FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3382, 421 aa 1>>>pF1KB3382 421 - 421 aa - 421 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7765+/-0.000403; mu= 14.5953+/- 0.025 mean_var=71.5226+/-14.505, 0's: 0 Z-trim(112.4): 132 B-trim: 68 in 1/50 Lambda= 0.151654 statistics sampled from 21164 (21299) to 21164 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.25), width: 16 Scan time: 8.100 The best scores are: opt bits E(85289) NP_001260 (OMIM: 179710) regulator of chromosome c ( 421) 2822 626.9 3e-179 NP_001041664 (OMIM: 179710) regulator of chromosom ( 421) 2822 626.9 3e-179 NP_001041660 (OMIM: 179710) regulator of chromosom ( 438) 2695 599.1 7.1e-171 NP_001041659 (OMIM: 179710) regulator of chromosom ( 452) 2676 594.9 1.3e-169 NP_061185 (OMIM: 609587) protein RCC2 [Homo sapien ( 522) 394 95.7 3e-19 NP_001129676 (OMIM: 609587) protein RCC2 [Homo sap ( 522) 394 95.7 3e-19 NP_001305434 (OMIM: 605200) probable E3 ubiquitin- ( 368) 310 77.2 7.4e-14 XP_016871530 (OMIM: 609248) PREDICTED: probable E3 ( 936) 311 77.6 1.4e-13 NP_001265114 (OMIM: 609248) probable E3 ubiquitin- ( 979) 311 77.6 1.5e-13 NP_056416 (OMIM: 609248) probable E3 ubiquitin-pro (1049) 311 77.6 1.6e-13 NP_071362 (OMIM: 609248) probable E3 ubiquitin-pro (1057) 311 77.6 1.6e-13 XP_005263389 (OMIM: 605200) PREDICTED: probable E3 ( 896) 310 77.4 1.6e-13 XP_005263388 (OMIM: 605200) PREDICTED: probable E3 ( 903) 310 77.4 1.6e-13 XP_016864296 (OMIM: 605200) PREDICTED: probable E3 ( 924) 310 77.4 1.7e-13 NP_001258531 (OMIM: 605200) probable E3 ubiquitin- ( 932) 310 77.4 1.7e-13 XP_005263387 (OMIM: 605200) PREDICTED: probable E3 ( 993) 310 77.4 1.8e-13 XP_005263386 (OMIM: 605200) PREDICTED: probable E3 (1042) 310 77.4 1.8e-13 XP_016864295 (OMIM: 605200) PREDICTED: probable E3 (1042) 310 77.4 1.8e-13 XP_005263384 (OMIM: 605200) PREDICTED: probable E3 (1050) 310 77.4 1.9e-13 NP_055421 (OMIM: 605200) probable E3 ubiquitin-pro (1050) 310 77.4 1.9e-13 NP_036271 (OMIM: 606051) secretion-regulating guan ( 458) 295 74.0 8.7e-13 NP_003913 (OMIM: 605109,617011) probable E3 ubiqui (4861) 298 75.1 4.4e-12 XP_016878194 (OMIM: 605109,617011) PREDICTED: prob (4883) 298 75.1 4.4e-12 XP_016878193 (OMIM: 605109,617011) PREDICTED: prob (4885) 298 75.1 4.4e-12 XP_016878192 (OMIM: 605109,617011) PREDICTED: prob (4891) 298 75.1 4.4e-12 XP_016878191 (OMIM: 605109,617011) PREDICTED: prob (4892) 298 75.1 4.4e-12 XP_016878190 (OMIM: 605109,617011) PREDICTED: prob (4892) 298 75.1 4.4e-12 XP_016878189 (OMIM: 605109,617011) PREDICTED: prob (4897) 298 75.1 4.4e-12 XP_016878188 (OMIM: 605109,617011) PREDICTED: prob (4909) 298 75.1 4.4e-12 XP_016879989 (OMIM: 609799,613824,615415) PREDICTE ( 666) 273 69.3 3.4e-11 XP_011537899 (OMIM: 609248) PREDICTED: probable E3 ( 960) 275 69.8 3.5e-11 NP_835464 (OMIM: 609799,613824,615415) serine/thre ( 692) 273 69.3 3.5e-11 XP_016879988 (OMIM: 609799,613824,615415) PREDICTE ( 705) 273 69.3 3.6e-11 XP_011537896 (OMIM: 609248) PREDICTED: probable E3 (1011) 275 69.8 3.6e-11 XP_011537897 (OMIM: 609248) PREDICTED: probable E3 (1011) 275 69.8 3.6e-11 XP_011522942 (OMIM: 609799,613824,615415) PREDICTE ( 716) 273 69.3 3.6e-11 XP_011522940 (OMIM: 609799,613824,615415) PREDICTE ( 729) 273 69.3 3.7e-11 XP_011537895 (OMIM: 609248) PREDICTED: probable E3 (1073) 275 69.8 3.8e-11 XP_011537894 (OMIM: 609248) PREDICTED: probable E3 (1081) 275 69.8 3.8e-11 XP_016878186 (OMIM: 176270,227220,605837,615516) P (2556) 271 69.1 1.5e-10 XP_016878187 (OMIM: 176270,227220,605837,615516) P (2556) 271 69.1 1.5e-10 XP_011520435 (OMIM: 176270,227220,605837,615516) P (3749) 271 69.1 2.1e-10 XP_011520433 (OMIM: 176270,227220,605837,615516) P (4673) 271 69.2 2.5e-10 XP_006720790 (OMIM: 176270,227220,605837,615516) P (4748) 271 69.2 2.6e-10 XP_005268333 (OMIM: 176270,227220,605837,615516) P (4796) 271 69.2 2.6e-10 XP_016878184 (OMIM: 176270,227220,605837,615516) P (4796) 271 69.2 2.6e-10 XP_016878185 (OMIM: 176270,227220,605837,615516) P (4796) 271 69.2 2.6e-10 XP_006720789 (OMIM: 176270,227220,605837,615516) P (4829) 271 69.2 2.6e-10 NP_004658 (OMIM: 176270,227220,605837,615516) E3 u (4834) 271 69.2 2.6e-10 NP_001158608 (OMIM: 609249) probable E3 ubiquitin- ( 986) 261 66.7 3e-10 >>NP_001260 (OMIM: 179710) regulator of chromosome conde (421 aa) initn: 2822 init1: 2822 opt: 2822 Z-score: 3339.1 bits: 626.9 E(85289): 3e-179 Smith-Waterman score: 2822; 100.0% identity (100.0% similar) in 421 aa overlap (1-421:1-421) 10 20 30 40 50 60 pF1KB3 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 370 380 390 400 410 420 pF1KB3 S : NP_001 S >>NP_001041664 (OMIM: 179710) regulator of chromosome co (421 aa) initn: 2822 init1: 2822 opt: 2822 Z-score: 3339.1 bits: 626.9 E(85289): 3e-179 Smith-Waterman score: 2822; 100.0% identity (100.0% similar) in 421 aa overlap (1-421:1-421) 10 20 30 40 50 60 pF1KB3 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 370 380 390 400 410 420 pF1KB3 S : NP_001 S >>NP_001041660 (OMIM: 179710) regulator of chromosome co (438 aa) initn: 2682 init1: 2682 opt: 2695 Z-score: 3188.7 bits: 599.1 E(85289): 7.1e-171 Smith-Waterman score: 2778; 96.1% identity (96.1% similar) in 438 aa overlap (1-421:1-438) 10 20 30 40 pF1KB3 MSPKRIAKRRSPPADAIPKSKKVK-----------------VSHRSHSTEPGLVLTLGQG :::::::::::::::::::::::: ::::::::::::::::::: NP_001 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB3 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSM 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB3 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB3 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIP 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB3 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB3 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 370 380 390 400 410 420 410 420 pF1KB3 VSSGGQHTVLLVKDKEQS :::::::::::::::::: NP_001 VSSGGQHTVLLVKDKEQS 430 >>NP_001041659 (OMIM: 179710) regulator of chromosome co (452 aa) initn: 2808 init1: 2665 opt: 2676 Z-score: 3166.0 bits: 594.9 E(85289): 1.3e-169 Smith-Waterman score: 2750; 93.1% identity (93.1% similar) in 452 aa overlap (1-421:1-452) 10 20 pF1KB3 MSPKRIAKRRSPPADAIPKSKKVK-------------------------------VSHRS :::::::::::::::::::::::: ::::: NP_001 MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGACGPSPPDQKTRPVSHRS 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB3 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVY 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB3 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB3 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPE 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB3 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB3 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB3 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 370 380 390 400 410 420 390 400 410 420 pF1KB3 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS :::::::::::::::::::::::::::::::: NP_001 EMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS 430 440 450 >>NP_061185 (OMIM: 609587) protein RCC2 [Homo sapiens] (522 aa) initn: 272 init1: 111 opt: 394 Z-score: 466.7 bits: 95.7 E(85289): 3e-19 Smith-Waterman score: 394; 24.8% identity (58.1% similar) in 387 aa overlap (50-421:132-506) 20 30 40 50 60 70 pF1KB3 SKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVM-ERKKPALVSIPEDVVQAEAGGMH ::.:. .. :... .: . . . : NP_061 CKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAH 110 120 130 140 150 160 80 90 100 110 120 130 pF1KB3 TVCLSKSGQVYSFGCNDEGALGR-DTS-VEGSEMVPGKVELQEKVVQVSAGDSHTAALTD .. .. :...:.: :..: ::. ::. ::. ... : .: .:... : .:: :::. NP_061 SLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS--HEVIVSAACGRNHTLALTE 170 180 190 200 210 140 150 160 170 180 190 pF1KB3 DGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDLYT : :: .: ... : .:: . :.:.. . :..:.: : . ... :.::. NP_061 TGSVFAFG--ENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYS 220 230 240 250 260 270 200 210 220 230 240 pF1KB3 LGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVML---KSRGSR----GHVRFQDAFC .:: : ::::. . : :. : . :::. : . :.. .. .: .:. : NP_061 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 280 290 300 310 320 330 250 260 270 280 290 300 pF1KB3 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV :: :.... . .:...:...: .:: .. ..:. . : .. . .: . NP_061 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 340 350 360 370 380 390 310 320 330 340 350 360 pF1KB3 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR .. : . : .. .: : : .. : . . :.::: : . :. : NP_061 AVSEVGGLFFWGATNTSR-------ESTMYPKAVQDLCGWRIRSLACGKS-SIIVAADES 400 410 420 430 440 370 380 390 400 410 420 pF1KB3 VFAWGMGTNY-QLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS ...:: . .. .:: :. . : . . : :.. .:. : .:......:. .. NP_061 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKE 450 460 470 480 490 500 NP_061 KIKKLPEYNPRTL 510 520 >>NP_001129676 (OMIM: 609587) protein RCC2 [Homo sapiens (522 aa) initn: 272 init1: 111 opt: 394 Z-score: 466.7 bits: 95.7 E(85289): 3e-19 Smith-Waterman score: 394; 24.8% identity (58.1% similar) in 387 aa overlap (50-421:132-506) 20 30 40 50 60 70 pF1KB3 SKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVM-ERKKPALVSIPEDVVQAEAGGMH ::.:. .. :... .: . . . : NP_001 CKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAH 110 120 130 140 150 160 80 90 100 110 120 130 pF1KB3 TVCLSKSGQVYSFGCNDEGALGR-DTS-VEGSEMVPGKVELQEKVVQVSAGDSHTAALTD .. .. :...:.: :..: ::. ::. ::. ... : .: .:... : .:: :::. NP_001 SLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS--HEVIVSAACGRNHTLALTE 170 180 190 200 210 140 150 160 170 180 190 pF1KB3 DGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLD-VPVVKVASGNDHLVMLTADGDLYT : :: .: ... : .:: . :.:.. . :..:.: : . ... :.::. NP_001 TGSVFAFG--ENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYS 220 230 240 250 260 270 200 210 220 230 240 pF1KB3 LGCGEQGQLGRVPE-LFANRGGRQGLERLLVPKCVML---KSRGSR----GHVRFQDAFC .:: : ::::. . : :. : . :::. : . :.. .. .: .:. : NP_001 FGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVAC 280 290 300 310 320 330 250 260 270 280 290 300 pF1KB3 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV :: :.... . .:...:...: .:: .. ..:. . : .. . .: . NP_001 GANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSF 340 350 360 370 380 390 310 320 330 340 350 360 pF1KB3 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR .. : . : .. .: : : .. : . . :.::: : . :. : NP_001 AVSEVGGLFFWGATNTSR-------ESTMYPKAVQDLCGWRIRSLACGKS-SIIVAADES 400 410 420 430 440 370 380 390 400 410 420 pF1KB3 VFAWGMGTNY-QLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQS ...:: . .. .:: :. . : . . : :.. .:. : .:......:. .. NP_001 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKE 450 460 470 480 490 500 NP_001 KIKKLPEYNPRTL 510 520 >>NP_001305434 (OMIM: 605200) probable E3 ubiquitin-prot (368 aa) initn: 268 init1: 191 opt: 310 Z-score: 369.8 bits: 77.2 E(85289): 7.4e-14 Smith-Waterman score: 362; 30.4% identity (57.3% similar) in 286 aa overlap (127-407:92-357) 100 110 120 130 140 150 pF1KB3 GALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLL :.::. ::.: :..: ::. : : .::. NP_001 TKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSD--GQLGLM 70 80 90 100 110 160 170 180 190 200 210 pF1KB3 EPMKKSMVPVQVQ-LDVP-VVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANR . :: .: :. ...:. :: : . :.:::...: : . .:::: : : .. NP_001 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FPSQ 120 130 140 150 160 170 220 230 240 250 260 270 pF1KB3 GGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGT .. : . :. .: : : ::. .::.: : :.:.:..: ::: NP_001 ASPQ-------------RVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWGMNNAGQLGL 180 190 200 210 220 280 290 300 310 320 330 pF1KB3 PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEE .. : .. .. :.. : .: :..::. . . : ....: . :.:: .: NP_001 SDEKDRESPCHVKLLR--TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE 230 240 250 260 270 280 340 350 360 370 380 390 pF1KB3 KSIPTLISRL--PAVSSVACGASVGYA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEM . : . .: :...::: . : : ..: ..:.: :. :::::. .. : . NP_001 VN-PRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPV 290 300 310 320 330 340 400 410 420 pF1KB3 MGKQLENRVVLSVSSGGQHTVLLVKDKEQS : . ::. .: NP_001 KGYWAAHSGQLSARAGKNDCLWNLKVF 350 360 >>XP_016871530 (OMIM: 609248) PREDICTED: probable E3 ubi (936 aa) initn: 308 init1: 155 opt: 311 Z-score: 364.6 bits: 77.6 E(85289): 1.4e-13 Smith-Waterman score: 515; 31.1% identity (60.2% similar) in 367 aa overlap (37-393:1-343) 10 20 30 40 50 60 pF1KB3 AKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLG----ENVMERKKPAL .: :... :::::: : :.: .: . XP_016 MLCWGNASFGQLGLGGIDEEIVLEPRKSDF 10 20 30 70 80 90 100 110 120 pF1KB3 VSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKV : . : .. : ::: . .: ::. :::: : ::.. : . :.: : :. ... XP_016 F-INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQV---VALDAQNI 40 50 60 70 80 130 140 150 160 170 pF1KB3 VQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVAS : :: :..:: ::.: :.:. :: :..: .::. . :: ... :. .:.:: XP_016 VAVSCGEAHTLALNDKGQVYAWGL--DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVAC 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB3 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH : : . :. .... : .. :::: ... .: .:: : .. : XP_016 GYYHSLALSKASEVFCWGQNKYGQLG-----LGTDCKKQTSPQLL--KSLL----G---- 150 160 170 180 240 250 260 270 280 290 pF1KB3 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF . :... :. .:... : ..:.: ... ::: .. ..:. : :.. ... : . XP_016 IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR--SQKIVYI 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB3 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVG :. ::. . .:: ....: . ::.:: . ..: . : . .: :. .::: . XP_016 CCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEIN-PRKVFELMGSIVTEIACGRQHT 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 YA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK : : ..::....:.: : :::::. . :: . : XP_016 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR 310 320 330 340 350 360 420 pF1KB3 DKEQS XP_016 IFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEI 370 380 390 400 410 420 >>NP_001265114 (OMIM: 609248) probable E3 ubiquitin-prot (979 aa) initn: 308 init1: 155 opt: 311 Z-score: 364.3 bits: 77.6 E(85289): 1.5e-13 Smith-Waterman score: 515; 31.1% identity (60.2% similar) in 367 aa overlap (37-393:1-343) 10 20 30 40 50 60 pF1KB3 AKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLG----ENVMERKKPAL .: :... :::::: : :.: .: . NP_001 MLCWGNASFGQLGLGGIDEEIVLEPRKSDF 10 20 30 70 80 90 100 110 120 pF1KB3 VSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKV : . : .. : ::: . .: ::. :::: : ::.. : . :.: : :. ... NP_001 F-INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQV---VALDAQNI 40 50 60 70 80 130 140 150 160 170 pF1KB3 VQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVAS : :: :..:: ::.: :.:. :: :..: .::. . :: ... :. .:.:: NP_001 VAVSCGEAHTLALNDKGQVYAWGL--DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVAC 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB3 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH : : . :. .... : .. :::: ... .: .:: : .. : NP_001 GYYHSLALSKASEVFCWGQNKYGQLG-----LGTDCKKQTSPQLL--KSLL----G---- 150 160 170 180 240 250 260 270 280 290 pF1KB3 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF . :... :. .:... : ..:.: ... ::: .. ..:. : :.. ... : . NP_001 IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR--SQKIVYI 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB3 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVG :. ::. . .:: ....: . ::.:: . ..: . : . .: :. .::: . NP_001 CCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEIN-PRKVFELMGSIVTEIACGRQHT 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 YA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK : : ..::....:.: : :::::. . :: . : NP_001 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR 310 320 330 340 350 360 420 pF1KB3 DKEQS NP_001 IFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEI 370 380 390 400 410 420 >>NP_056416 (OMIM: 609248) probable E3 ubiquitin-protein (1049 aa) initn: 308 init1: 155 opt: 311 Z-score: 363.8 bits: 77.6 E(85289): 1.6e-13 Smith-Waterman score: 515; 31.1% identity (60.2% similar) in 367 aa overlap (37-393:1-343) 10 20 30 40 50 60 pF1KB3 AKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLG----ENVMERKKPAL .: :... :::::: : :.: .: . NP_056 MLCWGNASFGQLGLGGIDEEIVLEPRKSDF 10 20 30 70 80 90 100 110 120 pF1KB3 VSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKV : . : .. : ::: . .: ::. :::: : ::.. : . :.: : :. ... NP_056 F-INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQV---VALDAQNI 40 50 60 70 80 130 140 150 160 170 pF1KB3 VQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVAS : :: :..:: ::.: :.:. :: :..: .::. . :: ... :. .:.:: NP_056 VAVSCGEAHTLALNDKGQVYAWGL--DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVAC 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB3 GNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGH : : . :. .... : .. :::: ... .: .:: : .. : NP_056 GYYHSLALSKASEVFCWGQNKYGQLG-----LGTDCKKQTSPQLL--KSLL----G---- 150 160 170 180 240 250 260 270 280 290 pF1KB3 VRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGF . :... :. .:... : ..:.: ... ::: .. ..:. : :.. ... : . NP_056 IPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR--SQKIVYI 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB3 SGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVG :. ::. . .:: ....: . ::.:: . ..: . : . .: :. .::: . NP_056 CCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEIN-PRKVFELMGSIVTEIACGRQHT 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB3 YA-VTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVK : : ..::....:.: : :::::. . :: . : NP_056 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR 310 320 330 340 350 360 420 pF1KB3 DKEQS NP_056 IFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEI 370 380 390 400 410 420 421 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:09:41 2016 done: Sat Nov 5 12:09:42 2016 Total Scan time: 8.100 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]