Result of FASTA (omim) for pF1KB3226
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3226, 620 aa
  1>>>pF1KB3226 620 - 620 aa - 620 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 14.0240+/-0.000437; mu= -20.2022+/- 0.027
 mean_var=553.2214+/-115.197, 0's: 0 Z-trim(124.5): 37  B-trim: 1529 in 1/58
 Lambda= 0.054529
 statistics sampled from 46186 (46223) to 46186 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.808), E-opt: 0.2 (0.542), width:  16
 Scan time: 11.880

The best scores are:                                      opt bits E(85289)
XP_011536311 (OMIM: 602582) PREDICTED: E3 ubiquiti ( 620) 4378 359.2 2.5e-98
NP_004407 (OMIM: 602582) E3 ubiquitin-protein liga ( 620) 4378 359.2 2.5e-98
NP_001287656 (OMIM: 616110) E3 ubiquitin-protein l ( 513) 1871 161.9   5e-39
XP_006718546 (OMIM: 616110) PREDICTED: E3 ubiquiti ( 513) 1871 161.9   5e-39
NP_055992 (OMIM: 616110) E3 ubiquitin-protein liga ( 619) 1871 162.0 5.8e-39
XP_005250189 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
NP_001096064 (OMIM: 613141) probable E3 ubiquitin- ( 622) 1808 157.0 1.8e-37
XP_011514077 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
NP_065943 (OMIM: 613141) probable E3 ubiquitin-pro ( 622) 1808 157.0 1.8e-37
XP_011514076 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
NP_001096065 (OMIM: 613141) probable E3 ubiquitin- ( 622) 1808 157.0 1.8e-37
XP_016867213 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
XP_011514075 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
XP_016867214 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
XP_005250188 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
XP_011514074 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
XP_016867212 (OMIM: 613141) PREDICTED: probable E3 ( 622) 1808 157.0 1.8e-37
XP_016867216 (OMIM: 613141) PREDICTED: probable E3 ( 575) 1197 108.9   5e-23
NP_001096066 (OMIM: 613141) probable E3 ubiquitin- ( 575) 1197 108.9   5e-23
XP_016867215 (OMIM: 613141) PREDICTED: probable E3 ( 575) 1197 108.9   5e-23
XP_016867219 (OMIM: 613141) PREDICTED: probable E3 ( 414)  687 68.7 4.7e-11
XP_016867218 (OMIM: 613141) PREDICTED: probable E3 ( 419)  687 68.7 4.7e-11
XP_016867217 (OMIM: 613141) PREDICTED: probable E3 ( 568)  567 59.3 4.1e-08
NP_612144 (OMIM: 613143) E3 ubiquitin-protein liga ( 740)  498 54.0 2.2e-06
XP_011536324 (OMIM: 613142) PREDICTED: probable E3 ( 347)  409 46.7 0.00016
NP_848597 (OMIM: 613142) probable E3 ubiquitin-pro ( 347)  409 46.7 0.00016
NP_001273175 (OMIM: 613142) probable E3 ubiquitin- ( 347)  409 46.7 0.00016
XP_005268760 (OMIM: 613142) PREDICTED: probable E3 ( 347)  409 46.7 0.00016
NP_001273174 (OMIM: 613142) probable E3 ubiquitin- ( 350)  409 46.7 0.00016
XP_005268757 (OMIM: 613142) PREDICTED: probable E3 ( 350)  409 46.7 0.00016
XP_005268754 (OMIM: 613142) PREDICTED: probable E3 ( 350)  409 46.7 0.00016
XP_005268755 (OMIM: 613142) PREDICTED: probable E3 ( 350)  409 46.7 0.00016


>>XP_011536311 (OMIM: 602582) PREDICTED: E3 ubiquitin-pr  (620 aa)
 initn: 4378 init1: 4378 opt: 4378  Z-score: 1886.4  bits: 359.2 E(85289): 2.5e-98
Smith-Waterman score: 4378; 100.0% identity (100.0% similar) in 620 aa overlap (1-620:1-620)

               10        20        30        40        50        60
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 VLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 VGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 ASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 TQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 NEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASY
              550       560       570       580       590       600

              610       620
pF1KB3 LDNVLAELTAQGVSEAAAKA
       ::::::::::::::::::::
XP_011 LDNVLAELTAQGVSEAAAKA
              610       620

>>NP_004407 (OMIM: 602582) E3 ubiquitin-protein ligase D  (620 aa)
 initn: 4378 init1: 4378 opt: 4378  Z-score: 1886.4  bits: 359.2 E(85289): 2.5e-98
Smith-Waterman score: 4378; 100.0% identity (100.0% similar) in 620 aa overlap (1-620:1-620)

               10        20        30        40        50        60
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 VLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 YDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 VGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 ASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 TQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 NEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASY
              550       560       570       580       590       600

              610       620
pF1KB3 LDNVLAELTAQGVSEAAAKA
       ::::::::::::::::::::
NP_004 LDNVLAELTAQGVSEAAAKA
              610       620

>>NP_001287656 (OMIM: 616110) E3 ubiquitin-protein ligas  (513 aa)
 initn: 2163 init1: 1130 opt: 1871  Z-score: 821.6  bits: 161.9 E(85289): 5e-39
Smith-Waterman score: 2186; 62.4% identity (83.1% similar) in 510 aa overlap (123-615:1-505)

            100       110       120       130       140       150  
pF1KB3 RRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIY
                                     :.. ::::.::::::::.::.:.:: :.: 
NP_001                               MEVGITIQHAYEKQHPWIDLTSIGFSYVID
                                             10        20        30

            160       170       180       190            200       
pF1KB3 FNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPV--GASSG---QPCSCQQCLL
       ::.:.:.::::.:.::.:::::: ::...:..::.:::::  : ...   .:::: ::.:
NP_001 FNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
               40        50        60        70        80        90

       210             220       230       240       250       260 
pF1KB3 VNSTRAA-----SNAI-LASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAA
       : :..::     .. . :   :.. ::   .  :: ::.  ::  .  ..:. :  : .:
NP_001 VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGS--GAKPLDSTGTIRGP-LKTA
              100       110       120         130       140        

             270         280        290          300       310     
pF1KB3 PAAGPAEPAP--PPGAPPRSPGAPGGARTP-GQ---NNLNRPGPQRTTSVSARASIPPGV
       :.    . :   : :.   ::..: :  .  :.    .::: . :: . ...:. :  ::
NP_001 PSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGV
       150       160       170       180       190       200       

         320       330       340       350       360       370     
pF1KB3 PALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVP
       :..:::::::..::.:::::.::::. :::::::::: :: .:::::::::..: .::: 
NP_001 PTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVS
       210       220       230       240       250       260       

         380       390       400       410       420       430     
pF1KB3 GVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRP
       .. ::: ::. ::.:.::.:...:.:::..:::::::::::::.. :::.:   .  :.:
NP_001 NTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGP--QPTVKP
       270       280       290       300       310         320     

         440       450       460       470       480       490     
pF1KB3 ELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHS
       .:::.:.::::.::. ::::::.::::::::::::::.::: :::::::::::.::::::
NP_001 DLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHS
         330       340       350       360       370       380     

         500       510       520       530       540       550     
pF1KB3 LPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAW
       ::: :: .::::.:.:: ::::::::::::.:.:::::::::::..:::::::.::..::
NP_001 LPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAW
         390       400       410       420       430       440     

         560       570       580       590       600       610     
pF1KB3 ERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSE
       .:::::.::::.::::::::.:::.::::::::::::::::::.:::::::::.:::.::
NP_001 DRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISE
         450       460       470       480       490       500     

         620   
pF1KB3 AAAKA   
               
NP_001 DSTAQEKD
         510   

>>XP_006718546 (OMIM: 616110) PREDICTED: E3 ubiquitin-pr  (513 aa)
 initn: 2163 init1: 1130 opt: 1871  Z-score: 821.6  bits: 161.9 E(85289): 5e-39
Smith-Waterman score: 2186; 62.4% identity (83.1% similar) in 510 aa overlap (123-615:1-505)

            100       110       120       130       140       150  
pF1KB3 RRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIY
                                     :.. ::::.::::::::.::.:.:: :.: 
XP_006                               MEVGITIQHAYEKQHPWIDLTSIGFSYVID
                                             10        20        30

            160       170       180       190            200       
pF1KB3 FNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPV--GASSG---QPCSCQQCLL
       ::.:.:.::::.:.::.:::::: ::...:..::.:::::  : ...   .:::: ::.:
XP_006 FNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
               40        50        60        70        80        90

       210             220       230       240       250       260 
pF1KB3 VNSTRAA-----SNAI-LASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAA
       : :..::     .. . :   :.. ::   .  :: ::.  ::  .  ..:. :  : .:
XP_006 VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGS--GAKPLDSTGTIRGP-LKTA
              100       110       120         130       140        

             270         280        290          300       310     
pF1KB3 PAAGPAEPAP--PPGAPPRSPGAPGGARTP-GQ---NNLNRPGPQRTTSVSARASIPPGV
       :.    . :   : :.   ::..: :  .  :.    .::: . :: . ...:. :  ::
XP_006 PSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGV
       150       160       170       180       190       200       

         320       330       340       350       360       370     
pF1KB3 PALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVP
       :..:::::::..::.:::::.::::. :::::::::: :: .:::::::::..: .::: 
XP_006 PTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVS
       210       220       230       240       250       260       

         380       390       400       410       420       430     
pF1KB3 GVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRP
       .. ::: ::. ::.:.::.:...:.:::..:::::::::::::.. :::.:   .  :.:
XP_006 NTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGP--QPTVKP
       270       280       290       300       310         320     

         440       450       460       470       480       490     
pF1KB3 ELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHS
       .:::.:.::::.::. ::::::.::::::::::::::.::: :::::::::::.::::::
XP_006 DLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHS
         330       340       350       360       370       380     

         500       510       520       530       540       550     
pF1KB3 LPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAW
       ::: :: .::::.:.:: ::::::::::::.:.:::::::::::..:::::::.::..::
XP_006 LPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAW
         390       400       410       420       430       440     

         560       570       580       590       600       610     
pF1KB3 ERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSE
       .:::::.::::.::::::::.:::.::::::::::::::::::.:::::::::.:::.::
XP_006 DRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISE
         450       460       470       480       490       500     

         620   
pF1KB3 AAAKA   
               
XP_006 DSTAQEKD
         510   

>>NP_055992 (OMIM: 616110) E3 ubiquitin-protein ligase D  (619 aa)
 initn: 2559 init1: 1130 opt: 1871  Z-score: 820.5  bits: 162.0 E(85289): 5.8e-39
Smith-Waterman score: 2758; 64.9% identity (84.4% similar) in 610 aa overlap (25-615:7-611)

               10        20        30        40        50          
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDAR--G
                               ::::::::::.:::::. .: :::: :..   :  :
NP_055                   MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGG
                                 10        20        30        40  

       60        70        80        90       100       110        
pF1KB3 SVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAW
       ::::::::..:.:::::::::.::::::::.::::::.::::::::::.:::::::.:.:
NP_055 SVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSW
             50        60        70        80        90       100  

      120       130       140       150       160       170        
pF1KB3 TAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYP
       : :::.. ::::.::::::::.::.:.:: :.: ::.:.:.::::.:.::.:::::: ::
NP_055 TPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYP
            110       120       130       140       150       160  

      180       190            200       210             220       
pF1KB3 LTVGSIPKSQSWPVG---ASSG--QPCSCQQCLLVNSTRAA-----SNAI-LASQRRKAP
       ...:..::.:::::.   :.:   .:::: ::.:: :..::     .. . :   :.. :
NP_055 MVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMP
            170       180       190       200       210       220  

       230       240       250       260       270         280     
pF1KB3 PAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAP--PPGAPPRSPGAPGG
       :   .  :: ::.  ::  .  ..:. :  : .::.    . :   : :.   ::..: :
NP_055 PPGVVKLPPLPGS--GAKPLDSTGTIRGP-LKTAPSQVIRRQASSMPTGTTMGSPASPPG
            230         240        250       260       270         

          290          300       310       320       330       340 
pF1KB3 ARTP-GQ---NNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILL
         .  :.    .::: . :: . ...:. :  :::..:::::::..::.:::::.::::.
NP_055 PNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILM
     280       290       300       310       320       330         

             350       360       370       380       390       400 
pF1KB3 CAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQ
        :::::::::: :: .:::::::::..: .::: .. ::: ::. ::.:.::.:...:.:
NP_055 SAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQ
     340       350       360       370       380       390         

             410       420       430       440       450       460 
pF1KB3 KVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGN
       ::..:::::::::::::.. :::.:   .  :.:.:::.:.::::.::. ::::::.:::
NP_055 KVRHPPDEDCTICMERLTAPSGYKGP--QPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGN
     400       410       420         430       440       450       

             470       480       490       500       510       520 
pF1KB3 KDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHP
       :::::::::::.::: :::::::::::.::::::::: :: .::::.:.:: ::::::::
NP_055 KDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHP
       460       470       480       490       500       510       

             530       540       550       560       570       580 
pF1KB3 NPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIH
       ::::.:.:::::::::::..:::::::.::..::.:::::.::::.::::::::.:::.:
NP_055 NPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVH
       520       530       540       550       560       570       

             590       600       610       620   
pF1KB3 HKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA   
       :::::::::::::::::.:::::::::.:::.::        
NP_055 HKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
       580       590       600       610         

>>XP_005250189 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1732 init1: 1108 opt: 1808  Z-score: 793.7  bits: 157.0 E(85289): 1.8e-37
Smith-Waterman score: 1810; 48.2% identity (67.6% similar) in 620 aa overlap (23-615:17-616)

               10        20        30        40        50          
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIEN--VLKEDAR-
                             : :.:::: .  . :.::.::::  ::.  : ..  : 
XP_005       MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRF
                     10        20        30        40        50    

          60            70        80        90       100       110 
pF1KB3 --GSVV----LGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEW
         ::..    :::.: .:.:::::: :  :::::::::: :::...   ::::.:.::::
XP_005 GLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEW
           60        70        80        90       100       110    

             120       130       140       150       160       170 
pF1KB3 ENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRR
        .: :.::::. ..:  ...   . .  .::. ::. : . ... .: :. .   : .::
XP_005 LSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRR
          120       130       140       150       160       170    

             180       190       200       210       220       230 
pF1KB3 RLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPP
       .    ::.:.   : ...       :  :::.:::  . :  .:.    :.     :: :
XP_005 QAGPPYPVTTIIAPPGHT-------GVACSCHQCLSGSRTGPVSGRYRHSMTNL--PAYP
          180       190              200       210       220       

                  240       250       260       270       280      
pF1KB3 LPPPPPPG-----GPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGA
       .:  ::       :   :.:   . ...::   .::  . ..     :: : : :.    
XP_005 VPQHPPHRTASVFGTHQAFAPYNKPSLSGAR--SAPRLNTTNAW---GAAPPSLGSQPLY
         230       240       250         260          270       280

        290       300            310              320       330    
pF1KB3 RTPGQNNLNRPGPQR-----TTSVSARASIP------PG-VPALPVKNLNGTGPVHPALA
       :.    .:.. :::.     .:: .. ::.:      :: :::    ..   . :. :::
XP_005 RS----SLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALA
                  290       300       310       320       330      

          340       350       360       370       380       390    
pF1KB3 GMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSK-NPE
       :::..:. : ::::::.:::.:    ::.:.   :   .:  . . . :    : . .::
XP_005 GMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPE
        340       350         360       370       380       390    

           400       410       420       430       440       450   
pF1KB3 DVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCL
       .:.. : ...: :::::: ::::.: :::::  :   :..    ::.: .:.: .:::::
XP_005 QVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCL
          400       410       420       430       440       450    

           460       470       480       490       500       510   
pF1KB3 VAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPT
       .::: :::::::::::.::.:::::::::: ::::   .  ::::  :  :: :::.:: 
XP_005 LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPH
          460       470       480       490       500       510    

           520       530       540       550       560       570   
pF1KB3 GIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESD
       :::::::::::: ::::::::.::::.: .:::::.:: .::.::::::.:::.::::.:
XP_005 GIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETD
          520       530       540       550       560       570    

           580       590       600       610       620 
pF1KB3 TVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA 
       ::::::::::::.  :.::::::: .::.::::::.::::.:      
XP_005 TVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
          580       590       600       610       620  

>>NP_001096064 (OMIM: 613141) probable E3 ubiquitin-prot  (622 aa)
 initn: 1732 init1: 1108 opt: 1808  Z-score: 793.7  bits: 157.0 E(85289): 1.8e-37
Smith-Waterman score: 1810; 48.2% identity (67.6% similar) in 620 aa overlap (23-615:17-616)

               10        20        30        40        50          
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIEN--VLKEDAR-
                             : :.:::: .  . :.::.::::  ::.  : ..  : 
NP_001       MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRF
                     10        20        30        40        50    

          60            70        80        90       100       110 
pF1KB3 --GSVV----LGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEW
         ::..    :::.: .:.:::::: :  :::::::::: :::...   ::::.:.::::
NP_001 GLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEW
           60        70        80        90       100       110    

             120       130       140       150       160       170 
pF1KB3 ENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRR
        .: :.::::. ..:  ...   . .  .::. ::. : . ... .: :. .   : .::
NP_001 LSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRR
          120       130       140       150       160       170    

             180       190       200       210       220       230 
pF1KB3 RLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPP
       .    ::.:.   : ...       :  :::.:::  . :  .:.    :.     :: :
NP_001 QAGPPYPVTTIIAPPGHT-------GVACSCHQCLSGSRTGPVSGRYRHSMTNL--PAYP
          180       190              200       210       220       

                  240       250       260       270       280      
pF1KB3 LPPPPPPG-----GPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGA
       .:  ::       :   :.:   . ...::   .::  . ..     :: : : :.    
NP_001 VPQHPPHRTASVFGTHQAFAPYNKPSLSGAR--SAPRLNTTNAW---GAAPPSLGSQPLY
         230       240       250         260          270       280

        290       300            310              320       330    
pF1KB3 RTPGQNNLNRPGPQR-----TTSVSARASIP------PG-VPALPVKNLNGTGPVHPALA
       :.    .:.. :::.     .:: .. ::.:      :: :::    ..   . :. :::
NP_001 RS----SLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALA
                  290       300       310       320       330      

          340       350       360       370       380       390    
pF1KB3 GMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSK-NPE
       :::..:. : ::::::.:::.:    ::.:.   :   .:  . . . :    : . .::
NP_001 GMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPE
        340       350         360       370       380       390    

           400       410       420       430       440       450   
pF1KB3 DVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCL
       .:.. : ...: :::::: ::::.: :::::  :   :..    ::.: .:.: .:::::
NP_001 QVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCL
          400       410       420       430       440       450    

           460       470       480       490       500       510   
pF1KB3 VAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPT
       .::: :::::::::::.::.:::::::::: ::::   .  ::::  :  :: :::.:: 
NP_001 LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPH
          460       470       480       490       500       510    

           520       530       540       550       560       570   
pF1KB3 GIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESD
       :::::::::::: ::::::::.::::.: .:::::.:: .::.::::::.:::.::::.:
NP_001 GIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETD
          520       530       540       550       560       570    

           580       590       600       610       620 
pF1KB3 TVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA 
       ::::::::::::.  :.::::::: .::.::::::.::::.:      
NP_001 TVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
          580       590       600       610       620  

>>XP_011514077 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1732 init1: 1108 opt: 1808  Z-score: 793.7  bits: 157.0 E(85289): 1.8e-37
Smith-Waterman score: 1810; 48.2% identity (67.6% similar) in 620 aa overlap (23-615:17-616)

               10        20        30        40        50          
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIEN--VLKEDAR-
                             : :.:::: .  . :.::.::::  ::.  : ..  : 
XP_011       MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRF
                     10        20        30        40        50    

          60            70        80        90       100       110 
pF1KB3 --GSVV----LGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEW
         ::..    :::.: .:.:::::: :  :::::::::: :::...   ::::.:.::::
XP_011 GLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEW
           60        70        80        90       100       110    

             120       130       140       150       160       170 
pF1KB3 ENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRR
        .: :.::::. ..:  ...   . .  .::. ::. : . ... .: :. .   : .::
XP_011 LSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRR
          120       130       140       150       160       170    

             180       190       200       210       220       230 
pF1KB3 RLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPP
       .    ::.:.   : ...       :  :::.:::  . :  .:.    :.     :: :
XP_011 QAGPPYPVTTIIAPPGHT-------GVACSCHQCLSGSRTGPVSGRYRHSMTNL--PAYP
          180       190              200       210       220       

                  240       250       260       270       280      
pF1KB3 LPPPPPPG-----GPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGA
       .:  ::       :   :.:   . ...::   .::  . ..     :: : : :.    
XP_011 VPQHPPHRTASVFGTHQAFAPYNKPSLSGAR--SAPRLNTTNAW---GAAPPSLGSQPLY
         230       240       250         260          270       280

        290       300            310              320       330    
pF1KB3 RTPGQNNLNRPGPQR-----TTSVSARASIP------PG-VPALPVKNLNGTGPVHPALA
       :.    .:.. :::.     .:: .. ::.:      :: :::    ..   . :. :::
XP_011 RS----SLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALA
                  290       300       310       320       330      

          340       350       360       370       380       390    
pF1KB3 GMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSK-NPE
       :::..:. : ::::::.:::.:    ::.:.   :   .:  . . . :    : . .::
XP_011 GMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPE
        340       350         360       370       380       390    

           400       410       420       430       440       450   
pF1KB3 DVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCL
       .:.. : ...: :::::: ::::.: :::::  :   :..    ::.: .:.: .:::::
XP_011 QVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCL
          400       410       420       430       440       450    

           460       470       480       490       500       510   
pF1KB3 VAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPT
       .::: :::::::::::.::.:::::::::: ::::   .  ::::  :  :: :::.:: 
XP_011 LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPH
          460       470       480       490       500       510    

           520       530       540       550       560       570   
pF1KB3 GIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESD
       :::::::::::: ::::::::.::::.: .:::::.:: .::.::::::.:::.::::.:
XP_011 GIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETD
          520       530       540       550       560       570    

           580       590       600       610       620 
pF1KB3 TVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA 
       ::::::::::::.  :.::::::: .::.::::::.::::.:      
XP_011 TVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
          580       590       600       610       620  

>>NP_065943 (OMIM: 613141) probable E3 ubiquitin-protein  (622 aa)
 initn: 1732 init1: 1108 opt: 1808  Z-score: 793.7  bits: 157.0 E(85289): 1.8e-37
Smith-Waterman score: 1810; 48.2% identity (67.6% similar) in 620 aa overlap (23-615:17-616)

               10        20        30        40        50          
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIEN--VLKEDAR-
                             : :.:::: .  . :.::.::::  ::.  : ..  : 
NP_065       MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRF
                     10        20        30        40        50    

          60            70        80        90       100       110 
pF1KB3 --GSVV----LGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEW
         ::..    :::.: .:.:::::: :  :::::::::: :::...   ::::.:.::::
NP_065 GLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEW
           60        70        80        90       100       110    

             120       130       140       150       160       170 
pF1KB3 ENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRR
        .: :.::::. ..:  ...   . .  .::. ::. : . ... .: :. .   : .::
NP_065 LSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRR
          120       130       140       150       160       170    

             180       190       200       210       220       230 
pF1KB3 RLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPP
       .    ::.:.   : ...       :  :::.:::  . :  .:.    :.     :: :
NP_065 QAGPPYPVTTIIAPPGHT-------GVACSCHQCLSGSRTGPVSGRYRHSMTNL--PAYP
          180       190              200       210       220       

                  240       250       260       270       280      
pF1KB3 LPPPPPPG-----GPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGA
       .:  ::       :   :.:   . ...::   .::  . ..     :: : : :.    
NP_065 VPQHPPHRTASVFGTHQAFAPYNKPSLSGAR--SAPRLNTTNAW---GAAPPSLGSQPLY
         230       240       250         260          270       280

        290       300            310              320       330    
pF1KB3 RTPGQNNLNRPGPQR-----TTSVSARASIP------PG-VPALPVKNLNGTGPVHPALA
       :.    .:.. :::.     .:: .. ::.:      :: :::    ..   . :. :::
NP_065 RS----SLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALA
                  290       300       310       320       330      

          340       350       360       370       380       390    
pF1KB3 GMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSK-NPE
       :::..:. : ::::::.:::.:    ::.:.   :   .:  . . . :    : . .::
NP_065 GMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPE
        340       350         360       370       380       390    

           400       410       420       430       440       450   
pF1KB3 DVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCL
       .:.. : ...: :::::: ::::.: :::::  :   :..    ::.: .:.: .:::::
NP_065 QVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCL
          400       410       420       430       440       450    

           460       470       480       490       500       510   
pF1KB3 VAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPT
       .::: :::::::::::.::.:::::::::: ::::   .  ::::  :  :: :::.:: 
NP_065 LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPH
          460       470       480       490       500       510    

           520       530       540       550       560       570   
pF1KB3 GIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESD
       :::::::::::: ::::::::.::::.: .:::::.:: .::.::::::.:::.::::.:
NP_065 GIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETD
          520       530       540       550       560       570    

           580       590       600       610       620 
pF1KB3 TVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA 
       ::::::::::::.  :.::::::: .::.::::::.::::.:      
NP_065 TVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
          580       590       600       610       620  

>>XP_011514076 (OMIM: 613141) PREDICTED: probable E3 ubi  (622 aa)
 initn: 1732 init1: 1108 opt: 1808  Z-score: 793.7  bits: 157.0 E(85289): 1.8e-37
Smith-Waterman score: 1810; 48.2% identity (67.6% similar) in 620 aa overlap (23-615:17-616)

               10        20        30        40        50          
pF1KB3 MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIEN--VLKEDAR-
                             : :.:::: .  . :.::.::::  ::.  : ..  : 
XP_011       MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRF
                     10        20        30        40        50    

          60            70        80        90       100       110 
pF1KB3 --GSVV----LGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEW
         ::..    :::.: .:.:::::: :  :::::::::: :::...   ::::.:.::::
XP_011 GLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEW
           60        70        80        90       100       110    

             120       130       140       150       160       170 
pF1KB3 ENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRR
        .: :.::::. ..:  ...   . .  .::. ::. : . ... .: :. .   : .::
XP_011 LSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRR
          120       130       140       150       160       170    

             180       190       200       210       220       230 
pF1KB3 RLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPP
       .    ::.:.   : ...       :  :::.:::  . :  .:.    :.     :: :
XP_011 QAGPPYPVTTIIAPPGHT-------GVACSCHQCLSGSRTGPVSGRYRHSMTNL--PAYP
          180       190              200       210       220       

                  240       250       260       270       280      
pF1KB3 LPPPPPPG-----GPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGA
       .:  ::       :   :.:   . ...::   .::  . ..     :: : : :.    
XP_011 VPQHPPHRTASVFGTHQAFAPYNKPSLSGAR--SAPRLNTTNAW---GAAPPSLGSQPLY
         230       240       250         260          270       280

        290       300            310              320       330    
pF1KB3 RTPGQNNLNRPGPQR-----TTSVSARASIP------PG-VPALPVKNLNGTGPVHPALA
       :.    .:.. :::.     .:: .. ::.:      :: :::    ..   . :. :::
XP_011 RS----SLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALA
                  290       300       310       320       330      

          340       350       360       370       380       390    
pF1KB3 GMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSK-NPE
       :::..:. : ::::::.:::.:    ::.:.   :   .:  . . . :    : . .::
XP_011 GMTSVLMSAIGLPVCLSRAPQPT--SPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPE
        340       350         360       370       380       390    

           400       410       420       430       440       450   
pF1KB3 DVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCL
       .:.. : ...: :::::: ::::.: :::::  :   :..    ::.: .:.: .:::::
XP_011 QVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCL
          400       410       420       430       440       450    

           460       470       480       490       500       510   
pF1KB3 VAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPT
       .::: :::::::::::.::.:::::::::: ::::   .  ::::  :  :: :::.:: 
XP_011 LAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPH
          460       470       480       490       500       510    

           520       530       540       550       560       570   
pF1KB3 GIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESD
       :::::::::::: ::::::::.::::.: .:::::.:: .::.::::::.:::.::::.:
XP_011 GIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETD
          520       530       540       550       560       570    

           580       590       600       610       620 
pF1KB3 TVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA 
       ::::::::::::.  :.::::::: .::.::::::.::::.:      
XP_011 TVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
          580       590       600       610       620  




620 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 12:35:19 2016 done: Thu Nov  3 12:35:20 2016
 Total Scan time: 11.880 Total Display time:  0.150

Function used was FASTA [36.3.4 Apr, 2011]
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