FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3288, 744 aa 1>>>pF1KB3288 744 - 744 aa - 744 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.4204+/-0.00138; mu= 0.2501+/- 0.085 mean_var=686.7062+/-142.782, 0's: 0 Z-trim(115.3): 238 B-trim: 411 in 1/53 Lambda= 0.048943 statistics sampled from 15655 (15890) to 15655 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.488), width: 16 Scan time: 4.930 The best scores are: opt bits E(32554) CCDS2934.1 COL8A1 gene_id:1295|Hs108|chr3 ( 744) 5593 410.5 4.8e-114 CCDS403.1 COL8A2 gene_id:1296|Hs108|chr1 ( 703) 2644 202.3 2.2e-51 CCDS72756.1 COL8A2 gene_id:1296|Hs108|chr1 ( 638) 2624 200.8 5.6e-51 CCDS5105.1 COL10A1 gene_id:1300|Hs108|chr6 ( 680) 1942 152.7 1.8e-36 CCDS6982.1 COL5A1 gene_id:1289|Hs108|chr9 (1838) 1631 131.3 1.3e-29 CCDS75932.1 COL5A1 gene_id:1289|Hs108|chr9 (1838) 1631 131.3 1.3e-29 CCDS14543.1 COL4A5 gene_id:1287|Hs108|chrX (1685) 1629 131.1 1.4e-29 CCDS35366.1 COL4A5 gene_id:1287|Hs108|chrX (1691) 1629 131.1 1.4e-29 CCDS780.2 COL11A1 gene_id:1301|Hs108|chr1 (1690) 1613 130.0 3e-29 CCDS53348.1 COL11A1 gene_id:1301|Hs108|chr1 (1767) 1613 130.0 3.1e-29 CCDS778.1 COL11A1 gene_id:1301|Hs108|chr1 (1806) 1613 130.1 3.1e-29 CCDS2297.1 COL3A1 gene_id:1281|Hs108|chr2 (1466) 1577 127.4 1.6e-28 CCDS43452.1 COL11A2 gene_id:1302|Hs108|chr6 (1650) 1534 124.4 1.4e-27 CCDS12222.1 COL5A3 gene_id:50509|Hs108|chr19 (1745) 1520 123.5 2.9e-27 CCDS42828.1 COL4A4 gene_id:1286|Hs108|chr2 (1690) 1485 121.0 1.6e-26 CCDS8759.1 COL2A1 gene_id:1280|Hs108|chr12 (1418) 1476 120.2 2.2e-26 CCDS41778.1 COL2A1 gene_id:1280|Hs108|chr12 (1487) 1476 120.3 2.3e-26 CCDS9511.1 COL4A1 gene_id:1282|Hs108|chr13 (1669) 1469 119.8 3.4e-26 CCDS33350.1 COL5A2 gene_id:1290|Hs108|chr2 (1499) 1462 119.3 4.5e-26 CCDS42829.1 COL4A3 gene_id:1285|Hs108|chr2 (1670) 1414 116.0 5e-25 CCDS6802.1 COL27A1 gene_id:85301|Hs108|chr9 (1860) 1399 115.0 1.1e-24 CCDS6376.1 COL22A1 gene_id:169044|Hs108|chr8 (1626) 1392 114.4 1.5e-24 CCDS41297.1 COL16A1 gene_id:1307|Hs108|chr1 (1604) 1363 112.3 6e-24 CCDS2773.1 COL7A1 gene_id:1294|Hs108|chr3 (2944) 1362 112.6 8.8e-24 CCDS47447.1 COL9A1 gene_id:1297|Hs108|chr6 ( 678) 1321 108.8 2.9e-23 CCDS76010.1 COL4A6 gene_id:1288|Hs108|chrX (1707) 1331 110.1 3e-23 CCDS4971.1 COL9A1 gene_id:1297|Hs108|chr6 ( 921) 1321 109.0 3.4e-23 CCDS41353.1 COL24A1 gene_id:255631|Hs108|chr1 (1714) 1322 109.5 4.6e-23 CCDS76649.1 COL4A1 gene_id:1282|Hs108|chr13 ( 519) 1308 107.7 4.7e-23 CCDS14542.1 COL4A6 gene_id:1288|Hs108|chrX (1690) 1315 109.0 6.4e-23 CCDS14541.1 COL4A6 gene_id:1288|Hs108|chrX (1691) 1315 109.0 6.4e-23 CCDS76008.1 COL4A6 gene_id:1288|Hs108|chrX (1633) 1312 108.7 7.3e-23 CCDS76009.1 COL4A6 gene_id:1288|Hs108|chrX (1666) 1312 108.7 7.4e-23 CCDS41907.1 COL4A2 gene_id:1284|Hs108|chr13 (1712) 1299 107.8 1.4e-22 CCDS44425.2 COL13A1 gene_id:1305|Hs108|chr10 ( 686) 1259 104.4 6e-22 CCDS44427.2 COL13A1 gene_id:1305|Hs108|chr10 ( 645) 1258 104.3 6.1e-22 CCDS44424.2 COL13A1 gene_id:1305|Hs108|chr10 ( 695) 1249 103.7 9.9e-22 CCDS44423.2 COL13A1 gene_id:1305|Hs108|chr10 ( 668) 1246 103.5 1.1e-21 CCDS44428.2 COL13A1 gene_id:1305|Hs108|chr10 ( 610) 1223 101.8 3.3e-21 CCDS58922.1 COL25A1 gene_id:84570|Hs108|chr4 ( 645) 1218 101.5 4.3e-21 CCDS44419.1 COL13A1 gene_id:1305|Hs108|chr10 ( 717) 1198 100.2 1.2e-20 CCDS4970.1 COL19A1 gene_id:1310|Hs108|chr6 (1142) 1175 98.8 4.9e-20 CCDS43553.1 COL28A1 gene_id:340267|Hs108|chr7 (1125) 1159 97.7 1.1e-19 CCDS450.1 COL9A2 gene_id:1298|Hs108|chr1 ( 689) 1124 94.9 4.5e-19 CCDS13505.1 COL9A3 gene_id:1299|Hs108|chr20 ( 684) 1101 93.3 1.4e-18 CCDS55025.1 COL21A1 gene_id:81578|Hs108|chr6 ( 957) 1076 91.7 5.6e-18 CCDS83099.1 COL21A1 gene_id:81578|Hs108|chr6 ( 954) 1069 91.2 7.9e-18 CCDS42971.1 COL18A1 gene_id:80781|Hs108|chr21 (1339) 1006 87.0 2.1e-16 CCDS42972.1 COL18A1 gene_id:80781|Hs108|chr21 (1519) 1006 87.1 2.2e-16 CCDS77643.1 COL18A1 gene_id:80781|Hs108|chr21 (1754) 1006 87.2 2.4e-16 >>CCDS2934.1 COL8A1 gene_id:1295|Hs108|chr3 (744 aa) initn: 5593 init1: 5593 opt: 5593 Z-score: 2161.0 bits: 410.5 E(32554): 4.8e-114 Smith-Waterman score: 5593; 100.0% identity (100.0% similar) in 744 aa overlap (1-744:1-744) 10 20 30 40 50 60 pF1KB3 MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 MPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 MPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 GPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 GPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 IGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 GDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 GDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 IGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 IGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 DRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 DRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 PQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 PKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 PKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 HGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 HGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 YGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 YGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 YYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 YYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPS 670 680 690 700 710 720 730 740 pF1KB3 EQAAGLYAGQYVHSSFSGYLLYPM :::::::::::::::::::::::: CCDS29 EQAAGLYAGQYVHSSFSGYLLYPM 730 740 >>CCDS403.1 COL8A2 gene_id:1296|Hs108|chr1 (703 aa) initn: 5240 init1: 2003 opt: 2644 Z-score: 1035.9 bits: 202.3 E(32554): 2.2e-51 Smith-Waterman score: 2644; 57.2% identity (71.1% similar) in 671 aa overlap (88-743:42-702) 60 70 80 90 100 110 pF1KB3 VPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGK--EIPLA- .:.. .: .: .: ::. :.:: CCDS40 LLLLLVLVLGCGPRASSGGGAGGAAGYAPVKYIQPMQKGP-VGPPFREGKGQYLEMPLPL 20 30 40 50 60 70 120 130 140 150 160 pF1KB3 ---SLRGEQGPRGEPGPRGPPGPPGLPGH---GIPGIKGKPGPQGYPG---VGKPGMPGM .:.:: :: :.:::::::::::.::. : ::..:.::: : :: .:: : ::. CCDS40 LPMDLKGEPGPPGKPGPRGPPGPPGFPGKPGMGKPGLHGQPGPAGPPGFSRMGKAGPPGL 80 90 100 110 120 130 170 180 190 200 210 220 pF1KB3 PGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDR ::: : :.:: .:: : .:. : : ::: : ::: :. ::::. :.:: :: .:. CCDS40 PGKVGPPGQPGLRGEPGIRGDQGLRGPPGPPGLPGPSGITIPGKPGAQGVPGPPGFQGEP 140 150 160 170 180 190 230 240 250 260 270 280 pF1KB3 GPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGP ::.: ::: : :: :::.: :.:: ::. : : :::: : :.::::. :.:: : CCDS40 GPQGEPGPPGDRGLKGDNGVGQPGLPGAPGQGGAPGPPGLPGPAGLGKPGLDGLPGAPGD 200 210 220 230 240 250 290 300 310 320 330 340 pF1KB3 LGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPP :. : :: :::.: :. : .::::. :.: :: :.:: : :.::: :: ::: CCDS40 KGESGPPGVPGPRGEPGAVGPKGPPGVDGVGVPGAAGLPGPQGPSGAKGE---PGTRGPP 260 270 280 290 300 350 360 370 380 390 400 pF1KB3 GL--P-GIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMG :: : : : ::.:::::::: .:::: :: ::: : : :: :: : : ::.:: : CCDS40 GLIGPTGYGMPGLPGPKGDRGPAGVPGLLGDRGEPGEDGEPGEQGPQGLGGPPGLPGSAG 310 320 330 340 350 360 410 420 430 440 450 460 pF1KB3 PPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKG :: : ::::::.: :: : :: .:. : .:. :::: :: : :: .: ::: :::: CCDS40 LPGRRGPPGPKGEAGPGGPPGVPGIRGDQGPSGLAGKPGVPGERGLPGAHGPPGPTGPKG 370 380 390 400 410 420 470 480 490 500 510 520 pF1KB3 EAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPG : : : :: ::: : :: ::. :.::. ::.:: ::::. ::.::::: :.:: ::::: CCDS40 EPGFTGRPGGPGVAGALGQKGDLGLPGQPGLRGPSGIPGLQGPAGPIGPQGLPGLKGEPG 430 440 450 460 470 480 530 540 550 560 570 580 pF1KB3 LPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQG :::::: :.::.:: :::: ::. : : : ::::::::::: :... : : CCDS40 LPGPPGEGRAGEPGTAGPTGPPGVPGS--P-GITGPPGPPGPPGPPGAPGAFDETGIA-G 490 500 510 520 530 540 590 600 610 620 630 640 pF1KB3 EYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNG .::. : :..:. .. . : . :. ::::: ::.::: : ::::.. :::: CCDS40 LHLPN-G-GVEGAVLGKGGKPQFGLGELSAHATPAFTAVLTSPFPASGMPVKFDRTLYNG 550 560 570 580 590 600 650 660 670 680 690 700 pF1KB3 RQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASG ...::: :::::: : :::::::::: :: ::::::.::: :. :::::::::.:::::: CCDS40 HSGYNPATGIFTCPVGGVYYFAYHVHVKGTNVWVALYKNNVPATYTYDEYKKGYLDQASG 610 620 630 640 650 660 710 720 730 740 pF1KB3 SAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM .::: :::.:.:..::::.:: :::. .:.::::::.:: : CCDS40 GAVLQLRPNDQVWVQMPSDQANGLYSTEYIHSSFSGFLLCPT 670 680 690 700 >>CCDS72756.1 COL8A2 gene_id:1296|Hs108|chr1 (638 aa) initn: 5232 init1: 1995 opt: 2624 Z-score: 1028.7 bits: 200.8 E(32554): 5.6e-51 Smith-Waterman score: 2624; 58.6% identity (72.1% similar) in 642 aa overlap (111-743:6-637) 90 100 110 120 130 140 pF1KB3 KEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGH .:. .:.:: :: :.:::::::::::.::. CCDS72 MPLPLLPM-DLKGEPGPPGKPGPRGPPGPPGFPGK 10 20 30 150 160 170 180 190 pF1KB3 ---GIPGIKGKPGPQGYPG---VGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPG : ::..:.::: : :: .:: : ::.::: : :.:: .:: : .:. : : :: CCDS72 PGMGKPGLHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGPPG 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB3 PQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVK : : ::: :. ::::. :.:: :: .:. ::.: ::: : :: :::.: :.:: ::. CCDS72 PPGLPGPSGITIPGKPGAQGVPGPPGFQGEPGPQGEPGPPGDRGLKGDNGVGQPGLPGAP 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB3 GPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPG : : :::: : :.::::. :.:: : :. : :: :::.: :. : .::::. : CCDS72 GQGGAPGPPGLPGPAGLGKPGLDGLPGAPGDKGESGPPGVPGPRGEPGAVGPKGPPGVDG 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB3 IGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGL--P-GIGKPGFPGPKGDRGMGGVPGAL .: :: :.:: : :.::: :: ::::: : : : ::.:::::::: .:::: : CCDS72 VGVPGAAGLPGPQGPSGAKGE---PGTRGPPGLIGPTGYGMPGLPGPKGDRGPAGVPGLL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB3 GPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEP : ::: : : :: :: : : ::.:: : :: : ::::::.: :: : :: .:. CCDS72 GDRGEPGEDGEPGEQGPQGLGGPPGLPGSAGLPGRRGPPGPKGEAGPGGPPGVPGIRGDQ 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB3 GLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQ : .:. :::: :: : :: .: ::: ::::: : : :: ::: : :: ::. :.::. CCDS72 GPSGLAGKPGVPGERGLPGAHGPPGPTGPKGEPGFTGRPGGPGVAGALGQKGDLGLPGQP 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB3 GLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALG ::.:: ::::. ::.::::: :.:: ::::::::::: :.::.:: :::: ::. : CCDS72 GLRGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTGPPGVPGSPG 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB3 PQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGP : : ::::::::::: :... : : .::. : :..:. .. . : . CCDS72 ITG-P--PGPPGPPGPPGAPGAFDETGIA-GLHLPN-G-GVEGAVLGKGGKPQFGLGELS 460 470 480 490 500 620 630 640 650 660 670 pF1KB3 AYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKG :. ::::: ::.::: : ::::.. ::::...::: :::::: : :::::::::: :: CCDS72 AHATPAFTAVLTSPFPASGMPVKFDRTLYNGHSGYNPATGIFTCPVGGVYYFAYHVHVKG 510 520 530 540 550 560 680 690 700 710 720 730 pF1KB3 GNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQY ::::::.::: :. :::::::::.::::::.::: :::.:.:..::::.:: :::. .: CCDS72 TNVWVALYKNNVPATYTYDEYKKGYLDQASGGAVLQLRPNDQVWVQMPSDQANGLYSTEY 570 580 590 600 610 620 740 pF1KB3 VHSSFSGYLLYPM .::::::.:: : CCDS72 IHSSFSGFLLCPT 630 >>CCDS5105.1 COL10A1 gene_id:1300|Hs108|chr6 (680 aa) initn: 1884 init1: 1884 opt: 1942 Z-score: 768.2 bits: 152.7 E(32554): 1.8e-36 Smith-Waterman score: 2509; 52.7% identity (67.7% similar) in 706 aa overlap (57-744:4-680) 30 40 50 60 70 80 pF1KB3 AGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHL :.: . :.. .:. : . :...: .. CCDS51 MLPQIPFLLLVSLNLVHG-----VFYAERY-QM 10 20 90 100 110 120 130 140 pF1KB3 PQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGP---PGP---PGLPGH : .: : . . .: : .: .::::: : ::: :: ::: :: ::. CCDS51 PTGIKGPLPNTKT-QFFIPYTIKSKGIA-VRGEQGTPGPPGPAGPRGHPGPSGPPGKPGY 30 40 50 60 70 80 150 160 170 180 190 pF1KB3 GIPGIKGKPGPQGYPG---VGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQG : ::..:.:: : :: :::::.::.::: :: .: : ::..:: :.:::.: CCDS51 GSPGLQGEPGLPGPPGPSAVGKPGVPGLPGK------PGERGPYGPKGDVGPAGLPGPRG 90 100 110 120 130 200 210 220 230 240 250 pF1KB3 PPGPHGLPGI------GKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAP :::: :.:: :::: : : :::.: : :: :: :. : ::. :.: :: : CCDS51 PPGPPGIPGPAGISVPGKPGQQGPTGAPGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRP 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB3 GVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPG : .: :: .:: :: : ::::: : .: :: : : : ::: :: :: :: ::::: CCDS51 GERGLPGPQGPTGPSGPPGVGKRGENGVPGQPGIKGDRGFPGEMGPIGP---PGPQGPPG 200 210 220 230 240 250 320 330 340 350 360 pF1KB3 I--P-GIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVP : :::::: : :::::.:: :: : ::. :::: ::.::::.:: ::.:: .:.: CCDS51 ERGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGPPGFGKPGLPGLKGERGPAGLP 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB3 GALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPK :. : .::.:: : :: : : :: : :: : ::. :.:::::: : .:: : :: : CCDS51 GGPGAKGEQGPAGLPGKPGLTGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGYPGAK 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB3 GEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIP :: : : ::::. :. : : .: :: ::::. : : ::::: : : :: :: CCDS51 GERGSPGSDGKPGYPGKPGLDGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHN 380 390 400 410 420 430 490 500 510 520 530 540 pF1KB3 GDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG :. : .: ::::: :: :: : ::.:: ::.:: ::::: ::. :. : :::: :: CCDS51 GEAGPRGAPGIPGTRGPIGPPGIPGFPGSKGDPGSPGPPGPAGIATKGLNGPTGPPGPPG 440 450 460 470 480 490 550 560 570 580 590 600 pF1KB3 ALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKN : .:.:::::::::::::: :::: :. :... : :. :..: . CCDS51 PRGHSGEPGLPGPPGPPGPPGQ-AVMPEGFIKAGQR-PSLS-GTPLVS------ANQGVT 500 510 520 530 540 610 620 630 640 650 660 pF1KB3 GGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVH : : . :::. :. .: .:.:. :.:.::: .:.:.:.::::::..::.:::.:::: CCDS51 GMP---VSAFTVILSKAYPAIGTPIPFDKILYNRQQHYDPRTGIFTCQIPGIYYFSYHVH 550 560 570 580 590 600 670 680 690 700 710 720 pF1KB3 CKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYA :: .:::.:.::. ::::::::: ::.::::::::.. : .:.:.::.:. .. :::. CCDS51 VKGTHVWVGLYKNGTPVMYTYDEYTKGYLDQASGSAIIDLTENDQVWLQLPNAESNGLYS 610 620 630 640 650 660 730 740 pF1KB3 GQYVHSSFSGYLLYPM ..::::::::.:. :: CCDS51 SEYVHSSFSGFLVAPM 670 680 >>CCDS6982.1 COL5A1 gene_id:1289|Hs108|chr9 (1838 aa) initn: 1846 init1: 655 opt: 1631 Z-score: 645.1 bits: 131.3 E(32554): 1.3e-29 Smith-Waterman score: 1720; 44.8% identity (52.7% similar) in 697 aa overlap (53-632:836-1530) 30 40 50 60 70 80 pF1KB3 RLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAM--GKEMPHLQYG : :.. :. : .. : : : . : CCDS69 TKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKG 810 820 830 840 850 860 90 100 110 120 130 pF1KB3 KE-YPHLPQYMKEIQPAPRMGKEAVP-----KKGKEIPLA----SLRGEQGPRGEPGPRG : : :: : . : .: . : : :. : . :: ::::: :::: CCDS69 KLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRG 870 880 890 900 910 920 140 150 160 170 180 pF1KB3 PPGPPGLPGH-------GIPGIKGKPGPQGYPGVGKP-GMPGMPGKPGAMGMPGAKGEIG : :: :. : :: .: :::: : : : :: ::: : : :: .:: : CCDS69 ITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETG 930 940 950 960 970 980 190 200 210 220 pF1KB3 QKGEIGPMGIPG---PQGP------------PGPHGLPGIGKPGGPGLPGQPGPKGDRGP .:. :: : :: :::: ::: : :: . : ::: :. : ::: :: CCDS69 FQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPG--EQGLPGLAGKEGTKGDPGP 990 1000 1010 1020 1030 1040 230 240 250 260 270 pF1KB3 KGLPG---PQGLRGPKGDKGFGMP-GAPGVKGPPGMHGPPGPVGLPG-------VGKPGV :::: : :::: ::.:. : :: :.:: : :::::.: :: .: :. CCDS69 AGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGI 1050 1060 1070 1080 1090 1100 280 290 300 310 320 pF1KB3 TGFPGPQGP---LGKPGAPGEPGPQGPIGVPGVQGPPGIPG----IGKPGQDGI------ : :::::: :. ::::: ::::: : :.::: :.:: .: ::.:: CCDS69 PGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGE 1110 1120 1130 1140 1150 1160 330 340 350 360 370 pF1KB3 PGQPGFPGGKGEQGLPGLPGP--P-GLPGI-GKPGFPGPKGDRGMGGVPGALGPRG---E ::: : : ::::: :: :: : : :: : : :::.:..:. : : :::: CCDS69 PGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGP 1170 1180 1190 1200 1210 1220 380 390 400 410 420 pF1KB3 KGPIGAPGIGGPPGEPGL---------PGIPGPMGPPGAIGFPGPKGE-GGI-----VGP ::.: :. ::::: : :: ::: :: :: : ::.: ::: :: CCDS69 PGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGE 1230 1240 1250 1260 1270 1280 430 440 450 460 pF1KB3 QGPPGPKGEPGLQGFPGKPGFLGE------------VGPPGMRGLPGPIGPKGEAGQKGV .: :: ::::: : : :: :: .:::: .: :: :::: : : CCDS69 KGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGF 1290 1300 1310 1320 1330 1340 470 480 490 500 510 520 pF1KB3 PGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGF :: :: :: :: :. : :::.: .: :: : ::.: :: : :: .: :: :: : CCDS69 PGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGR 1350 1360 1370 1380 1390 1400 530 540 550 560 570 pF1KB3 PG-IGKPGVAGLHGPPGKPGALGPQGQPGLPGP------PGP---------PGPPGPPAV : : : :::.::::: : .:::: :: ::: ::: ::: :::. CCDS69 QGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGP 1410 1420 1430 1440 1450 1460 580 590 600 610 620 pF1KB3 M-PP-TPPPQGEYLPDMGLGIDG----VKPPHAYGAK--KGKNGGPAYEMPAFTAELTAP : :: : .:. : : : . :: : : .: : . : .:.: CCDS69 MGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGP 1470 1480 1490 1500 1510 1520 630 640 650 660 670 680 pF1KB3 FPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPV :.: : CCDS69 SGPIGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRT 1530 1540 1550 1560 1570 1580 >-- initn: 2268 init1: 607 opt: 1184 Z-score: 474.6 bits: 99.8 E(32554): 4.1e-20 Smith-Waterman score: 1187; 39.9% identity (53.0% similar) in 589 aa overlap (32-563:287-835) 10 20 30 40 50 pF1KB3 AVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIP---PQMPPQIPQ-YQPLGQQ : .: : . : . ..:. : . CCDS69 PNPDEYYTEGDGEGETYYYEYPYYEDPEDLGKEPTPSKKPVEAAKETTEVPEELTPTPTE 260 270 280 290 300 310 60 70 80 90 100 pF1KB3 VPHMPLAKDGLAMGKE----------MPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKK . :: ...: ::: .: .: :. . : . : . . : CCDS69 AAPMPETSEG--AGKEEDVGIGDYDYVPSEDYYTPSPYDDLTYGEGEENPDQPTD--PGA 320 330 340 350 360 370 110 120 130 140 150 160 pF1KB3 GKEIPLASLRGEQGPRGEPGPRGPPGPPG--LPGH----GIPGIKGKPGPQGYPGVGKPG : ::: .. .. . ..:.: ::: . : :. : .. . : ...:. CCDS69 GAEIPTST--ADTSNSSNPAP--PPGEGADDLEGEFTEETIRNLDENYYDPYYDPTSSPS 380 390 400 410 420 170 180 190 200 210 pF1KB3 M--PGMPGKPGAM--GMPGAKGEIGQKGE---IGP-MGIPGPQGPPGPHGLPGIGKPGGP ::::.. .. :. : .:: ::::: : : : : :: :: :: ::: : :: CCDS69 EIGPGMPANQDTIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLP--GPPGTM 430 440 450 460 470 480 220 230 240 250 pF1KB3 GLPGQPGPKGDRGPKG---LPGPQGLRGPKGDK-----GFGMPGAPGVKGPP-------- : :: : :.::: : ::: .:: :: : :: : : ::: CCDS69 GPTGQVGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQA 490 500 510 520 530 540 260 270 280 290 300 pF1KB3 ---------GMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQG ...:: ::.:: .:.:: . :: : : : ::. ::::: :: : : CCDS69 QAILQQARLALRGPAGPMGL--TGRPGPV---GPPGSGGLKGEPGDVGPQGPRGVQGPPG 550 560 570 580 590 600 310 320 330 340 350 360 pF1KB3 PPGIPGI-GKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGV : : :: :. :.:: :.:: : ::..:. :: : :: : . : :::.: : CCDS69 PAGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKG--HRGDPGPSGP---PGP 610 620 630 640 650 370 380 390 400 410 420 pF1KB3 PGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGP :: : ::. : .: :. ::::: :. :: :::: ::: : ..: .: ::: CCDS69 PGDDGERGDDGEVGPRGL---PGEPGPRGLLGPKGPPGP---PGPPG---VTGMDGQPGP 660 670 680 690 700 430 440 450 460 470 480 pF1KB3 KGEPGLQGFPGKPGFLGEVGPPGMRGLPGP---IGPKGEAGQKGVPGLPGVPGLLGPKGE ::. : :: :: :: . : :: .::::: ::: :: : : :::::.:: :: :. CCDS69 KGNVGPQGEPGPPG---QQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGH 710 720 730 740 750 760 490 500 510 520 530 540 pF1KB3 PGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPP :: .:::: : :: :: :: : :::.: : : :. : : : : : CCDS69 PGK------EGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKG--TKGEKGEDGFP 770 780 790 800 810 550 560 570 580 590 600 pF1KB3 GKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAK : : .: .:. : :::: CCDS69 GFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYP 820 830 840 850 860 870 >>CCDS75932.1 COL5A1 gene_id:1289|Hs108|chr9 (1838 aa) initn: 1846 init1: 655 opt: 1631 Z-score: 645.1 bits: 131.3 E(32554): 1.3e-29 Smith-Waterman score: 1720; 44.8% identity (52.7% similar) in 697 aa overlap (53-632:836-1530) 30 40 50 60 70 80 pF1KB3 RLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAM--GKEMPHLQYG : :.. :. : .. : : : . : CCDS75 TKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKG 810 820 830 840 850 860 90 100 110 120 130 pF1KB3 KE-YPHLPQYMKEIQPAPRMGKEAVP-----KKGKEIPLA----SLRGEQGPRGEPGPRG : : :: : . : .: . : : :. : . :: ::::: :::: CCDS75 KLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRG 870 880 890 900 910 920 140 150 160 170 180 pF1KB3 PPGPPGLPGH-------GIPGIKGKPGPQGYPGVGKP-GMPGMPGKPGAMGMPGAKGEIG : :: :. : :: .: :::: : : : :: ::: : : :: .:: : CCDS75 ITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETG 930 940 950 960 970 980 190 200 210 220 pF1KB3 QKGEIGPMGIPG---PQGP------------PGPHGLPGIGKPGGPGLPGQPGPKGDRGP .:. :: : :: :::: ::: : :: . : ::: :. : ::: :: CCDS75 FQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPG--EQGLPGLAGKEGTKGDPGP 990 1000 1010 1020 1030 1040 230 240 250 260 270 pF1KB3 KGLPG---PQGLRGPKGDKGFGMP-GAPGVKGPPGMHGPPGPVGLPG-------VGKPGV :::: : :::: ::.:. : :: :.:: : :::::.: :: .: :. CCDS75 AGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGI 1050 1060 1070 1080 1090 1100 280 290 300 310 320 pF1KB3 TGFPGPQGP---LGKPGAPGEPGPQGPIGVPGVQGPPGIPG----IGKPGQDGI------ : :::::: :. ::::: ::::: : :.::: :.:: .: ::.:: CCDS75 PGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGE 1110 1120 1130 1140 1150 1160 330 340 350 360 370 pF1KB3 PGQPGFPGGKGEQGLPGLPGP--P-GLPGI-GKPGFPGPKGDRGMGGVPGALGPRG---E ::: : : ::::: :: :: : : :: : : :::.:..:. : : :::: CCDS75 PGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGP 1170 1180 1190 1200 1210 1220 380 390 400 410 420 pF1KB3 KGPIGAPGIGGPPGEPGL---------PGIPGPMGPPGAIGFPGPKGE-GGI-----VGP ::.: :. ::::: : :: ::: :: :: : ::.: ::: :: CCDS75 PGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGE 1230 1240 1250 1260 1270 1280 430 440 450 460 pF1KB3 QGPPGPKGEPGLQGFPGKPGFLGE------------VGPPGMRGLPGPIGPKGEAGQKGV .: :: ::::: : : :: :: .:::: .: :: :::: : : CCDS75 KGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGF 1290 1300 1310 1320 1330 1340 470 480 490 500 510 520 pF1KB3 PGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGF :: :: :: :: :. : :::.: .: :: : ::.: :: : :: .: :: :: : CCDS75 PGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGR 1350 1360 1370 1380 1390 1400 530 540 550 560 570 pF1KB3 PG-IGKPGVAGLHGPPGKPGALGPQGQPGLPGP------PGP---------PGPPGPPAV : : : :::.::::: : .:::: :: ::: ::: ::: :::. CCDS75 QGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGP 1410 1420 1430 1440 1450 1460 580 590 600 610 620 pF1KB3 M-PP-TPPPQGEYLPDMGLGIDG----VKPPHAYGAK--KGKNGGPAYEMPAFTAELTAP : :: : .:. : : : . :: : : .: : . : .:.: CCDS75 MGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGP 1470 1480 1490 1500 1510 1520 630 640 650 660 670 680 pF1KB3 FPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPV :.: : CCDS75 SGPIGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRT 1530 1540 1550 1560 1570 1580 >-- initn: 2268 init1: 607 opt: 1184 Z-score: 474.6 bits: 99.8 E(32554): 4.1e-20 Smith-Waterman score: 1187; 39.9% identity (53.0% similar) in 589 aa overlap (32-563:287-835) 10 20 30 40 50 pF1KB3 AVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIP---PQMPPQIPQ-YQPLGQQ : .: : . : . ..:. : . CCDS75 PNPDEYYTEGDGEGETYYYEYPYYEDPEDLGKEPTPSKKPVEAAKETTEVPEELTPTPTE 260 270 280 290 300 310 60 70 80 90 100 pF1KB3 VPHMPLAKDGLAMGKE----------MPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKK . :: ...: ::: .: .: :. . : . : . . : CCDS75 AAPMPETSEG--AGKEEDVGIGDYDYVPSEDYYTPSPYDDLTYGEGEENPDQPTD--PGA 320 330 340 350 360 370 110 120 130 140 150 160 pF1KB3 GKEIPLASLRGEQGPRGEPGPRGPPGPPG--LPGH----GIPGIKGKPGPQGYPGVGKPG : ::: .. .. . ..:.: ::: . : :. : .. . : ...:. CCDS75 GAEIPTST--ADTSNSSNPAP--PPGEGADDLEGEFTEETIRNLDENYYDPYYDPTSSPS 380 390 400 410 420 170 180 190 200 210 pF1KB3 M--PGMPGKPGAM--GMPGAKGEIGQKGE---IGP-MGIPGPQGPPGPHGLPGIGKPGGP ::::.. .. :. : .:: ::::: : : : : :: :: :: ::: : :: CCDS75 EIGPGMPANQDTIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLP--GPPGTM 430 440 450 460 470 480 220 230 240 250 pF1KB3 GLPGQPGPKGDRGPKG---LPGPQGLRGPKGDK-----GFGMPGAPGVKGPP-------- : :: : :.::: : ::: .:: :: : :: : : ::: CCDS75 GPTGQVGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQA 490 500 510 520 530 540 260 270 280 290 300 pF1KB3 ---------GMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQG ...:: ::.:: .:.:: . :: : : : ::. ::::: :: : : CCDS75 QAILQQARLALRGPAGPMGL--TGRPGPV---GPPGSGGLKGEPGDVGPQGPRGVQGPPG 550 560 570 580 590 600 310 320 330 340 350 360 pF1KB3 PPGIPGI-GKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGV : : :: :. :.:: :.:: : ::..:. :: : :: : . : :::.: : CCDS75 PAGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKG--HRGDPGPSGP---PGP 610 620 630 640 650 370 380 390 400 410 420 pF1KB3 PGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGP :: : ::. : .: :. ::::: :. :: :::: ::: : ..: .: ::: CCDS75 PGDDGERGDDGEVGPRGL---PGEPGPRGLLGPKGPPGP---PGPPG---VTGMDGQPGP 660 670 680 690 700 430 440 450 460 470 480 pF1KB3 KGEPGLQGFPGKPGFLGEVGPPGMRGLPGP---IGPKGEAGQKGVPGLPGVPGLLGPKGE ::. : :: :: :: . : :: .::::: ::: :: : : :::::.:: :: :. CCDS75 KGNVGPQGEPGPPG---QQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGH 710 720 730 740 750 760 490 500 510 520 530 540 pF1KB3 PGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPP :: .:::: : :: :: :: : :::.: : : :. : : : : : CCDS75 PGK------EGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKG--TKGEKGEDGFP 770 780 790 800 810 550 560 570 580 590 600 pF1KB3 GKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAK : : .: .:. : :::: CCDS75 GFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYP 820 830 840 850 860 870 >>CCDS14543.1 COL4A5 gene_id:1287|Hs108|chrX (1685 aa) initn: 1937 init1: 725 opt: 1629 Z-score: 644.8 bits: 131.1 E(32554): 1.4e-29 Smith-Waterman score: 1766; 46.5% identity (59.7% similar) in 635 aa overlap (32-632:609-1198) 10 20 30 40 50 60 pF1KB3 AVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHM :. :: .: :. :: . :.:.. CCDS14 GQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGFGPPGPVGEK---- 580 590 600 610 620 630 70 80 90 100 110 120 pF1KB3 PLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQG . .:.: . .: . : : : . ::. . : . : . .. : . : : CCDS14 --GIQGVAGNPGQPGIPGPKGDPG--QTIT--QPG-KPGLPGNPGRDGDVGLPGDPGLPG 640 650 660 670 680 130 140 150 160 170 180 pF1KB3 PRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGV-GKPGMPGMPGKPGAMGMPGAKGE : :: : : ::.:: :.:: :::.:.::. : :: :: ::. : : :: : CCDS14 QPGLPGIPGSKGEPGIPGIGLPG---PPGPKGFPGIPGPPGAPGTPGRIGLEGPPGPPGF 690 700 710 720 730 740 190 200 210 220 230 pF1KB3 IGQKGEIGPMGIPGPQGPPGPHGLPG-IGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGP : ::: : ...::: :::: :. : .: : :.:: ::: : : :::::.: :: CCDS14 PGPKGEPG-FALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGP 750 760 770 780 790 800 240 250 260 270 280 290 pF1KB3 KGDKG-FGMPGAPGVKGPPGMHGPPGPVGLPG-VGKPGVTGFPGPQGPLGKPG--APGEP .:. : .: :: ::. :..::::: :.:: .:.::. :.:: .: : :: .:: : CCDS14 NGQPGPMGPPGLPGI----GVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPP 810 820 830 840 850 300 310 320 330 340 350 pF1KB3 GPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGI-GKPG : .: :.::. :: : :: .:: : : :::: :::.:. : ::::: :: :. : CCDS14 GERGSPGIPGAPGPIGPPG--SPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSG 860 870 880 890 900 910 360 370 380 390 400 pF1KB3 FPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPG--------------EPGLPGIPGP :: ::: :. : :: :: :::: : ::. :::: ::::::::: CCDS14 VPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGV 920 930 940 950 960 970 410 420 430 440 450 pF1KB3 MGPPGAIGFPGPKGEGGIVG-P--QGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGP :: : :.:: :. :. : : :::::::.::: ::.::. .::::..: : CCDS14 SGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGL---PGQPGL---IGPPGLKGTIGD 980 990 1000 1010 1020 1030 460 470 480 490 500 510 pF1KB3 IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGP .: : : .: :: :::: : : ::.::..: .: ::: . :: ::.::: CCDS14 MGFPGPQGVEGPPGPSGVPGQ--P-GSPGLPGQKGDKGDPGISS-------IGLPGLPGP 1040 1050 1060 1070 1080 520 530 540 550 560 570 pF1KB3 KGEPGLPGPPGFPGI-GKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVM-P :::::::: :: ::: :. : :: : :: ::: .::::::: :: :::::: .. : CCDS14 KGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGA---KGQPGLPGFPGTPGPPGPKGISGP 1090 1100 1110 1120 1130 580 590 600 610 620 pF1KB3 PTPPP-QGEYLPDMGLGIDGVKPPHAYGAKKGKNG--GPAYE-----MPAFTAELTAPFP : : :: : : : : : . .: :..: ::: . .:.: : : CCDS14 PGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGF----GNPGP 1140 1150 1160 1170 1180 1190 630 640 650 660 670 680 pF1KB3 PVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMY : : : CCDS14 P-GLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGN 1200 1210 1220 1230 1240 1250 >-- initn: 849 init1: 494 opt: 871 Z-score: 355.5 bits: 77.6 E(32554): 1.8e-13 Smith-Waterman score: 989; 50.8% identity (63.2% similar) in 299 aa overlap (217-514:1199-1458) 190 200 210 220 230 240 pF1KB3 IGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFG : : ::: : :.:: :: ::::. CCDS14 PGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGE---- 1170 1180 1190 1200 1210 1220 250 260 270 280 290 300 pF1KB3 MPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGV :: .: ::..::::: : :: . : : :::::: :: :: :::.:: :.:: CCDS14 ----PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGP---PGRPGLPGPEGPPGLPGN 1230 1240 1250 1260 1270 310 320 330 340 350 360 pF1KB3 QGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGG : : : .::: :: ::.:: ::.:: ::: : :: .::. : ::: :. : CCDS14 GGIKGEKG--NPGQ---PGLPGLPGLKGDQGPPGLQGNPG-----RPGLNGMKGDPGLPG 1280 1290 1300 1310 1320 370 380 390 400 410 420 pF1KB3 VPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIV-GPQGPP ::: : : ::: :.:: .:: ::::: .:::: :.:::.:.. :. : ::: CCDS14 VPGF--P-GMKGPSGVPGSAGPEGEPGL------IGPPGPPGLPGPSGQSIIIKGDAGPP 1330 1340 1350 1360 1370 430 440 450 460 470 480 pF1KB3 GPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEP : :.:::.:.:: : : .::::: :: :. :..:.::. :. : : : : CCDS14 GIPGQPGLKGLPG---------PQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLP 1380 1390 1400 1410 1420 490 500 510 520 530 540 pF1KB3 GIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPG : :: .::.:::: :. :: :: : .. CCDS14 GQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQGTLQVYEGFSL 1430 1440 1450 1460 1470 1480 >-- initn: 660 init1: 660 opt: 864 Z-score: 352.8 bits: 77.1 E(32554): 2.5e-13 Smith-Waterman score: 1394; 49.2% identity (60.3% similar) in 451 aa overlap (144-571:42-462) 120 130 140 150 160 170 pF1KB3 ASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMG ::::. : .:.::. : ::.:: :: : CCDS14 LFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGL--EGHPGLPGFPGPEG 20 30 40 50 60 180 190 200 210 220 230 pF1KB3 MPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGP :: .: :::. : : :::.: :: ::::. :: :::::.:: : ::.:.:: CCDS14 PPGPRG---QKGDDGIPGPPGPKGIRGPPGLPGF--PGTPGLPGMPGHDGAPGPQGIPG- 70 80 90 100 110 120 240 250 260 270 280 pF1KB3 QGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGV-GKPG---VTGFPGPQGPLGKP : ::..:: ::.:: ::..::::: :.::. :.:: ....:::.: : : CCDS14 --CNGTKGERGF--PGSPGF---PGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYP 130 140 150 160 170 290 300 310 320 330 340 pF1KB3 GAPGEPGPQGPIGVPGVQGPPGIPGI-GKPGQDGIPGQPG-----FPGGKGEQGLPGLPG : :: : :: :.:: :::: ::. : :: :.:: : : : :::.: :: : CCDS14 GPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQG 180 190 200 210 220 230 350 360 370 380 390 pF1KB3 PPGLPG-IGKPGFPGP----KGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPG-LPGI ::: :: :.. : :::.:. :: ..:: : ::: :::: :: : CCDS14 PPGPPGQISEQKRPIDVEFQKGDQGL---PG------DRGPPGPPGIRGPPGPPGGEKGE 240 250 260 270 280 400 410 420 430 440 450 pF1KB3 PGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGL--P : .: :: : :: ::.: : : :: : :: : :. : :..:::: :: : CCDS14 KGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIP 290 300 310 320 330 340 460 470 480 490 500 510 pF1KB3 GPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIP : : :.:: ::::.:: : .: ::: : :: :::: .: : ::::.: CCDS14 RP-GTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAAVMGPP----GPPGFP 350 360 370 380 390 400 520 530 540 550 560 570 pF1KB3 GPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGP-----PGPPGPPGP : .:. : ::::. : ::. : : :: :: :: : : .: :::::::: CCDS14 GERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAG-PHIPPSDEICEPGPPGPPGS 410 420 430 440 450 460 580 590 600 610 620 630 pF1KB3 PAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVG : CCDS14 PGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAG 470 480 490 500 510 520 >>CCDS35366.1 COL4A5 gene_id:1287|Hs108|chrX (1691 aa) initn: 1937 init1: 725 opt: 1629 Z-score: 644.7 bits: 131.1 E(32554): 1.4e-29 Smith-Waterman score: 1766; 46.5% identity (59.7% similar) in 635 aa overlap (32-632:609-1198) 10 20 30 40 50 60 pF1KB3 AVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHM :. :: .: :. :: . :.:.. CCDS35 GQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGFGPPGPVGEK---- 580 590 600 610 620 630 70 80 90 100 110 120 pF1KB3 PLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQG . .:.: . .: . : : : . ::. . : . : . .. : . : : CCDS35 --GIQGVAGNPGQPGIPGPKGDPG--QTIT--QPG-KPGLPGNPGRDGDVGLPGDPGLPG 640 650 660 670 680 130 140 150 160 170 180 pF1KB3 PRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGV-GKPGMPGMPGKPGAMGMPGAKGE : :: : : ::.:: :.:: :::.:.::. : :: :: ::. : : :: : CCDS35 QPGLPGIPGSKGEPGIPGIGLPG---PPGPKGFPGIPGPPGAPGTPGRIGLEGPPGPPGF 690 700 710 720 730 740 190 200 210 220 230 pF1KB3 IGQKGEIGPMGIPGPQGPPGPHGLPG-IGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGP : ::: : ...::: :::: :. : .: : :.:: ::: : : :::::.: :: CCDS35 PGPKGEPG-FALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGP 750 760 770 780 790 800 240 250 260 270 280 290 pF1KB3 KGDKG-FGMPGAPGVKGPPGMHGPPGPVGLPG-VGKPGVTGFPGPQGPLGKPG--APGEP .:. : .: :: ::. :..::::: :.:: .:.::. :.:: .: : :: .:: : CCDS35 NGQPGPMGPPGLPGI----GVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPP 810 820 830 840 850 300 310 320 330 340 350 pF1KB3 GPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGI-GKPG : .: :.::. :: : :: .:: : : :::: :::.:. : ::::: :: :. : CCDS35 GERGSPGIPGAPGPIGPPG--SPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSG 860 870 880 890 900 910 360 370 380 390 400 pF1KB3 FPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPG--------------EPGLPGIPGP :: ::: :. : :: :: :::: : ::. :::: ::::::::: CCDS35 VPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGV 920 930 940 950 960 970 410 420 430 440 450 pF1KB3 MGPPGAIGFPGPKGEGGIVG-P--QGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGP :: : :.:: :. :. : : :::::::.::: ::.::. .::::..: : CCDS35 SGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGL---PGQPGL---IGPPGLKGTIGD 980 990 1000 1010 1020 1030 460 470 480 490 500 510 pF1KB3 IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGP .: : : .: :: :::: : : ::.::..: .: ::: . :: ::.::: CCDS35 MGFPGPQGVEGPPGPSGVPGQ--P-GSPGLPGQKGDKGDPGISS-------IGLPGLPGP 1040 1050 1060 1070 1080 520 530 540 550 560 570 pF1KB3 KGEPGLPGPPGFPGI-GKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVM-P :::::::: :: ::: :. : :: : :: ::: .::::::: :: :::::: .. : CCDS35 KGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGA---KGQPGLPGFPGTPGPPGPKGISGP 1090 1100 1110 1120 1130 580 590 600 610 620 pF1KB3 PTPPP-QGEYLPDMGLGIDGVKPPHAYGAKKGKNG--GPAYE-----MPAFTAELTAPFP : : :: : : : : : . .: :..: ::: . .:.: : : CCDS35 PGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGF----GNPGP 1140 1150 1160 1170 1180 1190 630 640 650 660 670 680 pF1KB3 PVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMY : : : CCDS35 P-GLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGN 1200 1210 1220 1230 1240 1250 >-- initn: 1338 init1: 527 opt: 894 Z-score: 364.3 bits: 79.2 E(32554): 5.7e-14 Smith-Waterman score: 1003; 50.8% identity (63.5% similar) in 301 aa overlap (217-514:1199-1464) 190 200 210 220 230 240 pF1KB3 IGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFG : : ::: : :.:: :: ::::. CCDS35 PGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGE---- 1170 1180 1190 1200 1210 1220 250 260 270 280 290 300 pF1KB3 MPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGV :: .: ::..::::: : :: . : : :::::: ::.::: : :.:: CCDS35 ----PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGP------PGRPGPTGFQGLPGP 1230 1240 1250 1260 1270 310 320 330 340 350 360 pF1KB3 QGPPGIPGIGK-PGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGI-GKPGFPGPKGDRGM .::::.:: : :. : :::::.:: :: : ::::: : :.::. : ::: :. CCDS35 EGPPGLPGNGGIKGEKGNPGQPGLPG---LPGLKGDQGPPGLQGNPGRPGLNGMKGDPGL 1280 1290 1300 1310 1320 1330 370 380 390 400 410 420 pF1KB3 GGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIV-GPQG :::: : : ::: :.:: .:: ::::: .:::: :.:::.:.. :. : : CCDS35 PGVPGF--P-GMKGPSGVPGSAGPEGEPGL------IGPPGPPGLPGPSGQSIIIKGDAG 1340 1350 1360 1370 1380 430 440 450 460 470 480 pF1KB3 PPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKG ::: :.:::.:.:: : : .::::: :: :. :..:.::. :. : : : CCDS35 PPGIPGQPGLKGLPG---------PQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPG 1390 1400 1410 1420 1430 490 500 510 520 530 540 pF1KB3 EPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGP :: :: .::.:::: :. :: :: : .. CCDS35 LPGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQGTLQVYEGF 1440 1450 1460 1470 1480 1490 550 560 570 580 590 600 pF1KB3 PGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGA CCDS35 SLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPM 1500 1510 1520 1530 1540 1550 >-- initn: 660 init1: 660 opt: 864 Z-score: 352.8 bits: 77.1 E(32554): 2.5e-13 Smith-Waterman score: 1394; 49.2% identity (60.3% similar) in 451 aa overlap (144-571:42-462) 120 130 140 150 160 170 pF1KB3 ASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMG ::::. : .:.::. : ::.:: :: : CCDS35 LFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGL--EGHPGLPGFPGPEG 20 30 40 50 60 180 190 200 210 220 230 pF1KB3 MPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGP :: .: :::. : : :::.: :: ::::. :: :::::.:: : ::.:.:: CCDS35 PPGPRG---QKGDDGIPGPPGPKGIRGPPGLPGF--PGTPGLPGMPGHDGAPGPQGIPG- 70 80 90 100 110 120 240 250 260 270 280 pF1KB3 QGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGV-GKPG---VTGFPGPQGPLGKP : ::..:: ::.:: ::..::::: :.::. :.:: ....:::.: : : CCDS35 --CNGTKGERGF--PGSPGF---PGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYP 130 140 150 160 170 290 300 310 320 330 340 pF1KB3 GAPGEPGPQGPIGVPGVQGPPGIPGI-GKPGQDGIPGQPG-----FPGGKGEQGLPGLPG : :: : :: :.:: :::: ::. : :: :.:: : : : :::.: :: : CCDS35 GPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQG 180 190 200 210 220 230 350 360 370 380 390 pF1KB3 PPGLPG-IGKPGFPGP----KGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPG-LPGI ::: :: :.. : :::.:. :: ..:: : ::: :::: :: : CCDS35 PPGPPGQISEQKRPIDVEFQKGDQGL---PG------DRGPPGPPGIRGPPGPPGGEKGE 240 250 260 270 280 400 410 420 430 440 450 pF1KB3 PGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGL--P : .: :: : :: ::.: : : :: : :: : :. : :..:::: :: : CCDS35 KGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIP 290 300 310 320 330 340 460 470 480 490 500 510 pF1KB3 GPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIP : : :.:: ::::.:: : .: ::: : :: :::: .: : ::::.: CCDS35 RP-GTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAAVMGPP----GPPGFP 350 360 370 380 390 400 520 530 540 550 560 570 pF1KB3 GPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGP-----PGPPGPPGP : .:. : ::::. : ::. : : :: :: :: : : .: :::::::: CCDS35 GERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAG-PHIPPSDEICEPGPPGPPGS 410 420 430 440 450 460 580 590 600 610 620 630 pF1KB3 PAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVG : CCDS35 PGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAG 470 480 490 500 510 520 >>CCDS780.2 COL11A1 gene_id:1301|Hs108|chr1 (1690 aa) initn: 644 init1: 644 opt: 1613 Z-score: 638.6 bits: 130.0 E(32554): 3e-29 Smith-Waterman score: 1721; 43.4% identity (53.2% similar) in 705 aa overlap (47-632:684-1384) 20 30 40 50 60 70 pF1KB3 ISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPH .. : : :.. :. : .. : : : CCDS78 VRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAG-PTGDPGPS 660 670 680 690 700 710 80 90 100 110 120 130 pF1KB3 LQYGKE----YPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGP- : :.. : :: : . : : . : . : .. :. ::::. :: :: CCDS78 GQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPR 720 730 740 750 760 770 140 150 160 170 pF1KB3 -----------PGPPGLPG-HGIPGIKGKPGPQGYPG-VGKPGM---PGMPGKPGAMGMP ::: : : : :: :. :::: : :: :: :: ::: : : : CCDS78 GSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHP 780 790 800 810 820 830 180 190 200 210 220 pF1KB3 GAKGEIGQKGEIGPMG---IPGPQGPPGPHGLPGI-GKPGGPGLPGQ---PGPKGDRGPK : .:: : .:. :: : . ::::: : : : :.:: :: ::. :: : .: : CCDS78 GQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAK 840 850 860 870 880 890 230 240 250 260 270 pF1KB3 GLPGPQGLRG---PKGDKGF----GMPGA---PGVKGPPGMHGPPGPVGLPG-------- : :::::. : : : .:: :.::: ::.:: : .::::::: :: CCDS78 GDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTA 900 910 920 930 940 950 280 290 300 310 320 pF1KB3 --VGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPG----IGKPGQDGIP .: :: : :: :: :. ::::: ::::: : ::::: :.:: :.::.:: CCDS78 GPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDK 960 970 980 990 1000 1010 330 340 350 360 370 pF1KB3 GQ---PGFPGGKGEQGLPGLPGPPGLPG-IGKPGF------PGPKGDRGMGGVPGALGPR :. :: :.::..: : :::::: : .: ::. :::.:..:: : : : : CCDS78 GEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGAR 1020 1030 1040 1050 1060 1070 380 390 400 410 420 pF1KB3 G---EKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGP---- : :::: :. ::::: : : ::::::: : ::.: .: ::::::: CCDS78 GFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSV 1080 1090 1100 1110 1120 1130 430 440 450 460 pF1KB3 -----KGEPGLQGFPGKPGFLG------------------EVGPPGMRGLPGPIGPKGEA ::::: : :: :: : .:::: .: :: ::::. CCDS78 GGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNP 1140 1150 1160 1170 1180 1190 470 480 490 500 510 520 pF1KB3 GQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLP : : :: :: :: :: :. :. ::.: .: :: :: :::: :::: :: .: :: CCDS78 GPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAA 1200 1210 1220 1230 1240 1250 530 540 550 560 pF1KB3 GPPGFPG-IGKPGVAGLHGPPGKPGALGPQGQPGLPGP------PGP------------- : : : : : :: .::::: : .:::: : ::: ::: CCDS78 GAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQD 1260 1270 1280 1290 1300 1310 570 580 590 600 610 pF1KB3 --PGPPGPPAV--MPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYE-MPAFT ::: :::.. . : .:: .:. : :: : .:: : :. . :. CCDS78 GPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIG--PPGEQG-EKGDRGLPGTQGSPGAK 1320 1330 1340 1350 1360 620 630 640 650 660 670 pF1KB3 AELTAPFP--PVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVA .. : : :.: : CCDS78 GDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQP 1370 1380 1390 1400 1410 1420 >-- initn: 603 init1: 603 opt: 1005 Z-score: 406.6 bits: 87.1 E(32554): 2.5e-16 Smith-Waterman score: 1132; 45.9% identity (58.4% similar) in 401 aa overlap (139-528:302-683) 110 120 130 140 150 160 pF1KB3 KEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGK ::: : ::. .: :.: .::: . : CCDS78 EYGEAEYKEAESVTEGPTVTEETIAQTEINGHGAYGEKGQ---KGEPAVVEPGML-VEGP 280 290 300 310 320 170 180 190 200 210 220 pF1KB3 PGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPK :: : : : : .: :: : :: .:::: .:: :: : ::: : CCDS78 PGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPG--------RPGLPGADGLPGPPGTM--L 330 340 350 360 370 230 240 250 260 270 280 pF1KB3 GLP---GPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGP :: : .: .:: . .. : .. ...:::::.:: .:.:: .: :: .: CCDS78 MLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGL--TGRPGPVGGPGSSGA 380 390 400 410 420 430 290 300 310 320 330 340 pF1KB3 LGKPGAPGEPGPQGPIGVPGVQGPPGIPGI-GKPGQDGIPGQPGFPGGKGEQGLPGLPGP :. : .:::::: :: : :: : :: :.:: :: :.:: ::.::..:. :::: CCDS78 KGESG---DPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGL 440 450 460 470 480 490 350 360 370 380 390 pF1KB3 PGLPGI----GKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGP---PGEPGLPGI :: : : : ::: :: :: : : .:::: : : :. :: :: :: ::. CCDS78 PGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGM 500 510 520 530 540 550 400 410 420 430 440 450 pF1KB3 PGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGP : :::: : ::.:: : : :: :::.: :: :: : :: : : ::. :::: CCDS78 AGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGA 560 570 580 590 600 610 460 470 480 490 500 510 pF1KB3 IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGP :: :. :..: : :. : ::.: : :: .:..: :. :. : .: : :.:: CCDS78 DGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGF 620 630 640 650 660 670 520 530 540 550 560 570 pF1KB3 KGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPT ::. :: : : CCDS78 KGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGR 680 690 700 710 720 730 >>CCDS53348.1 COL11A1 gene_id:1301|Hs108|chr1 (1767 aa) initn: 644 init1: 644 opt: 1613 Z-score: 638.4 bits: 130.0 E(32554): 3.1e-29 Smith-Waterman score: 1721; 43.4% identity (53.2% similar) in 705 aa overlap (47-632:761-1461) 20 30 40 50 60 70 pF1KB3 ISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPH .. : : :.. :. : .. : : : CCDS53 VRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAG-PTGDPGPS 740 750 760 770 780 80 90 100 110 120 130 pF1KB3 LQYGKE----YPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGP- : :.. : :: : . : : . : . : .. :. ::::. :: :: CCDS53 GQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPR 790 800 810 820 830 840 140 150 160 170 pF1KB3 -----------PGPPGLPG-HGIPGIKGKPGPQGYPG-VGKPGM---PGMPGKPGAMGMP ::: : : : :: :. :::: : :: :: :: ::: : : : CCDS53 GSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHP 850 860 870 880 890 900 180 190 200 210 220 pF1KB3 GAKGEIGQKGEIGPMG---IPGPQGPPGPHGLPGI-GKPGGPGLPGQ---PGPKGDRGPK : .:: : .:. :: : . ::::: : : : :.:: :: ::. :: : .: : CCDS53 GQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAK 910 920 930 940 950 960 230 240 250 260 270 pF1KB3 GLPGPQGLRG---PKGDKGF----GMPGA---PGVKGPPGMHGPPGPVGLPG-------- : :::::. : : : .:: :.::: ::.:: : .::::::: :: CCDS53 GDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTA 970 980 990 1000 1010 1020 280 290 300 310 320 pF1KB3 --VGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPG----IGKPGQDGIP .: :: : :: :: :. ::::: ::::: : ::::: :.:: :.::.:: CCDS53 GPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDK 1030 1040 1050 1060 1070 1080 330 340 350 360 370 pF1KB3 GQ---PGFPGGKGEQGLPGLPGPPGLPG-IGKPGF------PGPKGDRGMGGVPGALGPR :. :: :.::..: : :::::: : .: ::. :::.:..:: : : : : CCDS53 GEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGAR 1090 1100 1110 1120 1130 1140 380 390 400 410 420 pF1KB3 G---EKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGP---- : :::: :. ::::: : : ::::::: : ::.: .: ::::::: CCDS53 GFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSV 1150 1160 1170 1180 1190 1200 430 440 450 460 pF1KB3 -----KGEPGLQGFPGKPGFLG------------------EVGPPGMRGLPGPIGPKGEA ::::: : :: :: : .:::: .: :: ::::. CCDS53 GGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNP 1210 1220 1230 1240 1250 1260 470 480 490 500 510 520 pF1KB3 GQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLP : : :: :: :: :: :. :. ::.: .: :: :: :::: :::: :: .: :: CCDS53 GPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAA 1270 1280 1290 1300 1310 1320 530 540 550 560 pF1KB3 GPPGFPG-IGKPGVAGLHGPPGKPGALGPQGQPGLPGP------PGP------------- : : : : : :: .::::: : .:::: : ::: ::: CCDS53 GAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQD 1330 1340 1350 1360 1370 1380 570 580 590 600 610 pF1KB3 --PGPPGPPAV--MPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYE-MPAFT ::: :::.. . : .:: .:. : :: : .:: : :. . :. CCDS53 GPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIG--PPGEQG-EKGDRGLPGTQGSPGAK 1390 1400 1410 1420 1430 1440 620 630 640 650 660 670 pF1KB3 AELTAPFP--PVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVA .. : : :.: : CCDS53 GDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQP 1450 1460 1470 1480 1490 1500 >-- initn: 603 init1: 603 opt: 1021 Z-score: 412.5 bits: 88.2 E(32554): 1.2e-16 Smith-Waterman score: 1146; 44.3% identity (57.3% similar) in 429 aa overlap (119-528:351-760) 90 100 110 120 130 140 pF1KB3 YMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPG--------LPGH :. : . :. . :: :. . :: CCDS53 YENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGH 330 340 350 360 370 380 150 160 170 180 190 200 pF1KB3 GIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPG : : ::. .: :.: .::: . : :: : : : : .: :: : :: .::: CCDS53 GAYGEKGQ---KGEPAVVEPGML-VEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPP- 390 400 410 420 430 210 220 230 240 250 pF1KB3 PHGLPGIGKPGGPGLPGQPGPKGDRGPKGLP---GPQGLRGPKGDKGFGMPGAPGVKGPP :.:: :: : ::: : :: : .: .:: . .. : .. CCDS53 -------GRPGLPGADGLPGPPGTM--LMLPFRYGGDGSKGPTISAQEAQAQAILQQARI 440 450 460 470 480 260 270 280 290 300 310 pF1KB3 GMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGI-G ...:::::.:: .:.:: .: :: .: :. : .:::::: :: : :: : :: : CCDS53 ALRGPPGPMGL--TGRPGPVGGPGSSGAKGESG---DPGPQGPRGVQGPPGPTGKPGKRG 490 500 510 520 530 540 320 330 340 350 360 370 pF1KB3 KPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGI----GKPGFPGPKGDRGMGGVPGALG .:: :: :.:: ::.::..:. :::: :: : : : ::: :: :: : : .: CCDS53 RPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIG 550 560 570 580 590 600 380 390 400 410 420 pF1KB3 PRGEKGPIGAPGIGGP---PGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKG ::: : : :. :: :: :: ::. : :::: : ::.:: : : :: :::.: CCDS53 PRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQG 610 620 630 640 650 660 430 440 450 460 470 480 pF1KB3 EPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPG :: :: : :: : : ::. :::: :: :. :..: : :. : ::.: : :: CCDS53 LPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPG 670 680 690 700 710 720 490 500 510 520 530 540 pF1KB3 DQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGA .:..: :. :. : .: : :.:: ::. :: : : CCDS53 PRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAG 730 740 750 760 770 780 550 560 570 580 590 600 pF1KB3 LGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNG CCDS53 PTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRG 790 800 810 820 830 840 744 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:53:59 2016 done: Thu Nov 3 20:54:00 2016 Total Scan time: 4.930 Total Display time: 0.350 Function used was FASTA [36.3.4 Apr, 2011]