Result of FASTA (omim) for
pF1KB3264
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3264, 847 aa
1>>>pF1KB3264 847 - 847 aa - 847 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3400+/-0.000663; mu= 1.5651+/- 0.040
mean_var=386.6401+/-83.565, 0's: 0 Z-trim(114.5): 325 B-trim: 33 in 1/51
Lambda= 0.065226
statistics sampled from 24044 (24386) to 24044 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.286), width: 16
Scan time: 12.710
The best scores are: opt bits E(85289)
NP_006104 (OMIM: 605541) guanine nucleotide exchan ( 847) 5737 555.9 2.8e-157
XP_016855543 (OMIM: 605541) PREDICTED: guanine nuc ( 783) 5297 514.4 7.8e-145
XP_016855544 (OMIM: 605541) PREDICTED: guanine nuc ( 751) 4992 485.7 3.3e-136
XP_005270417 (OMIM: 605541) PREDICTED: guanine nuc ( 753) 4986 485.1 4.9e-136
XP_005270418 (OMIM: 605541) PREDICTED: guanine nuc ( 621) 3994 391.7 5.5e-108
XP_016855542 (OMIM: 605541) PREDICTED: guanine nuc ( 823) 3828 376.2 3.3e-103
NP_005419 (OMIM: 164875) proto-oncogene vav isofor ( 845) 3429 338.7 6.8e-92
XP_005259699 (OMIM: 164875) PREDICTED: proto-oncog ( 821) 3004 298.7 7.3e-80
XP_016855545 (OMIM: 605541) PREDICTED: guanine nuc ( 407) 2823 281.3 6.3e-75
NP_001127870 (OMIM: 600428) guanine nucleotide exc ( 878) 2675 267.8 1.6e-70
NP_001245135 (OMIM: 164875) proto-oncogene vav iso ( 823) 2674 267.6 1.6e-70
NP_001245136 (OMIM: 164875) proto-oncogene vav iso ( 813) 2416 243.3 3.3e-63
NP_003362 (OMIM: 600428) guanine nucleotide exchan ( 839) 2290 231.5 1.2e-59
XP_005272270 (OMIM: 600428) PREDICTED: guanine nuc ( 868) 2290 231.5 1.3e-59
XP_016870601 (OMIM: 600428) PREDICTED: guanine nuc ( 844) 2280 230.6 2.4e-59
XP_016870599 (OMIM: 600428) PREDICTED: guanine nuc ( 873) 2280 230.6 2.4e-59
XP_016870598 (OMIM: 600428) PREDICTED: guanine nuc ( 891) 1958 200.3 3.3e-50
XP_016870600 (OMIM: 600428) PREDICTED: guanine nuc ( 867) 1948 199.3 6.2e-50
XP_016870597 (OMIM: 600428) PREDICTED: guanine nuc ( 896) 1948 199.4 6.3e-50
NP_001073343 (OMIM: 605541) guanine nucleotide exc ( 287) 1914 195.5 2.9e-49
XP_016870602 (OMIM: 600428) PREDICTED: guanine nuc ( 620) 1767 182.1 6.7e-45
NP_001273724 (OMIM: 613324) spermatogenesis-associ ( 574) 363 50.0 3.8e-05
NP_001273723 (OMIM: 613324) spermatogenesis-associ ( 596) 363 50.0 3.9e-05
NP_694568 (OMIM: 613324) spermatogenesis-associate ( 652) 363 50.0 4.1e-05
XP_005263745 (OMIM: 605216) PREDICTED: rho guanine ( 483) 358 49.4 4.7e-05
XP_011509578 (OMIM: 605216) PREDICTED: rho guanine ( 483) 358 49.4 4.7e-05
XP_005263746 (OMIM: 605216) PREDICTED: rho guanine ( 483) 358 49.4 4.7e-05
XP_011509579 (OMIM: 605216) PREDICTED: rho guanine ( 483) 358 49.4 4.7e-05
XP_005263744 (OMIM: 605216) PREDICTED: rho guanine ( 567) 358 49.5 5.2e-05
NP_127462 (OMIM: 605216) rho guanine nucleotide ex ( 670) 358 49.6 5.8e-05
NP_056135 (OMIM: 605216) rho guanine nucleotide ex ( 690) 358 49.6 5.9e-05
NP_001159743 (OMIM: 613324) spermatogenesis-associ (1277) 363 50.4 6.2e-05
NP_001273721 (OMIM: 613324) spermatogenesis-associ (1339) 363 50.4 6.4e-05
XP_011509576 (OMIM: 605216) PREDICTED: rho guanine (1870) 358 50.2 0.00011
XP_005263738 (OMIM: 605216) PREDICTED: rho guanine (1876) 358 50.2 0.00011
XP_011529194 (OMIM: 300429,300607) PREDICTED: rho ( 456) 340 47.7 0.00015
NP_001166950 (OMIM: 300429,300607) rho guanine nuc ( 463) 340 47.7 0.00015
XP_016884862 (OMIM: 300429,300607) PREDICTED: rho ( 414) 335 47.1 0.00019
NP_001166951 (OMIM: 300429,300607) rho guanine nuc ( 414) 335 47.1 0.00019
NP_001273722 (OMIM: 613324) spermatogenesis-associ ( 512) 329 46.7 0.00032
XP_016874112 (OMIM: 617043) PREDICTED: rho guanine (1057) 322 46.4 0.0008
NP_055601 (OMIM: 617043) rho guanine nucleotide ex (2063) 323 46.9 0.0011
XP_006723397 (OMIM: 611893,616763) PREDICTED: plec (1327) 304 44.9 0.003
XP_005259220 (OMIM: 611893,616763) PREDICTED: plec (1386) 304 44.9 0.003
NP_073746 (OMIM: 611893,616763) pleckstrin homolog (1386) 304 44.9 0.003
XP_011525534 (OMIM: 611893,616763) PREDICTED: plec (1387) 304 44.9 0.003
XP_016882640 (OMIM: 611893,616763) PREDICTED: plec (1371) 302 44.7 0.0034
XP_016882639 (OMIM: 611893,616763) PREDICTED: plec (1374) 302 44.7 0.0034
XP_016884869 (OMIM: 300429,300607) PREDICTED: rho ( 305) 285 42.3 0.0042
NP_002652 (OMIM: 600220,614468,614878) 1-phosphati (1265) 298 44.3 0.0043
>>NP_006104 (OMIM: 605541) guanine nucleotide exchange f (847 aa)
initn: 5737 init1: 5737 opt: 5737 Z-score: 2944.6 bits: 555.9 E(85289): 2.8e-157
Smith-Waterman score: 5737; 99.9% identity (100.0% similar) in 847 aa overlap (1-847:1-847)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
NP_006 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
790 800 810 820 830 840
pF1KB3 TYVEEDE
:::::::
NP_006 TYVEEDE
>>XP_016855543 (OMIM: 605541) PREDICTED: guanine nucleot (783 aa)
initn: 5297 init1: 5297 opt: 5297 Z-score: 2721.2 bits: 514.4 E(85289): 7.8e-145
Smith-Waterman score: 5297; 99.9% identity (100.0% similar) in 783 aa overlap (1-783:1-783)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
:::
XP_016 GNS
>>XP_016855544 (OMIM: 605541) PREDICTED: guanine nucleot (751 aa)
initn: 4992 init1: 4992 opt: 4992 Z-score: 2566.3 bits: 485.7 E(85289): 3.3e-136
Smith-Waterman score: 4992; 99.9% identity (100.0% similar) in 741 aa overlap (107-847:11-751)
80 90 100 110 120 130
pF1KB3 TFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESIN
::::::::::::::::::::::::::::::
XP_016 MMMRMMTMTTKVIETLSRLSRTPIALATGIRPFPTEESIN
10 20 30 40
140 150 160 170 180 190
pF1KB3 DEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCC
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB3 LAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSI
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB3 VNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNG
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_016 VNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNG
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB3 KFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNE
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB3 TLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKG
290 300 310 320 330 340
440 450 460 470 480 490
pF1KB3 DNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQ
350 360 370 380 390 400
500 510 520 530 540 550
pF1KB3 FEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECL
410 420 430 440 450 460
560 570 580 590 600 610
pF1KB3 GRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPP
470 480 490 500 510 520
620 630 640 650 660 670
pF1KB3 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGA
530 540 550 560 570 580
680 690 700 710 720 730
pF1KB3 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKF
590 600 610 620 630 640
740 750 760 770 780 790
pF1KB3 KSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIAR
650 660 670 680 690 700
800 810 820 830 840
pF1KB3 YDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
710 720 730 740 750
>>XP_005270417 (OMIM: 605541) PREDICTED: guanine nucleot (753 aa)
initn: 4986 init1: 4986 opt: 4986 Z-score: 2563.2 bits: 485.1 E(85289): 4.9e-136
Smith-Waterman score: 4986; 99.9% identity (100.0% similar) in 740 aa overlap (108-847:14-753)
80 90 100 110 120 130
pF1KB3 FLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESIND
::::::::::::::::::::::::::::::
XP_005 MQLPDCPCRAHLPVIETLSRLSRTPIALATGIRPFPTEESIND
10 20 30 40
140 150 160 170 180 190
pF1KB3 EDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCL
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB3 AEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIV
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB3 NKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGK
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_005 NKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGK
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB3 FTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNET
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB3 LREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGD
290 300 310 320 330 340
440 450 460 470 480 490
pF1KB3 NYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQF
350 360 370 380 390 400
500 510 520 530 540 550
pF1KB3 EMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLG
410 420 430 440 450 460
560 570 580 590 600 610
pF1KB3 RVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPL
470 480 490 500 510 520
620 630 640 650 660 670
pF1KB3 QLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAM
530 540 550 560 570 580
680 690 700 710 720 730
pF1KB3 ERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFK
590 600 610 620 630 640
740 750 760 770 780 790
pF1KB3 SLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARY
650 660 670 680 690 700
800 810 820 830 840
pF1KB3 DFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE
710 720 730 740 750
>>XP_005270418 (OMIM: 605541) PREDICTED: guanine nucleot (621 aa)
initn: 4060 init1: 3994 opt: 3994 Z-score: 2059.6 bits: 391.7 E(85289): 5.5e-108
Smith-Waterman score: 3994; 99.5% identity (99.8% similar) in 595 aa overlap (1-595:1-595)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_005 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
:::::::::::::::::::::::::::::::::::::::::::::::::::: .:
XP_005 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPDVPCLLHF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
XP_005 FISMAPATRSIVKSQKKNKKF
610 620
>>XP_016855542 (OMIM: 605541) PREDICTED: guanine nucleot (823 aa)
initn: 5562 init1: 3823 opt: 3828 Z-score: 1973.9 bits: 376.2 E(85289): 3.3e-103
Smith-Waterman score: 5518; 97.0% identity (97.2% similar) in 847 aa overlap (1-847:1-823)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 GYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
:::::::::::::::::::::::::::: ::::::::
XP_016 GYLCFKCGARAHKECLGRVDNCGRVNSG------------------------GLPKMQVI
550 560 570
610 620 630 640 650 660
pF1KB3 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPC
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB3 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB3 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB3 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
760 770 780 790 800 810
pF1KB3 TYVEEDE
:::::::
XP_016 TYVEEDE
820
>>NP_005419 (OMIM: 164875) proto-oncogene vav isoform 1 (845 aa)
initn: 3081 init1: 1631 opt: 3429 Z-score: 1770.8 bits: 338.7 E(85289): 6.8e-92
Smith-Waterman score: 3429; 58.7% identity (82.6% similar) in 849 aa overlap (1-846:1-840)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
:: :.::..:::.:.::: .::::::.::: .:::.:::::::::::::: :.:::.:.
NP_005 MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
:::::::::::::::::::..::: ::...::::::::::::.:::::: ::: :: :::
NP_005 NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
70 80 90 100 110 120
130 140 150 160 170
pF1KB3 ALATGIRPFPTEE-SINDEDIYKGLPDLIDETLVEDEEDLYDCVYGED-EGGEVYEDLMK
: :: :::::: :..:::::.:: : ::.: ::..::::::: .:. :: :.:::::.
NP_005 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDT-VEEDEDLYDCVENEEAEGDEIYEDLMR
130 140 150 160 170
180 190 200 210 220 230
pF1KB3 AEEAHQP-KCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN
.: . .: : : : : ::: ::.:::::::.:: ::...:. ::.::: ... .:::
NP_005 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFIN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK
: .:...: ....:..... . . :::::::.::::...::.::: :::: . :: ..
NP_005 IEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 SKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA
..:::..::::::.:::::.:::::::.:::::::::::::::::::: . :: ::.::
NP_005 AREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK
::::.:::: ::::::::::::.: .::::::::.: . .:::. :::..::......:
NP_005 LDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ
..:. ::.: :...:::.::.:..:....:..... .. . :..:::::. : ::. ::
NP_005 MDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGA
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB3 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT
.: :.. ::..:::::.::::::.::: :. : .: :::.: .: ..::::.::::::::
NP_005 QGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGT
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB3 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM
::::: : .: : ::::::::: ::: .. ::.: . . . . :. . :::::
NP_005 FYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMK--KDKLHRRAQDKKRNELGLPKM
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB3 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP
.:...: : ::: :: :.:. :: ::: :..:.. .:.::: ...:.:.:: . :::
NP_005 EVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKP
600 610 620 630 640 650
660 670 680 690 700 710
pF1KB3 CPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAK
: : : : . :::: ::: ::. : :: ..:.:::.:.:...:.::::::: :.:
NP_005 YVHGP-PQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVK
660 670 680 690 700 710
720 730 740 750 760 770
pF1KB3 HIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG
::::.: .:...:.:.. :..: ::::.:...:::. :..::::::::.::::. . .:
NP_005 HIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRP
720 730 740 750 760 770
780 790 800 810 820 830
pF1KB3 NRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGW
.. : : .: : ::::::::: :::: .::..:: .: . .::::::. :::::
NP_005 -----AVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGW
780 790 800 810 820 830
840
pF1KB3 FPSTYVEEDE
::..:::::
NP_005 FPANYVEEDYSEYC
840
>>XP_005259699 (OMIM: 164875) PREDICTED: proto-oncogene (821 aa)
initn: 2633 init1: 1631 opt: 3004 Z-score: 1554.8 bits: 298.7 E(85289): 7.3e-80
Smith-Waterman score: 3004; 58.8% identity (83.0% similar) in 742 aa overlap (1-739:1-738)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
:: :.::..:::.:.::: .::::::.::: .:::.:::::::::::::: :.:::.:.
XP_005 MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
:::::::::::::::::::..::: ::...::::::::::::.:::::: ::: :: :::
XP_005 NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
70 80 90 100 110 120
130 140 150 160 170
pF1KB3 ALATGIRPFPTEE-SINDEDIYKGLPDLIDETLVEDEEDLYDCVYGED-EGGEVYEDLMK
: :: :::::: :..:::::.:: : ::.: ::..::::::: .:. :: :.:::::.
XP_005 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDT-VEEDEDLYDCVENEEAEGDEIYEDLMR
130 140 150 160 170
180 190 200 210 220 230
pF1KB3 AEEAHQP-KCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN
.: . .: : : : : ::: ::.:::::::.:: ::...:. ::.::: ... .:::
XP_005 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFIN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK
: .:...: ....:..... . . :::::::.::::...::.::: :::: . :: ..
XP_005 IEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 SKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA
..:::..::::::.:::::.:::::::.:::::::::::::::::::: . :: ::.::
XP_005 AREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK
::::.:::: ::::::::::::.: .::::::::.: . .:::. :::..::......:
XP_005 LDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB3 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ
..:. ::.: :...:::.::.:..:....:..... .. . :..:::::. : ::. ::
XP_005 MDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGA
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB3 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT
.: :.. ::..:::::.::::::.::: :. : .: :::.: .: ..::::.::::::::
XP_005 QGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGT
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB3 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM
::::: : .: : ::::::::: ::: .. ::.: . . . . :. . :::::
XP_005 FYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMK--KDKLHRRAQDKKRNELGLPKM
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB3 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP
.:...: : ::: :: :.:. :: ::: :..:.. .:.::: ...:.:.:: . :::
XP_005 EVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKP
600 610 620 630 640 650
660 670 680 690 700 710
pF1KB3 CPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAK
: : : : . :::: ::: ::. : :: ..:.:::.:.:...:.::::::: :.:
XP_005 YVHGP-PQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVK
660 670 680 690 700 710
720 730 740 750 760 770
pF1KB3 HIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG
::::.: .:...:.:.. :..:
XP_005 HIKIMTAEGLYRITEKKAFRGLTWEAQSILAQPKPAMTSAPETDQSCRSRRVTSSRSLTR
720 730 740 750 760 770
>>XP_016855545 (OMIM: 605541) PREDICTED: guanine nucleot (407 aa)
initn: 2823 init1: 2823 opt: 2823 Z-score: 1466.1 bits: 281.3 E(85289): 6.3e-75
Smith-Waterman score: 2823; 100.0% identity (100.0% similar) in 407 aa overlap (441-847:1-407)
420 430 440 450 460 470
pF1KB3 TLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFY
::::::::::::::::::::::::::::::
XP_016 MKEIIDLQQYKIANNPTTDKENKKWSYGFY
10 20 30
480 490 500 510 520 530
pF1KB3 LIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVC
40 50 60 70 80 90
540 550 560 570 580 590
pF1KB3 QMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQV
100 110 120 130 140 150
600 610 620 630 640 650
pF1KB3 DPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFF
160 170 180 190 200 210
660 670 680 690 700 710
pF1KB3 PSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISI
220 230 240 250 260 270
720 730 740 750 760 770
pF1KB3 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPE
280 290 300 310 320 330
780 790 800 810 820 830
pF1KB3 HSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGE
340 350 360 370 380 390
840
pF1KB3 VNGRVGWFPSTYVEEDE
:::::::::::::::::
XP_016 VNGRVGWFPSTYVEEDE
400
>>NP_001127870 (OMIM: 600428) guanine nucleotide exchang (878 aa)
initn: 2588 init1: 766 opt: 2675 Z-score: 1387.2 bits: 267.8 E(85289): 1.6e-70
Smith-Waterman score: 3105; 52.1% identity (76.8% similar) in 898 aa overlap (1-846:1-875)
10 20 30 40 50 60
pF1KB3 MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
:: :.::..::: ::::: ::::.: :: ::::::.:::::::::::.:: ::.::.:
NP_001 MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
:.::::::::::::::::: .: . ::.:.::::. ::::::::::::: ..:::: :
NP_001 NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
70 80 90 100 110 120
130 140 150 160 170
pF1KB3 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA
: ::::::.::. ::.:.:..: .: :: . ::.:::: :: : ..:::..:.
NP_001 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV
130 140 150 160 170
180 190 200 210 220 230
pF1KB3 EEAHQPKC--------PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEF
: ..:: :.: :.::: ::..:: :: .:::.::: .:.::. :. :..
NP_001 E-VQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADM
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 DSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISS
.::::. .:.:.:..... : : : . ..: .::...::::.:::.::: .: : ..
NP_001 AAVFINLEDLIKVHHSFLRAI-DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 LDYISKSKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK
:. . :.:: . :.:::. ....::: :.:::::::::::::::::.::..:... :.
NP_001 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPER
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB3 ANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITT
.:: ::.::.:::.:.::::::.::::.:..:: :::::. . ::::. :::... .
NP_001 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS
360 370 380 390 400 410
420 430 440 450 460
pF1KB3 LDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKK-----WS
. .::::.:..:::: .:::::::: .::.::::.: .:....: ..:. :: ::
NP_001 IVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB3 YGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTS
::::::: ::..:..:.:::.:.:.::.::::::.:::.:: :..: :.:.:.:: ..:.
NP_001 YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTN
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB3 CKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRT
::.:.:.:::::::::.: :::. :::::: . : : :.
NP_001 CKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPC---------------KFTSPADLD
540 550 560 570 580
590 600 610 620 630 640
pF1KB3 PKQVDPGLPKMQVIRNYSGTPPPALHEGPP-LQLQAGDTVELLKGDAHSLFWQGRNLASG
. . :: ::: ...:: :.: : : : : .:.::..:::.:: .: .:.:: . .
NP_001 ASGAGPG-PKMVAMQNYHGNPAPP---GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTR
590 600 610 620 630
650 660 670 680 690
pF1KB3 EVGFFPSDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLV
. :.:::..::::: .: .::. ::.:: ::: :... : .....:::.
NP_001 KSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLI
640 650 660 670 680 690
700 710 720 730 740 750
pF1KB3 RHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFR
:.: :. ..:::::.:.:.::::.. .:...::.: .:: ::.::::::. :::::.:.
NP_001 RERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFK
700 710 720 730 740 750
760 770 780
pF1KB3 TLDTTLQFPYKEPEHSAGQRGNRAGNS---------------------------LLSPKV
:::::..::: :.::.. ..:. : ...:.:
NP_001 QLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRV
760 770 780 790 800 810
790 800 810 820 830 840
pF1KB3 LGIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPSTYVEEDE
.: :.:::.: ::::::::: .::::.::...... :::.::.:::.::::::::::.
NP_001 IGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGI
820 830 840 850 860 870
NP_001 Q
847 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 01:05:16 2016 done: Sat Nov 5 01:05:18 2016
Total Scan time: 12.710 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]