FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3046, 1507 aa 1>>>pF1KB3046 1507 - 1507 aa - 1507 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9642+/-0.000581; mu= 26.1737+/- 0.036 mean_var=76.0530+/-16.120, 0's: 0 Z-trim(106.0): 74 B-trim: 698 in 1/50 Lambda= 0.147067 statistics sampled from 14023 (14097) to 14023 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.491), E-opt: 0.2 (0.165), width: 16 Scan time: 17.000 The best scores are: opt bits E(85289) NP_001116105 (OMIM: 237300,608307,615371) carbamoy (1506) 9830 2096.9 0 XP_011508942 (OMIM: 237300,608307,615371) PREDICTE (1511) 9823 2095.5 0 NP_001866 (OMIM: 237300,608307,615371) carbamoyl-p (1500) 9802 2091.0 0 XP_011508945 (OMIM: 237300,608307,615371) PREDICTE (1500) 9802 2091.0 0 XP_011508943 (OMIM: 237300,608307,615371) PREDICTE (1500) 9802 2091.0 0 XP_011508944 (OMIM: 237300,608307,615371) PREDICTE (1500) 9802 2091.0 0 XP_011508946 (OMIM: 237300,608307,615371) PREDICTE (1500) 9802 2091.0 0 NP_001116106 (OMIM: 237300,608307,615371) carbamoy (1049) 6855 1465.6 0 NP_004332 (OMIM: 114010,616457) CAD protein isofor (2225) 3231 697.0 4.5e-199 XP_005264612 (OMIM: 114010,616457) PREDICTED: CAD (2242) 3231 697.0 4.5e-199 NP_001293008 (OMIM: 114010,616457) CAD protein iso (2162) 2170 471.8 2.5e-131 XP_006712164 (OMIM: 114010,616457) PREDICTED: CAD (2179) 2170 471.8 2.6e-131 XP_005257324 (OMIM: 200350,613933) PREDICTED: acet (2268) 232 60.7 1.6e-07 XP_011523006 (OMIM: 200350,613933) PREDICTED: acet (2268) 232 60.7 1.6e-07 NP_942135 (OMIM: 200350,613933) acetyl-CoA carboxy (2268) 232 60.7 1.6e-07 NP_942134 (OMIM: 200350,613933) acetyl-CoA carboxy (2288) 232 60.7 1.6e-07 NP_942133 (OMIM: 200350,613933) acetyl-CoA carboxy (2346) 232 60.7 1.6e-07 XP_011523005 (OMIM: 200350,613933) PREDICTED: acet (2346) 232 60.7 1.6e-07 XP_016880044 (OMIM: 200350,613933) PREDICTED: acet (2346) 232 60.7 1.6e-07 NP_942136 (OMIM: 200350,613933) acetyl-CoA carboxy (2346) 232 60.7 1.6e-07 XP_011523003 (OMIM: 200350,613933) PREDICTED: acet (2353) 232 60.7 1.6e-07 XP_006721916 (OMIM: 200350,613933) PREDICTED: acet (2375) 232 60.7 1.6e-07 XP_016880043 (OMIM: 200350,613933) PREDICTED: acet (2383) 232 60.7 1.7e-07 NP_942131 (OMIM: 200350,613933) acetyl-CoA carboxy (2383) 232 60.7 1.7e-07 XP_016880042 (OMIM: 200350,613933) PREDICTED: acet (2391) 232 60.7 1.7e-07 XP_016876105 (OMIM: 232000,606054) PREDICTED: prop ( 551) 218 57.1 4.4e-07 XP_016876104 (OMIM: 232000,606054) PREDICTED: prop ( 624) 218 57.2 4.9e-07 XP_005254116 (OMIM: 232000,606054) PREDICTED: prop ( 640) 218 57.2 5e-07 XP_016876103 (OMIM: 232000,606054) PREDICTED: prop ( 655) 218 57.2 5e-07 XP_016876102 (OMIM: 232000,606054) PREDICTED: prop ( 669) 218 57.2 5.1e-07 NP_001171475 (OMIM: 232000,606054) propionyl-CoA c ( 681) 218 57.2 5.2e-07 XP_016876101 (OMIM: 232000,606054) PREDICTED: prop ( 681) 218 57.2 5.2e-07 XP_016876100 (OMIM: 232000,606054) PREDICTED: prop ( 683) 218 57.2 5.2e-07 XP_016876098 (OMIM: 232000,606054) PREDICTED: prop ( 695) 218 57.2 5.3e-07 XP_011519395 (OMIM: 232000,606054) PREDICTED: prop ( 699) 218 57.2 5.3e-07 NP_001121164 (OMIM: 232000,606054) propionyl-CoA c ( 702) 218 57.2 5.3e-07 XP_016876097 (OMIM: 232000,606054) PREDICTED: prop ( 710) 218 57.2 5.3e-07 XP_016876096 (OMIM: 232000,606054) PREDICTED: prop ( 711) 218 57.2 5.4e-07 XP_016876095 (OMIM: 232000,606054) PREDICTED: prop ( 718) 218 57.2 5.4e-07 NP_000273 (OMIM: 232000,606054) propionyl-CoA carb ( 728) 218 57.3 5.4e-07 XP_016876094 (OMIM: 232000,606054) PREDICTED: prop ( 744) 218 57.3 5.5e-07 NP_000911 (OMIM: 266150,608786) pyruvate carboxyla (1178) 214 56.6 1.4e-06 XP_006718641 (OMIM: 266150,608786) PREDICTED: pyru (1178) 214 56.6 1.4e-06 XP_016873357 (OMIM: 266150,608786) PREDICTED: pyru (1178) 214 56.6 1.4e-06 XP_016873361 (OMIM: 266150,608786) PREDICTED: pyru (1178) 214 56.6 1.4e-06 XP_011543388 (OMIM: 266150,608786) PREDICTED: pyru (1178) 214 56.6 1.4e-06 XP_005274089 (OMIM: 266150,608786) PREDICTED: pyru (1178) 214 56.6 1.4e-06 NP_071504 (OMIM: 266150,608786) pyruvate carboxyla (1178) 214 56.6 1.4e-06 NP_001035806 (OMIM: 266150,608786) pyruvate carbox (1178) 214 56.6 1.4e-06 XP_016873358 (OMIM: 266150,608786) PREDICTED: pyru (1178) 214 56.6 1.4e-06 >>NP_001116105 (OMIM: 237300,608307,615371) carbamoyl-ph (1506 aa) initn: 9813 init1: 9813 opt: 9830 Z-score: 11264.2 bits: 2096.9 E(85289): 0 Smith-Waterman score: 9830; 99.9% identity (99.9% similar) in 1507 aa overlap (1-1507:1-1506) 10 20 30 40 50 60 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPQII-KMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAGWKPLF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: NP_001 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB3 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB3 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB3 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB3 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB3 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ 1440 1450 1460 1470 1480 1490 pF1KB3 YSAGKAA ::::::: NP_001 YSAGKAA 1500 >>XP_011508942 (OMIM: 237300,608307,615371) PREDICTED: c (1511 aa) initn: 9813 init1: 9813 opt: 9823 Z-score: 11256.2 bits: 2095.5 E(85289): 0 Smith-Waterman score: 9823; 99.9% identity (99.9% similar) in 1506 aa overlap (2-1507:7-1511) 10 20 30 40 50 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHI :::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKMLEEPQII-KMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHI 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 VLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 TTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 LTKIIRDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTKIIRDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 NNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 PLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_011 PLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAG 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 WKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 VLPKPALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLPKPALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIAS 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 VQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKE 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 YGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRS 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB3 AYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVC 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB3 NMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSM 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB3 EYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDY 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB3 MVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLP 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 MNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNME 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB3 KTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLA 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KB3 AEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGK 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KB3 KTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPL 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB3 YKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLL 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KB3 RPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVI 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KB3 SHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKG 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KB3 NDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAI 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KB3 KAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQ 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KB3 SFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIR 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KB3 DGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSL 1440 1450 1460 1470 1480 1490 1500 pF1KB3 FHYRQYSAGKAA :::::::::::: XP_011 FHYRQYSAGKAA 1500 1510 >>NP_001866 (OMIM: 237300,608307,615371) carbamoyl-phosp (1500 aa) initn: 9802 init1: 9802 opt: 9802 Z-score: 11232.1 bits: 2091.0 E(85289): 0 Smith-Waterman score: 9802; 99.9% identity (100.0% similar) in 1500 aa overlap (8-1507:1-1500) 10 20 30 40 50 60 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAGWKPLF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: NP_001 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB3 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB3 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB3 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB3 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB3 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ 1440 1450 1460 1470 1480 1490 pF1KB3 YSAGKAA ::::::: NP_001 YSAGKAA 1500 >>XP_011508945 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa) initn: 9802 init1: 9802 opt: 9802 Z-score: 11232.1 bits: 2091.0 E(85289): 0 Smith-Waterman score: 9802; 99.9% identity (100.0% similar) in 1500 aa overlap (8-1507:1-1500) 10 20 30 40 50 60 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAGWKPLF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: XP_011 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB3 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB3 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB3 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB3 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB3 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ 1440 1450 1460 1470 1480 1490 pF1KB3 YSAGKAA ::::::: XP_011 YSAGKAA 1500 >>XP_011508943 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa) initn: 9802 init1: 9802 opt: 9802 Z-score: 11232.1 bits: 2091.0 E(85289): 0 Smith-Waterman score: 9802; 99.9% identity (100.0% similar) in 1500 aa overlap (8-1507:1-1500) 10 20 30 40 50 60 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAGWKPLF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: XP_011 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB3 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB3 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB3 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB3 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB3 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ 1440 1450 1460 1470 1480 1490 pF1KB3 YSAGKAA ::::::: XP_011 YSAGKAA 1500 >>XP_011508944 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa) initn: 9802 init1: 9802 opt: 9802 Z-score: 11232.1 bits: 2091.0 E(85289): 0 Smith-Waterman score: 9802; 99.9% identity (100.0% similar) in 1500 aa overlap (8-1507:1-1500) 10 20 30 40 50 60 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAGWKPLF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: XP_011 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB3 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB3 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB3 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB3 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB3 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ 1440 1450 1460 1470 1480 1490 pF1KB3 YSAGKAA ::::::: XP_011 YSAGKAA 1500 >>XP_011508946 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa) initn: 9802 init1: 9802 opt: 9802 Z-score: 11232.1 bits: 2091.0 E(85289): 0 Smith-Waterman score: 9802; 99.9% identity (100.0% similar) in 1500 aa overlap (8-1507:1-1500) 10 20 30 40 50 60 pF1KB3 MPQIIFKMTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDG 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKII 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNALPAGWKPLF ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: XP_011 STGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALG 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCII 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB3 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEW 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB3 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKG 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB3 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB3 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVV 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB3 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB3 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYV 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB3 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAIS 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB3 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLV 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KB3 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMF 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KB3 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KB3 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSID 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KB3 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQ 1440 1450 1460 1470 1480 1490 pF1KB3 YSAGKAA ::::::: XP_011 YSAGKAA 1500 >>NP_001116106 (OMIM: 237300,608307,615371) carbamoyl-ph (1049 aa) initn: 6855 init1: 6855 opt: 6855 Z-score: 7854.9 bits: 1465.6 E(85289): 0 Smith-Waterman score: 6855; 100.0% identity (100.0% similar) in 1049 aa overlap (459-1507:1-1049) 430 440 450 460 470 480 pF1KB3 VSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADT :::::::::::::::::::::::::::::: NP_001 MKEENVKTVLMNPNIASVQTNEVGLKQADT 10 20 30 490 500 510 520 530 540 pF1KB3 VYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESI 40 50 60 70 80 90 550 560 570 580 590 600 pF1KB3 MATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICP 100 110 120 130 140 150 610 620 630 640 650 660 pF1KB3 NRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG 160 170 180 190 200 210 670 680 690 700 710 720 pF1KB3 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSR 220 230 240 250 260 270 730 740 750 760 770 780 pF1KB3 SSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRF 280 290 300 310 320 330 790 800 810 820 830 840 pF1KB3 HGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEWPSNLDLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEWPSNLDLRK 340 350 360 370 380 390 850 860 870 880 890 900 pF1KB3 ELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTE 400 410 420 430 440 450 910 920 930 940 950 960 pF1KB3 ETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVT 460 470 480 490 500 510 970 980 990 1000 1010 1020 pF1KB3 YNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVS 520 530 540 550 560 570 1030 1040 1050 1060 1070 1080 pF1KB3 TDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPL 580 590 600 610 620 630 1090 1100 1110 1120 1130 1140 pF1KB3 QIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNV 640 650 660 670 680 690 1150 1160 1170 1180 1190 1200 pF1KB3 VFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGV 700 710 720 730 740 750 1210 1220 1230 1240 1250 1260 pF1KB3 HSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRAS 760 770 780 790 800 810 1270 1280 1290 1300 1310 1320 pF1KB3 RSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDA 820 830 840 850 860 870 1330 1340 1350 1360 1370 1380 pF1KB3 DPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQL 880 890 900 910 920 930 1390 1400 1410 1420 1430 1440 pF1KB3 HNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNN 940 950 960 970 980 990 1450 1460 1470 1480 1490 1500 pF1KB3 NTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA 1000 1010 1020 1030 1040 >>NP_004332 (OMIM: 114010,616457) CAD protein isoform 1 (2225 aa) initn: 4206 init1: 1545 opt: 3231 Z-score: 3695.1 bits: 697.0 E(85289): 4.5e-199 Smith-Waterman score: 4842; 51.4% identity (77.5% similar) in 1460 aa overlap (53-1484:2-1440) 30 40 50 60 70 80 pF1KB3 TGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNT : .:::::. ..: :: :.::::::.: NP_004 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQT 10 20 30 90 100 110 120 130 140 pF1KB3 GLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALDELGLSKYLESNGIKVSGLLVLD :. :::::.:::.::.:::... :.::: : : .::.:: :..::.::.:..:.: . NP_004 GMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDE-MDEFGLCKWFESSGIHVAALVVGE 40 50 60 70 80 90 150 160 170 180 190 pF1KB3 YSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDF .:: ::..: .:::.. .:.. ::::: ::: .:..:..:::. .: .: . : NP_004 CCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPF 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 VDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFT .::: . :. ::: : .:.. :. ...:.:::.: : :: : .::::: .:::.: . NP_004 LDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALD 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 KMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGISTGNLITGLAAGAKTYKMS ..::.:.....:::.:: ..... ..: .:.::: :. . .:: ::::::: NP_004 SQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB3 MANRGQNQPVLNITNKQAFITAQNHGYALD-NALPAGWKPLFVNVNDQTNEGIMHESKPF ..:::.::: : . . . :.:.::::.:.. ..::: : :::.:.:: .::::.:.: :: NP_004 YGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPF 280 290 300 310 320 330 380 390 400 410 420 pF1KB3 FAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATT---------ITSVLPKPALVASRVEV :.:::::: :: : : ::: :. .:.. : . .: : :.. . . NP_004 FSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB3 S---KVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQA :::::::::::::::::::::::::.::.::::..:.:.:::::.:::.. :: : NP_004 PPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQ-GL--A 400 410 420 430 440 490 500 510 520 530 540 pF1KB3 DTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVE : ::::::::..::.::. :.:::..: .:::::::::::: : ::: .:::.:::: :: NP_004 DKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVE 450 460 470 480 490 500 550 560 570 580 590 600 pF1KB3 SIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGI .: ::::. :. .. ::.:..::: :..:.:.: ::. .::::..:.:.::::::::. NP_004 TIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGF 510 520 530 540 550 560 610 620 630 640 650 660 pF1KB3 CPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVH ::: : : . ::: :.:.::.::. ::::::::::::: ::::::::::.: .:.: NP_004 ASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIH 570 580 590 600 610 620 670 680 690 700 710 720 pF1KB3 TGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARL ::.:.::::.:::.. :.:.::.:.:.:..:::::::::.:.::.: : .: :::::::: NP_004 TGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARL 630 640 650 660 670 680 730 740 750 760 770 780 pF1KB3 SRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLD ::::::::::::::::..:::.::::::::..: :.: :.: ::::.:: :.:::::::. NP_004 SRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLS 690 700 710 720 730 740 790 800 810 820 830 840 pF1KB3 RFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLD .: .:..::: ::::::::.:::.:::.::::::: . :: . :.. : NP_004 KFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVS-------D 750 760 770 780 790 850 860 870 880 890 900 pF1KB3 LRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSES . :: :.. ::...: :. ..:.:.. .:: ::.:::..:. :. . :. .. NP_004 M--ELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQP 800 810 820 830 840 850 910 920 930 940 950 960 pF1KB3 MTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYL . . :..:: .:::::::. . :: .:.:: . .: : ::::::.:::.:. :::: NP_004 LPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYL 860 870 880 890 900 910 970 980 990 1000 1010 1020 pF1KB3 YVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPE :.:: : ::..: ..::: : :.::::::::::::. :. ::..: ::..:: ::: NP_004 YLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPE 920 930 940 950 960 970 1030 1040 1050 1060 1070 1080 pF1KB3 TVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGT :::::.: ::.:::.:.:.: ..:::. : : :.:.:::.:::.:. :... ...:: NP_004 TVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGT 980 990 1000 1010 1020 1030 1090 1100 1110 1120 1130 1140 pF1KB3 SPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSA :: :: ::.: :: .:: . ..: :. .. :. : .: ..: :::..::::::::.: NP_004 SPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAA 1040 1050 1060 1070 1080 1090 1150 1160 1170 1180 1190 1200 pF1KB3 MNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVED :::.... ....:: :. ::.:::::..::.. :.:...:::..:: : . :::::::. NP_004 MNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVEN 1100 1110 1120 1130 1140 1150 1210 1220 1230 1240 1250 1260 pF1KB3 AGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNL ::::::::::. : : :. ..:..: .. ... . ..::::.:...: ... :::::. NP_004 AGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNV 1160 1170 1180 1190 1200 1210 1270 1280 1290 1300 1310 1320 pF1KB3 RASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRL :.::::::::::::::.. .::.:..::.:. : : . :..:.:.::. :: NP_004 RVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMT------GSGVVGVKVPQFSFSRL 1220 1230 1240 1250 1260 1270 1330 1340 1350 1360 1370 1380 pF1KB3 RDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR--FLG :: .: ::.:::::: :::. :.::::::::::::.:.::. : :.. . .: NP_004 AGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG-SYKNKSELLP 1280 1290 1300 1310 1320 1330 1390 1400 1410 1420 1430 1440 pF1KB3 VAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQE---GQNPSLSSIRKLIRDGSID ... :.. :..:.:. .:.:. . ..: .: : : .: :. : :: . . . ... NP_004 TVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFE 1340 1350 1360 1370 1380 1390 1450 1460 1470 1480 1490 pF1KB3 LVINLPNNN------TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKS ::::: . ..:: .: :: :.: ..::. ... ::::.::. NP_004 LVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLK 1400 1410 1420 1430 1440 1450 1500 pF1KB3 LFHYRQYSAGKAA NP_004 VHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPI 1460 1470 1480 1490 1500 1510 >>XP_005264612 (OMIM: 114010,616457) PREDICTED: CAD prot (2242 aa) initn: 4206 init1: 1545 opt: 3231 Z-score: 3695.0 bits: 697.0 E(85289): 4.5e-199 Smith-Waterman score: 4842; 51.4% identity (77.5% similar) in 1460 aa overlap (53-1484:2-1440) 30 40 50 60 70 80 pF1KB3 TGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNT : .:::::. ..: :: :.::::::.: XP_005 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQT 10 20 30 90 100 110 120 130 140 pF1KB3 GLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALDELGLSKYLESNGIKVSGLLVLD :. :::::.:::.::.:::... :.::: : : .::.:: :..::.::.:..:.: . XP_005 GMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDE-MDEFGLCKWFESSGIHVAALVVGE 40 50 60 70 80 90 150 160 170 180 190 pF1KB3 YSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDF .:: ::..: .:::.. .:.. ::::: ::: .:..:..:::. .: .: . : XP_005 CCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPF 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 VDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFT .::: . :. ::: : .:.. :. ...:.:::.: : :: : .::::: .:::.: . XP_005 LDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALD 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 KMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGISTGNLITGLAAGAKTYKMS ..::.:.....:::.:: ..... ..: .:.::: :. . .:: ::::::: XP_005 SQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB3 MANRGQNQPVLNITNKQAFITAQNHGYALD-NALPAGWKPLFVNVNDQTNEGIMHESKPF ..:::.::: : . . . :.:.::::.:.. ..::: : :::.:.:: .::::.:.: :: XP_005 YGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPF 280 290 300 310 320 330 380 390 400 410 420 pF1KB3 FAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATT---------ITSVLPKPALVASRVEV :.:::::: :: : : ::: :. .:.. : . .: : :.. . . XP_005 FSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB3 S---KVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQA :::::::::::::::::::::::::.::.::::..:.:.:::::.:::.. :: : XP_005 PPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQ-GL--A 400 410 420 430 440 490 500 510 520 530 540 pF1KB3 DTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVE : ::::::::..::.::. :.:::..: .:::::::::::: : ::: .:::.:::: :: XP_005 DKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVE 450 460 470 480 490 500 550 560 570 580 590 600 pF1KB3 SIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGI .: ::::. :. .. ::.:..::: :..:.:.: ::. .::::..:.:.::::::::. XP_005 TIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGF 510 520 530 540 550 560 610 620 630 640 650 660 pF1KB3 CPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVH ::: : : . ::: :.:.::.::. ::::::::::::: ::::::::::.: .:.: XP_005 ASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIH 570 580 590 600 610 620 670 680 690 700 710 720 pF1KB3 TGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARL ::.:.::::.:::.. :.:.::.:.:.:..:::::::::.:.::.: : .: :::::::: XP_005 TGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARL 630 640 650 660 670 680 730 740 750 760 770 780 pF1KB3 SRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLD ::::::::::::::::..:::.::::::::..: :.: :.: ::::.:: :.:::::::. XP_005 SRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLS 690 700 710 720 730 740 790 800 810 820 830 840 pF1KB3 RFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLD .: .:..::: ::::::::.:::.:::.::::::: . :: . :.. : XP_005 KFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVS-------D 750 760 770 780 790 850 860 870 880 890 900 pF1KB3 LRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSES . :: :.. ::...: :. ..:.:.. .:: ::.:::..:. :. . :. .. XP_005 M--ELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQP 800 810 820 830 840 850 910 920 930 940 950 960 pF1KB3 MTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYL . . :..:: .:::::::. . :: .:.:: . .: : ::::::.:::.:. :::: XP_005 LPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYL 860 870 880 890 900 910 970 980 990 1000 1010 1020 pF1KB3 YVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPE :.:: : ::..: ..::: : :.::::::::::::. :. ::..: ::..:: ::: XP_005 YLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPE 920 930 940 950 960 970 1030 1040 1050 1060 1070 1080 pF1KB3 TVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGT :::::.: ::.:::.:.:.: ..:::. : : :.:.:::.:::.:. :... ...:: XP_005 TVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGT 980 990 1000 1010 1020 1030 1090 1100 1110 1120 1130 1140 pF1KB3 SPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSA :: :: ::.: :: .:: . ..: :. .. :. : .: ..: :::..::::::::.: XP_005 SPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAA 1040 1050 1060 1070 1080 1090 1150 1160 1170 1180 1190 1200 pF1KB3 MNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVED :::.... ....:: :. ::.:::::..::.. :.:...:::..:: : . :::::::. XP_005 MNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVEN 1100 1110 1120 1130 1140 1150 1210 1220 1230 1240 1250 1260 pF1KB3 AGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNL ::::::::::. : : :. ..:..: .. ... . ..::::.:...: ... :::::. XP_005 AGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNV 1160 1170 1180 1190 1200 1210 1270 1280 1290 1300 1310 1320 pF1KB3 RASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRL :.::::::::::::::.. .::.:..::.:. : : . :..:.:.::. :: XP_005 RVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMT------GSGVVGVKVPQFSFSRL 1220 1230 1240 1250 1260 1270 1330 1340 1350 1360 1370 1380 pF1KB3 RDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR--FLG :: .: ::.:::::: :::. :.::::::::::::.:.::. : :.. . .: XP_005 AGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG-SYKNKSELLP 1280 1290 1300 1310 1320 1330 1390 1400 1410 1420 1430 1440 pF1KB3 VAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQE---GQNPSLSSIRKLIRDGSID ... :.. :..:.:. .:.:. . ..: .: : : .: :. : :: . . . ... XP_005 TVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFE 1340 1350 1360 1370 1380 1390 1450 1460 1470 1480 1490 pF1KB3 LVINLPNNN------TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKS ::::: . ..:: .: :: :.: ..::. ... ::::.::. XP_005 LVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLK 1400 1410 1420 1430 1440 1450 1500 pF1KB3 LFHYRQYSAGKAA XP_005 VHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPI 1460 1470 1480 1490 1500 1510 1507 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:35:12 2016 done: Thu Nov 3 20:35:15 2016 Total Scan time: 17.000 Total Display time: 0.820 Function used was FASTA [36.3.4 Apr, 2011]