FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3219, 669 aa
1>>>pF1KB3219 669 - 669 aa - 669 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2969+/-0.000468; mu= 10.2063+/- 0.029
mean_var=182.5214+/-38.255, 0's: 0 Z-trim(115.5): 574 B-trim: 547 in 2/50
Lambda= 0.094933
statistics sampled from 25301 (25993) to 25301 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.305), width: 16
Scan time: 12.510
The best scores are: opt bits E(85289)
NP_061178 (OMIM: 613538) protein fem-1 homolog A [ ( 669) 4470 625.6 1.8e-178
XP_016865136 (OMIM: 608767) PREDICTED: protein fem ( 464) 1702 246.4 1.8e-64
XP_005272092 (OMIM: 608767) PREDICTED: protein fem ( 617) 1702 246.5 2.2e-64
NP_064562 (OMIM: 608767) protein fem-1 homolog C [ ( 617) 1702 246.5 2.2e-64
NP_056137 (OMIM: 613539) protein fem-1 homolog B [ ( 627) 672 105.4 6.6e-22
XP_016877348 (OMIM: 613539) PREDICTED: protein fem ( 469) 631 99.7 2.6e-20
NP_001183959 (OMIM: 610500) ankyrin repeat and KH ( 581) 316 56.6 3e-07
NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616) 316 56.7 3.1e-07
NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627) 316 56.7 3.1e-07
XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116) 316 56.9 4.7e-07
XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229) 316 57.0 5e-07
XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367) 316 57.0 5.4e-07
XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479) 316 57.1 5.7e-07
XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480) 316 57.1 5.7e-07
XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543) 316 57.1 5.8e-07
XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238) 316 57.2 7.5e-07
XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239) 316 57.2 7.5e-07
XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351) 316 57.3 7.8e-07
NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352) 316 57.3 7.8e-07
XP_016863500 (OMIM: 615929) PREDICTED: ankyrin rep (2489) 316 57.3 8.1e-07
NP_001273700 (OMIM: 615929) ankyrin repeat domain- (2490) 316 57.3 8.1e-07
NP_060217 (OMIM: 610500) ankyrin repeat and KH dom (2542) 316 57.3 8.2e-07
NP_056389 (OMIM: 615929) ankyrin repeat domain-con (2602) 316 57.3 8.4e-07
NP_115593 (OMIM: 615929) ankyrin repeat domain-con (2603) 316 57.3 8.4e-07
NP_001139381 (OMIM: 611397) protein TANC1 isoform (1390) 306 55.7 1.4e-06
XP_011510364 (OMIM: 611397) PREDICTED: protein TAN (1554) 306 55.7 1.5e-06
XP_016860646 (OMIM: 611397) PREDICTED: protein TAN (1660) 306 55.7 1.6e-06
XP_006712877 (OMIM: 611397) PREDICTED: protein TAN (1677) 306 55.7 1.6e-06
XP_016860645 (OMIM: 611397) PREDICTED: protein TAN (1685) 306 55.7 1.6e-06
XP_011510361 (OMIM: 611397) PREDICTED: protein TAN (1697) 306 55.7 1.6e-06
XP_016860644 (OMIM: 611397) PREDICTED: protein TAN (1738) 306 55.8 1.6e-06
XP_011510360 (OMIM: 611397) PREDICTED: protein TAN (1755) 306 55.8 1.6e-06
XP_016860643 (OMIM: 611397) PREDICTED: protein TAN (1773) 306 55.8 1.7e-06
XP_016860642 (OMIM: 611397) PREDICTED: protein TAN (1773) 306 55.8 1.7e-06
XP_016860641 (OMIM: 611397) PREDICTED: protein TAN (1790) 306 55.8 1.7e-06
XP_016860640 (OMIM: 611397) PREDICTED: protein TAN (1791) 306 55.8 1.7e-06
XP_006712875 (OMIM: 611397) PREDICTED: protein TAN (1826) 306 55.8 1.7e-06
XP_016860639 (OMIM: 611397) PREDICTED: protein TAN (1838) 306 55.8 1.7e-06
XP_016860638 (OMIM: 611397) PREDICTED: protein TAN (1844) 306 55.8 1.7e-06
XP_011510357 (OMIM: 611397) PREDICTED: protein TAN (1853) 306 55.8 1.7e-06
XP_016860636 (OMIM: 611397) PREDICTED: protein TAN (1854) 306 55.8 1.7e-06
XP_016860637 (OMIM: 611397) PREDICTED: protein TAN (1854) 306 55.8 1.7e-06
NP_203752 (OMIM: 611397) protein TANC1 isoform 1 [ (1861) 306 55.8 1.7e-06
XP_006712873 (OMIM: 611397) PREDICTED: protein TAN (1861) 306 55.8 1.7e-06
XP_005246975 (OMIM: 611397) PREDICTED: protein TAN (1871) 306 55.8 1.7e-06
XP_016860633 (OMIM: 611397) PREDICTED: protein TAN (1871) 306 55.8 1.7e-06
XP_016860635 (OMIM: 611397) PREDICTED: protein TAN (1872) 306 55.8 1.7e-06
XP_016860630 (OMIM: 611397) PREDICTED: protein TAN (1878) 306 55.8 1.7e-06
XP_016860634 (OMIM: 611397) PREDICTED: protein TAN (1879) 306 55.8 1.7e-06
XP_011510353 (OMIM: 611397) PREDICTED: protein TAN (1879) 306 55.8 1.7e-06
>>NP_061178 (OMIM: 613538) protein fem-1 homolog A [Homo (669 aa)
initn: 4470 init1: 4470 opt: 4470 Z-score: 3325.2 bits: 625.6 E(85289): 1.8e-178
Smith-Waterman score: 4470; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669)
10 20 30 40 50 60
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNAL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 IEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPE
610 620 630 640 650 660
pF1KB3 DLEAFIELH
:::::::::
NP_061 DLEAFIELH
>>XP_016865136 (OMIM: 608767) PREDICTED: protein fem-1 h (464 aa)
initn: 1264 init1: 969 opt: 1702 Z-score: 1278.4 bits: 246.4 E(85289): 1.8e-64
Smith-Waterman score: 1875; 59.8% identity (77.7% similar) in 503 aa overlap (168-669:15-463)
140 150 160 170 180 190
pF1KB3 EHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLE
.:: . .. ::: ::::::::::::::.
XP_016 MLIEKVSKASTWLIFLLPKEHHIVFRSA-GNTALHDCAESGSLD
10 20 30 40
200 210 220 230 240 250
pF1KB3 ILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQED
:...:: :.::.:::::::::.::::::::::..: .. ::
XP_016 IMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH-----------AQ-------
50 60 70 80
260 270 280 290 300 310
pF1KB3 PSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLG
::. ..::::::::.:::::::::
XP_016 ----------------------------------TSKTERINALELLGATFVDKKRDLLG
90 100 110
320 330 340 350 360 370
pF1KB3 ALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALL
:::.:..::..:.. . . :: : :..::::..:::..::::.::.:::::::::::
XP_016 ALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALL
120 130 140 150 160 170
380 390 400 410 420 430
pF1KB3 IRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFL
::::::::::::::::::::::::::::::.::: :::::::::::::.:::::::::.:
XP_016 IRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLL
180 190 200 210 220 230
440 450 460 470 480 490
pF1KB3 SFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALA
:::::::..::::: :: ::: . : ::::.: :.: :.:::.. . :.: :..:::.
XP_016 SFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALS
240 250 260 270 280 290
500 510 520 530 540 550
pF1KB3 IILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVG
:::::. ::::: :: :.:.:.::.::.:: :::::.:.:::.::::.:: ::::::
XP_016 IILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVC
300 310 320 330 340 350
560 570 580 590 600 610
pF1KB3 RFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKT
.::::.:. .:..:::: . :: :.:.:::::: :: : ::: ::..:::.:::: :.:
XP_016 KFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT
360 370 380 390 400 410
620 630 640 650 660
pF1KB3 AYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH
: .::::: .:.. .::.:..::::::::.. ...: ::: ::: ::.:. ::
XP_016 ASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR
420 430 440 450 460
>>XP_005272092 (OMIM: 608767) PREDICTED: protein fem-1 h (617 aa)
initn: 2238 init1: 969 opt: 1702 Z-score: 1276.8 bits: 246.5 E(85289): 2.2e-64
Smith-Waterman score: 2791; 64.8% identity (82.8% similar) in 670 aa overlap (1-669:1-616)
10 20 30 40 50 60
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL
:::.:::.::::::::.:: :::...:.::.. : .: ..:.::::.::::::::.::.:
XP_005 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL
...:.::.:.::::.::::::::::::::::::::: ::.::: .::::: :: ::::::
XP_005 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS
::::::::::.:.::: ::.:::::.::::::::::::::::.:::.::::.::.:::.:
XP_005 RAACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS
130 140 150 160 170
190 200 210 220 230 240
pF1KB3 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG
.:::::::::::::::.:...:: :.::.:::::::::.::::::::::..: ..
XP_005 VKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH---
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
:: ::. ..:
XP_005 --------AQ-----------------------------------------TSKTERINA
240
310 320 330 340 350
pF1KB3 LELLGATYVDKKRDLLGALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEE
:::::::.::::::::::::.:..::..:.. . . :: : :..::::..:::..::
XP_005 LELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEE
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB3 LEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDM
::.::.:::::::::::::::::::::::::::::::::::::::::.::: ::::::::
XP_005 LEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDM
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB3 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL
:::::.:::::::::.::::::::..::::: :: ::: . : ::::.: :.: :.:::.
XP_005 QQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAI
370 380 390 400 410 420
480 490 500 510 520 530
pF1KB3 QLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPL
. . :.: :..:::.:::::. ::::: :: :.:.:.::.::.:: :::::.:.::
XP_005 KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPL
430 440 450 460 470 480
540 550 560 570 580 590
pF1KB3 HMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNA
:.::::.:: :::::: .::::.:. .:..:::: . :: :.:.:::::: :: : :::
XP_005 HLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNL
490 500 510 520 530 540
600 610 620 630 640 650
pF1KB3 LIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIP
::..:::.:::: :.:: .::::: .:.. .::.:..::::::::.. ...: ::: ::
XP_005 LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIP
550 560 570 580 590 600
660
pF1KB3 EDLEAFIELH
: ::.:. ::
XP_005 EKLETFVSLHR
610
>>NP_064562 (OMIM: 608767) protein fem-1 homolog C [Homo (617 aa)
initn: 2238 init1: 969 opt: 1702 Z-score: 1276.8 bits: 246.5 E(85289): 2.2e-64
Smith-Waterman score: 2791; 64.8% identity (82.8% similar) in 670 aa overlap (1-669:1-616)
10 20 30 40 50 60
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL
:::.:::.::::::::.:: :::...:.::.. : .: ..:.::::.::::::::.::.:
NP_064 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL
...:.::.:.::::.::::::::::::::::::::: ::.::: .::::: :: ::::::
NP_064 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS
::::::::::.:.::: ::.:::::.::::::::::::::::.:::.::::.::.:::.:
NP_064 RAACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS
130 140 150 160 170
190 200 210 220 230 240
pF1KB3 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG
.:::::::::::::::.:...:: :.::.:::::::::.::::::::::..: ..
NP_064 VKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH---
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
:: ::. ..:
NP_064 --------AQ-----------------------------------------TSKTERINA
240
310 320 330 340 350
pF1KB3 LELLGATYVDKKRDLLGALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEE
:::::::.::::::::::::.:..::..:.. . . :: : :..::::..:::..::
NP_064 LELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEE
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB3 LEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDM
::.::.:::::::::::::::::::::::::::::::::::::::::.::: ::::::::
NP_064 LEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDM
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB3 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL
:::::.:::::::::.::::::::..::::: :: ::: . : ::::.: :.: :.:::.
NP_064 QQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAI
370 380 390 400 410 420
480 490 500 510 520 530
pF1KB3 QLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPL
. . :.: :..:::.:::::. ::::: :: :.:.:.::.::.:: :::::.:.::
NP_064 KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPL
430 440 450 460 470 480
540 550 560 570 580 590
pF1KB3 HMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNA
:.::::.:: :::::: .::::.:. .:..:::: . :: :.:.:::::: :: : :::
NP_064 HLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNL
490 500 510 520 530 540
600 610 620 630 640 650
pF1KB3 LIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIP
::..:::.:::: :.:: .::::: .:.. .::.:..::::::::.. ...: ::: ::
NP_064 LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIP
550 560 570 580 590 600
660
pF1KB3 EDLEAFIELH
: ::.:. ::
NP_064 EKLETFVSLHR
610
>>NP_056137 (OMIM: 613539) protein fem-1 homolog B [Homo (627 aa)
initn: 1114 init1: 349 opt: 672 Z-score: 514.3 bits: 105.4 E(85289): 6.6e-22
Smith-Waterman score: 1232; 35.8% identity (63.0% similar) in 689 aa overlap (7-669:8-627)
10 20 30 40 50
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVA--GG--GTPLLIAARYGHLD
::.:: .::. : :: .::. .. : : :. :: .:::.:::: ::
NP_056 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 VVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRT
::. :... .... :.:.::: .:.:: :: :..:::..::. :. .::.::.:: :
NP_056 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 NSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQ
::::::::::::.:..:.::: :..:.. .::.. .:::::. :::: ...:::::: :.
NP_056 NSTPLRAACFDGRLDIVKYLV-ENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRAD
130 140 150 160 170
180 190 200 210 220 230
pF1KB3 VNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLI
: .. : :::: ::.: ..:.. :. .: . .:.::::: .:. . ....:: :.
NP_056 PNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 QEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSRE
:. .: .:.
NP_056 -------------------------------------------------SHADC---DRR
240
300 310 320 330 340 350
pF1KB3 AAVEALELLGATYVDKKR--DLLGALKHWRRAMELRHQGGEYLPKPE--PPQLVLAYDYS
. .::::::::.... .. :.. . .. :: : : :. . . : :: . ::
NP_056 SRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP--IHAYGNR
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB3 REVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIR
: . .:::.. : : ..:..:..:::::: .. :.:. : ::::::::. .::.::.
NP_056 TECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIK
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB3 LWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKG
:: .:: ..:.. . : ...: ::..:: ... :. . :. :: .
NP_056 LWLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH-------LNETVKAPDIECVLRCS
370 380 390 400 410
480 490 500 510 520
pF1KB3 VREVERALQLPREPGDSA------QFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRL
: :.:.... .. .:. .. : .:.:. . :..:. .. .. .: :
NP_056 VLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNL
420 430 440 450 460 470
530 540 550 560 570 580
pF1KB3 LKCAPRGKNGFTPLHMAVDKDTT--NVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNT
.. :: ..::: ::.::...: . : ::. :.:.::::::. .. : ..:.
NP_056 IHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNS
480 490 500 510 520 530
590 600 610 620 630
pF1KB3 PLHIAAQNNCP--------AIMNALIEAGAHMDATNAFKKTAYELLDEKL--LARGTMQP
::: .: : : .:. .:.::::: : :: .:: ::.. ... ..
NP_056 ALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTP---LDKSTTGVSEILLKT
540 550 560 570 580 590
640 650 660
pF1KB3 FNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH
..:.::::::. : : :. ::. :: :. .:
NP_056 QMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH
600 610 620
>>XP_016877348 (OMIM: 613539) PREDICTED: protein fem-1 h (469 aa)
initn: 779 init1: 257 opt: 631 Z-score: 485.5 bits: 99.7 E(85289): 2.6e-20
Smith-Waterman score: 775; 31.8% identity (58.7% similar) in 537 aa overlap (155-669:1-469)
130 140 150 160 170 180
pF1KB3 FDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGN
::. :::: ...:::::: :. : .. :
XP_016 MIAAYKGHTDVVRYLLEQRADPNAKAHCGA
10 20 30
190 200 210 220 230 240
pF1KB3 TALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQV
:::: ::.: ..:.. :. .: . .:.::::: .:. . ....:: :.
XP_016 TALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLL---------
40 50 60 70 80
250 260 270 280 290 300
pF1KB3 AGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELL
:. .: .:.. .::::::
XP_016 ----------------------------------------SHADC---DRRSRIEALELL
90
310 320 330 340 350 360
pF1KB3 GATYVDKKR--DLLGALKHWRRAMELRHQGGEYLPKPE--PPQLVLAYDYSREVNTTEEL
::.... .. :.. . .. :: : : :. . . : :: . :: : . .::
XP_016 GASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP--IHAYGNRTECRNPQEL
100 110 120 130 140 150
370 380 390 400 410 420
pF1KB3 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ
:.. : : ..:..:..:::::: .. :.:. : ::::::::. .::.::.:: .:: ..
XP_016 ESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLR
160 170 180 190 200 210
430 440 450 460 470 480
pF1KB3 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ
:.. . : ...: ::..:: ... :. . :. :: .: :.:....
XP_016 QKG----NRNTHKDLLRFAQVFSQMIH-------LNETVKAPDIECVLRCSVLEIEQSMN
220 230 240 250 260
490 500 510 520 530
pF1KB3 LPREPGDSA------QFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKN
.. .:. .. : .:.:. . :..:. .. .. .: :.. :: ..
XP_016 RVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTRE
270 280 290 300 310 320
540 550 560 570 580 590
pF1KB3 GFTPLHMAVDKDTT--NVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN
::: ::.::...: . : ::. :.:.::::::. .. : ..:. ::: .: :
XP_016 GFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYN
330 340 350 360 370 380
600 610 620 630 640
pF1KB3 CP--------AIMNALIEAGAHMDATNAFKKTAYELLDEKL--LARGTMQPFNYVTLQCL
: .:. .:.::::: : :: .:: ::.. ... .. ..:.::
XP_016 RPISDFLTLHSIIISLVEAGAHTDMTNKQNKTP---LDKSTTGVSEILLKTQMKMSLKCL
390 400 410 420 430 440
650 660
pF1KB3 AARALDKNKIPYKGFIPEDLEAFIELH
::::. : : :. ::. :: :. .:
XP_016 AARAVRANDINYQDQIPRTLEEFVGFH
450 460
>>NP_001183959 (OMIM: 610500) ankyrin repeat and KH doma (581 aa)
initn: 295 init1: 242 opt: 316 Z-score: 251.2 bits: 56.6 E(85289): 3e-07
Smith-Waterman score: 376; 33.6% identity (59.9% similar) in 262 aa overlap (5-264:274-514)
10 20 30
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL
: .. :. : :.... :: . ..
NP_001 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-----DV
250 260 270 280 290
40 50 60 70 80 90
pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG
... : :.: : : : .:.:. :... ::..: : . .: :: :..::
NP_001 NSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED----HNE----NGHTPLMEAASAG
300 310 320 330 340
100 110 120 130 140 150
pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC
:..:.: :: .::..: .... . . : ::. :::..::.:. : :: : . . ::
NP_001 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEMHTA
350 360 370 380 390 400
160 170 180 190 200 210
pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D
:: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. .
NP_001 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN
410 420 430 440 450 460
220 230 240 250 260 270
pF1KB3 GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPC
:.:::. :. :: ..: :. : :. .:: :: : :
NP_001 DEGYTPLMEAAREGHEEMVALLLA------QGANINAQTEETQETALTLACCGGFSEVAD
470 480 490 500 510 520
280 290 300 310 320 330
pF1KB3 CSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQG
NP_001 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGQAGGHEDYFGGHRSGQASGEGGL
530 540 550 560 570 580
>>NP_060448 (OMIM: 610500) ankyrin repeat and KH domain- (616 aa)
initn: 295 init1: 242 opt: 316 Z-score: 250.9 bits: 56.7 E(85289): 3.1e-07
Smith-Waterman score: 376; 33.6% identity (59.9% similar) in 262 aa overlap (5-264:263-503)
10 20 30
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL
: .. :. : :.... :: . ..
NP_060 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-----DV
240 250 260 270 280
40 50 60 70 80 90
pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG
... : :.: : : : .:.:. :... ::..: : . .: :: :..::
NP_060 NSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED----HNE----NGHTPLMEAASAG
290 300 310 320 330
100 110 120 130 140 150
pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC
:..:.: :: .::..: .... . . : ::. :::..::.:. : :: : . . ::
NP_060 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEMHTA
340 350 360 370 380 390
160 170 180 190 200 210
pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D
:: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. .
NP_060 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN
400 410 420 430 440 450
220 230 240 250 260 270
pF1KB3 GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPC
:.:::. :. :: ..: :. : :. .:: :: : :
NP_060 DEGYTPLMEAAREGHEEMVALLLA------QGANINAQTEETQETALTLACCGGFSEVAD
460 470 480 490 500 510
280 290 300 310 320 330
pF1KB3 CSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQG
NP_060 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD
520 530 540 550 560 570
>>NP_078944 (OMIM: 610500) ankyrin repeat and KH domain- (627 aa)
initn: 295 init1: 242 opt: 316 Z-score: 250.8 bits: 56.7 E(85289): 3.1e-07
Smith-Waterman score: 376; 33.6% identity (59.9% similar) in 262 aa overlap (5-264:274-514)
10 20 30
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL
: .. :. : :.... :: . ..
NP_078 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA-----DV
250 260 270 280 290
40 50 60 70 80 90
pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG
... : :.: : : : .:.:. :... ::..: : . .: :: :..::
NP_078 NSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED----HNE----NGHTPLMEAASAG
300 310 320 330 340
100 110 120 130 140 150
pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC
:..:.: :: .::..: .... . . : ::. :::..::.:. : :: : . . ::
NP_078 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEMHTA
350 360 370 380 390 400
160 170 180 190 200 210
pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D
:: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. .
NP_078 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN
410 420 430 440 450 460
220 230 240 250 260 270
pF1KB3 GYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPC
:.:::. :. :: ..: :. : :. .:: :: : :
NP_078 DEGYTPLMEAAREGHEEMVALLLA------QGANINAQTEETQETALTLACCGGFSEVAD
470 480 490 500 510 520
280 290 300 310 320 330
pF1KB3 CSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQG
NP_078 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD
530 540 550 560 570 580
>>XP_016863506 (OMIM: 615929) PREDICTED: ankyrin repeat (1116 aa)
initn: 250 init1: 250 opt: 316 Z-score: 247.7 bits: 56.9 E(85289): 4.7e-07
Smith-Waterman score: 397; 25.3% identity (50.5% similar) in 673 aa overlap (5-620:190-825)
10 20 30
pF1KB3 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDEL
: .. :: :...... ::. .. ..
XP_016 LACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA-----DV
160 170 180 190 200 210
40 50 60 70 80 90
pF1KB3 TGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAG
... . :.: : : :..:::. :.. :::.: : . .: :: :..::
XP_016 NAQSSTGNTALTYACAGGYVDVVKVLLES-GASIED----HNE----NGHTPLMEAGSAG
220 230 240 250 260
100 110 120 130 140 150
pF1KB3 HLDVVRSLLRRGASVN-RTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTC
:..:.: ::. ::..: .... . . : ::. ::::.::.:. : :: : . . ::
XP_016 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL-EAGADQEHKTDEMHTA
270 280 290 300 310 320
160 170 180 190 200 210
pF1KB3 LMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMER-D
:: .:. :: :.:: ::..::::: . . .. : : .: .:. ::. : .:. .
XP_016 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN
330 340 350 360 370 380
220 230 240 250
pF1KB3 GYGMTPLLAASVTGHTNIVEYLI--------QEQPGQEQV-----AGG--EAQPGLPQED
:.:::. :. :: ..: :. : . :: . :: :. : .
XP_016 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG
390 400 410 420 430 440
260 270 280 290 300
pF1KB3 PSTSQGCAQP------QG---------APCCSSSPEEPLNGESYESCCPTSREAAVEALE
. ::. : .: : . . . : ... ....:
XP_016 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL
450 460 470 480 490 500
310 320 330 340 350
pF1KB3 LLGATYVDK----KRDLLGALK--HWRRAMELRHQGGEY-LPKPEPPQLVLAYDYSR-EV
:: . . :. : . : .. : .:.. . . ::. . ..
XP_016 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL
510 520 530 540 550 560
360 370 380 390 400
pF1KB3 NTTEELEALITDPDE-MRMQALLIRERILGPSHPDTSYYIRYRGAVYA-----------D
..: : : .:: . .. . .. : : . : . : . . .
XP_016 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPP
570 580 590 600 610 620
410 420 430 440 450 460
pF1KB3 SGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRA-AKGSLGTQIGF
: ...: :. :: : :: .: .. . . . ... :: : .. :.
XP_016 SHDLNRAPRVPVQALPMVVPPQEPDKP--PANVATTLPIRNKAVSGRASAMSNTPTHSIA
630 640 650 660 670 680
470 480 490 500 510
pF1KB3 ADLMGVLTKGVREV-ERALQLPREPG-D-SAQFTKALAIILHLLYLLEKVECTPSQEHLK
:.. : . . .:: :. : .:: . : : :. ..:.:
XP_016 ASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTL-------ACAGGHEELV
690 700 710 720 730
520 530 540 550 560 570
pF1KB3 HQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSR-
. . : . : :.::::: .:. ..:. :: ::..::: ::: ...
XP_016 QTLLERGASIEHRDKKGFTPLILAA-----TAGH--VG------VVEILLDNGADIEAQS
740 750 760 770 780
580 590 600 610 620 630
pF1KB3 DFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYV
. ..::: .: ... ... :. ::. . :. : :
XP_016 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG
790 800 810 820 830 840
640 650 660
pF1KB3 TLQCLAARALDKNKIPYKGFIPEDLEAFIELH
XP_016 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE
850 860 870 880 890 900
669 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 12:31:39 2016 done: Thu Nov 3 12:31:41 2016
Total Scan time: 12.510 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]