FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3253, 621 aa 1>>>pF1KB3253 621 - 621 aa - 621 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7442+/-0.000435; mu= 17.9841+/- 0.027 mean_var=94.2684+/-19.144, 0's: 0 Z-trim(111.2): 118 B-trim: 16 in 1/52 Lambda= 0.132096 statistics sampled from 19581 (19699) to 19581 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.581), E-opt: 0.2 (0.231), width: 16 Scan time: 6.150 The best scores are: opt bits E(85289) NP_004676 (OMIM: 603561) myotubularin-related prot ( 621) 4182 808.0 0 XP_016876334 (OMIM: 603561) PREDICTED: myotubulari ( 535) 3348 649.0 1.2e-185 XP_016876335 (OMIM: 603561) PREDICTED: myotubulari ( 426) 2549 496.7 6.9e-140 XP_011533608 (OMIM: 603561) PREDICTED: myotubulari ( 659) 2549 496.8 9.6e-140 NP_004677 (OMIM: 603562) myotubularin-related prot ( 660) 2460 479.9 1.2e-134 XP_011533609 (OMIM: 603561) PREDICTED: myotubulari ( 573) 1715 337.8 6e-92 XP_011542994 (OMIM: 603562) PREDICTED: myotubulari ( 439) 1456 288.4 3.6e-77 XP_011542995 (OMIM: 603562) PREDICTED: myotubulari ( 423) 1354 268.9 2.5e-71 XP_006716477 (OMIM: 603562) PREDICTED: myotubulari ( 423) 1354 268.9 2.5e-71 XP_016874007 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 XP_006718998 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 XP_006718999 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 XP_006718997 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 NP_001230500 (OMIM: 601382,603557) myotubularin-re ( 571) 1278 254.6 7.1e-67 NP_958438 (OMIM: 601382,603557) myotubularin-relat ( 571) 1278 254.6 7.1e-67 XP_005274431 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 XP_016874006 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 XP_005274432 (OMIM: 601382,603557) PREDICTED: myot ( 571) 1278 254.6 7.1e-67 NP_958435 (OMIM: 601382,603557) myotubularin-relat ( 571) 1278 254.6 7.1e-67 XP_011541361 (OMIM: 601382,603557) PREDICTED: myot ( 596) 1278 254.6 7.3e-67 XP_011541360 (OMIM: 601382,603557) PREDICTED: myot ( 596) 1278 254.6 7.3e-67 NP_057240 (OMIM: 601382,603557) myotubularin-relat ( 643) 1278 254.6 7.7e-67 NP_000243 (OMIM: 300415,310400) myotubularin [Homo ( 603) 1244 248.1 6.6e-65 XP_011529475 (OMIM: 300415,310400) PREDICTED: myot ( 603) 1244 248.1 6.6e-65 XP_005274744 (OMIM: 300415,310400) PREDICTED: myot ( 603) 1244 248.1 6.6e-65 XP_016885038 (OMIM: 300415,310400) PREDICTED: myot ( 602) 1243 247.9 7.5e-65 XP_011529473 (OMIM: 300415,310400) PREDICTED: myot ( 618) 1237 246.8 1.7e-64 XP_011529474 (OMIM: 300415,310400) PREDICTED: myot ( 618) 1237 246.8 1.7e-64 XP_016885037 (OMIM: 300415,310400) PREDICTED: myot ( 618) 1237 246.8 1.7e-64 XP_016885036 (OMIM: 300415,310400) PREDICTED: myot ( 617) 1236 246.6 1.9e-64 XP_016885412 (OMIM: 300171) PREDICTED: myotubulari ( 552) 1212 242.0 4.2e-63 XP_016885410 (OMIM: 300171) PREDICTED: myotubulari ( 571) 1212 242.0 4.3e-63 XP_011529511 (OMIM: 300171) PREDICTED: myotubulari ( 571) 1212 242.0 4.3e-63 XP_016885411 (OMIM: 300171) PREDICTED: myotubulari ( 571) 1212 242.0 4.3e-63 XP_006724918 (OMIM: 300171) PREDICTED: myotubulari ( 665) 1212 242.0 4.9e-63 NP_003819 (OMIM: 300171) myotubularin-related prot ( 665) 1212 242.0 4.9e-63 NP_001293073 (OMIM: 300171) myotubularin-related p ( 673) 1212 242.0 4.9e-63 XP_005274824 (OMIM: 300171) PREDICTED: myotubulari ( 682) 1212 242.0 5e-63 XP_005274823 (OMIM: 300171) PREDICTED: myotubulari ( 682) 1212 242.0 5e-63 XP_005274822 (OMIM: 300171) PREDICTED: myotubulari ( 699) 1212 242.1 5e-63 XP_016885039 (OMIM: 300415,310400) PREDICTED: myot ( 566) 1206 240.8 9.5e-63 NP_056273 (OMIM: 606260) myotubularin-related prot ( 549) 1145 229.2 2.9e-59 XP_016885409 (OMIM: 300171) PREDICTED: myotubulari ( 602) 1103 221.2 8.1e-57 XP_016869445 (OMIM: 603562) PREDICTED: myotubulari ( 372) 1085 217.6 6e-56 XP_011542132 (OMIM: 606260) PREDICTED: myotubulari ( 442) 985 198.6 3.8e-50 XP_016885040 (OMIM: 300415,310400) PREDICTED: myot ( 355) 912 184.6 4.9e-46 XP_011542133 (OMIM: 606260) PREDICTED: myotubulari ( 353) 795 162.3 2.5e-39 XP_016884522 (OMIM: 603558) PREDICTED: myotubulari (1069) 761 156.3 5.2e-37 NP_694691 (OMIM: 603558) myotubularin-related prot (1161) 761 156.3 5.5e-37 XP_016884521 (OMIM: 603558) PREDICTED: myotubulari (1161) 761 156.3 5.5e-37 >>NP_004676 (OMIM: 603561) myotubularin-related protein (621 aa) initn: 4182 init1: 4182 opt: 4182 Z-score: 4312.1 bits: 808.0 E(85289): 0 Smith-Waterman score: 4182; 99.8% identity (100.0% similar) in 621 aa overlap (1-621:1-621) 10 20 30 40 50 60 pF1KB3 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 PKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 GLESSGWLRHIKAVMDAAVFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRT ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_004 GLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 IKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 FLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 KNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAE 550 560 570 580 590 600 610 620 pF1KB3 EFSKSEPAVVSLEYGVARMTC ::::::::::::::::::::: NP_004 EFSKSEPAVVSLEYGVARMTC 610 620 >>XP_016876334 (OMIM: 603561) PREDICTED: myotubularin-re (535 aa) initn: 3335 init1: 3335 opt: 3348 Z-score: 3454.0 bits: 649.0 E(85289): 1.2e-185 Smith-Waterman score: 3348; 95.9% identity (97.7% similar) in 518 aa overlap (1-518:1-518) 10 20 30 40 50 60 pF1KB3 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 PKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 GLESSGWLRHIKAVMDAAVFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRT ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 GLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 IKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 FLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQR ::::::::::::: : . . . ::. ...:.: XP_016 TVLEPNTVSFNFKKLNNAKISKQMASSPRNCYIQFILNHLTSKLPCVLKSRLCYP 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 KNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAE >>XP_016876335 (OMIM: 603561) PREDICTED: myotubularin-re (426 aa) initn: 2549 init1: 2549 opt: 2549 Z-score: 2632.4 bits: 496.7 E(85289): 6.9e-140 Smith-Waterman score: 2549; 98.4% identity (99.5% similar) in 384 aa overlap (238-621:43-426) 210 220 230 240 250 260 pF1KB3 SGFSARCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQ . . .::::::::::::::::::::::::: XP_016 QSWWATQKDIGRIIVRISSKIQNDEKIRESNEKKRLNAMANRAAGKGYENEDNYSNIRFQ 20 30 40 50 60 70 270 280 290 300 310 320 pF1KB3 FVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLAKAITV :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 FVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITV 80 90 100 110 120 130 330 340 350 360 370 380 pF1KB3 ENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLD 140 150 160 170 180 190 390 400 410 420 430 440 pF1KB3 GDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREE 200 210 220 230 240 250 450 460 470 480 490 500 pF1KB3 LKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLH 260 270 280 290 300 310 510 520 530 540 550 560 pF1KB3 PRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTS 320 330 340 350 360 370 570 580 590 600 610 620 pF1KB3 LCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC 380 390 400 410 420 >>XP_011533608 (OMIM: 603561) PREDICTED: myotubularin-re (659 aa) initn: 2549 init1: 2549 opt: 2549 Z-score: 2629.9 bits: 496.8 E(85289): 9.6e-140 Smith-Waterman score: 4056; 94.0% identity (94.2% similar) in 653 aa overlap (7-621:7-659) 10 20 30 40 50 60 pF1KB3 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR 190 200 210 220 230 240 250 260 pF1KB3 PK--------------------------------------LNAMANRAAGKGYENEDNYS :: :::::::::::::::::::: XP_011 PKRRMQSWWATQKDIGRIIVRISSKIQNDEKIRESNEKKRLNAMANRAAGKGYENEDNYS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB3 NIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: XP_011 NIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLA 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB3 KAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSER 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB3 CGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQ 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB3 KEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQF 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB3 DRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB3 NLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC 610 620 630 640 650 >>NP_004677 (OMIM: 603562) myotubularin-related protein (660 aa) initn: 2448 init1: 2171 opt: 2460 Z-score: 2538.2 bits: 479.9 E(85289): 1.2e-134 Smith-Waterman score: 2471; 57.3% identity (81.5% similar) in 634 aa overlap (1-621:1-632) 10 20 30 40 50 pF1KB3 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSH---QKETWILHHHIASVE :::::: :::.:.:.:: : .. .: :::::::::..:... .::::::: .:...: NP_004 MEHIRTPKVENVRLVDRVSPKKAAL-GTLYLTATHVIFVENSPDPRKETWILHSQISTIE 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 KLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQN : : :..::::.:.::::. ...:.:.::::::.: ::..:.. .:::.:: ::.:: . NP_004 KQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 DSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGS :: ::: ::::.::: :::.:: .:::::.::::..:..:: :::::. :. ::::: NP_004 KEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 SKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVM :::::. ::::::::..:..:.::: :::::::::::::::..:::: :::: . ..::. NP_004 SKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 DTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVND :::::::::::::::::::::::::::.:::.:::::::::.::::.::: :. :..: NP_004 DTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSD 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 FYSGLESSGWLRHIKAVMDAAVFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSY : :::.:::::::::.:::..:.:::.. :.::::::::::::::.::::..::::: . NP_004 FLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPH 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 YRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEF :::.::::::::::::::::::..: :.:::::::.:::. ::.::::.: :::: :::: NP_004 YRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEF 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 SEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSES .: ::..:..::.:::::::: : ::::.:::..:.::::: : ... :::::. .. NP_004 NERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADH 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 HRF--TVLEPNT-VSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLE . :. :.: .: .::: .::..:.. ..::::: . .: ..:...:::.... :: NP_004 SQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALE 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 SKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPA--- .... .. : . .: .: . ...:: .: . .... . ::. NP_004 ERLEKIQKVQLNCTKVKSK-QSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGD 540 550 560 570 580 590 600 610 620 pF1KB3 -DNRYSEYAEEFSKSEP---AVVSLEYGVARMTC :. .....:.: : . : :: ..: NP_004 EDSALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFL 600 610 620 630 640 650 NP_004 TA 660 >>XP_011533609 (OMIM: 603561) PREDICTED: myotubularin-re (573 aa) initn: 1702 init1: 1702 opt: 1715 Z-score: 1771.7 bits: 337.8 E(85289): 6e-92 Smith-Waterman score: 3222; 89.3% identity (90.9% similar) in 550 aa overlap (7-518:7-556) 10 20 30 40 50 60 pF1KB3 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTR 190 200 210 220 230 240 250 260 pF1KB3 PK--------------------------------------LNAMANRAAGKGYENEDNYS :: :::::::::::::::::::: XP_011 PKRRMQSWWATQKDIGRIIVRISSKIQNDEKIRESNEKKRLNAMANRAAGKGYENEDNYS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB3 NIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: XP_011 NIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLA 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB3 KAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSER 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB3 CGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQ 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB3 KEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQF ::::::::::::::::::::::::::::::::::::::::::::::::::: : . XP_011 KEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKKLNNAKISK 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB3 DRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESP . . ::. ...:.: XP_011 QMASSPRNCYIQFILNHLTSKLPCVLKSRLCYP 550 560 570 >>XP_011542994 (OMIM: 603562) PREDICTED: myotubularin-re (439 aa) initn: 1443 init1: 1305 opt: 1456 Z-score: 1506.5 bits: 288.4 E(85289): 3.6e-77 Smith-Waterman score: 1467; 54.1% identity (78.9% similar) in 412 aa overlap (220-621:1-411) 190 200 210 220 230 240 pF1KB3 SYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANR .:::: :::: . ..::.:::::::::::: XP_011 MLQAIRKANPGSDFVYVVDTRPKLNAMANR 10 20 30 250 260 270 280 290 300 pF1KB3 AAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLR :::::::::::::::.:::.:::::::::.::::.::: :. :..:: :::.::::: XP_011 AAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLR 40 50 60 70 80 90 310 320 330 340 350 360 pF1KB3 HIKAVMDAAVFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIE ::::.:::..:.:::.. :.::::::::::::::.::::..::::: .:::.:::::::: XP_011 HIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIE 100 110 120 130 140 150 370 380 390 400 410 420 pF1KB3 KDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHI ::::::::::..: :.:::::::.:::. ::.::::.: :::: ::::.: ::..:..:: XP_011 KDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHI 160 170 180 190 200 210 430 440 450 460 470 480 pF1KB3 HSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRF--TVLEPNT .:::::::: : ::::.:::..:.::::: : ... :::::. .. . :. :.: XP_011 YSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTT 220 230 240 250 260 270 490 500 510 520 530 540 pF1KB3 -VSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTD .: .::: .::..:.. ..::::: . .: ..:...:::.... :: .... .. : . XP_011 PCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLN 280 290 300 310 320 330 550 560 570 580 590 600 pF1KB3 GILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPA----DNRYSEYAEEF .: .: . ...:: .: . .... . ::. :. ... XP_011 CTKVKSK-QSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNL 340 350 360 370 380 610 620 pF1KB3 SKSEP---AVVSLEYGVARMTC ..:.: : . : :: ..: XP_011 KSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA 390 400 410 420 430 >>XP_011542995 (OMIM: 603562) PREDICTED: myotubularin-re (423 aa) initn: 1341 init1: 1203 opt: 1354 Z-score: 1401.7 bits: 268.9 E(85289): 2.5e-71 Smith-Waterman score: 1365; 53.5% identity (78.4% similar) in 389 aa overlap (243-621:8-395) 220 230 240 250 260 270 pF1KB3 RCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIE ::::::::::::::::::::::.:::.::: XP_011 MEIFYLNLNAMANRAAGKGYENEDNYSNIKFQFIGIE 10 20 30 280 290 300 310 320 330 pF1KB3 NIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLAKAITVENASV ::::::.::::.::: :. :..:: :::.:::::::::.:::..:.:::.. :.::: XP_011 NIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV 40 50 60 70 80 90 340 350 360 370 380 390 pF1KB3 LVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKE :::::::::::.::::..::::: .:::.::::::::::::::::::..: :.::::::: XP_011 LVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKE 100 110 120 130 140 150 400 410 420 430 440 450 pF1KB3 VSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKE .:::. ::.::::.: :::: ::::.: ::..:..::.:::::::: : ::::.:::..: XP_011 ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQE 160 170 180 190 200 210 460 470 480 490 500 pF1KB3 KTYSLWPFLLEDQKKYLNPLYSSESHRF--TVLEPNT-VSFNFKFWRNMYHQFDRTLHPR .::::: : ... :::::. .. . :. :.: .: .::: .::..:.. ..:: XP_011 RTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPR 220 230 240 250 260 270 510 520 530 540 550 560 pF1KB3 QSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLC ::: . .: ..:...:::.... :: .... .. : . .: .: . ...:: XP_011 QSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSK-QSEPSKHSGFSTSDN 280 290 300 310 320 330 570 580 590 600 610 620 pF1KB3 FKEQTLLPVNDALRTIEGSSPA----DNRYSEYAEEFSKSEP---AVVSLEYGVARMTC .: . .... . ::. :. .....:.: : . : :: ..: XP_011 SIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCR 340 350 360 370 380 390 XP_011 SPSGGEHAPSEDSGKDRDSDEAVFLTA 400 410 420 >>XP_006716477 (OMIM: 603562) PREDICTED: myotubularin-re (423 aa) initn: 1341 init1: 1203 opt: 1354 Z-score: 1401.7 bits: 268.9 E(85289): 2.5e-71 Smith-Waterman score: 1365; 53.5% identity (78.4% similar) in 389 aa overlap (243-621:8-395) 220 230 240 250 260 270 pF1KB3 RCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIE ::::::::::::::::::::::.:::.::: XP_006 MEIFYLNLNAMANRAAGKGYENEDNYSNIKFQFIGIE 10 20 30 280 290 300 310 320 330 pF1KB3 NIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLAKAITVENASV ::::::.::::.::: :. :..:: :::.:::::::::.:::..:.:::.. :.::: XP_006 NIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV 40 50 60 70 80 90 340 350 360 370 380 390 pF1KB3 LVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKE :::::::::::.::::..::::: .:::.::::::::::::::::::..: :.::::::: XP_006 LVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKE 100 110 120 130 140 150 400 410 420 430 440 450 pF1KB3 VSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKE .:::. ::.::::.: :::: ::::.: ::..:..::.:::::::: : ::::.:::..: XP_006 ISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQE 160 170 180 190 200 210 460 470 480 490 500 pF1KB3 KTYSLWPFLLEDQKKYLNPLYSSESHRF--TVLEPNT-VSFNFKFWRNMYHQFDRTLHPR .::::: : ... :::::. .. . :. :.: .: .::: .::..:.. ..:: XP_006 RTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPR 220 230 240 250 260 270 510 520 530 540 550 560 pF1KB3 QSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLC ::: . .: ..:...:::.... :: .... .. : . .: .: . ...:: XP_006 QSVTDYLMAVKEETQQLEEELEALEERLEKIQKVQLNCTKVKSK-QSEPSKHSGFSTSDN 280 290 300 310 320 330 570 580 590 600 610 620 pF1KB3 FKEQTLLPVNDALRTIEGSSPA----DNRYSEYAEEFSKSEP---AVVSLEYGVARMTC .: . .... . ::. :. .....:.: : . : :: ..: XP_006 SIANTPQDYSGNMKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSANSDQESGVEDLSCR 340 350 360 370 380 390 XP_006 SPSGGEHAPSEDSGKDRDSDEAVFLTA 400 410 420 >>XP_016874007 (OMIM: 601382,603557) PREDICTED: myotubul (571 aa) initn: 851 init1: 556 opt: 1278 Z-score: 1321.6 bits: 254.6 E(85289): 7.1e-67 Smith-Waterman score: 1278; 38.2% identity (70.2% similar) in 534 aa overlap (24-546:28-555) 10 20 30 40 50 pF1KB3 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHH---I .. ::: .: .: : . .. ..: : XP_016 MEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVI 10 20 30 40 50 60 60 70 80 90 100 pF1KB3 ASVEKLALTTS----GCPLVIQCKNFRTVHFI-VPRERDCHDIYNSLLQLSKQAKYEDLY :::.. ..: . : ::..:...: :. : ..:...:.. . .. ..: XP_016 NRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVS-NNLP 70 80 90 100 110 110 120 130 140 150 160 pF1KB3 AFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRI :... :. : .::.: : ::.:.:.:: :... :. :..:.::: : :: XP_016 LFAFEYKEVFPE--NGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPAN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB3 ASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSA-RCLEDEHLLQAISKA . ..:::.::.::::. : ...:.: :::::. : :. : :::. :::: . XP_016 IPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB3 NPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEV : .. ....:.::..::.::.: : :::.:: :.: .. :. :.:::::: ::.:: :. XP_016 NAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEI 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB3 NGTKGLSVNDFYSGLESSGWLRHIKAVMDAAVFLAKAITVENASVLVHCSDGWDRTSQVC .. . . :.:::. ::.::: .. .:. .: . ..::.::::::::::.:. XP_016 V-YPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB3 SLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEV--SPVFTQFLECVW ::. :.::.:::::.:: ::.::.:.::::.:. : :. : . .. :::: ::..::: XP_016 SLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVW 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB3 HLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQ ..:.::: ::::.: ::. : .:..:: ::.:: : ...: . .: ..: ::: .. . XP_016 QMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQL 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB3 KKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQ . . ::::.: :.. :: : . ....: ..: ... ..:.. . : .. . . XP_016 EDFTNPLYGSYSNH--VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAE 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB3 LEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTI :.: ...:. .:..:...... XP_016 LQKKVEELQREISNRSTSSSERASSPAQCVTPVQTVV 540 550 560 570 621 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:39:52 2016 done: Thu Nov 3 12:39:53 2016 Total Scan time: 6.150 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]