FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3013, 456 aa 1>>>pF1KB3013 456 - 456 aa - 456 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3901+/-0.000509; mu= 12.2434+/- 0.031 mean_var=96.6394+/-19.016, 0's: 0 Z-trim(108.4): 72 B-trim: 25 in 1/50 Lambda= 0.130466 statistics sampled from 16403 (16454) to 16403 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.538), E-opt: 0.2 (0.193), width: 16 Scan time: 7.150 The best scores are: opt bits E(85289) NP_002807 (OMIM: 604450) 26S proteasome non-ATPase ( 456) 2902 557.4 2.8e-158 NP_777360 (OMIM: 604450) 26S proteasome non-ATPase ( 436) 2551 491.3 2.1e-138 NP_001303270 (OMIM: 604450) 26S proteasome non-ATP ( 397) 2533 487.9 2e-137 NP_001244935 (OMIM: 616008) COP9 signalosome compl ( 352) 162 41.6 0.004 >>NP_002807 (OMIM: 604450) 26S proteasome non-ATPase reg (456 aa) initn: 2902 init1: 2902 opt: 2902 Z-score: 2962.6 bits: 557.4 E(85289): 2.8e-158 Smith-Waterman score: 2902; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456) 10 20 30 40 50 60 pF1KB3 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 370 380 390 400 410 420 430 440 450 pF1KB3 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ :::::::::::::::::::::::::::::::::::: NP_002 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 430 440 450 >>NP_777360 (OMIM: 604450) 26S proteasome non-ATPase reg (436 aa) initn: 2551 init1: 2551 opt: 2551 Z-score: 2605.8 bits: 491.3 E(85289): 2.1e-138 Smith-Waterman score: 2736; 95.6% identity (95.6% similar) in 456 aa overlap (1-456:1-436) 10 20 30 40 50 60 pF1KB3 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM :::::::::::::::::::::::::::::::::::: :::: NP_777 MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAK--------------------ASDM 10 20 30 40 70 80 90 100 110 120 pF1KB3 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB3 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD 350 360 370 380 390 400 430 440 450 pF1KB3 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ :::::::::::::::::::::::::::::::::::: NP_777 PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 410 420 430 >>NP_001303270 (OMIM: 604450) 26S proteasome non-ATPase (397 aa) initn: 2533 init1: 2533 opt: 2533 Z-score: 2588.1 bits: 487.9 E(85289): 2e-137 Smith-Waterman score: 2533; 100.0% identity (100.0% similar) in 397 aa overlap (60-456:1-397) 30 40 50 60 70 80 pF1KB3 ECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIML :::::::::::::::::::::::::::::: NP_001 MVSTSRILVAVVKMCYEAKEWDLLNENIML 10 20 30 90 100 110 120 130 140 pF1KB3 LSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB3 ATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB3 NTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKS 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB3 VVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELR 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB3 KGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDES 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB3 EAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKE 340 350 360 370 380 390 450 pF1KB3 EMIHNLQ ::::::: NP_001 EMIHNLQ >>NP_001244935 (OMIM: 616008) COP9 signalosome complex s (352 aa) initn: 129 init1: 82 opt: 162 Z-score: 177.1 bits: 41.6 E(85289): 0.004 Smith-Waterman score: 208; 24.4% identity (56.2% similar) in 315 aa overlap (82-390:52-336) 60 70 80 90 100 110 pF1KB3 KQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTY ..:::. :. .: ... . ::. NP_001 LAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISR---------QLLTDFCTH 30 40 50 60 70 120 130 140 150 160 170 pF1KB3 VEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQV . .. : : ::. . : : . : . . ::.: :.. : ..::..: . . NP_001 LPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPL 80 90 100 110 120 130 180 190 200 210 220 pF1KB3 ETYGSMEKKERVEFILEQM----RLCLAVKDYIRTQIISKKINTKFFQEENT-EKLKLKY :: : .:. :.. :: . :: : : .... .. . ..:.:.: :.:...: NP_001 ET-G--QKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRAS--LLQNESTNEQLQIHY 140 150 160 170 180 230 240 250 260 270 280 pF1KB3 YNLMIQLDQHEGSYLSICKHYRAI-YDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSD . .. ... ... ..: . : : : :::. . ::: .. .::: ...: NP_001 KVCYARVLDYRRKFIEAAQRYNELSYKT--IVHESERLE-ALKHALHCTILASAGQQRSR 190 200 210 220 230 240 290 300 310 320 330 340 pF1KB3 LVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTE .. . :.. ... : : :.. ...: . : : .: . . . :: . ::. NP_001 MLATLFKDERCQQLAAYGILEKMYLD-RIIRGNQLQEFAAMLMPH----QKATTADGSSI 250 260 270 280 290 350 360 370 380 390 400 pF1KB3 EGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAK : :.:::. .: :. ::..... ::.. . . : NP_001 --------LDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKHEKPCQRGISRSNHFVS 300 310 320 330 340 350 410 420 430 440 450 pF1KB3 VDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ NP_001 K 456 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:05:05 2016 done: Thu Nov 3 12:05:06 2016 Total Scan time: 7.150 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]