FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3300, 723 aa 1>>>pF1KB3300 723 - 723 aa - 723 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.1423+/-0.000571; mu= -10.2351+/- 0.035 mean_var=581.7748+/-121.869, 0's: 0 Z-trim(119.9): 101 B-trim: 0 in 0/56 Lambda= 0.053174 statistics sampled from 34325 (34426) to 34325 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.404), width: 16 Scan time: 12.000 The best scores are: opt bits E(85289) XP_016870772 (OMIM: 610933,614436) PREDICTED: E3 u ( 723) 4682 375.0 5.9e-103 NP_001005373 (OMIM: 610933,614436) E3 ubiquitin-pr ( 723) 4682 375.0 5.9e-103 NP_001005374 (OMIM: 610933,614436) E3 ubiquitin-pr ( 723) 4682 375.0 5.9e-103 NP_612370 (OMIM: 610933,614436) E3 ubiquitin-prote ( 723) 4682 375.0 5.9e-103 XP_006717379 (OMIM: 610933,614436) PREDICTED: E3 u ( 690) 3395 276.2 3e-73 NP_001177652 (OMIM: 610933,614436) E3 ubiquitin-pr ( 696) 3074 251.6 7.9e-66 XP_016870773 (OMIM: 610933,614436) PREDICTED: E3 u ( 460) 2961 242.7 2.5e-63 >>XP_016870772 (OMIM: 610933,614436) PREDICTED: E3 ubiqu (723 aa) initn: 4682 init1: 4682 opt: 4682 Z-score: 1969.3 bits: 375.0 E(85289): 5.9e-103 Smith-Waterman score: 4682; 99.7% identity (100.0% similar) in 723 aa overlap (1-723:1-723) 10 20 30 40 50 60 pF1KB3 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE :::::::::::::::::.:::.:::::::::::::::::::::::::::::::::::::: XP_016 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 670 680 690 700 710 720 pF1KB3 HSS ::: XP_016 HSS >>NP_001005373 (OMIM: 610933,614436) E3 ubiquitin-protei (723 aa) initn: 4682 init1: 4682 opt: 4682 Z-score: 1969.3 bits: 375.0 E(85289): 5.9e-103 Smith-Waterman score: 4682; 99.7% identity (100.0% similar) in 723 aa overlap (1-723:1-723) 10 20 30 40 50 60 pF1KB3 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE :::::::::::::::::.:::.:::::::::::::::::::::::::::::::::::::: NP_001 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 670 680 690 700 710 720 pF1KB3 HSS ::: NP_001 HSS >>NP_001005374 (OMIM: 610933,614436) E3 ubiquitin-protei (723 aa) initn: 4682 init1: 4682 opt: 4682 Z-score: 1969.3 bits: 375.0 E(85289): 5.9e-103 Smith-Waterman score: 4682; 99.7% identity (100.0% similar) in 723 aa overlap (1-723:1-723) 10 20 30 40 50 60 pF1KB3 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE :::::::::::::::::.:::.:::::::::::::::::::::::::::::::::::::: NP_001 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 670 680 690 700 710 720 pF1KB3 HSS ::: NP_001 HSS >>NP_612370 (OMIM: 610933,614436) E3 ubiquitin-protein l (723 aa) initn: 4682 init1: 4682 opt: 4682 Z-score: 1969.3 bits: 375.0 E(85289): 5.9e-103 Smith-Waterman score: 4682; 99.7% identity (100.0% similar) in 723 aa overlap (1-723:1-723) 10 20 30 40 50 60 pF1KB3 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE :::::::::::::::::.:::.:::::::::::::::::::::::::::::::::::::: NP_612 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 670 680 690 700 710 720 pF1KB3 HSS ::: NP_612 HSS >>XP_006717379 (OMIM: 610933,614436) PREDICTED: E3 ubiqu (690 aa) initn: 3391 init1: 3391 opt: 3395 Z-score: 1436.0 bits: 276.2 E(85289): 3e-73 Smith-Waterman score: 4395; 95.2% identity (95.4% similar) in 723 aa overlap (1-723:1-690) 10 20 30 40 50 60 pF1KB3 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE :::::::::::::::::.:::.:::::::::::::::::::::::::::::::::::::: XP_006 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREIL------- 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL :::::::::::::::::::::::::::::::::: XP_006 --------------------------EEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 540 550 560 610 620 630 640 650 660 pF1KB3 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 570 580 590 600 610 620 670 680 690 700 710 720 pF1KB3 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 630 640 650 660 670 680 pF1KB3 HSS ::: XP_006 HSS 690 >>NP_001177652 (OMIM: 610933,614436) E3 ubiquitin-protei (696 aa) initn: 3036 init1: 3036 opt: 3074 Z-score: 1302.8 bits: 251.6 E(85289): 7.9e-66 Smith-Waterman score: 4465; 96.0% identity (96.3% similar) in 723 aa overlap (1-723:1-696) 10 20 30 40 50 60 pF1KB3 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 EEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE :::::::::::::::::.:::.:::::::::::::::::::::::::::::::::::::: NP_001 EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQ------ 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS ::::::::::::::::::::::::::::::::::::::: NP_001 ---------------------EMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS 480 490 500 510 550 560 570 580 590 600 pF1KB3 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB3 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB3 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY 640 650 660 670 680 690 pF1KB3 HSS ::: NP_001 HSS >>XP_016870773 (OMIM: 610933,614436) PREDICTED: E3 ubiqu (460 aa) initn: 2961 init1: 2961 opt: 2961 Z-score: 1258.1 bits: 242.7 E(85289): 2.5e-63 Smith-Waterman score: 2961; 99.6% identity (100.0% similar) in 460 aa overlap (264-723:1-460) 240 250 260 270 280 290 pF1KB3 SPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKD :::::::::::::::::::::::::::::: XP_016 MLEKLEFERRLELGQREHTQLLQQSSSQKD 10 20 30 300 310 320 330 340 350 pF1KB3 EILQTVKEEQSRLEQGLSEHQRHLDAERRRLQEQLKQTEQNISSRIQKLLQDNQRQKKSS ::::::::::::::::::::::::.:::.::::::::::::::::::::::::::::::: XP_016 EILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSS 40 50 60 70 80 90 360 370 380 390 400 410 pF1KB3 EILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNL 100 110 120 130 140 150 420 430 440 450 460 470 pF1KB3 VQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRS 160 170 180 190 200 210 480 490 500 510 520 530 pF1KB3 QIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREIL 220 230 240 250 260 270 540 550 560 570 580 590 pF1KB3 TELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHH 280 290 300 310 320 330 600 610 620 630 640 650 pF1KB3 RLSLDLLSQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLSLDLLSQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQ 340 350 360 370 380 390 660 670 680 690 700 710 pF1KB3 EPPESVRPSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPPESVRPSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDI 400 410 420 430 440 450 720 pF1KB3 AQRLRIYHSS :::::::::: XP_016 AQRLRIYHSS 460 723 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:54:44 2016 done: Thu Nov 3 20:54:45 2016 Total Scan time: 12.000 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]