FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3110, 297 aa 1>>>pF1KB3110 297 - 297 aa - 297 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2726+/-0.00031; mu= 16.4277+/- 0.019 mean_var=78.2624+/-15.623, 0's: 0 Z-trim(117.1): 47 B-trim: 0 in 0/54 Lambda= 0.144977 statistics sampled from 28836 (28883) to 28836 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.339), width: 16 Scan time: 7.880 The best scores are: opt bits E(85289) NP_001013454 (OMIM: 602496) 3-mercaptopyruvate sul ( 297) 2072 442.5 4.7e-124 XP_005261667 (OMIM: 602496) PREDICTED: 3-mercaptop ( 297) 2072 442.5 4.7e-124 NP_001123989 (OMIM: 602496) 3-mercaptopyruvate sul ( 297) 2072 442.5 4.7e-124 NP_066949 (OMIM: 602496) 3-mercaptopyruvate sulfur ( 317) 2072 442.5 5e-124 XP_011528498 (OMIM: 602496) PREDICTED: 3-mercaptop ( 294) 1384 298.6 9.8e-81 XP_011528497 (OMIM: 602496) PREDICTED: 3-mercaptop ( 237) 1378 297.3 2e-80 NP_001257412 (OMIM: 180370) thiosulfate sulfurtran ( 297) 1278 276.4 4.7e-74 NP_003303 (OMIM: 180370) thiosulfate sulfurtransfe ( 297) 1278 276.4 4.7e-74 >>NP_001013454 (OMIM: 602496) 3-mercaptopyruvate sulfurt (297 aa) initn: 2072 init1: 2072 opt: 2072 Z-score: 2348.1 bits: 442.5 E(85289): 4.7e-124 Smith-Waterman score: 2072; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH 250 260 270 280 290 >>XP_005261667 (OMIM: 602496) PREDICTED: 3-mercaptopyruv (297 aa) initn: 2072 init1: 2072 opt: 2072 Z-score: 2348.1 bits: 442.5 E(85289): 4.7e-124 Smith-Waterman score: 2072; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH 250 260 270 280 290 >>NP_001123989 (OMIM: 602496) 3-mercaptopyruvate sulfurt (297 aa) initn: 2072 init1: 2072 opt: 2072 Z-score: 2348.1 bits: 442.5 E(85289): 4.7e-124 Smith-Waterman score: 2072; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH 250 260 270 280 290 >>NP_066949 (OMIM: 602496) 3-mercaptopyruvate sulfurtran (317 aa) initn: 2072 init1: 2072 opt: 2072 Z-score: 2347.7 bits: 442.5 E(85289): 5e-124 Smith-Waterman score: 2072; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:21-317) 10 20 30 40 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPK :::::::::::::::::::::::::::::::::::::::: NP_066 MAEPGSRESETRARSPSVAAMASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 LGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 LGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 DASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 DASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB3 AFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 AFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQE 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB3 GLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 GLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWY 250 260 270 280 290 300 290 pF1KB3 MRARPEDVISEGRGKTH ::::::::::::::::: NP_066 MRARPEDVISEGRGKTH 310 >>XP_011528498 (OMIM: 602496) PREDICTED: 3-mercaptopyruv (294 aa) initn: 1384 init1: 1384 opt: 1384 Z-score: 1570.4 bits: 298.6 E(85289): 9.8e-81 Smith-Waterman score: 1384; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL ::::::::::::::::::: XP_011 VDSRATGRFRGTEPEPRDGNAGEGGRRSSGARPLRPEQCPGLDLSFIFLIYLAFISFPFF 190 200 210 220 230 240 >>XP_011528497 (OMIM: 602496) PREDICTED: 3-mercaptopyruv (237 aa) initn: 1376 init1: 1376 opt: 1378 Z-score: 1564.9 bits: 297.3 E(85289): 2e-80 Smith-Waterman score: 1378; 98.5% identity (99.5% similar) in 202 aa overlap (1-201:21-222) 10 20 30 40 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPK :::::::::::::::::::::::::::::::::::::::: XP_011 MAEPGSRESETRARSPSVAAMASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 LGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 DASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDP 130 140 150 160 170 180 170 180 190 200 210 pF1KB3 AFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRD-GIEPGHIPGTVNIPFTDFLSQ :::::::::::::::::::::::::::::::::::::: :.. XP_011 AFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRDAGVQWRNLGSPQPPPPGFK 190 200 210 220 230 220 230 240 250 260 270 pF1KB3 EGLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEW >>NP_001257412 (OMIM: 180370) thiosulfate sulfurtransfer (297 aa) initn: 1180 init1: 691 opt: 1278 Z-score: 1450.6 bits: 276.4 E(85289): 4.7e-74 Smith-Waterman score: 1278; 59.5% identity (83.1% similar) in 296 aa overlap (1-295:1-295) 10 20 30 40 50 60 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF :. : :::::..:.::..:. . : :..:::::: : :.::.:. :::.:::.:: NP_001 MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGT-REARKEYLERHVPGASFF 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF ::..: : .:::. :::. ::::.::::.. ::::.::. : . :::::::::.: NP_001 DIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV ::..::.:.::.:.::... :..: :.: :: :.: :: ...::::.. :::::.:::. NP_001 GHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQL 120 130 140 150 160 170 190 200 210 220 230 pF1KB3 VDSRATGRFRGTEPEPRD-GIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVD ::::. ::: :::::: :.. ::: :.::.:: :::...:.::.:::.: ::: :::: NP_001 VDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 LSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH ::.::.::: .:::::::::.::::::::: .::::: ::. :: ::. .:.:... NP_001 LSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA 240 250 260 270 280 290 >>NP_003303 (OMIM: 180370) thiosulfate sulfurtransferase (297 aa) initn: 1180 init1: 691 opt: 1278 Z-score: 1450.6 bits: 276.4 E(85289): 4.7e-74 Smith-Waterman score: 1278; 59.5% identity (83.1% similar) in 296 aa overlap (1-295:1-295) 10 20 30 40 50 60 pF1KB3 MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF :. : :::::..:.::..:. . : :..:::::: : :.::.:. :::.:::.:: NP_003 MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGT-REARKEYLERHVPGASFF 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF ::..: : .:::. :::. ::::.::::.. ::::.::. : . :::::::::.: NP_003 DIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV ::..::.:.::.:.::... :..: :.: :: :.: :: ...::::.. :::::.:::. NP_003 GHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQL 120 130 140 150 160 170 190 200 210 220 230 pF1KB3 VDSRATGRFRGTEPEPRD-GIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVD ::::. ::: :::::: :.. ::: :.::.:: :::...:.::.:::.: ::: :::: NP_003 VDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 LSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH ::.::.::: .:::::::::.::::::::: .::::: ::. :: ::. .:.:... NP_003 LSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA 240 250 260 270 280 290 297 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:10:21 2016 done: Fri Nov 4 02:10:22 2016 Total Scan time: 7.880 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]