FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3350, 635 aa 1>>>pF1KB3350 635 - 635 aa - 635 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6346+/-0.000774; mu= -3.9742+/- 0.046 mean_var=940.0431+/-217.425, 0's: 0 Z-trim(113.9): 1148 B-trim: 0 in 0/52 Lambda= 0.041831 statistics sampled from 22202 (23519) to 22202 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.634), E-opt: 0.2 (0.276), width: 16 Scan time: 9.830 The best scores are: opt bits E(85289) XP_011517248 (OMIM: 600085) PREDICTED: tyrosine-pr ( 635) 4320 278.1 6.5e-74 XP_005252204 (OMIM: 600085) PREDICTED: tyrosine-pr ( 635) 4320 278.1 6.5e-74 NP_003168 (OMIM: 600085) tyrosine-protein kinase S ( 635) 4320 278.1 6.5e-74 NP_001167638 (OMIM: 600085) tyrosine-protein kinas ( 635) 4320 278.1 6.5e-74 NP_001128524 (OMIM: 600085) tyrosine-protein kinas ( 612) 2258 153.7 1.8e-36 NP_001167639 (OMIM: 600085) tyrosine-protein kinas ( 612) 2258 153.7 1.8e-36 NP_997402 (OMIM: 176947,269840,617006) tyrosine-pr ( 312) 1286 94.5 6.2e-19 NP_001070 (OMIM: 176947,269840,617006) tyrosine-pr ( 619) 1094 83.4 2.6e-15 XP_016860359 (OMIM: 176947,269840,617006) PREDICTE ( 707) 1094 83.5 2.8e-15 XP_016860358 (OMIM: 176947,269840,617006) PREDICTE ( 730) 1094 83.5 2.8e-15 XP_016860356 (OMIM: 176947,269840,617006) PREDICTE ( 742) 1094 83.6 2.8e-15 XP_016860357 (OMIM: 176947,269840,617006) PREDICTE ( 736) 1092 83.4 3.1e-15 XP_016869170 (OMIM: 600758) PREDICTED: focal adhes ( 980) 738 62.3 9.4e-09 XP_006716673 (OMIM: 600758) PREDICTED: focal adhes ( 983) 738 62.3 9.4e-09 XP_006716672 (OMIM: 600758) PREDICTED: focal adhes ( 983) 738 62.3 9.4e-09 XP_005251070 (OMIM: 600758) PREDICTED: focal adhes ( 983) 738 62.3 9.4e-09 XP_016869169 (OMIM: 600758) PREDICTED: focal adhes ( 995) 738 62.3 9.4e-09 XP_016869141 (OMIM: 600758) PREDICTED: focal adhes (1075) 738 62.4 9.8e-09 XP_016869140 (OMIM: 600758) PREDICTED: focal adhes (1093) 738 62.4 9.8e-09 XP_006716671 (OMIM: 600758) PREDICTED: focal adhes (1096) 738 62.4 9.9e-09 XP_005251069 (OMIM: 600758) PREDICTED: focal adhes (1096) 738 62.4 9.9e-09 XP_011515496 (OMIM: 600758) PREDICTED: focal adhes (1096) 738 62.4 9.9e-09 XP_005251060 (OMIM: 600758) PREDICTED: focal adhes (1140) 738 62.4 1e-08 XP_016869179 (OMIM: 600758) PREDICTED: focal adhes ( 913) 730 61.8 1.3e-08 XP_016869178 (OMIM: 600758) PREDICTED: focal adhes ( 919) 730 61.8 1.3e-08 XP_016869177 (OMIM: 600758) PREDICTED: focal adhes ( 919) 730 61.8 1.3e-08 XP_016869176 (OMIM: 600758) PREDICTED: focal adhes ( 934) 730 61.8 1.3e-08 XP_016869173 (OMIM: 600758) PREDICTED: focal adhes ( 949) 730 61.8 1.3e-08 XP_016869172 (OMIM: 600758) PREDICTED: focal adhes ( 955) 730 61.8 1.3e-08 NP_001303271 (OMIM: 600758) focal adhesion kinase ( 955) 730 61.8 1.3e-08 XP_016869168 (OMIM: 600758) PREDICTED: focal adhes (1011) 730 61.8 1.3e-08 XP_016869166 (OMIM: 600758) PREDICTED: focal adhes (1032) 730 61.9 1.3e-08 XP_016869164 (OMIM: 600758) PREDICTED: focal adhes (1047) 730 61.9 1.3e-08 XP_016869163 (OMIM: 600758) PREDICTED: focal adhes (1047) 730 61.9 1.3e-08 XP_016869158 (OMIM: 600758) PREDICTED: focal adhes (1059) 730 61.9 1.4e-08 XP_016869156 (OMIM: 600758) PREDICTED: focal adhes (1060) 730 61.9 1.4e-08 XP_016869157 (OMIM: 600758) PREDICTED: focal adhes (1060) 730 61.9 1.4e-08 XP_016869151 (OMIM: 600758) PREDICTED: focal adhes (1062) 730 61.9 1.4e-08 XP_016869152 (OMIM: 600758) PREDICTED: focal adhes (1062) 730 61.9 1.4e-08 XP_016869149 (OMIM: 600758) PREDICTED: focal adhes (1068) 730 61.9 1.4e-08 XP_016869150 (OMIM: 600758) PREDICTED: focal adhes (1068) 730 61.9 1.4e-08 XP_016869145 (OMIM: 600758) PREDICTED: focal adhes (1103) 730 61.9 1.4e-08 XP_016869144 (OMIM: 600758) PREDICTED: focal adhes (1104) 730 61.9 1.4e-08 XP_016869143 (OMIM: 600758) PREDICTED: focal adhes (1106) 730 61.9 1.4e-08 XP_016869142 (OMIM: 600758) PREDICTED: focal adhes (1112) 730 61.9 1.4e-08 XP_016869175 (OMIM: 600758) PREDICTED: focal adhes ( 942) 724 61.4 1.7e-08 XP_016869167 (OMIM: 600758) PREDICTED: focal adhes (1016) 724 61.5 1.7e-08 XP_016869148 (OMIM: 600758) PREDICTED: focal adhes (1031) 724 61.5 1.7e-08 XP_016869165 (OMIM: 600758) PREDICTED: focal adhes (1034) 724 61.5 1.7e-08 XP_016869174 (OMIM: 600758) PREDICTED: focal adhes ( 948) 723 61.4 1.7e-08 >>XP_011517248 (OMIM: 600085) PREDICTED: tyrosine-protei (635 aa) initn: 4320 init1: 4320 opt: 4320 Z-score: 1448.0 bits: 278.1 E(85289): 6.5e-74 Smith-Waterman score: 4320; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 550 560 570 580 590 600 610 620 630 pF1KB3 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN ::::::::::::::::::::::::::::::::::: XP_011 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 610 620 630 >>XP_005252204 (OMIM: 600085) PREDICTED: tyrosine-protei (635 aa) initn: 4320 init1: 4320 opt: 4320 Z-score: 1448.0 bits: 278.1 E(85289): 6.5e-74 Smith-Waterman score: 4320; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 550 560 570 580 590 600 610 620 630 pF1KB3 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN ::::::::::::::::::::::::::::::::::: XP_005 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 610 620 630 >>NP_003168 (OMIM: 600085) tyrosine-protein kinase SYK i (635 aa) initn: 4320 init1: 4320 opt: 4320 Z-score: 1448.0 bits: 278.1 E(85289): 6.5e-74 Smith-Waterman score: 4320; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 550 560 570 580 590 600 610 620 630 pF1KB3 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN ::::::::::::::::::::::::::::::::::: NP_003 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 610 620 630 >>NP_001167638 (OMIM: 600085) tyrosine-protein kinase SY (635 aa) initn: 4320 init1: 4320 opt: 4320 Z-score: 1448.0 bits: 278.1 E(85289): 6.5e-74 Smith-Waterman score: 4320; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 550 560 570 580 590 600 610 620 630 pF1KB3 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN ::::::::::::::::::::::::::::::::::: NP_001 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 610 620 630 >>NP_001128524 (OMIM: 600085) tyrosine-protein kinase SY (612 aa) initn: 2334 init1: 2252 opt: 2258 Z-score: 775.5 bits: 153.7 E(85289): 1.8e-36 Smith-Waterman score: 4102; 96.4% identity (96.4% similar) in 635 aa overlap (1-635:1-612) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK :::::::::::::::::::::::::::::::::::::::::: NP_001 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA------------------ 250 260 270 280 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 290 300 310 320 330 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB3 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB3 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 520 530 540 550 560 570 610 620 630 pF1KB3 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN ::::::::::::::::::::::::::::::::::: NP_001 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 580 590 600 610 >>NP_001167639 (OMIM: 600085) tyrosine-protein kinase SY (612 aa) initn: 2334 init1: 2252 opt: 2258 Z-score: 775.5 bits: 153.7 E(85289): 1.8e-36 Smith-Waterman score: 4102; 96.4% identity (96.4% similar) in 635 aa overlap (1-635:1-612) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK :::::::::::::::::::::::::::::::::::::::::: NP_001 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA------------------ 250 260 270 280 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 290 300 310 320 330 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB3 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB3 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 520 530 540 550 560 570 610 620 630 pF1KB3 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN ::::::::::::::::::::::::::::::::::: NP_001 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 580 590 600 610 >>NP_997402 (OMIM: 176947,269840,617006) tyrosine-protei (312 aa) initn: 1219 init1: 1029 opt: 1286 Z-score: 460.9 bits: 94.5 E(85289): 6.2e-19 Smith-Waterman score: 1286; 61.8% identity (83.1% similar) in 296 aa overlap (341-635:1-295) 320 330 340 350 360 370 pF1KB3 GNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLL .:::: ::::::.::::.. :...: : : NP_997 MPMDTSVYESPYSDPEELKDKKLFLKRDNL 10 20 30 380 390 400 410 420 430 pF1KB3 TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP . : ::: ::::.:..: :.:.: ::.:.:: .... : .:.. ::..:.::::: NP_997 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNP 40 50 60 70 80 440 450 460 470 480 pF1KB3 YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESN ::::.::.:.::. ::::::: :::.:.: .:. . .:. ::.::::::::::::.: NP_997 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 90 100 110 120 130 140 490 500 510 520 530 540 pF1KB3 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF ::::::::::::::..:::::::::::::: ::..:: :.. ::::.:::::::::. :: NP_997 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 150 160 170 180 190 200 550 560 570 580 590 600 pF1KB3 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW ::.:::::.:: ::::.:::::::. ::: :: :..:.:.:: :: :: :.: ::. :: NP_997 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 210 220 230 240 250 260 610 620 630 pF1KB3 TYDVENRPGFAAVELRLRNYYYDVVN : :.:: : .:: :.: ::.... NP_997 IYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 270 280 290 300 310 >>NP_001070 (OMIM: 176947,269840,617006) tyrosine-protei (619 aa) initn: 2251 init1: 1046 opt: 1094 Z-score: 395.9 bits: 83.4 E(85289): 2.6e-15 Smith-Waterman score: 2324; 54.4% identity (77.7% similar) in 631 aa overlap (6-635:1-602) 10 20 30 40 50 60 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK : : : :::::.:.:.: :::..: .::.:::.:::: :::..::..: . NP_001 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF ::. :::.::::::::::..: .::.::...:.. ::: : :.:: :::.:..:. : : NP_001 FHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ . :.. ..:.::.:::.:.:.::::::::: ::.::::::::::.:::.:....:::.:. NP_001 DCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAER 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB3 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL . :..:.::::.: : ..:.::: :.. : :: :..::.:: :::: :::::::: NP_001 KLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB3 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK ::. . :::::. : : . .. .:.. .. : :: .::.: . :. NP_001 VEYLKLKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPST------------LTHPQ 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP :. .:.. . : :: : .. :. .:::: ::::::.::::.. NP_001 ------------RRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKD 290 300 310 320 370 380 390 400 410 420 pF1KB3 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE :...: : : . : ::: ::::.:..: :.:.: ::.:.:: .... : .:.. : NP_001 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMRE 330 340 350 360 370 380 430 440 450 460 470 pF1KB3 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVS :..:.:::::::::.::.:.::. ::::::: :::.:.: .:. . .:. ::.:::: NP_001 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 390 400 410 420 430 440 480 490 500 510 520 530 pF1KB3 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY ::::::::.:::::::::::::::..:::::::::::::: ::..:: :.. ::::.::: NP_001 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 450 460 470 480 490 500 540 550 560 570 580 590 pF1KB3 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR ::::::. ::::.:::::.:: ::::.:::::::. ::: :: :..:.:.:: :: :: NP_001 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 510 520 530 540 550 560 600 610 620 630 pF1KB3 EMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN :.: ::. :: : :.:: : .:: :.: ::.... NP_001 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 570 580 590 600 610 >>XP_016860359 (OMIM: 176947,269840,617006) PREDICTED: t (707 aa) initn: 2187 init1: 1046 opt: 1094 Z-score: 395.4 bits: 83.5 E(85289): 2.8e-15 Smith-Waterman score: 2260; 54.8% identity (78.0% similar) in 608 aa overlap (6-612:124-702) 10 20 30 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMS : : : :::::.:.:.: :::..: .::. XP_016 WREAGKCVPGRKHPRQEGTGVHEVSGGPGAMPDPAAHLPFFYGSISRAEAEEHLKLAGMA 100 110 120 130 140 150 40 50 60 70 80 90 pF1KB3 DGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQE :::.:::: :::..::..: . ::. :::.::::::::::..: .::.::...:.. XP_016 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD 160 170 180 190 200 210 100 110 120 130 140 150 pF1KB3 SDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLE ::: : :.:: :::.:..:. : :. :.. ..:.::.:::.:.:.::::::::: ::.: XP_016 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KB3 KLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLH :::::::::.:::.:....:::.:. . :..:.::::.: : ..:.::: :.. : : XP_016 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KB3 YRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQ : :..::.:: :::: ::::::::::. . :::::. : : . .. .:.. .. : XP_016 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPN-SSASNASGAAAPT 340 350 360 370 380 390 280 290 300 310 320 330 pF1KB3 LPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKG :: .::.: . :. :. .:.. . : :: : .. XP_016 LP-AHPST------------LTHPQ------------RRIDTLNSDGYTPEPARITSPDK 400 410 420 340 350 360 370 380 390 pF1KB3 PQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKV :. .:::: ::::::.::::.. :...: : : . : ::: ::::.:..: :.:.: XP_016 PR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKK 430 440 450 460 470 480 400 410 420 430 440 450 pF1KB3 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGP ::.:.:: .... : .:.. ::..:.:::::::::.::.:.::. ::::::: :: XP_016 QIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGP 490 500 510 520 530 540 460 470 480 490 500 510 pF1KB3 LNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG :.:.: .:. . .:. ::.::::::::::::.:::::::::::::::..::::::::: XP_016 LHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG 550 560 570 580 590 600 520 530 540 550 560 570 pF1KB3 LSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYR ::::: ::..:: :.. ::::.:::::::::. ::::.:::::.:: ::::.:::::::. XP_016 LSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KB3 GMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV ::: :: :..:.:.:: :: :: :.: ::. :: :. XP_016 KMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYNPSPSS 670 680 690 700 pF1KB3 N >>XP_016860358 (OMIM: 176947,269840,617006) PREDICTED: t (730 aa) initn: 2189 init1: 1046 opt: 1094 Z-score: 395.3 bits: 83.5 E(85289): 2.8e-15 Smith-Waterman score: 2262; 54.8% identity (77.8% similar) in 609 aa overlap (6-613:124-703) 10 20 30 pF1KB3 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMS : : : :::::.:.:.: :::..: .::. XP_016 WREAGKCVPGRKHPRQEGTGVHEVSGGPGAMPDPAAHLPFFYGSISRAEAEEHLKLAGMA 100 110 120 130 140 150 40 50 60 70 80 90 pF1KB3 DGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQE :::.:::: :::..::..: . ::. :::.::::::::::..: .::.::...:.. XP_016 DGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRD 160 170 180 190 200 210 100 110 120 130 140 150 pF1KB3 SDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLE ::: : :.:: :::.:..:. : :. :.. ..:.::.:::.:.:.::::::::: ::.: XP_016 PDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KB3 KLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLH :::::::::.:::.:....:::.:. . :..:.::::.: : ..:.::: :.. : : XP_016 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KB3 YRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQ : :..::.:: :::: ::::::::::. . :::::. : : . .. .:.. .. : XP_016 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPN-SSASNASGAAAPT 340 350 360 370 380 390 280 290 300 310 320 330 pF1KB3 LPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKG :: .::.: . :. :. .:.. . : :: : .. XP_016 LP-AHPST------------LTHPQ------------RRIDTLNSDGYTPEPARITSPDK 400 410 420 340 350 360 370 380 390 pF1KB3 PQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKV :. .:::: ::::::.::::.. :...: : : . : ::: ::::.:..: :.:.: XP_016 PR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKK 430 440 450 460 470 480 400 410 420 430 440 450 pF1KB3 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGP ::.:.:: .... : .:.. ::..:.:::::::::.::.:.::. ::::::: :: XP_016 QIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGP 490 500 510 520 530 540 460 470 480 490 500 510 pF1KB3 LNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG :.:.: .:. . .:. ::.::::::::::::.:::::::::::::::..::::::::: XP_016 LHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG 550 560 570 580 590 600 520 530 540 550 560 570 pF1KB3 LSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYR ::::: ::..:: :.. ::::.:::::::::. ::::.:::::.:: ::::.:::::::. XP_016 LSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KB3 GMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV ::: :: :..:.:.:: :: :: :.: ::. :: : : XP_016 KMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKVSSAHADSPLGLCIHRCRCLES 670 680 690 700 710 720 pF1KB3 N XP_016 SPRPHR 730 635 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:00:45 2016 done: Thu Nov 3 13:00:47 2016 Total Scan time: 9.830 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]