FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3332, 1130 aa 1>>>pF1KB3332 1130 - 1130 aa - 1130 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 18.0245+/-0.000519; mu= -35.4779+/- 0.033 mean_var=942.8132+/-190.868, 0's: 0 Z-trim(126.2): 47 B-trim: 33 in 1/60 Lambda= 0.041770 statistics sampled from 51611 (51690) to 51611 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.829), E-opt: 0.2 (0.606), width: 16 Scan time: 22.730 The best scores are: opt bits E(85289) NP_055204 (OMIM: 609455) proline-, glutamic acid- (1180) 7674 478.8 8.4e-134 NP_001265170 (OMIM: 609455) proline-, glutamic aci ( 906) 5637 356.0 6.1e-97 >>NP_055204 (OMIM: 609455) proline-, glutamic acid- and (1180 aa) initn: 7674 init1: 7674 opt: 7674 Z-score: 2523.2 bits: 478.8 E(85289): 8.4e-134 Smith-Waterman score: 7674; 100.0% identity (100.0% similar) in 1130 aa overlap (1-1130:51-1180) 10 20 30 pF1KB3 MAAAVLSGPSAGSAAGVPGGTGGLSAVSSG :::::::::::::::::::::::::::::: NP_055 QPPPHAPSPVGGRRGVFASSRHATTGTRGKMAAAVLSGPSAGSAAGVPGGTGGLSAVSSG 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB3 PRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGA 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB3 LVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMEL 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB3 AVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRAC 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB3 GSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLAS 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB3 LHTLLGALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LHTLLGALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEF 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB3 GAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSR 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB3 LLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQ 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB3 GGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSH 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB3 RKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPY 570 580 590 600 610 620 580 590 600 610 620 630 pF1KB3 TSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAAL 630 640 650 660 670 680 640 650 660 670 680 690 pF1KB3 THPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 THPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMP 690 700 710 720 730 740 700 710 720 730 740 750 pF1KB3 SAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTI 750 760 770 780 790 800 760 770 780 790 800 810 pF1KB3 PPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPP 810 820 830 840 850 860 820 830 840 850 860 870 pF1KB3 IAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGG 870 880 890 900 910 920 880 890 900 910 920 930 pF1KB3 PPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEE 930 940 950 960 970 980 940 950 960 970 980 990 pF1KB3 FEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPE 990 1000 1010 1020 1030 1040 1000 1010 1020 1030 1040 1050 pF1KB3 SPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPP 1050 1060 1070 1080 1090 1100 1060 1070 1080 1090 1100 1110 pF1KB3 QELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLA 1110 1120 1130 1140 1150 1160 1120 1130 pF1KB3 DFIDCPPDDEKPPPPTEPDS :::::::::::::::::::: NP_055 DFIDCPPDDEKPPPPTEPDS 1170 1180 >>NP_001265170 (OMIM: 609455) proline-, glutamic acid- a (906 aa) initn: 5545 init1: 5545 opt: 5637 Z-score: 1861.3 bits: 356.0 E(85289): 6.1e-97 Smith-Waterman score: 6017; 92.2% identity (92.2% similar) in 983 aa overlap (148-1130:1-906) 120 130 140 150 160 170 pF1KB3 ESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHL :::::::::::::::::::::::::::::: NP_001 MELAVAVLRDLLRYAAQLPALFRDISMNHL 10 20 30 180 190 200 210 220 230 pF1KB3 PGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLAC 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB3 ECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEML 100 110 120 130 140 150 300 310 320 330 340 350 pF1KB3 LSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNIS 160 170 180 190 200 210 360 370 380 390 400 410 pF1KB3 LHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLS 220 230 240 250 260 270 420 430 440 450 460 470 pF1KB3 PGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRS 280 290 300 310 320 330 480 490 500 510 520 530 pF1KB3 PRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCG 340 350 360 370 380 390 540 550 560 570 580 590 pF1KB3 PLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPP 400 410 420 430 440 450 600 610 620 630 640 650 pF1KB3 LACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAP 460 470 480 490 500 510 660 670 680 690 700 710 pF1KB3 SPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLV 520 530 540 550 560 570 720 730 740 750 760 770 pF1KB3 SVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVE 580 590 600 610 620 630 780 790 800 810 820 830 pF1KB3 ISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPG 640 650 660 670 680 690 840 850 860 870 880 890 pF1KB3 PLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEE 700 710 720 730 740 750 900 910 920 930 940 950 pF1KB3 EEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEEL 760 770 780 790 800 810 960 970 980 990 1000 1010 pF1KB3 EEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEE :::: NP_001 EEVE-------------------------------------------------------- 1020 1030 1040 1050 1060 1070 pF1KB3 RGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQ ::::::::::::::::::::::::::::::::::::::: NP_001 ---------------------REGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQ 820 830 840 850 1080 1090 1100 1110 1120 1130 pF1KB3 PPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEPDS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEPDS 860 870 880 890 900 1130 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:54:22 2016 done: Thu Nov 3 12:54:25 2016 Total Scan time: 22.730 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]