FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3113, 323 aa 1>>>pF1KB3113 323 - 323 aa - 323 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6021+/-0.00048; mu= 8.7667+/- 0.029 mean_var=162.6033+/-35.378, 0's: 0 Z-trim(114.0): 415 B-trim: 892 in 1/49 Lambda= 0.100580 statistics sampled from 22948 (23545) to 22948 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.276), width: 16 Scan time: 6.260 The best scores are: opt bits E(85289) NP_000279 (OMIM: 215100,266500,601757,614879) pero ( 323) 2274 342.5 6.9e-94 XP_005267076 (OMIM: 215100,266500,601757,614879) P ( 285) 1970 298.4 1.2e-80 XP_016866423 (OMIM: 215100,266500,601757,614879) P ( 199) 1239 192.1 8.1e-49 XP_006715565 (OMIM: 215100,266500,601757,614879) P ( 225) 794 127.6 2.4e-29 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 312 58.0 4.5e-08 XP_011519465 (OMIM: 604447) PREDICTED: guanine nuc ( 301) 298 55.8 1.4e-07 XP_011519464 (OMIM: 604447) PREDICTED: guanine nuc ( 353) 298 55.8 1.5e-07 NP_006569 (OMIM: 604447) guanine nucleotide-bindin ( 353) 298 55.8 1.5e-07 NP_057278 (OMIM: 604447) guanine nucleotide-bindin ( 395) 298 55.9 1.6e-07 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 293 55.0 2.1e-07 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 293 55.0 2.1e-07 NP_113673 (OMIM: 610597) glutamate-rich WD repeat- ( 446) 295 55.5 2.4e-07 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 293 55.3 3.2e-07 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 293 55.3 3.2e-07 XP_016863186 (OMIM: 609005) PREDICTED: WD repeat-c ( 982) 296 56.0 3.6e-07 XP_005262782 (OMIM: 609005) PREDICTED: WD repeat-c (1216) 296 56.1 4.2e-07 NP_851782 (OMIM: 609005) WD repeat-containing prot (1283) 296 56.2 4.4e-07 XP_011529884 (OMIM: 609005) PREDICTED: WD repeat-c (1290) 296 56.2 4.4e-07 XP_016863178 (OMIM: 609005) PREDICTED: WD repeat-c (1307) 296 56.2 4.4e-07 XP_016863179 (OMIM: 609005) PREDICTED: WD repeat-c (1307) 296 56.2 4.4e-07 XP_016863177 (OMIM: 609005) PREDICTED: WD repeat-c (1314) 296 56.2 4.4e-07 XP_016863175 (OMIM: 609005) PREDICTED: WD repeat-c (1314) 296 56.2 4.4e-07 XP_016863176 (OMIM: 609005) PREDICTED: WD repeat-c (1314) 296 56.2 4.4e-07 NP_733828 (OMIM: 609005) WD repeat-containing prot (1322) 296 56.2 4.4e-07 XP_016877356 (OMIM: 604447) PREDICTED: guanine nuc ( 212) 281 53.1 6e-07 XP_011531867 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 279 52.9 8e-07 XP_011531865 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 279 52.9 8e-07 XP_011531866 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 279 52.9 8e-07 XP_011510137 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 280 53.2 8.7e-07 XP_016860389 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 280 53.2 8.7e-07 XP_016860390 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 280 53.2 8.7e-07 XP_016860391 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 280 53.2 8.7e-07 XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 ( 300) 279 53.0 9.2e-07 XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 ( 326) 279 53.0 9.7e-07 XP_016860387 (OMIM: 612173) PREDICTED: sperm-assoc ( 390) 280 53.3 9.9e-07 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 279 53.1 1e-06 XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 ( 374) 279 53.1 1.1e-06 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 279 53.1 1.1e-06 XP_016860385 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 280 53.4 1.2e-06 XP_016860386 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 280 53.4 1.2e-06 XP_011510125 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 280 53.4 1.2e-06 XP_011510124 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 280 53.4 1.2e-06 XP_011510123 (OMIM: 612173) PREDICTED: sperm-assoc ( 537) 280 53.4 1.2e-06 XP_011510121 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 280 53.5 1.3e-06 XP_011510116 (OMIM: 612173) PREDICTED: sperm-assoc ( 600) 280 53.5 1.3e-06 NP_078808 (OMIM: 612173) sperm-associated antigen ( 631) 280 53.5 1.4e-06 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 279 53.4 1.5e-06 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 279 53.4 1.5e-06 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 279 53.4 1.5e-06 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 279 53.4 1.5e-06 >>NP_000279 (OMIM: 215100,266500,601757,614879) peroxiso (323 aa) initn: 2274 init1: 2274 opt: 2274 Z-score: 1806.6 bits: 342.5 E(85289): 6.9e-94 Smith-Waterman score: 2274; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KB3 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT 250 260 270 280 290 300 310 320 pF1KB3 QVADCSWDETIKIYDPACLTIPA ::::::::::::::::::::::: NP_000 QVADCSWDETIKIYDPACLTIPA 310 320 >>XP_005267076 (OMIM: 215100,266500,601757,614879) PREDI (285 aa) initn: 1970 init1: 1970 opt: 1970 Z-score: 1568.8 bits: 298.4 E(85289): 1.2e-80 Smith-Waterman score: 1970; 99.6% identity (100.0% similar) in 281 aa overlap (43-323:5-285) 20 30 40 50 60 70 pF1KB3 RTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFD :.:::::::::::::::::::::::::::: XP_005 MHTFASCGTLLILDPDEAGLRLFRSFDWNDGLFD 10 20 30 80 90 100 110 120 130 pF1KB3 VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB3 WDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB3 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSP 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB3 FHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIK 220 230 240 250 260 270 320 pF1KB3 IYDPACLTIPA ::::::::::: XP_005 IYDPACLTIPA 280 >>XP_016866423 (OMIM: 215100,266500,601757,614879) PREDI (199 aa) initn: 1239 init1: 1239 opt: 1239 Z-score: 997.4 bits: 192.1 E(85289): 8.1e-49 Smith-Waterman score: 1239; 97.2% identity (98.9% similar) in 181 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KB3 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: . :. XP_016 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASDSGTF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG . XP_016 QSLTLFLKQWSIIQSLLVV 190 >>XP_006715565 (OMIM: 215100,266500,601757,614879) PREDI (225 aa) initn: 886 init1: 794 opt: 794 Z-score: 647.8 bits: 127.6 E(85289): 2.4e-29 Smith-Waterman score: 1369; 69.7% identity (69.7% similar) in 323 aa overlap (1-323:1-225) 10 20 30 40 50 60 pF1KB3 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWS ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE------- 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 QTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTL XP_006 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KB3 RIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLG ::::::::::::::::::::::::::::: XP_006 -------------------------------NLLVTGAVDCSLRGWDLRNVRQPVFELLG 120 130 140 250 260 270 280 290 300 pF1KB3 HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPT 150 160 170 180 190 200 310 320 pF1KB3 QVADCSWDETIKIYDPACLTIPA ::::::::::::::::::::::: XP_006 QVADCSWDETIKIYDPACLTIPA 210 220 >>NP_758440 (OMIM: 614784,615973) POC1 centriolar protei (478 aa) initn: 167 init1: 85 opt: 312 Z-score: 265.9 bits: 58.0 E(85289): 4.5e-08 Smith-Waterman score: 312; 30.1% identity (61.2% similar) in 209 aa overlap (107-315:14-214) 80 90 100 110 120 130 pF1KB3 ENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQT .: : . :.: : . :.::. ..::: NP_758 MASATEDPVLERYFKGHKAAITSLDLSPN-GKQLA-TASWDTF 10 20 30 40 140 150 160 170 180 190 pF1KB3 VKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPA . ::. . ::.... :. .::: . .:::: :.:.:.: : . : NP_758 LMLWNFKPHARAYRYVGHKDVVTSVQFSPH-GNLLASASRDRTVRLWIPDKRGKFSEFKA 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB3 HQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHAS : : . : :. . ..:.:.. : :.. :.. : .. : ::. .: .:::: . NP_758 HTAPVRSVDFSA-DGQFLATASEDKSIKVWSMYRQRF-LYSLYRHTHWVRCAKFSP-DGR 110 120 130 140 150 260 270 280 290 300 310 pF1KB3 VLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDP ...::: : :...:. .. . . .. . :. .::. : : .:. . :.:.:..: NP_758 LIVSCSEDKTIKIWDTTNKQCV-NNFSDSVGFANFVDFN-PSGTCIASAGSDQTVKVWDV 160 170 180 190 200 210 320 pF1KB3 ACLTIPA NP_758 RVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFT 220 230 240 250 260 270 >>XP_011519465 (OMIM: 604447) PREDICTED: guanine nucleot (301 aa) initn: 165 init1: 109 opt: 298 Z-score: 257.3 bits: 55.8 E(85289): 1.4e-07 Smith-Waterman score: 298; 27.6% identity (56.4% similar) in 250 aa overlap (32-270:57-300) 10 20 30 40 50 pF1KB3 SAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTL--------LILDP .::: : .:: : : .: XP_011 VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 30 40 50 60 70 80 60 70 80 90 100 110 pF1KB3 DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE .: .: . . ... :.. ..: ::::. :::. ... :: .. :. . XP_011 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDV-ESGQLLQSFHGHGAD 90 100 110 120 130 140 120 130 140 150 160 170 pF1KB3 VYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFAS : .: . .. . :::. :. . .:: :. . .:. ::: : :. . : ::: XP_011 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPS-GDAFAS 150 160 170 180 190 200 180 190 200 210 220 230 pF1KB3 ASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNEN--LLVTGAVDCSLRGWD-LRN .: : : :..:..: ...: .... :.. . .. . :: .: : .. :: :.. XP_011 GSDDATCRLYDLRA-DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG 210 220 230 240 250 260 240 250 260 270 280 290 pF1KB3 VRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC : . :.:: . .. :: .... : :.: :.: : XP_011 SRVSI--LFGHENRVSTLRVSP-DGTAFCSGSWDHTLRVWA 270 280 290 300 300 310 320 pF1KB3 GLDFSLQSPTQVADCSWDETIKIYDPACLTIPA >>XP_011519464 (OMIM: 604447) PREDICTED: guanine nucleot (353 aa) initn: 165 init1: 109 opt: 298 Z-score: 256.5 bits: 55.8 E(85289): 1.5e-07 Smith-Waterman score: 298; 27.6% identity (56.4% similar) in 250 aa overlap (32-270:109-352) 10 20 30 40 50 pF1KB3 SAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTL--------LILDP .::: : .:: : : .: XP_011 VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 80 90 100 110 120 130 60 70 80 90 100 110 pF1KB3 DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE .: .: . . ... :.. ..: ::::. :::. ... :: .. :. . XP_011 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDV-ESGQLLQSFHGHGAD 140 150 160 170 180 190 120 130 140 150 160 170 pF1KB3 VYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFAS : .: . .. . :::. :. . .:: :. . .:. ::: : :. . : ::: XP_011 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPS-GDAFAS 200 210 220 230 240 250 180 190 200 210 220 230 pF1KB3 ASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNEN--LLVTGAVDCSLRGWD-LRN .: : : :..:..: ...: .... :.. . .. . :: .: : .. :: :.. XP_011 GSDDATCRLYDLRA-DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG 260 270 280 290 300 310 240 250 260 270 280 290 pF1KB3 VRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC : . :.:: . .. :: .... : :.: :.: : XP_011 SRVSI--LFGHENRVSTLRVSP-DGTAFCSGSWDHTLRVWA 320 330 340 350 300 310 320 pF1KB3 GLDFSLQSPTQVADCSWDETIKIYDPACLTIPA >>NP_006569 (OMIM: 604447) guanine nucleotide-binding pr (353 aa) initn: 165 init1: 109 opt: 298 Z-score: 256.5 bits: 55.8 E(85289): 1.5e-07 Smith-Waterman score: 298; 27.6% identity (56.4% similar) in 250 aa overlap (32-270:109-352) 10 20 30 40 50 pF1KB3 SAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTL--------LILDP .::: : .:: : : .: NP_006 VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 80 90 100 110 120 130 60 70 80 90 100 110 pF1KB3 DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE .: .: . . ... :.. ..: ::::. :::. ... :: .. :. . NP_006 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDV-ESGQLLQSFHGHGAD 140 150 160 170 180 190 120 130 140 150 160 170 pF1KB3 VYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFAS : .: . .. . :::. :. . .:: :. . .:. ::: : :. . : ::: NP_006 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPS-GDAFAS 200 210 220 230 240 250 180 190 200 210 220 230 pF1KB3 ASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNEN--LLVTGAVDCSLRGWD-LRN .: : : :..:..: ...: .... :.. . .. . :: .: : .. :: :.. NP_006 GSDDATCRLYDLRA-DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG 260 270 280 290 300 310 240 250 260 270 280 290 pF1KB3 VRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC : . :.:: . .. :: .... : :.: :.: : NP_006 SRVSI--LFGHENRVSTLRVSP-DGTAFCSGSWDHTLRVWA 320 330 340 350 300 310 320 pF1KB3 GLDFSLQSPTQVADCSWDETIKIYDPACLTIPA >>NP_057278 (OMIM: 604447) guanine nucleotide-binding pr (395 aa) initn: 165 init1: 109 opt: 298 Z-score: 255.9 bits: 55.9 E(85289): 1.6e-07 Smith-Waterman score: 298; 27.6% identity (56.4% similar) in 250 aa overlap (32-270:151-394) 10 20 30 40 50 pF1KB3 SAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTL--------LILDP .::: : .:: : : .: NP_057 VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 130 140 150 160 170 180 60 70 80 90 100 110 pF1KB3 DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQE .: .: . . ... :.. ..: ::::. :::. ... :: .. :. . NP_057 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDV-ESGQLLQSFHGHGAD 190 200 210 220 230 120 130 140 150 160 170 pF1KB3 VYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFAS : .: . .. . :::. :. . .:: :. . .:. ::: : :. . : ::: NP_057 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPS-GDAFAS 240 250 260 270 280 290 180 190 200 210 220 230 pF1KB3 ASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNEN--LLVTGAVDCSLRGWD-LRN .: : : :..:..: ...: .... :.. . .. . :: .: : .. :: :.. NP_057 GSDDATCRLYDLRA-DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG 300 310 320 330 340 350 240 250 260 270 280 290 pF1KB3 VRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTC : . :.:: . .. :: .... : :.: :.: : NP_057 SRVSI--LFGHENRVSTLRVSP-DGTAFCSGSWDHTLRVWA 360 370 380 390 300 310 320 pF1KB3 GLDFSLQSPTQVADCSWDETIKIYDPACLTIPA >>NP_001309196 (OMIM: 607795,615922) U4/U6 small nuclear (279 aa) initn: 230 init1: 126 opt: 293 Z-score: 253.8 bits: 55.0 E(85289): 2.1e-07 Smith-Waterman score: 336; 29.3% identity (58.9% similar) in 270 aa overlap (53-314:18-276) 30 40 50 60 70 pF1KB3 EFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDG--LFD--VTWSEN :: :. .:. . : : .: : : . NP_001 MLSFVFDRSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLD 10 20 30 40 80 90 100 110 120 130 pF1KB3 NEHV-LITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTV . : : .:..:::..:: . . :. . :. .: : : . : ... . .:.. NP_001 PKDVNLASCAADGSVKLW-SLDSDEPVADIEGHTVRVARVMWHPS-G-RFLGTTCYDRSW 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB3 KLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASG-DQTLRIWDVKAAGVRIVIPA .::: . . . .:: .:. . : : .:...: : :.::.... . . . NP_001 RLWDLEAQEEILHQEGHSMGVYDIAF--HQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB3 HQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHAS : :: . .. : ..::. : . . ::::. :. :. . .: . ::: :.:.. NP_001 HLKEIYGINFSP-NGYHIATGSGDNTCKVWDLRQ-RRCVYTIPAHQNLVTGVKFEPIHGN 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB3 VLASCSYDFTVRFWNFSKPD-SLLETVEHHTEFTCGLDFSLQSPTQ-VADCSWDETIKIY : . .:: :...: ..: : :.:. : . :::.: : : .: ::.:.:.:.. NP_001 FLLTGAYDNTAKIW--THPGWSPLKTLAGHEGKVMGLDIS--SDGQLIATCSYDRTFKLW 230 240 250 260 270 320 pF1KB3 DPACLTIPA NP_001 MAE 323 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:50:35 2016 done: Sat Nov 5 04:50:36 2016 Total Scan time: 6.260 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]