FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB2389, 1058 aa 1>>>pF1KB2389 1058 - 1058 aa - 1058 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4925+/-0.000422; mu= 20.4643+/- 0.026 mean_var=68.9510+/-13.826, 0's: 0 Z-trim(110.7): 17 B-trim: 664 in 1/50 Lambda= 0.154456 statistics sampled from 19076 (19085) to 19076 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.573), E-opt: 0.2 (0.224), width: 16 Scan time: 14.600 The best scores are: opt bits E(85289) NP_056536 (OMIM: 606969) gem-associated protein 4 (1058) 7047 1580.3 0 XP_005256724 (OMIM: 606969) PREDICTED: gem-associa (1062) 7027 1575.8 0 XP_011522212 (OMIM: 606969) PREDICTED: gem-associa (1062) 7027 1575.8 0 XP_016880198 (OMIM: 606969) PREDICTED: gem-associa (1062) 7027 1575.8 0 XP_011522213 (OMIM: 606969) PREDICTED: gem-associa (1062) 7027 1575.8 0 XP_005256727 (OMIM: 606969) PREDICTED: gem-associa (1047) 6967 1562.5 0 XP_011522214 (OMIM: 606969) PREDICTED: gem-associa (1047) 6967 1562.5 0 XP_011522215 (OMIM: 606969) PREDICTED: gem-associa (1047) 6967 1562.5 0 >>NP_056536 (OMIM: 606969) gem-associated protein 4 [Hom (1058 aa) initn: 7047 init1: 7047 opt: 7047 Z-score: 8477.6 bits: 1580.3 E(85289): 0 Smith-Waterman score: 7047; 99.7% identity (99.9% similar) in 1058 aa overlap (1-1058:1-1058) 10 20 30 40 50 60 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB2 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB2 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB2 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB2 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB2 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB2 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB2 VCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQIRQVI :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: NP_056 VCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB2 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB2 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGPNSSA :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_056 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB2 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB2 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB2 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB2 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB2 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB2 NLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_056 NLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB2 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP 970 980 990 1000 1010 1020 1030 1040 1050 pF1KB2 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::: NP_056 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1030 1040 1050 >>XP_005256724 (OMIM: 606969) PREDICTED: gem-associated (1062 aa) initn: 7027 init1: 7027 opt: 7027 Z-score: 8453.5 bits: 1575.8 E(85289): 0 Smith-Waterman score: 7027; 99.7% identity (99.9% similar) in 1055 aa overlap (4-1058:8-1062) 10 20 30 40 50 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFEACSQGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB2 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB2 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB2 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB2 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB2 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB2 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB2 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQI :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_005 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQI 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB2 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB2 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_005 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB2 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB2 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB2 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB2 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB2 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB2 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRA ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_005 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRA 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB2 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 pF1KB2 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::::::: XP_005 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1030 1040 1050 1060 >>XP_011522212 (OMIM: 606969) PREDICTED: gem-associated (1062 aa) initn: 7027 init1: 7027 opt: 7027 Z-score: 8453.5 bits: 1575.8 E(85289): 0 Smith-Waterman score: 7027; 99.7% identity (99.9% similar) in 1055 aa overlap (4-1058:8-1062) 10 20 30 40 50 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFEACSQGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB2 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB2 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB2 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB2 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB2 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB2 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB2 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQI :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQI 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB2 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB2 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_011 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB2 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB2 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB2 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB2 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB2 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB2 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRA ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_011 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRA 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB2 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 pF1KB2 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::::::: XP_011 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1030 1040 1050 1060 >>XP_016880198 (OMIM: 606969) PREDICTED: gem-associated (1062 aa) initn: 7027 init1: 7027 opt: 7027 Z-score: 8453.5 bits: 1575.8 E(85289): 0 Smith-Waterman score: 7027; 99.7% identity (99.9% similar) in 1055 aa overlap (4-1058:8-1062) 10 20 30 40 50 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFEACSQGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB2 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB2 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB2 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB2 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB2 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB2 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB2 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQI :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_016 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQI 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB2 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB2 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_016 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB2 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB2 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB2 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB2 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB2 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB2 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRA ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_016 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRA 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB2 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 pF1KB2 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::::::: XP_016 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1030 1040 1050 1060 >>XP_011522213 (OMIM: 606969) PREDICTED: gem-associated (1062 aa) initn: 7027 init1: 7027 opt: 7027 Z-score: 8453.5 bits: 1575.8 E(85289): 0 Smith-Waterman score: 7027; 99.7% identity (99.9% similar) in 1055 aa overlap (4-1058:8-1062) 10 20 30 40 50 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFEACSQGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB2 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAHSQPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB2 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSLEASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB2 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLSQFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB2 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CCALANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB2 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERDVSLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB2 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNATLYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB2 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQI :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 RHMEVCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQI 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB2 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQVIHLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB2 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_011 ASEQGLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB2 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSSATFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB2 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPFLRLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB2 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRCLSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB2 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFEGHFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB2 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVDVGNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQF 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB2 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRA ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_011 VPLLNLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRA 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB2 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQAAGPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 pF1KB2 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::::::: XP_011 KTNPSVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1030 1040 1050 1060 >>XP_005256727 (OMIM: 606969) PREDICTED: gem-associated (1047 aa) initn: 6967 init1: 6967 opt: 6967 Z-score: 8381.3 bits: 1562.5 E(85289): 0 Smith-Waterman score: 6967; 99.7% identity (99.9% similar) in 1047 aa overlap (12-1058:1-1047) 10 20 30 40 50 60 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS 10 20 30 40 70 80 90 100 110 120 pF1KB2 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB2 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB2 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB2 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB2 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB2 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB2 VCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQIRQVI :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_005 VCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVI 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB2 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB2 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGPNSSA :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_005 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSA 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB2 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB2 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB2 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB2 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB2 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB2 NLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_005 NLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB2 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP 950 960 970 980 990 1000 1030 1040 1050 pF1KB2 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::: XP_005 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1010 1020 1030 1040 >>XP_011522214 (OMIM: 606969) PREDICTED: gem-associated (1047 aa) initn: 6967 init1: 6967 opt: 6967 Z-score: 8381.3 bits: 1562.5 E(85289): 0 Smith-Waterman score: 6967; 99.7% identity (99.9% similar) in 1047 aa overlap (12-1058:1-1047) 10 20 30 40 50 60 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS 10 20 30 40 70 80 90 100 110 120 pF1KB2 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB2 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB2 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB2 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB2 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB2 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB2 VCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQIRQVI :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_011 VCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVI 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB2 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB2 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGPNSSA :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_011 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSA 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB2 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB2 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB2 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB2 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB2 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB2 NLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 NLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB2 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP 950 960 970 980 990 1000 1030 1040 1050 pF1KB2 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::: XP_011 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1010 1020 1030 1040 >>XP_011522215 (OMIM: 606969) PREDICTED: gem-associated (1047 aa) initn: 6967 init1: 6967 opt: 6967 Z-score: 8381.3 bits: 1562.5 E(85289): 0 Smith-Waterman score: 6967; 99.7% identity (99.9% similar) in 1047 aa overlap (12-1058:1-1047) 10 20 30 40 50 60 pF1KB2 MDLGPLNICEEMTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTILHGGFLLAEQLFHPKALAELTKSDWERVGRPIVEALREISSAAAHS 10 20 30 40 70 80 90 100 110 120 pF1KB2 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPFAWKKKALIIIWAKVLQPHPVTPSDTETRWQEDLFFSVGNMIPTINHTILFELLKSLE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB2 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASGLFIQLLMALPTTICHAELERFLEHVTVDTSAEDVAFFLDVWWEVMKHKGHPQDPLLS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB2 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QFSAMAHKYLPALDEFPHPPKRLRSDPDACPTMPLLAMLLRGLTQIQSRILGPGRKCCAL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB2 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANLADMLTVFALTEDDPQEVSATVYLDKLATVISVWNSDTQNPYHQQALAEKVKEAERDV 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB2 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLTSLAKLPSETIFVGCEFLHHLLREWGEELQAVLRSSQGTSYDSYRLCDSLTSFSQNAT 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB2 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYLNRTSLSKEDRQVVSELAECVRDFLRKTSTVLKNRALEDITASIAMAVIQQKMDRHME 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB2 VCYIFASEKKWAFSDEWVACLGSNRALFREPDLVLRLLETVIDVSTADRAIPESQIRQVI :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_011 VCYIFASEKKWAFSDEWVACLGSNRALFRQPDLVLRLLETVIDVSTADRAIPESQIRQVI 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB2 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLILECYADLSLPGKNKVLAGILRSWGRKGLSEKLLAYVEGFQEDLNTTFNQLTQSASEQ 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB2 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEVQGPNSSA :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_011 GLAKAVASVARLVIVHPEVTVKKMCSLAVVNLGTHKFLAQILTAFPALRFVEEQGPNSSA 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB2 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFMVSCLKETVWMKFSTPKEEKQFLELLNCLMSPVKPQGIPVAALLEPDEVLKEFVLPFL 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB2 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLDVEEVDLSLRIFIQTLEANACREEYWLQTCSPFPLLFSLCQLLDRFSKYWQLPKEKRC 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB2 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSLDRKDLAIHILELLCEIVSANAETFSPDVWIKSLSWLHRKLEQLDWTVGLRLKSFFEG 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB2 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFKCEVPATLFEICKLSEDEWTSQAHPGYGAGTGLLAWMECCCVSSGISERMLSLLVVDV 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB2 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNPEEVRLFSKGFLVALVQVMPWCSPQEWQRLHQLTRRLLEKQLLHVPYSLEYIQFVPLL 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB2 NLKPFAQELQLSVLFLRTFQFLCSHSCRNWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 NLKPFAQELQLSVLFLRTFQFLCSHSCRDWLPLEGWNHVVKLLCGSLTRLLDSVRAIQAA 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB2 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPWVQGPEQDLTQEALFVYTQVFCHALHIMAMLHPEVCEPLYVLALETLTCYETLSKTNP 950 960 970 980 990 1000 1030 1040 1050 pF1KB2 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF :::::::::::::::::::::::::::::::::::::: XP_011 SVSSLLQRAHEQRFLKSIAEGIGPEERRQTLLQKMSSF 1010 1020 1030 1040 1058 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:00:59 2016 done: Thu Nov 3 12:01:01 2016 Total Scan time: 14.600 Total Display time: 0.350 Function used was FASTA [36.3.4 Apr, 2011]