FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3329, 949 aa 1>>>pF1KB3329 949 - 949 aa - 949 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7767+/-0.00042; mu= 10.2629+/- 0.026 mean_var=160.5118+/-32.118, 0's: 0 Z-trim(116.1): 405 B-trim: 38 in 1/55 Lambda= 0.101233 statistics sampled from 26657 (27076) to 26657 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.317), width: 16 Scan time: 13.300 The best scores are: opt bits E(85289) NP_061725 (OMIM: 606317) protocadherin alpha-11 is ( 949) 6213 920.4 0 NP_114067 (OMIM: 606317) protocadherin alpha-11 is ( 810) 5168 767.7 0 NP_061727 (OMIM: 606319) protocadherin alpha-13 is ( 950) 5035 748.3 4.1e-215 NP_061734 (OMIM: 606314) protocadherin alpha-8 iso ( 950) 5034 748.2 4.6e-215 NP_061732 (OMIM: 606312) protocadherin alpha-6 iso ( 950) 5003 743.7 1.1e-213 NP_061723 (OMIM: 606307) protocadherin alpha-1 iso ( 950) 5000 743.2 1.4e-213 NP_061730 (OMIM: 606310) protocadherin alpha-4 iso ( 947) 4991 741.9 3.5e-213 NP_061724 (OMIM: 606316) protocadherin alpha-10 is ( 948) 4967 738.4 4e-212 NP_061728 (OMIM: 606308) protocadherin alpha-2 iso ( 948) 4963 737.8 6e-212 NP_061729 (OMIM: 606309) protocadherin alpha-3 iso ( 950) 4940 734.5 6.2e-211 NP_114063 (OMIM: 606315) protocadherin alpha-9 iso ( 950) 4876 725.1 4e-208 NP_114071 (OMIM: 606319) protocadherin alpha-13 is ( 807) 4005 597.9 7e-170 NP_114062 (OMIM: 606314) protocadherin alpha-8 iso ( 814) 3993 596.1 2.4e-169 NP_061726 (OMIM: 606318) protocadherin alpha-12 is ( 941) 3968 592.5 3.3e-168 NP_113688 (OMIM: 606310) protocadherin alpha-4 iso ( 798) 3964 591.9 4.4e-168 NP_114036 (OMIM: 606312) protocadherin alpha-6 iso ( 803) 3960 591.3 6.6e-168 NP_113598 (OMIM: 606307) protocadherin alpha-1 iso ( 807) 3955 590.6 1.1e-167 NP_114070 (OMIM: 606318) protocadherin alpha-12 is ( 792) 3934 587.5 9.1e-167 NP_061731 (OMIM: 606311) protocadherin alpha-5 iso ( 936) 3931 587.1 1.4e-166 NP_061733 (OMIM: 606313) protocadherin alpha-7 iso ( 937) 3929 586.8 1.7e-166 NP_114065 (OMIM: 606316) protocadherin alpha-10 is ( 844) 3924 586.0 2.6e-166 NP_113684 (OMIM: 606308) protocadherin alpha-2 iso ( 808) 3918 585.1 4.7e-166 NP_113683 (OMIM: 606308) protocadherin alpha-2 iso ( 824) 3918 585.2 4.7e-166 NP_113689 (OMIM: 606311) protocadherin alpha-5 iso ( 816) 3906 583.4 1.6e-165 NP_114040 (OMIM: 606313) protocadherin alpha-7 iso ( 789) 3903 583.0 2.1e-165 NP_113685 (OMIM: 606309) protocadherin alpha-3 iso ( 824) 3901 582.7 2.6e-165 NP_054724 (OMIM: 606315) protocadherin alpha-9 iso ( 842) 3831 572.5 3.2e-162 NP_113599 (OMIM: 606307) protocadherin alpha-1 iso ( 686) 2608 393.8 1.6e-108 NP_114037 (OMIM: 606312) protocadherin alpha-6 iso ( 686) 2604 393.2 2.4e-108 NP_114066 (OMIM: 606316) protocadherin alpha-10 is ( 685) 2602 392.9 2.9e-108 NP_002579 (OMIM: 603627) protocadherin gamma-C3 is ( 934) 1979 302.0 9.2e-81 NP_061748 (OMIM: 606302) protocadherin gamma-B5 is ( 923) 1975 301.4 1.4e-80 NP_003727 (OMIM: 603058) protocadherin gamma-B4 is ( 923) 1946 297.2 2.6e-79 NP_061750 (OMIM: 606304) protocadherin gamma-B7 is ( 929) 1946 297.2 2.6e-79 NP_115778 (OMIM: 603627) protocadherin gamma-C3 is ( 863) 1943 296.7 3.3e-79 NP_115265 (OMIM: 603059) protocadherin gamma-A12 i ( 820) 1936 295.7 6.5e-79 NP_003726 (OMIM: 603059) protocadherin gamma-A12 i ( 932) 1936 295.7 7.2e-79 NP_114480 (OMIM: 606298) protocadherin gamma-A11 i ( 837) 1925 294.1 2e-78 NP_061737 (OMIM: 606298) protocadherin gamma-A11 i ( 935) 1925 294.1 2.2e-78 NP_114479 (OMIM: 606297) protocadherin gamma-A10 i ( 850) 1922 293.7 2.7e-78 NP_061736 (OMIM: 606297) protocadherin gamma-A10 i ( 936) 1922 293.7 3e-78 NP_115272 (OMIM: 606304) protocadherin gamma-B7 is ( 808) 1920 293.3 3.2e-78 NP_114443 (OMIM: 606292) protocadherin gamma-A5 is ( 813) 1919 293.2 3.6e-78 NP_114442 (OMIM: 606291) protocadherin gamma-A4 is ( 851) 1919 293.2 3.7e-78 NP_061741 (OMIM: 606292) protocadherin gamma-A5 is ( 931) 1919 293.2 4e-78 NP_114475 (OMIM: 606293) protocadherin gamma-A6 is ( 818) 1917 292.9 4.4e-78 NP_061742 (OMIM: 606293) protocadherin gamma-A6 is ( 932) 1917 293.0 4.9e-78 NP_115266 (OMIM: 606299) protocadherin gamma-B1 is ( 810) 1914 292.5 5.9e-78 NP_061745 (OMIM: 606299) protocadherin gamma-B1 is ( 927) 1914 292.5 6.6e-78 NP_061740 (OMIM: 606291) protocadherin gamma-A4 is ( 962) 1914 292.5 6.8e-78 >>NP_061725 (OMIM: 606317) protocadherin alpha-11 isofor (949 aa) initn: 6213 init1: 6213 opt: 6213 Z-score: 4912.7 bits: 920.4 E(85289): 0 Smith-Waterman score: 6213; 100.0% identity (100.0% similar) in 949 aa overlap (1-949:1-949) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 VRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVRE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 DAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 DAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 VPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 GYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 GYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 TATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTAL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 WWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 WWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGLN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB3 KEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB3 VSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQ 850 860 870 880 890 900 910 920 930 940 pF1KB3 EPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ ::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 910 920 930 940 >>NP_114067 (OMIM: 606317) protocadherin alpha-11 isofor (810 aa) initn: 5168 init1: 5168 opt: 5168 Z-score: 4088.9 bits: 767.7 E(85289): 0 Smith-Waterman score: 5168; 100.0% identity (100.0% similar) in 797 aa overlap (1-797:1-797) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 VRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 VRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVRE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 DAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 DAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 ADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 ADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 VPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 VPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 GYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 GYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB3 TATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTAL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB3 WWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 WWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGLN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB3 KEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPT ::::::::::::::::: NP_114 KEEEGERQEPGSNHPGQVSFLQIPPIRKCM 790 800 810 >>NP_061727 (OMIM: 606319) protocadherin alpha-13 isofor (950 aa) initn: 5026 init1: 3756 opt: 5035 Z-score: 3982.9 bits: 748.3 E(85289): 4.1e-215 Smith-Waterman score: 5035; 81.7% identity (92.4% similar) in 945 aa overlap (10-949:7-950) 10 20 30 40 50 pF1KB3 MFGFQRRGLGTPR---LQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELA : :: : ::::.: ::.::::::::: ::::::::::::::::::::: NP_061 MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELA 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 ELVQRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVF ::: :::::::: :::::::::::::::::::::::::::.::::::::::::::::::: NP_061 ELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 HVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEY ::.:.:.:::::::.: .....::::. ..::::.::::::: :. :::::. :.: NP_061 HVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 FSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVND :.::. .. .:.. :::.:.:.::::. : .:::::.:::::::::::.::. .::::: NP_061 FTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVND 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 NDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQ : ::: .: :::...::: . :::.:::::: :.:.::...::. . : . ::.. NP_061 NAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 NNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSL ::::.:..: ::.::.:.:.: :.:.:::. :::::::. ::.::.:::.:::..::::: NP_061 NNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 PVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDREN :.:::.:::..:::::::::::: ::::::.::::::::::::.:::::::::::::::. NP_061 PIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRES 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 VWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTV : :::::::::::::::::::: ::: ::::::::::::::::::::::::::::::::: NP_061 VSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTV 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 SARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSA ::.::::::::::::::::::.:.:::::::::::::::::::::::::::::::::::: NP_061 SAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSA 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 RDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAV ::.:::::.::::::::::::::::::::. ::::::.:..:.:::::::::::::::: NP_061 RDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAV 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB3 DADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEP ::::::::::::::: :: :.::::::::::::::::: :::.:.:.::::::::::::: NP_061 DADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEP 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB3 ALTATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLL :::::::::.:::::::::.::::. :::..:::::::::::::::::.::::::::::: NP_061 ALTATATVLLSLVESGQAPQASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLL 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB3 YTALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLP :::: :: :::::::::::::::: :.:::::::::: :::: ::: :::::::::::: NP_061 YTALRCSAPPTEGACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAFSPSLP 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB3 LGLNKEE-EGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPD :.. : :.:.: :. .:::::::::::::::::::::::::::::::::::::: NP_061 PCLGSAEGTGQREED-SECLKEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPD 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 QQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAI 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 ISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 950 >>NP_061734 (OMIM: 606314) protocadherin alpha-8 isoform (950 aa) initn: 5039 init1: 3758 opt: 5034 Z-score: 3982.1 bits: 748.2 E(85289): 4.6e-215 Smith-Waterman score: 5034; 81.6% identity (91.8% similar) in 948 aa overlap (4-949:3-950) 10 20 30 40 50 pF1KB3 MFGFQRRG-LGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAEL .. :: ::. :: : :::: :.:::::::::: ::::::::::::::::::::::: NP_061 MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAEL 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 VQRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHV : :::::::: : :::::.:::::::::::::::::::.::::::::::::::::::::: NP_061 VPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 NVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFS .:::::.::::::: ...:::...::.. :::::::::::::. :..::::::...:: NP_061 DVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 LDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDND :: ... . : . :.:.:::::: .: .:.:::::::::::::::.::: ::::::: NP_061 LDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 PEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNN : :..:::.: ..::: . : :.::::.: :::.:: ..::. : .. :..:.:. NP_061 PTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNT 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 GEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPV ::. . :.::.:....::: ..::::: ::::::::: :.::: ::: ::.:.::::::: NP_061 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 REDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVW ::::: .::::::::.: :::.:::::::: :::::::::::::::::::::::::: : NP_061 REDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 AYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA :::::::::::::::::::: .:::::::::::::::::::::::::::::::::::::: NP_061 AYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 RDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARD :::::::::::::::::::.:.:.::::.:::.::::::::::::::::::::::::::: NP_061 RDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARD 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 AGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDA ::::::.:::::::::::::::::::: ..:..:::..::::::::::::::::::::: NP_061 AGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB3 DSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPAL ::::::::::::::::.. :::::::::::::::::.::::::::::::::::::::::: NP_061 DSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPAL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB3 TATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYT :::::::::::::::::::::: ::. .:::::::::::::::::.::::::::::::: NP_061 TATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYT 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB3 ALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLG :: :: ::::.: :::::::: ::::::::::. ::::: ::::::::::::: :: NP_061 ALRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPD 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB3 LNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQW :.. . ::.:. . .: .::::::::::::::::::::::::::::::::::::::::: NP_061 LGSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQW 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 PTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISI 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 RQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 950 >>NP_061732 (OMIM: 606312) protocadherin alpha-6 isoform (950 aa) initn: 5008 init1: 3742 opt: 5003 Z-score: 3957.7 bits: 743.7 E(85289): 1.1e-213 Smith-Waterman score: 5003; 81.7% identity (92.1% similar) in 946 aa overlap (9-949:9-950) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV :: : : :::: :.:::::::::: :::::::::::::::::::::::: NP_061 MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN ::::.::: . :::::::::::::::::::::::::.:::::::::::::::::::::. NP_061 PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL :::.:::::::.: ..::..:: ::. :: ::::::::::. :..:::.::..:::.: NP_061 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP : :. . :...:.::::::::..: ::.:::::::::::::::.::: ::::::: : NP_061 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNG--RHLFTLDQNN :..:::.: ..::: . : :..:::.:::::.:: ..::. :. : :..:.:. NP_061 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDH-FSIDRNT 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 GEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPV ::. . :.::.:....::: ..::::: ::::::::: :.::: ::: ::.:.::::::: NP_061 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 REDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVW ::::: .::::::::.: :::.::::.::::::::::::::::::::::::::::::.: NP_061 REDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 AYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA :::::::::::::::::::: .::::::.::::::::::::::::::::::::::::::: NP_061 AYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 RDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARD :::::::::::::::::::.:.::::::.::::::::::::::::::::::::::::::: NP_061 RDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARD 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 AGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDA ::::::.::::::::::::::::::::: ..:..::::..:::::.:::.:::::::::: NP_061 AGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB3 DSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPAL :::::::::::::: :...:.:::::::::::::::.::::::::::::::::::::::: NP_061 DSGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPAL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB3 TATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYT ::::::::::::::::::::::. .:::.:::::::::::::::::.::::::::::::: NP_061 TATATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYT 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB3 ALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSL--- :: :: ::::::. ::::::: ::::::::::::::::: ::::: ::::::::: NP_061 ALRCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGPPKMDLMAFSPSLSPC 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB3 PLGLNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPD :. ..: .: :. . .: ..:::::::::::::::::::::::::::::::::::::: NP_061 PIMMGK---AENQDLNEDHDAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPD 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 QQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAI 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 ISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 950 >>NP_061723 (OMIM: 606307) protocadherin alpha-1 isoform (950 aa) initn: 4995 init1: 3729 opt: 5000 Z-score: 3955.3 bits: 743.2 E(85289): 1.4e-213 Smith-Waterman score: 5000; 81.9% identity (91.7% similar) in 948 aa overlap (4-949:3-950) 10 20 30 40 50 pF1KB3 MFGFQRRG-LGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAEL :.::: ::. : :::::: :::::::::::. :::::::::::.::::::::::: NP_061 MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAEL 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 VQRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHV : :::::::::: :::::::::::::::::::::::: :::::::::.:.::::::::: NP_061 VPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 NVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFS .:.::::::::::: ::: ..: ::. .::::.:::.:::: :::::: :: ..::: NP_061 EVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 LDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDND :: .. . : : : :.: ::::.::::.::::::::::::: :::.::. ::::::: NP_061 LDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 PEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNN : ::.. :.: :.:..:. ::: :::.: ::::::::..:. : :. . .. : .:... NP_061 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 GEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPV ::.:. :::::.: :.:.:.:.:::.:::..:: : :..::.:::.::.::::: ::. NP_061 GEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 REDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVW :::: :::::::.:::::::.:::::::: ::::::::::::::::::::::::::.. NP_061 REDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 AYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 RDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARD :::::::::::::::::::.:.::::.::::::::::::::::::::::::::::::::: NP_061 RDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARD 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 AGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDA ::::::.::::::::::::::::::::: ..:.. :::..:::: ::::::::::::::: NP_061 AGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB3 DSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPAL ::::::::::::::::::.:::::::::::::::::.::::: :.:::::::::::::: NP_061 DSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPAL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB3 TATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYT ::::::::::::::::::::::. .:.:.:::::::::::::::::.::::::::::::: NP_061 TATATVLVSLVESGQAPKASSRASVGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYT 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB3 ALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLG :: :. ::::: .::::::::: :.:::: :::::::::: :::::::::::::.: . NP_061 ALRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQRRQRVCSSEGPPKTDLMAFSPGLSPS 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB3 LNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQW :: :..:. : . . :.::::::::::::::::::::::::::::::::::::::::: NP_061 LNTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQW 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 PTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISI 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 RQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 950 >>NP_061730 (OMIM: 606310) protocadherin alpha-4 isoform (947 aa) initn: 3980 init1: 2688 opt: 4991 Z-score: 3948.2 bits: 741.9 E(85289): 3.5e-213 Smith-Waterman score: 4991; 81.9% identity (91.5% similar) in 943 aa overlap (8-949:8-947) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV : . :: : :::: ::.:.:::::::::::::::::::::::::::::::: NP_061 MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN :::::::: .: ::::::::::::::::::::::: .:::::::::::::::::::::. NP_061 PRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL :::.::::::::: ...: ::::. :::::::::::::: :::::::::: :::::: NP_061 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP ..: . . .: :.:::.::::::..::. :.:::::::::::::::.::. :::.::: : NP_061 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNG ::.. ::: :.::. . :::.::::.: :::.::...::. . :.:: . : .: .: NP_061 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR .. :.: .:.::.: :.: :.. ::: :..::: : ::. :.::: :.. :::::.: NP_061 QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIR 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWA ::: .::::::::::.: :::: :::::: :::::::::::::::::::::::::.: : NP_061 EDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR ::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_061 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB3 DADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA ::::::::::::::::::.:.::::::::::::::::::::::::::::::::::.:::: NP_061 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB3 GVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDAD :::::.::::::::::::::::::::: .::..::::..::: :::.::::::::::::: NP_061 GVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDAD 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB3 SGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALT :::::::::::::..::.:::::::::::::::::::::.:.:::::::::::::::::: NP_061 SGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALT 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB3 ATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTA :::::::::::::::::::::.:.::..:.:::::::::::::::.:::::::::::::: NP_061 ATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTA 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB3 LWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGL : :: :::::::::::::::: :::::::::::: :::: :::::::::::::::: . NP_061 LRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSR 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB3 NKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP ..:.. . : . ..:::::::::::::::::::::::::::::::::::::::::: NP_061 DREDQLQTTEESF---AKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ :::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 >>NP_061724 (OMIM: 606316) protocadherin alpha-10 isofor (948 aa) initn: 2431 init1: 2431 opt: 4967 Z-score: 3929.3 bits: 738.4 E(85289): 4e-212 Smith-Waterman score: 4967; 82.1% identity (91.6% similar) in 942 aa overlap (9-949:8-948) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV ::. : : :::: :::::::::::: :::.:::::::::::::::::::: NP_061 MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELV 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN ::::::::: :::::::::::::::::::::::::::.:.:::::::::::::::::::. NP_061 QRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL ::::::::::: ::. :::: : ::. :::::::::::::. :::::::.:: :::: : NP_061 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP : .. . : :.:.: ::::..:.:.::::::::::::.::.: ::. :::.::: : NP_061 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 180 190 200 210 220 230 250 260 270 280 290 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNG ::. :.:...:: ...:::..:::.: :::.: :. ::. : . :. :. : ... .: NP_061 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR :..:: ..:.:... :.:.:..::::.:::.::::: ::.:: ::::::: ::::::::. NP_061 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB3 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWA :::: .::::::::::.:::.:::::::::::::::::::.::::::::::::::: : : NP_061 EDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSA 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB3 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR ::::::::::::: ::::: ::::::::::::::::: ::::::::::::::::::::: NP_061 YELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAW 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB3 DADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA ::::::::::::::::::::.:.::::::::::::::::::::::::::::::::::::. NP_061 DADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDG 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB3 GVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDAD :::::.::.::::::::::::::::::. ::::::::..:: ::: :::::::::::::: NP_061 GVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVVAGHVVAKVRAVDAD 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB3 SGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALT :::::::::::: :: :.:::::::::::::::::::::.::::.::::::::::::.:: NP_061 SGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRALDETDSPRQRLLVLVKDHGEPSLT 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB3 ATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTA :::::::::::..::::::::. .:.: ::.::::::::::::::.:::::::::::::: NP_061 ATATVLVSLVEGSQAPKASSRASVGVA-PEVALVDVNVYLIIAICAVSSLLVLTLLLYTA 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB3 LWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGL : ::.::::::.: ::::::: ::::::::::::::::: :: ::.:::::::::: NP_061 LRCSAAPTEGACGPVKPTLVCSSAVGSWSYSQQRRQRVCSGEGLPKADLMAFSPSLPPCP 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB3 NKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP . .:: : :..: .:::::::::::::::::::::::::::::::::::::::::: NP_061 MVDVDGEDQSIGGDHSRKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ :::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 >>NP_061728 (OMIM: 606308) protocadherin alpha-2 isoform (948 aa) initn: 4966 init1: 2662 opt: 4963 Z-score: 3926.1 bits: 737.8 E(85289): 6e-212 Smith-Waterman score: 4963; 81.6% identity (91.5% similar) in 945 aa overlap (6-949:6-948) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV ::: :. : :::: ::::::::.::: :::::::::::::::::::: ::: NP_061 MASSIRRGRGAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN :::::::: :::::::::::::::::::::::::::.:::::::.:::::::::::::. NP_061 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL :::::::::::.: . . . . ::. :::::::::::::: ::::.:.::..:.: : NP_061 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP : .: . . :::.: ::::::.: :.::::.:::::::::::::..:..:::::::.: NP_061 DIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEP 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNG : .: :::.:.::.:. :::.::::.: ::: :.:..::: : .. . . ::.: .: NP_061 TFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR :.:..: ::::: : :.:.: ::::::: :.::: . ....: :::.:::..::::::. NP_061 EIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWA :.:. .::::::.:::::::.::.::::::::::::::::::::::::::::::::.: : NP_061 ENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR ::::::::::::::::::. ::.:::::::::::::::::::::::::::::::::::: NP_061 YELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB3 DADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA ::::::::::::::::::.:.::::::::::::::::::::::::::.:::::::::::: NP_061 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB3 GVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDAD :::::.::::::::::::::::::::: .::.:.:::..::: ::::::::::::::::: NP_061 GVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDAD 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB3 SGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALT :::::::::::: ..:..:::::::::::::::::::::::::::::::::::::::::: NP_061 SGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALT 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB3 ATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTA :::::::::::::::::::::. .:::. ::.:::::::::::::.::::::::.::::: NP_061 ATATVLVSLVESGQAPKASSRAWVGAAGSEATLVDVNVYLIIAICAVSSLLVLTVLLYTA 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB3 LWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGL : :. ::::: :::::::::: ::::::::::::::::: : ::::::::::::: : NP_061 LRCSVPPTEGARAPGKPTLVCSSAVGSWSYSQQRRQRVCSGEDPPKTDLMAFSPSLSQGP 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB3 NKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP .. :: .: :.. :.:::::::::::::::::::::::::::::::::::::::::: NP_061 DSAEE--KQLSESEYVGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ :::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 >>NP_061729 (OMIM: 606309) protocadherin alpha-3 isoform (950 aa) initn: 4940 init1: 3727 opt: 4940 Z-score: 3907.9 bits: 734.5 E(85289): 6.2e-211 Smith-Waterman score: 4940; 81.2% identity (91.0% similar) in 946 aa overlap (6-949:6-950) 10 20 30 40 50 60 pF1KB3 MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV :. :. : : :::: :::::::::::::::::::::::::::::::::::: NP_061 MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 QRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVN :::::::: :::::::::::::::::::::::::::.:::::::::::::::::::::. NP_061 PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSL ::::::::: ::: . ..:.:.::.: ::: ::::::::: :.:::: :...:::.: NP_061 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 DSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDP : : ..:: :.:.:::.:.:: ::. ::.:: ::::::::::..: . ::::::: : NP_061 DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAP 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 EFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNG :... ::: :.::: . :::. .:::: ::::: ...::. . .. . : :: :: NP_061 AFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR .. :.:..:.::.: :.:.:.:::::.:::. :::: .::.: ::: ::... :::::: NP_061 QISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWA ::. :::::::::::::::::::::::::::::::::::::::::::::: ::::.: : NP_061 EDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR ::::::::::::::::::: :::::::::::::::.: :::::::::::::::::::::: NP_061 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSAR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB3 DADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA ::::::::::::::::::.:.::::::::::::::::::::::::::::::::::::::: NP_061 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB3 GVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDAD :::::.:::::::::::::::::::: ..:. ::::..::::::::::::::::::::: NP_061 GVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDAD 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB3 SGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALT :::::::::::::..::.:::::::::::::::::::::.:.:::::::::::::::.:: NP_061 SGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLT 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB3 ATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTA ::::::::::::::::::::.. :::..:::::::::::::.:::.:::::::::::::: NP_061 ATATVLVSLVESGQAPKASSQASAGATGPEAALVDVNVYLIVAICAVSSLLVLTLLLYTA 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB3 LWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLP-LG : :: :::: :.::::::::: :::::::::::.::::: :: ::::::::::::: NP_061 LRCSAPPTEGDCGPGKPTLVCSSAVGSWSYSQQRQQRVCSGEGLPKTDLMAFSPSLPPCP 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB3 LNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQW .....: :.:. . ..::::::::::::::::::::::::::::::::::::::::: NP_061 ISRDRE-EKQDVDVDLSAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQW 790 800 810 820 830 840 850 860 870 880 890 pF1KB3 PTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISI 840 850 860 870 880 890 900 910 920 930 940 pF1KB3 RQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 900 910 920 930 940 950 949 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:53:28 2016 done: Thu Nov 3 12:53:30 2016 Total Scan time: 13.300 Total Display time: 0.430 Function used was FASTA [36.3.4 Apr, 2011]