FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3219, 669 aa 1>>>pF1KB3219 669 - 669 aa - 669 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2969+/-0.000468; mu= 10.2063+/- 0.029 mean_var=182.5214+/-38.255, 0's: 0 Z-trim(115.5): 574 B-trim: 547 in 2/50 Lambda= 0.094933 statistics sampled from 25301 (25993) to 25301 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.305), width: 16 Scan time: 12.510 The best scores are: opt bits E(85289) NP_061178 (OMIM: 613538) protein fem-1 homolog A [ ( 669) 4470 625.6 1.8e-178 XP_016865136 (OMIM: 608767) PREDICTED: protein fem ( 464) 1702 246.4 1.8e-64 XP_005272092 (OMIM: 608767) PREDICTED: protein fem ( 617) 1702 246.5 2.2e-64 NP_064562 (OMIM: 608767) protein fem-1 homolog C [ ( 617) 1702 246.5 2.2e-64 NP_056137 (OMIM: 613539) protein fem-1 homolog B [ ( 627) 672 105.4 6.6e-22 XP_016877348 (OMIM: 613539) PREDICTED: protein fem ( 469) 631 99.7 2.6e-20 NP_001183959 (OMIM: 610500) ankyrin repeat and KH ( 581) 316 56.6 3e-07 NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616) 316 56.7 3.1e-07 NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627) 316 56.7 3.1e-07 XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116) 316 56.9 4.7e-07 XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229) 316 57.0 5e-07 XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367) 316 57.0 5.4e-07 XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479) 316 57.1 5.7e-07 XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480) 316 57.1 5.7e-07 XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543) 316 57.1 5.8e-07 XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238) 316 57.2 7.5e-07 XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239) 316 57.2 7.5e-07 XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351) 316 57.3 7.8e-07 NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352) 316 57.3 7.8e-07 XP_016863500 (OMIM: 615929) PREDICTED: ankyrin rep (2489) 316 57.3 8.1e-07 NP_001273700 (OMIM: 615929) ankyrin repeat domain- (2490) 316 57.3 8.1e-07 NP_060217 (OMIM: 610500) ankyrin repeat and KH dom (2542) 316 57.3 8.2e-07 NP_056389 (OMIM: 615929) ankyrin repeat domain-con (2602) 316 57.3 8.4e-07 NP_115593 (OMIM: 615929) ankyrin repeat domain-con (2603) 316 57.3 8.4e-07 NP_001139381 (OMIM: 611397) protein TANC1 isoform (1390) 306 55.7 1.4e-06 XP_011510364 (OMIM: 611397) PREDICTED: protein TAN (1554) 306 55.7 1.5e-06 XP_016860646 (OMIM: 611397) PREDICTED: protein TAN (1660) 306 55.7 1.6e-06 XP_006712877 (OMIM: 611397) PREDICTED: protein TAN (1677) 306 55.7 1.6e-06 XP_016860645 (OMIM: 611397) PREDICTED: protein TAN (1685) 306 55.7 1.6e-06 XP_011510361 (OMIM: 611397) PREDICTED: protein TAN (1697) 306 55.7 1.6e-06 XP_016860644 (OMIM: 611397) PREDICTED: protein TAN (1738) 306 55.8 1.6e-06 XP_011510360 (OMIM: 611397) PREDICTED: protein TAN (1755) 306 55.8 1.6e-06 XP_016860643 (OMIM: 611397) PREDICTED: protein TAN (1773) 306 55.8 1.7e-06 XP_016860642 (OMIM: 611397) PREDICTED: protein TAN (1773) 306 55.8 1.7e-06 XP_016860641 (OMIM: 611397) PREDICTED: protein TAN (1790) 306 55.8 1.7e-06 XP_016860640 (OMIM: 611397) PREDICTED: protein TAN (1791) 306 55.8 1.7e-06 XP_006712875 (OMIM: 611397) PREDICTED: protein TAN (1826) 306 55.8 1.7e-06 XP_016860639 (OMIM: 611397) PREDICTED: protein TAN (1838) 306 55.8 1.7e-06 XP_016860638 (OMIM: 611397) PREDICTED: protein TAN (1844) 306 55.8 1.7e-06 XP_011510357 (OMIM: 611397) PREDICTED: protein TAN (1853) 306 55.8 1.7e-06 XP_016860636 (OMIM: 611397) PREDICTED: protein TAN (1854) 306 55.8 1.7e-06 XP_016860637 (OMIM: 611397) PREDICTED: protein TAN (1854) 306 55.8 1.7e-06 NP_203752 (OMIM: 611397) protein TANC1 isoform 1 [ (1861) 306 55.8 1.7e-06 XP_006712873 (OMIM: 611397) PREDICTED: protein TAN (1861) 306 55.8 1.7e-06 XP_005246975 (OMIM: 611397) PREDICTED: protein TAN (1871) 306 55.8 1.7e-06 XP_016860633 (OMIM: 611397) PREDICTED: protein TAN (1871) 306 55.8 1.7e-06 XP_016860635 (OMIM: 611397) PREDICTED: protein TAN (1872) 306 55.8 1.7e-06 XP_016860630 (OMIM: 611397) PREDICTED: protein TAN (1878) 306 55.8 1.7e-06 XP_016860634 (OMIM: 611397) PREDICTED: protein TAN (1879) 306 55.8 1.7e-06 XP_011510353 (OMIM: 611397) PREDICTED: protein TAN (1879) 306 55.8 1.7e-06 >>NP_061178 (OMIM: 613538) protein fem-1 homolog A [Homo (669 aa) initn: 4470 init1: 4470 opt: 4470 Z-score: 3325.2 bits: 625.6 E(85289): 1.8e-178 Smith-Waterman score: 4470; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669) 10 20 30 40 50 60 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE 610 620 630 640 650 660 pF1KB3 DLEAFIELH ::::::::: NP_061 DLEAFIELH >>XP_016865136 (OMIM: 608767) PREDICTED: protein fem-1 h (464 aa) initn: 1264 init1: 969 opt: 1702 Z-score: 1278.4 bits: 246.4 E(85289): 1.8e-64 Smith-Waterman score: 1875; 59.8% identity (77.7% similar) in 503 aa overlap (168-669:15-463) 140 150 160 170 180 190 pF1KB3 EHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLE .:: . .. ::: ::::::::::::::. XP_016 MLIEKVSKASTWLIFLLPKEHHIVFRSA-GNTALHDCAESGSLD 10 20 30 40 200 210 220 230 240 250 pF1KB3 ILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQED :...:: :.::.:::::::::.::::::::::..: .. :: XP_016 IMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH-----------AQ------- 50 60 70 80 260 270 280 290 300 310 pF1KB3 PSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLG ::. ..::::::::.::::::::: XP_016 ----------------------------------TSKTERINALELLGATFVDKKRDLLG 90 100 110 320 330 340 350 360 370 pF1KB3 ALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALL :::.:..::..:.. . . :: : :..::::..:::..::::.::.::::::::::: XP_016 ALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALL 120 130 140 150 160 170 380 390 400 410 420 430 pF1KB3 IRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFL ::::::::::::::::::::::::::::::.::: :::::::::::::.:::::::::.: XP_016 IRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLL 180 190 200 210 220 230 440 450 460 470 480 490 pF1KB3 SFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALA :::::::..::::: :: ::: . : ::::.: :.: :.:::.. . :.: :..:::. XP_016 SFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALS 240 250 260 270 280 290 500 510 520 530 540 550 pF1KB3 IILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVG :::::. ::::: :: :.:.:.::.::.:: :::::.:.:::.::::.:: :::::: XP_016 IILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVC 300 310 320 330 340 350 560 570 580 590 600 610 pF1KB3 RFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT .::::.:. .:..:::: . :: :.:.:::::: :: : ::: ::..:::.:::: :.: XP_016 KFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 360 370 380 390 400 410 620 630 640 650 660 pF1KB3 AYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH : .::::: .:.. .::.:..::::::::.. ...: ::: ::: ::.:. :: XP_016 ASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR 420 430 440 450 460 >>XP_005272092 (OMIM: 608767) PREDICTED: protein fem-1 h (617 aa) initn: 2238 init1: 969 opt: 1702 Z-score: 1276.8 bits: 246.5 E(85289): 2.2e-64 Smith-Waterman score: 2791; 64.8% identity (82.8% similar) in 670 aa overlap (1-669:1-616) 10 20 30 40 50 60 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL :::.:::.::::::::.:: :::...:.::.. : .: ..:.::::.::::::::.::.: XP_005 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL ...:.::.:.::::.::::::::::::::::::::: ::.::: .::::: :: :::::: XP_005 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS ::::::::::.:.::: ::.:::::.::::::::::::::::.:::.::::.::.:::.: XP_005 RAACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG .:::::::::::::::.:...:: :.::.:::::::::.::::::::::..: .. XP_005 VKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH--- 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA :: ::. ..: XP_005 --------AQ-----------------------------------------TSKTERINA 240 310 320 330 340 350 pF1KB3 LELLGATYVDKKRDLLGALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEE :::::::.::::::::::::.:..::..:.. . . :: : :..::::..:::..:: XP_005 LELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEE 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 LEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDM ::.::.:::::::::::::::::::::::::::::::::::::::::.::: :::::::: XP_005 LEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDM 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB3 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL :::::.:::::::::.::::::::..::::: :: ::: . : ::::.: :.: :.:::. XP_005 QQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAI 370 380 390 400 410 420 480 490 500 510 520 530 pF1KB3 QLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPL . . :.: :..:::.:::::. ::::: :: :.:.:.::.::.:: :::::.:.:: XP_005 KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPL 430 440 450 460 470 480 540 550 560 570 580 590 pF1KB3 HMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNA :.::::.:: :::::: .::::.:. .:..:::: . :: :.:.:::::: :: : ::: XP_005 HLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNL 490 500 510 520 530 540 600 610 620 630 640 650 pF1KB3 LIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIP ::..:::.:::: :.:: .::::: .:.. .::.:..::::::::.. ...: ::: :: XP_005 LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIP 550 560 570 580 590 600 660 pF1KB3 EDLEAFIELH : ::.:. :: XP_005 EKLETFVSLHR 610 >>NP_064562 (OMIM: 608767) protein fem-1 homolog C [Homo (617 aa) initn: 2238 init1: 969 opt: 1702 Z-score: 1276.8 bits: 246.5 E(85289): 2.2e-64 Smith-Waterman score: 2791; 64.8% identity (82.8% similar) in 670 aa overlap (1-669:1-616) 10 20 30 40 50 60 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL :::.:::.::::::::.:: :::...:.::.. : .: ..:.::::.::::::::.::.: NP_064 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL ...:.::.:.::::.::::::::::::::::::::: ::.::: .::::: :: :::::: NP_064 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS ::::::::::.:.::: ::.:::::.::::::::::::::::.:::.::::.::.:::.: NP_064 RAACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG .:::::::::::::::.:...:: :.::.:::::::::.::::::::::..: .. NP_064 VKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH--- 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA :: ::. ..: NP_064 --------AQ-----------------------------------------TSKTERINA 240 310 320 330 340 350 pF1KB3 LELLGATYVDKKRDLLGALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEE :::::::.::::::::::::.:..::..:.. . . :: : :..::::..:::..:: NP_064 LELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEE 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 LEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDM ::.::.:::::::::::::::::::::::::::::::::::::::::.::: :::::::: NP_064 LEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDM 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB3 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL :::::.:::::::::.::::::::..::::: :: ::: . : ::::.: :.: :.:::. NP_064 QQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAI 370 380 390 400 410 420 480 490 500 510 520 530 pF1KB3 QLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPL . . :.: :..:::.:::::. ::::: :: :.:.:.::.::.:: :::::.:.:: NP_064 KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPL 430 440 450 460 470 480 540 550 560 570 580 590 pF1KB3 HMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNA :.::::.:: :::::: .::::.:. .:..:::: . :: :.:.:::::: :: : ::: NP_064 HLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNL 490 500 510 520 530 540 600 610 620 630 640 650 pF1KB3 LIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIP ::..:::.:::: :.:: .::::: .:.. .::.:..::::::::.. ...: ::: :: NP_064 LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIP 550 560 570 580 590 600 660 pF1KB3 EDLEAFIELH : ::.:. :: NP_064 EKLETFVSLHR 610 >>NP_056137 (OMIM: 613539) protein fem-1 homolog B [Homo (627 aa) initn: 1114 init1: 349 opt: 672 Z-score: 514.3 bits: 105.4 E(85289): 6.6e-22 Smith-Waterman score: 1232; 35.8% identity (63.0% similar) in 689 aa overlap (7-669:8-627) 10 20 30 40 50 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVA--GG--GTPLLIAARYGHLD ::.:: .::. : :: .::. .. : : :. :: .:::.:::: :: NP_056 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 VVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRT ::. :... .... :.:.::: .:.:: :: :..:::..::. :. .::.::.:: : NP_056 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 NSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQ ::::::::::::.:..:.::: :..:.. .::.. .:::::. :::: ...:::::: :. NP_056 NSTPLRAACFDGRLDIVKYLV-ENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRAD 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 VNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLI : .. : :::: ::.: ..:.. :. .: . .:.::::: .:. . ....:: :. NP_056 PNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 QEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSRE :. .: .:. NP_056 -------------------------------------------------SHADC---DRR 240 300 310 320 330 340 350 pF1KB3 AAVEALELLGATYVDKKR--DLLGALKHWRRAMELRHQGGEYLPKPE--PPQLVLAYDYS . .::::::::.... .. :.. . .. :: : : :. . . : :: . :: NP_056 SRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP--IHAYGNR 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 REVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIR : . .:::.. : : ..:..:..:::::: .. :.:. : ::::::::. .::.::. NP_056 TECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIK 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB3 LWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKG :: .:: ..:.. . : ...: ::..:: ... :. . :. :: . NP_056 LWLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH-------LNETVKAPDIECVLRCS 370 380 390 400 410 480 490 500 510 520 pF1KB3 VREVERALQLPREPGDSA------QFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRL : :.:.... .. .:. .. : .:.:. . :..:. .. .. .: : NP_056 VLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNL 420 430 440 450 460 470 530 540 550 560 570 580 pF1KB3 LKCAPRGKNGFTPLHMAVDKDTT--NVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNT .. :: ..::: ::.::...: . : ::. :.:.::::::. .. : ..:. NP_056 IHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNS 480 490 500 510 520 530 590 600 610 620 630 pF1KB3 PLHIAAQNNCP--------AIMNALIEAGAHMDATNAFKKTAYELLDEKL--LARGTMQP ::: .: : : .:. .:.::::: : :: .:: ::.. ... .. NP_056 ALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTP---LDKSTTGVSEILLKT 540 550 560 570 580 590 640 650 660 pF1KB3 FNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH ..:.::::::. : : :. ::. :: :. .: NP_056 QMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 600 610 620 >>XP_016877348 (OMIM: 613539) PREDICTED: protein fem-1 h (469 aa) initn: 779 init1: 257 opt: 631 Z-score: 485.5 bits: 99.7 E(85289): 2.6e-20 Smith-Waterman score: 775; 31.8% identity (58.7% similar) in 537 aa overlap (155-669:1-469) 130 140 150 160 170 180 pF1KB3 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN ::. :::: ...:::::: :. : .. : XP_016 MIAAYKGHTDVVRYLLEQRADPNAKAHCGA 10 20 30 190 200 210 220 230 240 pF1KB3 TALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV :::: ::.: ..:.. :. .: . .:.::::: .:. . ....:: :. XP_016 TALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLL--------- 40 50 60 70 80 250 260 270 280 290 300 pF1KB3 AGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELL :. .: .:.. .:::::: XP_016 ----------------------------------------SHADC---DRRSRIEALELL 90 310 320 330 340 350 360 pF1KB3 GATYVDKKR--DLLGALKHWRRAMELRHQGGEYLPKPE--PPQLVLAYDYSREVNTTEEL ::.... .. :.. . .. :: : : :. . . : :: . :: : . .:: XP_016 GASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP--IHAYGNRTECRNPQEL 100 110 120 130 140 150 370 380 390 400 410 420 pF1KB3 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ :.. : : ..:..:..:::::: .. :.:. : ::::::::. .::.::.:: .:: .. XP_016 ESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLR 160 170 180 190 200 210 430 440 450 460 470 480 pF1KB3 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ :.. . : ...: ::..:: ... :. . :. :: .: :.:.... XP_016 QKG----NRNTHKDLLRFAQVFSQMIH-------LNETVKAPDIECVLRCSVLEIEQSMN 220 230 240 250 260 490 500 510 520 530 pF1KB3 LPREPGDSA------QFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKN .. .:. .. : .:.:. . :..:. .. .. .: :.. :: .. XP_016 RVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTRE 270 280 290 300 310 320 540 550 560 570 580 590 pF1KB3 GFTPLHMAVDKDTT--NVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN ::: ::.::...: . : ::. :.:.::::::. .. : ..:. ::: .: : XP_016 GFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYN 330 340 350 360 370 380 600 610 620 630 640 pF1KB3 CP--------AIMNALIEAGAHMDATNAFKKTAYELLDEKL--LARGTMQPFNYVTLQCL : .:. .:.::::: : :: .:: ::.. ... .. ..:.:: XP_016 RPISDFLTLHSIIISLVEAGAHTDMTNKQNKTP---LDKSTTGVSEILLKTQMKMSLKCL 390 400 410 420 430 440 650 660 pF1KB3 AARALDKNKIPYKGFIPEDLEAFIELH ::::. : : :. ::. :: :. .: XP_016 AARAVRANDINYQDQIPRTLEEFVGFH 450 460 >>NP_001183959 (OMIM: 610500) ankyrin repeat and KH doma (581 aa) initn: 295 init1: 242 opt: 316 Z-score: 251.2 bits: 56.6 E(85289): 3e-07 Smith-Waterman score: 376; 33.6% identity (59.9% similar) in 262 aa overlap (5-264:274-514) 10 20 30 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL : .. :. : :.... :: . .. NP_001 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-----DV 250 260 270 280 290 40 50 60 70 80 90 pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG ... : :.: : : : .:.:. :... ::..: : . .: :: :..:: NP_001 NSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED----HNE----NGHTPLMEAASAG 300 310 320 330 340 100 110 120 130 140 150 pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC :..:.: :: .::..: .... . . : ::. :::..::.:. : :: : . . :: NP_001 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEMHTA 350 360 370 380 390 400 160 170 180 190 200 210 pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D :: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. . NP_001 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 410 420 430 440 450 460 220 230 240 250 260 270 pF1KB3 GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPC :.:::. :. :: ..: :. : :. .:: :: : : NP_001 DEGYTPLMEAAREGHEEMVALLLA------QGANINAQTEETQETALTLACCGGFSEVAD 470 480 490 500 510 520 280 290 300 310 320 330 pF1KB3 CSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQG NP_001 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGQAGGHEDYFGGHRSGQASGEGGL 530 540 550 560 570 580 >>NP_060448 (OMIM: 610500) ankyrin repeat and KH domain- (616 aa) initn: 295 init1: 242 opt: 316 Z-score: 250.9 bits: 56.7 E(85289): 3.1e-07 Smith-Waterman score: 376; 33.6% identity (59.9% similar) in 262 aa overlap (5-264:263-503) 10 20 30 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL : .. :. : :.... :: . .. NP_060 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-----DV 240 250 260 270 280 40 50 60 70 80 90 pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG ... : :.: : : : .:.:. :... ::..: : . .: :: :..:: NP_060 NSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED----HNE----NGHTPLMEAASAG 290 300 310 320 330 100 110 120 130 140 150 pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC :..:.: :: .::..: .... . . : ::. :::..::.:. : :: : . . :: NP_060 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEMHTA 340 350 360 370 380 390 160 170 180 190 200 210 pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D :: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. . NP_060 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 400 410 420 430 440 450 220 230 240 250 260 270 pF1KB3 GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPC :.:::. :. :: ..: :. : :. .:: :: : : NP_060 DEGYTPLMEAAREGHEEMVALLLA------QGANINAQTEETQETALTLACCGGFSEVAD 460 470 480 490 500 510 280 290 300 310 320 330 pF1KB3 CSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQG NP_060 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 520 530 540 550 560 570 >>NP_078944 (OMIM: 610500) ankyrin repeat and KH domain- (627 aa) initn: 295 init1: 242 opt: 316 Z-score: 250.8 bits: 56.7 E(85289): 3.1e-07 Smith-Waterman score: 376; 33.6% identity (59.9% similar) in 262 aa overlap (5-264:274-514) 10 20 30 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL : .. :. : :.... :: . .. NP_078 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-----DV 250 260 270 280 290 40 50 60 70 80 90 pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG ... : :.: : : : .:.:. :... ::..: : . .: :: :..:: NP_078 NSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED----HNE----NGHTPLMEAASAG 300 310 320 330 340 100 110 120 130 140 150 pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC :..:.: :: .::..: .... . . : ::. :::..::.:. : :: : . . :: NP_078 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEMHTA 350 360 370 380 390 400 160 170 180 190 200 210 pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D :: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. . NP_078 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 410 420 430 440 450 460 220 230 240 250 260 270 pF1KB3 GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPC :.:::. :. :: ..: :. : :. .:: :: : : NP_078 DEGYTPLMEAAREGHEEMVALLLA------QGANINAQTEETQETALTLACCGGFSEVAD 470 480 490 500 510 520 280 290 300 310 320 330 pF1KB3 CSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQG NP_078 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 530 540 550 560 570 580 >>XP_016863506 (OMIM: 615929) PREDICTED: ankyrin repeat (1116 aa) initn: 250 init1: 250 opt: 316 Z-score: 247.7 bits: 56.9 E(85289): 4.7e-07 Smith-Waterman score: 397; 25.3% identity (50.5% similar) in 673 aa overlap (5-620:190-825) 10 20 30 pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL : .. :: :...... ::. .. .. XP_016 LACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA-----DV 160 170 180 190 200 210 40 50 60 70 80 90 pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG ... . :.: : : :..:::. :.. :::.: : . .: :: :..:: XP_016 NAQSSTGNTALTYACAGGYVDVVKVLLES-GASIED----HNE----NGHTPLMEAGSAG 220 230 240 250 260 100 110 120 130 140 150 pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC :..:.: ::. ::..: .... . . : ::. ::::.::.:. : :: : . . :: XP_016 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL-EAGADQEHKTDEMHTA 270 280 290 300 310 320 160 170 180 190 200 210 pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D :: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. . XP_016 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 330 340 350 360 370 380 220 230 240 250 pF1KB3 GYGMTPLLAASVTGHTNIVEYLI--------QEQPGQEQV-----AGG--EAQPGLPQED :.:::. :. :: ..: :. : . :: . :: :. : . XP_016 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 390 400 410 420 430 440 260 270 280 290 300 pF1KB3 PSTSQGCAQP------QG---------APCCSSSPEEPLNGESYESCCPTSREAAVEALE . ::. : .: : . . . : ... ....: XP_016 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL 450 460 470 480 490 500 310 320 330 340 350 pF1KB3 LLGATYVDK----KRDLLGALK--HWRRAMELRHQGGEY-LPKPEPPQLVLAYDYSR-EV :: . . :. : . : .. : .:.. . . ::. . .. XP_016 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 510 520 530 540 550 560 360 370 380 390 400 pF1KB3 NTTEELEALITDPDE-MRMQALLIRERILGPSHPDTSYYIRYRGAVYA-----------D ..: : : .:: . .. . .. : : . : . : . . . XP_016 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPP 570 580 590 600 610 620 410 420 430 440 450 460 pF1KB3 SGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRA-AKGSLGTQIGF : ...: :. :: : :: .: .. . . . ... :: : .. :. XP_016 SHDLNRAPRVPVQALPMVVPPQEPDKP--PANVATTLPIRNKAVSGRASAMSNTPTHSIA 630 640 650 660 670 680 470 480 490 500 510 pF1KB3 ADLMGVLTKGVREV-ERALQLPREPG-D-SAQFTKALAIILHLLYLLEKVECTPSQEHLK :.. : . . .:: :. : .:: . : : :. ..:.: XP_016 ASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL-------ACAGGHEELV 690 700 710 720 730 520 530 540 550 560 570 pF1KB3 HQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSR- . . : . : :.::::: .:. ..:. :: ::..::: ::: ... XP_016 QTLLERGASIEHRDKKGFTPLILAA-----TAGH--VG------VVEILLDNGADIEAQS 740 750 760 770 780 580 590 600 610 620 630 pF1KB3 DFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYV . ..::: .: ... ... :. ::. . :. : : XP_016 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 790 800 810 820 830 840 640 650 660 pF1KB3 TLQCLAARALDKNKIPYKGFIPEDLEAFIELH XP_016 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 850 860 870 880 890 900 669 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:31:39 2016 done: Thu Nov 3 12:31:41 2016 Total Scan time: 12.510 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]