FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3319, 806 aa 1>>>pF1KB3319 806 - 806 aa - 806 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6334+/-0.000419; mu= 18.9875+/- 0.026 mean_var=94.0052+/-18.337, 0's: 0 Z-trim(113.2): 301 B-trim: 2 in 1/53 Lambda= 0.132281 statistics sampled from 22074 (22431) to 22074 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.263), width: 16 Scan time: 10.730 The best scores are: opt bits E(85289) XP_011537154 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 5430 1047.5 0 XP_006719704 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 5430 1047.5 0 XP_005254007 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 5430 1047.5 0 NP_001180449 (OMIM: 604118) rasGAP-activating-like ( 806) 5430 1047.5 0 XP_006719705 (OMIM: 604118) PREDICTED: rasGAP-acti ( 805) 5412 1044.1 0 NP_001288131 (OMIM: 604118) rasGAP-activating-like ( 805) 5411 1043.9 0 XP_016875517 (OMIM: 604118) PREDICTED: rasGAP-acti ( 805) 5411 1043.9 0 NP_004649 (OMIM: 604118) rasGAP-activating-like pr ( 804) 5393 1040.5 0 XP_011537155 (OMIM: 604118) PREDICTED: rasGAP-acti ( 804) 5393 1040.5 0 XP_016875518 (OMIM: 604118) PREDICTED: rasGAP-acti ( 780) 4760 919.6 0 XP_016875519 (OMIM: 604118) PREDICTED: rasGAP-acti ( 780) 4760 919.6 0 XP_016875520 (OMIM: 604118) PREDICTED: rasGAP-acti ( 779) 4741 916.0 0 NP_001180450 (OMIM: 604118) rasGAP-activating-like ( 776) 4073 788.5 0 XP_011537156 (OMIM: 604118) PREDICTED: rasGAP-acti ( 447) 3010 585.5 1.8e-166 NP_008920 (OMIM: 607943) ras GTPase-activating pro ( 803) 2486 485.7 3.4e-136 XP_016867150 (OMIM: 607943) PREDICTED: ras GTPase- ( 840) 2449 478.6 4.8e-134 XP_011514025 (OMIM: 607943) PREDICTED: ras GTPase- ( 682) 1986 390.2 1.6e-107 NP_001073346 (OMIM: 607943) ras GTPase-activating ( 757) 1986 390.2 1.7e-107 XP_016867151 (OMIM: 607943) PREDICTED: ras GTPase- ( 794) 1986 390.3 1.8e-107 NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 682 141.4 1.6e-32 NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 677 140.5 3e-32 XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase- ( 871) 676 140.3 3.5e-32 NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 672 139.5 5.9e-32 XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase- ( 853) 666 138.4 1.3e-31 XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase- ( 872) 666 138.4 1.3e-31 XP_016862461 (OMIM: 601589) PREDICTED: ras GTPase- ( 442) 537 113.5 2.1e-24 XP_016875927 (OMIM: 605182) PREDICTED: ras GTPase- ( 451) 450 96.9 2.1e-19 XP_016875928 (OMIM: 605182) PREDICTED: ras GTPase- ( 451) 450 96.9 2.1e-19 NP_001307750 (OMIM: 605182) ras GTPase-activating ( 451) 450 96.9 2.1e-19 XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase- ( 707) 437 94.6 1.6e-18 NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 422 91.8 1.3e-17 XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 422 91.8 1.3e-17 XP_011533144 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 422 91.8 1.3e-17 NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 422 91.8 1.3e-17 XP_016862460 (OMIM: 601589) PREDICTED: ras GTPase- ( 573) 334 74.9 1.1e-12 XP_006718799 (OMIM: 604146) PREDICTED: synaptotagm ( 293) 284 65.1 5.2e-10 NP_004191 (OMIM: 604146) synaptotagmin-7 isoform 2 ( 403) 284 65.2 6.6e-10 XP_011543645 (OMIM: 604146) PREDICTED: synaptotagm ( 409) 284 65.2 6.6e-10 NP_001287702 (OMIM: 604146) synaptotagmin-7 isofor ( 447) 284 65.2 7.1e-10 XP_005274444 (OMIM: 604146) PREDICTED: synaptotagm ( 449) 284 65.2 7.1e-10 XP_011543643 (OMIM: 604146) PREDICTED: synaptotagm ( 453) 284 65.2 7.2e-10 NP_001238994 (OMIM: 604146) synaptotagmin-7 isofor ( 478) 284 65.3 7.4e-10 XP_011543642 (OMIM: 604146) PREDICTED: synaptotagm ( 484) 284 65.3 7.5e-10 XP_011543641 (OMIM: 604146) PREDICTED: synaptotagm ( 528) 284 65.3 8e-10 XP_005274442 (OMIM: 604146) PREDICTED: synaptotagm ( 611) 284 65.3 8.9e-10 XP_011543640 (OMIM: 604146) PREDICTED: synaptotagm ( 617) 284 65.4 9e-10 XP_005274441 (OMIM: 604146) PREDICTED: synaptotagm ( 642) 284 65.4 9.3e-10 XP_011543639 (OMIM: 604146) PREDICTED: synaptotagm ( 648) 284 65.4 9.3e-10 XP_011543638 (OMIM: 604146) PREDICTED: synaptotagm ( 651) 284 65.4 9.4e-10 XP_005274440 (OMIM: 604146) PREDICTED: synaptotagm ( 686) 284 65.4 9.8e-10 >>XP_011537154 (OMIM: 604118) PREDICTED: rasGAP-activati (806 aa) initn: 5430 init1: 5430 opt: 5430 Z-score: 5602.4 bits: 1047.5 E(85289): 0 Smith-Waterman score: 5430; 99.9% identity (100.0% similar) in 806 aa overlap (1-806:1-806) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_011 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 730 740 750 760 770 780 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: XP_011 LADLDRAHEEFQQQERGKAALGPLGP 790 800 >>XP_006719704 (OMIM: 604118) PREDICTED: rasGAP-activati (806 aa) initn: 5430 init1: 5430 opt: 5430 Z-score: 5602.4 bits: 1047.5 E(85289): 0 Smith-Waterman score: 5430; 99.9% identity (100.0% similar) in 806 aa overlap (1-806:1-806) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_006 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 730 740 750 760 770 780 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: XP_006 LADLDRAHEEFQQQERGKAALGPLGP 790 800 >>XP_005254007 (OMIM: 604118) PREDICTED: rasGAP-activati (806 aa) initn: 5430 init1: 5430 opt: 5430 Z-score: 5602.4 bits: 1047.5 E(85289): 0 Smith-Waterman score: 5430; 99.9% identity (100.0% similar) in 806 aa overlap (1-806:1-806) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_005 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 730 740 750 760 770 780 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: XP_005 LADLDRAHEEFQQQERGKAALGPLGP 790 800 >>NP_001180449 (OMIM: 604118) rasGAP-activating-like pro (806 aa) initn: 5430 init1: 5430 opt: 5430 Z-score: 5602.4 bits: 1047.5 E(85289): 0 Smith-Waterman score: 5430; 99.9% identity (100.0% similar) in 806 aa overlap (1-806:1-806) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_001 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 730 740 750 760 770 780 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: NP_001 LADLDRAHEEFQQQERGKAALGPLGP 790 800 >>XP_006719705 (OMIM: 604118) PREDICTED: rasGAP-activati (805 aa) initn: 3721 init1: 3721 opt: 5412 Z-score: 5583.9 bits: 1044.1 E(85289): 0 Smith-Waterman score: 5412; 99.8% identity (99.9% similar) in 806 aa overlap (1-806:1-805) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_006 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: XP_006 DFLDRLVDVDGDE-AGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 720 730 740 750 760 770 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: XP_006 LADLDRAHEEFQQQERGKAALGPLGP 780 790 800 >>NP_001288131 (OMIM: 604118) rasGAP-activating-like pro (805 aa) initn: 3086 init1: 3086 opt: 5411 Z-score: 5582.8 bits: 1043.9 E(85289): 0 Smith-Waterman score: 5411; 99.8% identity (99.9% similar) in 806 aa overlap (1-806:1-805) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_001 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: NP_001 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQ-DVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 720 730 740 750 760 770 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: NP_001 LADLDRAHEEFQQQERGKAALGPLGP 780 790 800 >>XP_016875517 (OMIM: 604118) PREDICTED: rasGAP-activati (805 aa) initn: 3086 init1: 3086 opt: 5411 Z-score: 5582.8 bits: 1043.9 E(85289): 0 Smith-Waterman score: 5411; 99.8% identity (99.9% similar) in 806 aa overlap (1-806:1-805) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_016 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: XP_016 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQ-DVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 720 730 740 750 760 770 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: XP_016 LADLDRAHEEFQQQERGKAALGPLGP 780 790 800 >>NP_004649 (OMIM: 604118) rasGAP-activating-like protei (804 aa) initn: 4783 init1: 3086 opt: 5393 Z-score: 5564.3 bits: 1040.5 E(85289): 0 Smith-Waterman score: 5393; 99.6% identity (99.8% similar) in 806 aa overlap (1-806:1-804) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_004 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: NP_004 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQ-DVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_004 DFLDRLVDVDGDE-AGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 720 730 740 750 760 770 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: NP_004 LADLDRAHEEFQQQERGKAALGPLGP 780 790 800 >>XP_011537155 (OMIM: 604118) PREDICTED: rasGAP-activati (804 aa) initn: 4783 init1: 3086 opt: 5393 Z-score: 5564.3 bits: 1040.5 E(85289): 0 Smith-Waterman score: 5393; 99.6% identity (99.8% similar) in 806 aa overlap (1-806:1-804) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_011 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: XP_011 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQ-DVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFLDRLVDVDGDE-AGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV 720 730 740 750 760 770 790 800 pF1KB3 LADLDRAHEEFQQQERGKAALGPLGP :::::::::::::::::::::::::: XP_011 LADLDRAHEEFQQQERGKAALGPLGP 780 790 800 >>XP_016875518 (OMIM: 604118) PREDICTED: rasGAP-activati (780 aa) initn: 4760 init1: 4760 opt: 4760 Z-score: 4911.6 bits: 919.6 E(85289): 0 Smith-Waterman score: 4760; 99.7% identity (100.0% similar) in 705 aa overlap (1-705:1-705) 10 20 30 40 50 60 pF1KB3 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_016 CRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFLDRLVDVDGDEEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSD :::::::::::::::::::::::::::::::::::::::::::.: XP_016 ELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSASGWGLKEGFLEEVLLKC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 PLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEV XP_016 DLSRAEVKQRHWRQNWEMGPPAAAVHTQLSPWGTGVTHWILMLRPRQCIGSCSWGGTSSG 730 740 750 760 770 780 806 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:50:34 2016 done: Thu Nov 3 12:50:36 2016 Total Scan time: 10.730 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]