FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3088, 418 aa 1>>>pF1KB3088 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1164+/-0.000385; mu= 13.2774+/- 0.024 mean_var=88.4586+/-17.641, 0's: 0 Z-trim(113.9): 56 B-trim: 0 in 0/52 Lambda= 0.136365 statistics sampled from 23394 (23451) to 23394 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.275), width: 16 Scan time: 8.640 The best scores are: opt bits E(85289) NP_002727 (OMIM: 176912) cAMP-dependent protein ki ( 418) 2758 552.8 5.7e-157 XP_011514700 (OMIM: 176912) PREDICTED: cAMP-depend ( 390) 1684 341.5 2.2e-93 XP_011532244 (OMIM: 176910) PREDICTED: cAMP-depend ( 404) 1601 325.2 1.8e-88 XP_016862304 (OMIM: 176910) PREDICTED: cAMP-depend ( 404) 1601 325.2 1.8e-88 NP_004148 (OMIM: 176910) cAMP-dependent protein ki ( 404) 1601 325.2 1.8e-88 NP_001308911 (OMIM: 176910) cAMP-dependent protein ( 404) 1601 325.2 1.8e-88 NP_001308918 (OMIM: 176910) cAMP-dependent protein ( 376) 1300 266.0 1.2e-70 XP_005265372 (OMIM: 176910) PREDICTED: cAMP-depend ( 330) 1186 243.5 5.9e-64 XP_016862305 (OMIM: 176910) PREDICTED: cAMP-depend ( 330) 1186 243.5 5.9e-64 XP_011532245 (OMIM: 176910) PREDICTED: cAMP-depend ( 349) 1186 243.5 6.1e-64 NP_001308912 (OMIM: 176910) cAMP-dependent protein ( 382) 1100 226.6 8.2e-59 XP_011513748 (OMIM: 176911) PREDICTED: cAMP-depend ( 326) 788 165.2 2.2e-40 NP_002726 (OMIM: 176911) cAMP-dependent protein ki ( 381) 788 165.2 2.5e-40 NP_001158232 (OMIM: 176911) cAMP-dependent protein ( 381) 788 165.2 2.5e-40 NP_001158231 (OMIM: 176911) cAMP-dependent protein ( 381) 788 165.2 2.5e-40 NP_001158230 (OMIM: 176911) cAMP-dependent protein ( 381) 788 165.2 2.5e-40 NP_001158233 (OMIM: 176911) cAMP-dependent protein ( 381) 788 165.2 2.5e-40 NP_001158234 (OMIM: 176911) cAMP-dependent protein ( 381) 788 165.2 2.5e-40 XP_011523285 (OMIM: 101800,160980,188550,188830,25 ( 381) 775 162.7 1.4e-39 XP_011523286 (OMIM: 101800,160980,188550,188830,25 ( 381) 775 162.7 1.4e-39 NP_997636 (OMIM: 101800,160980,188550,188830,25596 ( 381) 775 162.7 1.4e-39 NP_997637 (OMIM: 101800,160980,188550,188830,25596 ( 381) 775 162.7 1.4e-39 NP_002725 (OMIM: 101800,160980,188550,188830,25596 ( 381) 775 162.7 1.4e-39 NP_001265362 (OMIM: 101800,160980,188550,188830,25 ( 381) 775 162.7 1.4e-39 NP_001263218 (OMIM: 101800,160980,188550,188830,25 ( 381) 775 162.7 1.4e-39 XP_011523287 (OMIM: 101800,160980,188550,188830,25 ( 381) 775 162.7 1.4e-39 XP_016867923 (OMIM: 176911) PREDICTED: cAMP-depend ( 229) 684 144.7 2.3e-34 NP_001263219 (OMIM: 101800,160980,188550,188830,25 ( 337) 598 127.8 4e-29 XP_016867922 (OMIM: 176911) PREDICTED: cAMP-depend ( 251) 573 122.8 9.4e-28 XP_016863907 (OMIM: 601591) PREDICTED: cGMP-depend ( 462) 459 100.6 8.8e-21 NP_001269414 (OMIM: 601591) cGMP-dependent protein ( 733) 459 100.7 1.3e-20 XP_016863906 (OMIM: 601591) PREDICTED: cGMP-depend ( 745) 459 100.7 1.3e-20 XP_005263183 (OMIM: 601591) PREDICTED: cGMP-depend ( 762) 459 100.7 1.3e-20 NP_006250 (OMIM: 601591) cGMP-dependent protein ki ( 762) 459 100.7 1.3e-20 XP_016863904 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 459 100.7 1.4e-20 XP_016863905 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 459 100.7 1.4e-20 XP_016863902 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 459 100.7 1.4e-20 XP_016863903 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 459 100.7 1.4e-20 XP_011538254 (OMIM: 176894,615436) PREDICTED: cGMP ( 406) 443 97.4 7e-20 NP_006249 (OMIM: 176894,615436) cGMP-dependent pro ( 686) 443 97.5 1.1e-19 NP_001091982 (OMIM: 176894,615436) cGMP-dependent ( 671) 426 94.2 1.1e-18 XP_016871901 (OMIM: 176894,615436) PREDICTED: cGMP ( 591) 410 91.0 8.6e-18 XP_016871902 (OMIM: 176894,615436) PREDICTED: cGMP ( 585) 408 90.6 1.1e-17 XP_006717167 (OMIM: 612122) PREDICTED: patatin-lik (1309) 171 44.2 0.0024 XP_016870198 (OMIM: 612122) PREDICTED: patatin-lik (1309) 171 44.2 0.0024 NP_689499 (OMIM: 612122) patatin-like phospholipas (1317) 171 44.2 0.0024 >>NP_002727 (OMIM: 176912) cAMP-dependent protein kinase (418 aa) initn: 2758 init1: 2758 opt: 2758 Z-score: 2939.1 bits: 552.8 E(85289): 5.7e-157 Smith-Waterman score: 2758; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 370 380 390 400 410 >>XP_011514700 (OMIM: 176912) PREDICTED: cAMP-dependent (390 aa) initn: 2550 init1: 1684 opt: 1684 Z-score: 1797.6 bits: 341.5 E(85289): 2.2e-93 Smith-Waterman score: 2498; 93.3% identity (93.3% similar) in 418 aa overlap (1-418:1-390) 10 20 30 40 50 60 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH :::::::::::: :::::::::::::::::::: XP_011 NPDEEEDDAESR----------------------------EQMSQVLDAMFEKLVKDGEH 130 140 150 190 200 210 220 230 240 pF1KB3 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB3 PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB3 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP 280 290 300 310 320 330 370 380 390 400 410 pF1KB3 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 340 350 360 370 380 390 >>XP_011532244 (OMIM: 176910) PREDICTED: cAMP-dependent (404 aa) initn: 1767 init1: 1187 opt: 1601 Z-score: 1709.2 bits: 325.2 E(85289): 1.8e-88 Smith-Waterman score: 1759; 66.7% identity (84.0% similar) in 412 aa overlap (3-413:4-399) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . XP_011 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. XP_011 SLGHPP----PEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : XP_011 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: XP_011 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: XP_011 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEE-NGAVEIARCSRGQYFGELALVTN ::.::.::..::::.:.:::::.: .. . ::. . : :::::: .:::::::::::: XP_011 GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB3 KPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::.:.: ::::.::::::::::::::.::::::. :::::: .::...:. XP_011 KPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 350 360 370 380 390 400 >>XP_016862304 (OMIM: 176910) PREDICTED: cAMP-dependent (404 aa) initn: 1767 init1: 1187 opt: 1601 Z-score: 1709.2 bits: 325.2 E(85289): 1.8e-88 Smith-Waterman score: 1759; 66.7% identity (84.0% similar) in 412 aa overlap (3-413:4-399) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . XP_016 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. XP_016 SLGHPP----PEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : XP_016 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: XP_016 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: XP_016 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEE-NGAVEIARCSRGQYFGELALVTN ::.::.::..::::.:.:::::.: .. . ::. . : :::::: .:::::::::::: XP_016 GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB3 KPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::.:.: ::::.::::::::::::::.::::::. :::::: .::...:. XP_016 KPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 350 360 370 380 390 400 >>NP_004148 (OMIM: 176910) cAMP-dependent protein kinase (404 aa) initn: 1767 init1: 1187 opt: 1601 Z-score: 1709.2 bits: 325.2 E(85289): 1.8e-88 Smith-Waterman score: 1759; 66.7% identity (84.0% similar) in 412 aa overlap (3-413:4-399) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . NP_004 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. NP_004 SLGHPP----PEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : NP_004 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: NP_004 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: NP_004 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEE-NGAVEIARCSRGQYFGELALVTN ::.::.::..::::.:.:::::.: .. . ::. . : :::::: .:::::::::::: NP_004 GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB3 KPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::.:.: ::::.::::::::::::::.::::::. :::::: .::...:. NP_004 KPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 350 360 370 380 390 400 >>NP_001308911 (OMIM: 176910) cAMP-dependent protein kin (404 aa) initn: 1767 init1: 1187 opt: 1601 Z-score: 1709.2 bits: 325.2 E(85289): 1.8e-88 Smith-Waterman score: 1759; 66.7% identity (84.0% similar) in 412 aa overlap (3-413:4-399) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . NP_001 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. NP_001 SLGHPP----PEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : NP_001 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: NP_001 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: NP_001 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEE-NGAVEIARCSRGQYFGELALVTN ::.::.::..::::.:.:::::.: .. . ::. . : :::::: .:::::::::::: NP_001 GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB3 KPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::.:.: ::::.::::::::::::::.::::::. :::::: .::...:. NP_001 KPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 350 360 370 380 390 400 >>NP_001308918 (OMIM: 176910) cAMP-dependent protein kin (376 aa) initn: 1586 init1: 874 opt: 1300 Z-score: 1389.6 bits: 266.0 E(85289): 1.2e-70 Smith-Waterman score: 1526; 60.9% identity (77.7% similar) in 412 aa overlap (3-413:4-371) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . NP_001 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. NP_001 SLGHPP----PEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. : ::.:::::::::..:: : NP_001 YNPDEEEEDTDPR----------------------------EQLSQVLDAMFERIVKADE 110 120 130 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: NP_001 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: NP_001 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEE-NGAVEIARCSRGQYFGELALVTN ::.::.::..::::.:.:::::.: .. . ::. . : :::::: .:::::::::::: NP_001 GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTN 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB3 KPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA :::::::.:.: ::::.::::::::::::::.::::::. :::::: .::...:. NP_001 KPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ 320 330 340 350 360 370 >>XP_005265372 (OMIM: 176910) PREDICTED: cAMP-dependent (330 aa) initn: 1477 init1: 1177 opt: 1186 Z-score: 1269.2 bits: 243.5 E(85289): 5.9e-64 Smith-Waterman score: 1344; 65.0% identity (82.8% similar) in 326 aa overlap (3-328:4-313) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . XP_005 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. XP_005 SLGHP----PPEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : XP_005 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: XP_005 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: XP_005 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNK ::.::.::..::::.:.:::::.: .. . XP_005 GERIITQGEKADSFYIIESGEVSILIRSRLWMYKHSRGFWGPAWTS 290 300 310 320 330 >>XP_016862305 (OMIM: 176910) PREDICTED: cAMP-dependent (330 aa) initn: 1477 init1: 1177 opt: 1186 Z-score: 1269.2 bits: 243.5 E(85289): 5.9e-64 Smith-Waterman score: 1344; 65.0% identity (82.8% similar) in 326 aa overlap (3-328:4-313) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . XP_016 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. XP_016 SLGHP----PPEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : XP_016 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: XP_016 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: XP_016 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNK ::.::.::..::::.:.:::::.: .. . XP_016 GERIITQGEKADSFYIIESGEVSILIRSRLWMYKHSRGFWGPAWTS 290 300 310 320 330 >>XP_011532245 (OMIM: 176910) PREDICTED: cAMP-dependent (349 aa) initn: 1477 init1: 1177 opt: 1186 Z-score: 1268.9 bits: 243.5 E(85289): 6.1e-64 Smith-Waterman score: 1344; 65.0% identity (82.8% similar) in 326 aa overlap (3-328:4-313) 10 20 30 40 50 pF1KB3 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWG :.:: ::::::::.::::::.:: ::.:::...::::. : .. : . XP_011 MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLR---EARAPASVLPAATPRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEA .:: : : . . . ..:::. :.:. ...:: .::.::.:::::. XP_011 SLGHP----PPEPGPDRVADA-KGDSESEEDED--------LEVPVPSRFNRRVSVCAET 60 70 80 90 100 120 130 140 150 160 170 pF1KB3 YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGE :::::::.:.. :.::::::.:: :::::::::::::::: ::.:::::::::..:: : XP_011 YNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB3 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT :::::::::::::::.:::.:: : :. : ::.::::::::::::::::::::::.:: XP_011 HVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVAT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYND : :.:::::::::::::::::::::::.::::::.:.::::: :::.:.::::: :.:.: XP_011 SEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB3 GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNK ::.::.::..::::.:.:::::.: .. . XP_011 GERIITQGEKADSFYIIESGEVSILIRSRQALTYSAIFYCCLGLGSLCDQPEMDEWMLSA 290 300 310 320 330 340 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:19:13 2016 done: Thu Nov 3 12:19:15 2016 Total Scan time: 8.640 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]