FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3044, 624 aa 1>>>pF1KB3044 624 - 624 aa - 624 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2116+/-0.000424; mu= 15.3330+/- 0.026 mean_var=101.8880+/-20.352, 0's: 0 Z-trim(113.0): 128 B-trim: 704 in 1/53 Lambda= 0.127061 statistics sampled from 22014 (22145) to 22014 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.26), width: 16 Scan time: 10.240 The best scores are: opt bits E(85289) XP_006714576 (OMIM: 604677,616351) PREDICTED: coll ( 624) 4214 783.7 0 NP_005704 (OMIM: 604677,616351) collagen type IV a ( 624) 4214 783.7 0 NP_001123577 (OMIM: 604677,616351) collagen type I ( 752) 4214 783.7 0 XP_011541392 (OMIM: 604677,616351) PREDICTED: coll ( 631) 3938 733.1 7e-211 XP_016864408 (OMIM: 604677,616351) PREDICTED: coll ( 598) 2509 471.1 4.8e-132 NP_112729 (OMIM: 604677,616351) collagen type IV a ( 598) 2509 471.1 4.8e-132 XP_011541393 (OMIM: 604677,616351) PREDICTED: coll ( 605) 2509 471.1 4.8e-132 XP_011538903 (OMIM: 606737) PREDICTED: oxysterol-b ( 736) 288 64.1 2e-09 XP_011538902 (OMIM: 606737) PREDICTED: oxysterol-b ( 749) 288 64.1 2.1e-09 NP_683707 (OMIM: 606737) oxysterol-binding protein ( 746) 286 63.7 2.7e-09 XP_011538901 (OMIM: 606737) PREDICTED: oxysterol-b ( 759) 286 63.7 2.7e-09 XP_016855707 (OMIM: 606737) PREDICTED: oxysterol-b ( 713) 263 59.5 4.8e-08 NP_683706 (OMIM: 606737) oxysterol-binding protein ( 723) 263 59.5 4.8e-08 XP_006710381 (OMIM: 606737) PREDICTED: oxysterol-b ( 726) 263 59.5 4.9e-08 NP_078862 (OMIM: 606737) oxysterol-binding protein ( 736) 263 59.5 4.9e-08 NP_002547 (OMIM: 167040) oxysterol-binding protein ( 807) 261 59.1 6.8e-08 XP_011513897 (OMIM: 608639) PREDICTED: pleckstrin ( 439) 252 57.3 1.3e-07 NP_116028 (OMIM: 608639) pleckstrin homology domai ( 440) 252 57.3 1.3e-07 XP_016868234 (OMIM: 608639) PREDICTED: pleckstrin ( 441) 252 57.3 1.3e-07 XP_011513896 (OMIM: 608639) PREDICTED: pleckstrin ( 455) 252 57.3 1.4e-07 XP_005249954 (OMIM: 608639) PREDICTED: pleckstrin ( 459) 252 57.3 1.4e-07 NP_001183956 (OMIM: 608639) pleckstrin homology do ( 459) 252 57.3 1.4e-07 XP_011513894 (OMIM: 608639) PREDICTED: pleckstrin ( 475) 252 57.3 1.4e-07 XP_016868233 (OMIM: 608639) PREDICTED: pleckstrin ( 491) 252 57.3 1.4e-07 XP_011513893 (OMIM: 608639) PREDICTED: pleckstrin ( 491) 252 57.3 1.4e-07 NP_001183955 (OMIM: 608639) pleckstrin homology do ( 519) 252 57.3 1.5e-07 NP_061964 (OMIM: 607774) pleckstrin homology domai ( 300) 247 56.3 1.8e-07 XP_016884198 (OMIM: 606729) PREDICTED: oxysterol-b ( 818) 245 56.2 5.2e-07 XP_011528361 (OMIM: 606729) PREDICTED: oxysterol-b ( 819) 245 56.2 5.3e-07 XP_006724266 (OMIM: 606729) PREDICTED: oxysterol-b ( 866) 245 56.2 5.5e-07 XP_016884197 (OMIM: 606729) PREDICTED: oxysterol-b ( 867) 245 56.2 5.5e-07 XP_005261522 (OMIM: 606729) PREDICTED: oxysterol-b ( 874) 245 56.2 5.5e-07 XP_011528360 (OMIM: 606729) PREDICTED: oxysterol-b ( 905) 245 56.2 5.7e-07 XP_011528359 (OMIM: 606729) PREDICTED: oxysterol-b ( 906) 245 56.2 5.7e-07 NP_001269668 (OMIM: 606729) oxysterol-binding prot ( 915) 245 56.2 5.7e-07 NP_110385 (OMIM: 606729) oxysterol-binding protein ( 916) 245 56.2 5.7e-07 NP_073613 (OMIM: 606739) oxysterol-binding protein ( 747) 213 50.3 2.8e-05 NP_060254 (OMIM: 606738) oxysterol-binding protein ( 764) 176 43.5 0.0032 XP_005264900 (OMIM: 606738) PREDICTED: oxysterol-b ( 769) 176 43.5 0.0032 NP_001167531 (OMIM: 606738) oxysterol-binding prot ( 700) 170 42.4 0.0064 XP_005264901 (OMIM: 606738) PREDICTED: oxysterol-b ( 705) 170 42.4 0.0064 XP_005252887 (OMIM: 604762) PREDICTED: switch-asso ( 436) 166 41.5 0.0073 NP_001284643 (OMIM: 604762) switch-associated prot ( 527) 166 41.6 0.0085 XP_016858842 (OMIM: 612723) PREDICTED: pleckstrin ( 930) 169 42.3 0.0091 NP_055870 (OMIM: 604762) switch-associated protein ( 585) 166 41.6 0.0092 XP_016858841 (OMIM: 612723) PREDICTED: pleckstrin (1013) 169 42.3 0.0097 >>XP_006714576 (OMIM: 604677,616351) PREDICTED: collagen (624 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 4180.5 bits: 783.7 E(85289): 0 Smith-Waterman score: 4214; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624) 10 20 30 40 50 60 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR 550 560 570 580 590 600 610 620 pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF :::::::::::::::::::::::: XP_006 EYPKFLKRFTSYVQEKTAGKPILF 610 620 >>NP_005704 (OMIM: 604677,616351) collagen type IV alpha (624 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 4180.5 bits: 783.7 E(85289): 0 Smith-Waterman score: 4214; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624) 10 20 30 40 50 60 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR 550 560 570 580 590 600 610 620 pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF :::::::::::::::::::::::: NP_005 EYPKFLKRFTSYVQEKTAGKPILF 610 620 >>NP_001123577 (OMIM: 604677,616351) collagen type IV al (752 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 4179.3 bits: 783.7 E(85289): 0 Smith-Waterman score: 4214; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:129-752) 10 20 30 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVL :::::::::::::::::::::::::::::: NP_001 SPDPSPRGLGASSGAAEGAGAGLLLGCRASMSDNQSWNSSGSEEDPETESGPPVERCGVL 100 110 120 130 140 150 40 50 60 70 80 90 pF1KB3 SKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISV 160 170 180 190 200 210 100 110 120 130 140 150 pF1KB3 NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSS 220 230 240 250 260 270 160 170 180 190 200 210 pF1KB3 FKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTT 280 290 300 310 320 330 220 230 240 250 260 270 pF1KB3 RSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKRE 340 350 360 370 380 390 280 290 300 310 320 330 pF1KB3 DSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAAL 400 410 420 430 440 450 340 350 360 370 380 390 pF1KB3 DRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDV 460 470 480 490 500 510 400 410 420 430 440 450 pF1KB3 HRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAV 520 530 540 550 560 570 460 470 480 490 500 510 pF1KB3 KGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLS 580 590 600 610 620 630 520 530 540 550 560 570 pF1KB3 VIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISR 640 650 660 670 680 690 580 590 600 610 620 pF1KB3 DNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF 700 710 720 730 740 750 >>XP_011541392 (OMIM: 604677,616351) PREDICTED: collagen (631 aa) initn: 3938 init1: 3938 opt: 3938 Z-score: 3907.0 bits: 733.1 E(85289): 7e-211 Smith-Waterman score: 3938; 100.0% identity (100.0% similar) in 583 aa overlap (1-583:1-583) 10 20 30 40 50 60 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR ::::::::::::::::::::::::::::::::::::::::::: XP_011 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVTEARLCDIPCWRKKEKK 550 560 570 580 590 600 610 620 pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF XP_011 KLNALSWNVGSIALSVAQDLGLVYKNDKILQ 610 620 630 >>XP_016864408 (OMIM: 604677,616351) PREDICTED: collagen (598 aa) initn: 2509 init1: 2509 opt: 2509 Z-score: 2491.6 bits: 471.1 E(85289): 4.8e-132 Smith-Waterman score: 3989; 95.8% identity (95.8% similar) in 624 aa overlap (1-624:1-598) 10 20 30 40 50 60 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL :::::::::: :::::::::::::::::::::::: XP_016 SVGTHRFVQK--------------------------VEEMVQNHMTYSLQDVGGDANWQL 370 380 390 430 440 450 460 470 480 pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR 520 530 540 550 560 570 610 620 pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF :::::::::::::::::::::::: XP_016 EYPKFLKRFTSYVQEKTAGKPILF 580 590 >>NP_112729 (OMIM: 604677,616351) collagen type IV alpha (598 aa) initn: 2509 init1: 2509 opt: 2509 Z-score: 2491.6 bits: 471.1 E(85289): 4.8e-132 Smith-Waterman score: 3989; 95.8% identity (95.8% similar) in 624 aa overlap (1-624:1-598) 10 20 30 40 50 60 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL :::::::::: :::::::::::::::::::::::: NP_112 SVGTHRFVQK--------------------------VEEMVQNHMTYSLQDVGGDANWQL 370 380 390 430 440 450 460 470 480 pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR 520 530 540 550 560 570 610 620 pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF :::::::::::::::::::::::: NP_112 EYPKFLKRFTSYVQEKTAGKPILF 580 590 >>XP_011541393 (OMIM: 604677,616351) PREDICTED: collagen (605 aa) initn: 2509 init1: 2509 opt: 2509 Z-score: 2491.6 bits: 471.1 E(85289): 4.8e-132 Smith-Waterman score: 3713; 95.5% identity (95.5% similar) in 583 aa overlap (1-583:1-557) 10 20 30 40 50 60 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL :::::::::: :::::::::::::::::::::::: XP_011 SVGTHRFVQK--------------------------VEEMVQNHMTYSLQDVGGDANWQL 370 380 390 430 440 450 460 470 480 pF1KB3 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB3 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB3 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR ::::::::::::::::::::::::::::::::::::::::::: XP_011 NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVTEARLCDIPCWRKKEKK 520 530 540 550 560 570 610 620 pF1KB3 EYPKFLKRFTSYVQEKTAGKPILF XP_011 KLNALSWNVGSIALSVAQDLGLVYKNDKILQ 580 590 600 >>XP_011538903 (OMIM: 606737) PREDICTED: oxysterol-bindi (736 aa) initn: 232 init1: 130 opt: 288 Z-score: 290.0 bits: 64.1 E(85289): 2e-09 Smith-Waterman score: 288; 35.0% identity (62.2% similar) in 180 aa overlap (28-201:7-181) 10 20 30 40 50 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSE : :::::: ..::: :: :: :: :::: :. XP_011 MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK 10 20 30 60 70 80 90 100 110 pF1KB3 DETEYGCR-GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQ--- :. : : : . : ::: : :. : :.:........:.: :.:..:: :.:. XP_011 DKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETIL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB3 HKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQ ..: . : . ..: .: : : . ... . ... .::.: ... .:: .: XP_011 RHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQ 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB3 VDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPK . : :: . ..:: :: ..:: XP_011 L----KLFDDKLQNCKEDE-QRKSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVIS 160 170 180 190 200 210 >>XP_011538902 (OMIM: 606737) PREDICTED: oxysterol-bindi (749 aa) initn: 232 init1: 130 opt: 288 Z-score: 289.9 bits: 64.1 E(85289): 2.1e-09 Smith-Waterman score: 288; 35.0% identity (62.2% similar) in 180 aa overlap (28-201:7-181) 10 20 30 40 50 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSE : :::::: ..::: :: :: :: :::: :. XP_011 MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK 10 20 30 60 70 80 90 100 110 pF1KB3 DETEYGCR-GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQ--- :. : : : . : ::: : :. : :.:........:.: :.:..:: :.:. XP_011 DKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETIL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB3 HKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQ ..: . : . ..: .: : : . ... . ... .::.: ... .:: .: XP_011 RHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQ 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB3 VDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPK . : :: . ..:: :: ..:: XP_011 L----KLFDDKLQNCKEDE-QRKSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVD 160 170 180 190 200 210 >>NP_683707 (OMIM: 606737) oxysterol-binding protein-rel (746 aa) initn: 266 init1: 130 opt: 286 Z-score: 288.0 bits: 63.7 E(85289): 2.7e-09 Smith-Waterman score: 286; 34.8% identity (61.8% similar) in 178 aa overlap (28-199:7-179) 10 20 30 40 50 pF1KB3 MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSE : :::::: ..::: :: :: :: :::: :. NP_683 MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSK 10 20 30 60 70 80 90 100 110 pF1KB3 DETEYGCR-GSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQ--- :. : : : . : ::: : :. : :.:........:.: :.:..:: :.:. NP_683 DKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETIL 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB3 HKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQ ..: . : . ..: .: : : . ... . ... .::.: ... .:: .: NP_683 RHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQ 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB3 VDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPK . : :: . ..:: :: :. NP_683 L----KLFDDKLQNCKEDE-QRKKIETLKETTNSMVESIKHCIVLLQIAKSTINPVDAIY 160 170 180 190 200 210 624 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:03:05 2016 done: Sat Nov 5 07:03:07 2016 Total Scan time: 10.240 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]