS------------------------------------------------- 550 560 570 580 590 600 pF1KB2 QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVS :: :: : . .: : . . :::::::::::::: CCDS75 ---------------PGLVGIRP--TPLPVSPMAL-----------VHLCEVDSPQDLVS 460 470 480 490 610 620 630 640 650 660 pF1KB2 LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL 500 510 520 530 540 550 670 680 690 700 710 720 pF1KB2 CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL 560 570 580 590 600 610 730 740 750 760 770 780 pF1KB2 ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM 620 630 640 650 660 670 790 800 810 820 830 840 pF1KB2 GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 GKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACP 680 690 700 710 720 730 850 860 870 pF1KB2 QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV :::::::::::::::::::::::::::::::::::: CCDS75 QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 740 750 760 >>CCDS1241.1 DDR2 gene_id:4921|Hs108|chr1 (855 aa) initn: 3015 init1: 887 opt: 1250 Z-score: 619.4 bits: 125.7 E(32554): 3.5e-28 Smith-Waterman score: 3152; 54.8% identity (75.9% similar) in 887 aa overlap (3-868:5-849) 10 20 30 40 50 pF1KB2 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTA :. : :.::: . :. :.. .:: ::: :::. ::: ::.:::.::.::: CCDS12 MILIPRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTA 10 20 30 40 50 60 70 80 90 100 110 pF1KB2 ARHSRLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRS :...::.: .::::::: : : . .:.::.::. ::...::::::::::: : ::. CCDS12 AKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPM 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB2 YRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVC :.. ::::: ::..:..: :..:..:: .: . :::: ::.:::.::: : .:. :.:: CCDS12 YKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB2 LRVELYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGV .:::::::.: :::.::.::.:: . : . .:::::.::: .:: . :::::.::: CCDS12 MRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB2 VGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGA ::::: ...: .:::::::::: :.: ..::.:. :::::.: : .:.:::::: . :. CCDS12 SGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB2 RLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGP .. :.: :: . : :: . . : . .: :: :.::: :.: ..:.. :: CCDS12 KIFKEVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADT 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB2 WLLFSEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGS :..::::.: ::. . :.: :: : .: . : .:. :.. : CCDS12 WMMFSEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDS 360 370 380 390 420 430 440 450 460 470 pF1KB2 PTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINN : ::::::::::..:: ::...::: :...: :: ::.:..:.:: ::.:.:. ..:: CCDS12 NTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNN 400 410 420 430 440 450 480 490 500 510 pF1KB2 R--PGPRE-----------P--PPYQEP-RPRGNPPHSAPCVPNGSAYSGDYMEPEKPGA .: : : : :::: : . :. :: . :. :: ..: .:.. CCDS12 NRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEE-SGCSG-VVKPVQPSG 460 470 480 490 500 510 520 530 540 550 560 570 pF1KB2 PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVD-FPRSRLRFKE : ..::::::::::.::::::::::.:::. .. :. :::. : ::: CCDS12 P-------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKE 520 530 540 550 560 580 590 600 610 620 630 pF1KB2 KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVK :::::::::::::::.. . . . :: :.: ..:.:::::.:: ::.::::::::::.: CCDS12 KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIK 570 580 590 600 610 620 640 650 660 670 680 690 pF1KB2 IMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQ :::::::::::.::.::. ::::::::.:::::::::::: :. : ...... CCDS12 IMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSD 630 640 650 660 670 700 710 720 730 740 750 pF1KB2 GPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG :.:: : .:.::::::.::..::::::::::::::::.:.::::::::::::::.: CCDS12 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG 680 690 700 710 720 730 760 770 780 790 800 810 pF1KB2 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVI ::::.:::::::::::.:: ::.::::::::::::::::::.. .:. ::..::.::::: CCDS12 DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI 740 750 760 770 780 790 820 830 840 850 860 870 pF1KB2 ENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV ::.::::::::::.:: .: ::...:.::: :: :....:: :...: .: CCDS12 ENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE 800 810 820 830 840 850 >>CCDS35050.1 NTRK2 gene_id:4915|Hs108|chr9 (822 aa) initn: 869 init1: 450 opt: 831 Z-score: 419.5 bits: 88.7 E(32554): 4.8e-17 Smith-Waterman score: 860; 47.7% identity (71.2% similar) in 302 aa overlap (570-868:535-807) 540 550 560 570 580 590 pF1KB2 LQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLV : . .:..:::: ::.: : : CCDS35 MTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAEC------- 510 520 530 540 550 600 610 620 630 640 650 pF1KB2 SLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP . : .. . .::::: :. ::. :::.:: .:..... :. .:... ::::. :: CCDS35 ---YNLCPEQDK-ILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDP 560 570 580 590 600 610 660 670 680 690 700 710 pF1KB2 LCMITDYMENGDLNQFLSAHQLEDKA--AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASG : :. .::..::::.:: :: : . ::: : :: .. ..::.: :::.: CCDS35 LIMVFEYMKHGDLNKFLRAHG-PDAVLMAEGNP--------PTELTQSQMLHIAQQIAAG 620 630 640 650 660 720 730 740 750 760 770 pF1KB2 MRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWE : :::. .::::::::::::::::. .::.::::::..:. ::::: :...:::::: : CCDS35 MVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 670 680 690 700 710 720 780 790 800 810 820 830 pF1KB2 CILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRP :.. :::: ::::..::.:::.. . ::. ::....::: ::: :.:: CCDS35 SIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNNEVIECI-----TQGR--VLQRP 730 740 750 760 770 840 850 860 870 pF1KB2 PACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV .::: .::::: ::.:: ..: .. .: .: CCDS35 RTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 780 790 800 810 820 >>CCDS6671.1 NTRK2 gene_id:4915|Hs108|chr9 (838 aa) initn: 869 init1: 450 opt: 831 Z-score: 419.4 bits: 88.7 E(32554): 4.9e-17 Smith-Waterman score: 860; 47.7% identity (71.2% similar) in 302 aa overlap (570-868:551-823) 540 550 560 570 580 590 pF1KB2 LQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLV : . .:..:::: ::.: : : CCDS66 MTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAEC------- 530 540 550 560 570 600 610 620 630 640 650 pF1KB2 SLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP . : .. . .::::: :. ::. :::.:: .:..... :. .:... ::::. :: CCDS66 ---YNLCPEQDK-ILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDP 580 590 600 610 620 660 670 680 690 700 710 pF1KB2 LCMITDYMENGDLNQFLSAHQLEDKA--AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASG : :. .::..::::.:: :: : . ::: : :: .. ..::.: :::.: CCDS66 LIMVFEYMKHGDLNKFLRAHG-PDAVLMAEGNP--------PTELTQSQMLHIAQQIAAG 630 640 650 660 670 720 730 740 750 760 770 pF1KB2 MRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWE : :::. .::::::::::::::::. .::.::::::..:. ::::: :...:::::: : CCDS66 MVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 680 690 700 710 720 730 780 790 800 810 820 830 pF1KB2 CILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRP :.. :::: ::::..::.:::.. . ::. ::....::: ::: :.:: CCDS66 SIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNNEVIECI-----TQGR--VLQRP 740 750 760 770 780 790 840 850 860 870 pF1KB2 PACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV .::: .::::: ::.:: ..: .. .: .: CCDS66 RTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 800 810 820 830 >>CCDS58399.1 NTRK3 gene_id:4916|Hs108|chr15 (817 aa) initn: 848 init1: 455 opt: 803 Z-score: 406.2 bits: 86.2 E(32554): 2.6e-16 Smith-Waterman score: 837; 46.2% identity (70.9% similar) in 299 aa overlap (570-868:527-802) 540 550 560 570 580 590 pF1KB2 LQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLV : . .:..:::: ::.: : : CCDS58 MTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAEC------- 500 510 520 530 540 600 610 620 630 640 650 pF1KB2 SLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP . :. : . .::::: :. : : ::.:: .:..... :. .:... ::: . :: CCDS58 ---YNLSPTKDK-MLVAVKALK-DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDP 550 560 570 580 590 600 660 670 680 690 700 710 pF1KB2 LCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRY : :. .::..::::.:: :: . : . :. . :.: .. ..::.:.:::::: : CCDS58 LIMVFEYMKHGDLNKFLRAHGPD--AMILVDGQPRQAKGE-LGLSQMLHIASQIASGMVY 610 620 630 640 650 660 720 730 740 750 760 770 pF1KB2 LATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL ::. .:::::::::::::: :. .::.::::::..:. ::::: :...:::::: : :. CCDS58 LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM 670 680 690 700 710 720 780 790 800 810 820 830 pF1KB2 MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPAC . :::: ::::.::: :::.. . ::. ::.. .::: ::: : :: .: CCDS58 YRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVC 730 740 750 760 770 840 850 860 870 pF1KB2 PQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV :. .:..:: ::.:: .:: .......: CCDS58 PKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 780 790 800 810 >>CCDS10340.1 NTRK3 gene_id:4916|Hs108|chr15 (825 aa) initn: 848 init1: 455 opt: 803 Z-score: 406.1 bits: 86.2 E(32554): 2.7e-16 Smith-Waterman score: 837; 46.2% identity (70.9% similar) in 299 aa overlap (570-868:535-810) 540 550 560 570 580 590 pF1KB2 LQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLV : . .:..:::: ::.: : : CCDS10 MTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAEC------- 510 520 530 540 550 600 610 620 630 640 650 pF1KB2 SLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP . :. : . .::::: :. : : ::.:: .:..... :. .:... ::: . :: CCDS10 ---YNLSPTKDK-MLVAVKALK-DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDP 560 570 580 590 600 610 660 670 680 690 700 710 pF1KB2 LCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRY : :. .::..::::.:: :: . : . :. . :.: .. ..::.:.:::::: : CCDS10 LIMVFEYMKHGDLNKFLRAHGPD--AMILVDGQPRQAKGE-LGLSQMLHIASQIASGMVY 620 630 640 650 660 720 730 740 750 760 770 pF1KB2 LATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL ::. .:::::::::::::: :. .::.::::::..:. ::::: :...:::::: : :. CCDS10 LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM 670 680 690 700 710 720 780 790 800 810 820 830 pF1KB2 MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPAC . :::: ::::.::: :::.. . ::. ::.. .::: ::: : :: .: CCDS10 YRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVC 730 740 750 760 770 780 840 850 860 870 pF1KB2 PQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV :. .:..:: ::.:: .:: .......: CCDS10 PKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 790 800 810 820 876 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:07:11 2016 done: Fri Nov 4 02:07:12 2016 Total Scan time: 5.180 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]