FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3331, 514 aa 1>>>pF1KB3331 514 - 514 aa - 514 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3133+/-0.00048; mu= 9.6042+/- 0.030 mean_var=212.4812+/-45.940, 0's: 0 Z-trim(114.6): 399 B-trim: 362 in 1/54 Lambda= 0.087986 statistics sampled from 24077 (24576) to 24077 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.288), width: 16 Scan time: 9.520 The best scores are: opt bits E(85289) NP_002660 (OMIM: 605961) pleiotropic regulator 1 i ( 514) 3484 455.9 1.3e-127 NP_001188493 (OMIM: 605961) pleiotropic regulator ( 505) 2770 365.2 2.5e-100 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 501 77.0 9.7e-14 XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 501 77.0 9.7e-14 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 501 77.0 9.7e-14 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 462 72.4 4.6e-12 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 462 72.4 4.6e-12 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 462 72.4 4.6e-12 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 462 72.4 4.6e-12 XP_016878351 (OMIM: 602703,616212) PREDICTED: kata ( 672) 462 72.4 4.7e-12 XP_005255829 (OMIM: 602703,616212) PREDICTED: kata ( 672) 462 72.4 4.7e-12 XP_016878350 (OMIM: 602703,616212) PREDICTED: kata ( 672) 462 72.4 4.7e-12 XP_016878349 (OMIM: 602703,616212) PREDICTED: kata ( 675) 462 72.4 4.7e-12 XP_006721184 (OMIM: 602703,616212) PREDICTED: kata ( 675) 462 72.4 4.7e-12 XP_006721185 (OMIM: 602703,616212) PREDICTED: kata ( 675) 462 72.4 4.7e-12 XP_011521112 (OMIM: 602703,616212) PREDICTED: kata ( 675) 462 72.4 4.7e-12 XP_016880191 (OMIM: 601545,607432) PREDICTED: plat ( 345) 392 63.2 1.4e-09 XP_016880190 (OMIM: 601545,607432) PREDICTED: plat ( 410) 392 63.3 1.6e-09 XP_016880189 (OMIM: 601545,607432) PREDICTED: plat ( 410) 392 63.3 1.6e-09 NP_000421 (OMIM: 601545,607432) platelet-activatin ( 410) 392 63.3 1.6e-09 XP_016880188 (OMIM: 601545,607432) PREDICTED: plat ( 410) 392 63.3 1.6e-09 XP_011522204 (OMIM: 601545,607432) PREDICTED: plat ( 428) 392 63.3 1.7e-09 XP_011522203 (OMIM: 601545,607432) PREDICTED: plat ( 428) 392 63.3 1.7e-09 XP_011522205 (OMIM: 601545,607432) PREDICTED: plat ( 428) 392 63.3 1.7e-09 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 388 62.6 1.8e-09 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 388 62.6 1.8e-09 XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 390 63.2 2.3e-09 NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 390 63.2 2.4e-09 NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 390 63.2 2.5e-09 XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 390 63.3 2.7e-09 XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 390 63.3 2.7e-09 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 388 62.9 2.7e-09 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 388 62.9 2.7e-09 XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 390 63.3 2.7e-09 XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 390 63.3 2.7e-09 XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 390 63.3 2.7e-09 NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 390 63.3 2.7e-09 XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 390 63.3 2.7e-09 XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 ( 374) 364 59.7 1.8e-08 XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 360 59.1 2.3e-08 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 360 59.1 2.5e-08 NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 360 59.2 2.5e-08 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 360 59.2 2.7e-08 XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 ( 300) 352 58.0 4.5e-08 XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 ( 326) 352 58.1 4.7e-08 NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 332 55.7 3.3e-07 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 332 55.7 3.5e-07 XP_016860391 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 320 54.0 7.8e-07 XP_011510137 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 320 54.0 7.8e-07 XP_016860389 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 320 54.0 7.8e-07 >>NP_002660 (OMIM: 605961) pleiotropic regulator 1 isofo (514 aa) initn: 3484 init1: 3484 opt: 3484 Z-score: 2411.9 bits: 455.9 E(85289): 1.3e-127 Smith-Waterman score: 3484; 100.0% identity (100.0% similar) in 514 aa overlap (1-514:1-514) 10 20 30 40 50 60 pF1KB3 MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA 430 440 450 460 470 480 490 500 510 pF1KB3 EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF :::::::::::::::::::::::::::::::::: NP_002 EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF 490 500 510 >>NP_001188493 (OMIM: 605961) pleiotropic regulator 1 is (505 aa) initn: 2770 init1: 2770 opt: 2770 Z-score: 1922.2 bits: 365.2 E(85289): 2.5e-100 Smith-Waterman score: 3377; 98.2% identity (98.2% similar) in 514 aa overlap (1-514:1-505) 10 20 30 40 50 60 pF1KB3 MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE :::::::::::::::::::::::::::::::::::: ::::::::::::::: NP_001 SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAG---------VALTADTKIQRMPSE 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB3 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB3 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB3 VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA 420 430 440 450 460 470 490 500 510 pF1KB3 EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF :::::::::::::::::::::::::::::::::: NP_001 EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF 480 490 500 >>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 371 init1: 371 opt: 501 Z-score: 367.7 bits: 77.0 E(85289): 9.7e-14 Smith-Waterman score: 501; 26.7% identity (60.6% similar) in 348 aa overlap (153-492:2-333) 130 140 150 160 170 180 pF1KB3 AQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKA :... .: . . .. : .. :: ..: . NP_060 MATEEKKPETEAARAQPTPSS--SATQSKPT 10 20 190 200 210 220 230 240 pF1KB3 PTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL :. :. . : ...:: : . :...:....:::. :::: .::.. .. NP_060 PVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 30 40 50 60 70 80 250 260 270 280 290 300 pF1KB3 TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV .:: . : :. : : : ..:: .: ::. .: .. .:: . :. ...: .. NP_060 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 90 100 110 120 130 140 310 320 330 340 350 360 pF1KB3 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG .:. : : ..:::::.: ..:: .:.. :..:. . :...:.: :.:: ..: NP_060 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 150 160 170 180 190 200 370 380 390 400 410 pF1KB3 KTRVTLTNHKKS-VRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNA----II . :: . . : : . : .: .:. ...: : . :. ... .::. :. NP_060 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 210 220 230 240 250 260 420 430 440 450 460 470 pF1KB3 NTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR ...:.. .:::.... ...:. .: :... : : ... : .:. NP_060 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VISTACHPTENI 270 280 290 300 310 480 490 500 510 pF1KB3 LLTA--EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF . .: : :::::... : NP_060 IASAALENDKTIKLWKSDC 320 330 >>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa) initn: 371 init1: 371 opt: 501 Z-score: 367.7 bits: 77.0 E(85289): 9.7e-14 Smith-Waterman score: 501; 26.7% identity (60.6% similar) in 348 aa overlap (153-492:2-333) 130 140 150 160 170 180 pF1KB3 AQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKA :... .: . . .. : .. :: ..: . XP_005 MATEEKKPETEAARAQPTPSS--SATQSKPT 10 20 190 200 210 220 230 240 pF1KB3 PTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL :. :. . : ...:: : . :...:....:::. :::: .::.. .. XP_005 PVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 30 40 50 60 70 80 250 260 270 280 290 300 pF1KB3 TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV .:: . : :. : : : ..:: .: ::. .: .. .:: . :. ...: .. XP_005 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 90 100 110 120 130 140 310 320 330 340 350 360 pF1KB3 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG .:. : : ..:::::.: ..:: .:.. :..:. . :...:.: :.:: ..: XP_005 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 150 160 170 180 190 200 370 380 390 400 410 pF1KB3 KTRVTLTNHKKS-VRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNA----II . :: . . : : . : .: .:. ...: : . :. ... .::. :. XP_005 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 210 220 230 240 250 260 420 430 440 450 460 470 pF1KB3 NTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR ...:.. .:::.... ...:. .: :... : : ... : .:. XP_005 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VISTACHPTENI 270 280 290 300 310 480 490 500 510 pF1KB3 LLTA--EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF . .: : :::::... : XP_005 IASAALENDKTIKLWKSDC 320 330 >>NP_438172 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 371 init1: 371 opt: 501 Z-score: 367.7 bits: 77.0 E(85289): 9.7e-14 Smith-Waterman score: 501; 26.7% identity (60.6% similar) in 348 aa overlap (153-492:2-333) 130 140 150 160 170 180 pF1KB3 AQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKA :... .: . . .. : .. :: ..: . NP_438 MATEEKKPETEAARAQPTPSS--SATQSKPT 10 20 190 200 210 220 230 240 pF1KB3 PTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL :. :. . : ...:: : . :...:....:::. :::: .::.. .. NP_438 PVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 30 40 50 60 70 80 250 260 270 280 290 300 pF1KB3 TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDV .:: . : :. : : : ..:: .: ::. .: .. .:: . :. ...: .. NP_438 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 90 100 110 120 130 140 310 320 330 340 350 360 pF1KB3 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG .:. : : ..:::::.: ..:: .:.. :..:. . :...:.: :.:: ..: NP_438 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 150 160 170 180 190 200 370 380 390 400 410 pF1KB3 KTRVTLTNHKKS-VRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNA----II . :: . . : : . : .: .:. ...: : . :. ... .::. :. NP_438 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 210 220 230 240 250 260 420 430 440 450 460 470 pF1KB3 NTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR ...:.. .:::.... ...:. .: :... : : ... : .:. NP_438 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VISTACHPTENI 270 280 290 300 310 480 490 500 510 pF1KB3 LLTA--EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF . .: : :::::... : NP_438 IASAALENDKTIKLWKSDC 320 330 >>XP_016878353 (OMIM: 602703,616212) PREDICTED: katanin (655 aa) initn: 728 init1: 409 opt: 462 Z-score: 337.5 bits: 72.4 E(85289): 4.6e-12 Smith-Waterman score: 462; 28.5% identity (63.1% similar) in 260 aa overlap (194-450:11-268) 170 180 190 200 210 220 pF1KB3 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV-EPGNQWFVTG ::: .... : . : ... . ... ..:: XP_016 MATPVVTKTAWKLQEIVA-HASNVSSLVLGKASGRLLATG 10 20 30 230 240 250 260 270 280 pF1KB3 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR . : ...:.. . . .::::: : :..: ..: . . ... ... :::: :..: XP_016 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB3 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE :: . . .::.:: . ... :.:.. ..::.: :. : ::..:: .: . XP_016 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB3 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFP . ... : :..::::.::: . .: : .: .:: .: .:::: : .:. : . XP_016 KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB3 DGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLD . .. . :. . . .. : :: : :: .. ..... :. :. : XP_016 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADL 220 230 240 250 260 270 470 480 490 500 510 pF1KB3 SESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF XP_016 AICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYE 280 290 300 310 320 330 >>NP_005877 (OMIM: 602703,616212) katanin p80 WD40 repea (655 aa) initn: 728 init1: 409 opt: 462 Z-score: 337.5 bits: 72.4 E(85289): 4.6e-12 Smith-Waterman score: 462; 28.5% identity (63.1% similar) in 260 aa overlap (194-450:11-268) 170 180 190 200 210 220 pF1KB3 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV-EPGNQWFVTG ::: .... : . : ... . ... ..:: NP_005 MATPVVTKTAWKLQEIVA-HASNVSSLVLGKASGRLLATG 10 20 30 230 240 250 260 270 280 pF1KB3 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR . : ...:.. . . .::::: : :..: ..: . . ... ... :::: :..: NP_005 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB3 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE :: . . .::.:: . ... :.:.. ..::.: :. : ::..:: .: . NP_005 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB3 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFP . ... : :..::::.::: . .: : .: .:: .: .:::: : .:. : . NP_005 KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB3 DGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLD . .. . :. . . .. : :: : :: .. ..... :. :. : NP_005 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADL 220 230 240 250 260 270 470 480 490 500 510 pF1KB3 SESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF NP_005 AICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYE 280 290 300 310 320 330 >>XP_016878352 (OMIM: 602703,616212) PREDICTED: katanin (655 aa) initn: 728 init1: 409 opt: 462 Z-score: 337.5 bits: 72.4 E(85289): 4.6e-12 Smith-Waterman score: 462; 28.5% identity (63.1% similar) in 260 aa overlap (194-450:11-268) 170 180 190 200 210 220 pF1KB3 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV-EPGNQWFVTG ::: .... : . : ... . ... ..:: XP_016 MATPVVTKTAWKLQEIVA-HASNVSSLVLGKASGRLLATG 10 20 30 230 240 250 260 270 280 pF1KB3 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR . : ...:.. . . .::::: : :..: ..: . . ... ... :::: :..: XP_016 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB3 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE :: . . .::.:: . ... :.:.. ..::.: :. : ::..:: .: . XP_016 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB3 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFP . ... : :..::::.::: . .: : .: .:: .: .:::: : .:. : . XP_016 KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB3 DGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLD . .. . :. . . .. : :: : :: .. ..... :. :. : XP_016 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADL 220 230 240 250 260 270 470 480 490 500 510 pF1KB3 SESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF XP_016 AICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYE 280 290 300 310 320 330 >>XP_006721186 (OMIM: 602703,616212) PREDICTED: katanin (658 aa) initn: 728 init1: 409 opt: 462 Z-score: 337.5 bits: 72.4 E(85289): 4.6e-12 Smith-Waterman score: 462; 28.5% identity (63.1% similar) in 260 aa overlap (194-450:11-268) 170 180 190 200 210 220 pF1KB3 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV-EPGNQWFVTG ::: .... : . : ... . ... ..:: XP_006 MATPVVTKTAWKLQEIVA-HASNVSSLVLGKASGRLLATG 10 20 30 230 240 250 260 270 280 pF1KB3 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR . : ...:.. . . .::::: : :..: ..: . . ... ... :::: :..: XP_006 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB3 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE :: . . .::.:: . ... :.:.. ..::.: :. : ::..:: .: . XP_006 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB3 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFP . ... : :..::::.::: . .: : .: .:: .: .:::: : .:. : . XP_006 KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB3 DGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLD . .. . :. . . .. : :: : :: .. ..... :. :. : XP_006 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADL 220 230 240 250 260 270 470 480 490 500 510 pF1KB3 SESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF XP_006 AICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYE 280 290 300 310 320 330 >>XP_016878351 (OMIM: 602703,616212) PREDICTED: katanin (672 aa) initn: 728 init1: 409 opt: 462 Z-score: 337.4 bits: 72.4 E(85289): 4.7e-12 Smith-Waterman score: 462; 28.5% identity (63.1% similar) in 260 aa overlap (194-450:11-268) 170 180 190 200 210 220 pF1KB3 SIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV-EPGNQWFVTG ::: .... : . : ... . ... ..:: XP_016 MATPVVTKTAWKLQEIVA-HASNVSSLVLGKASGRLLATG 10 20 30 230 240 250 260 270 280 pF1KB3 SADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR . : ...:.. . . .::::: : :..: ..: . . ... ... :::: :..: XP_016 GDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB3 HYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE :: . . .::.:: . ... :.:.. ..::.: :. : ::..:: .: . XP_016 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB3 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFP . ... : :..::::.::: . .: : .: .:: .: .:::: : .:. : . XP_016 KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB3 DGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLD . .. . :. . . .. : :: : :: .. ..... :. :. : XP_016 KFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERCFDVVLVNWGKVADL 220 230 240 250 260 270 470 480 490 500 510 pF1KB3 SESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF XP_016 AICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYE 280 290 300 310 320 330 514 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:55:26 2016 done: Sat Nov 5 04:55:28 2016 Total Scan time: 9.520 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]