FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3384, 699 aa 1>>>pF1KB3384 699 - 699 aa - 699 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.7306+/-0.000441; mu= -5.1431+/- 0.028 mean_var=495.2501+/-100.865, 0's: 0 Z-trim(124.7): 120 B-trim: 676 in 1/58 Lambda= 0.057632 statistics sampled from 46637 (46782) to 46637 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.798), E-opt: 0.2 (0.549), width: 16 Scan time: 13.210 The best scores are: opt bits E(85289) NP_872634 (OMIM: 602980) SRSF protein kinase 2 iso ( 699) 4804 414.1 9.4e-115 XP_016868051 (OMIM: 602980) PREDICTED: SRSF protei ( 780) 4777 411.9 4.8e-114 XP_016868052 (OMIM: 602980) PREDICTED: SRSF protei ( 780) 4719 407.0 1.4e-112 NP_872633 (OMIM: 602980) SRSF protein kinase 2 iso ( 688) 4653 401.5 5.6e-111 XP_016868055 (OMIM: 602980) PREDICTED: SRSF protei ( 688) 4653 401.5 5.6e-111 NP_001265202 (OMIM: 602980) SRSF protein kinase 2 ( 688) 4653 401.5 5.6e-111 XP_016868049 (OMIM: 602980) PREDICTED: SRSF protei ( 725) 4653 401.5 5.8e-111 XP_016868050 (OMIM: 602980) PREDICTED: SRSF protei ( 688) 4595 396.7 1.6e-109 XP_005250607 (OMIM: 602980) PREDICTED: SRSF protei ( 730) 4373 378.3 5.9e-104 XP_005250606 (OMIM: 602980) PREDICTED: SRSF protei ( 811) 4346 376.1 3e-103 XP_011514838 (OMIM: 602980) PREDICTED: SRSF protei ( 730) 4223 365.8 3.4e-100 XP_006716161 (OMIM: 602980) PREDICTED: SRSF protei ( 719) 4222 365.7 3.5e-100 XP_005250608 (OMIM: 602980) PREDICTED: SRSF protei ( 719) 4222 365.7 3.5e-100 XP_016868053 (OMIM: 602980) PREDICTED: SRSF protei ( 719) 4222 365.7 3.5e-100 XP_011514840 (OMIM: 602980) PREDICTED: SRSF protei ( 719) 4222 365.7 3.5e-100 XP_016868054 (OMIM: 602980) PREDICTED: SRSF protei ( 618) 3849 334.6 6.9e-91 NP_003128 (OMIM: 601939) SRSF protein kinase 1 [Ho ( 655) 1527 141.6 9.4e-33 >>NP_872634 (OMIM: 602980) SRSF protein kinase 2 isoform (699 aa) initn: 4804 init1: 4804 opt: 4804 Z-score: 2181.2 bits: 414.1 E(85289): 9.4e-115 Smith-Waterman score: 4804; 100.0% identity (100.0% similar) in 699 aa overlap (1-699:1-699) 10 20 30 40 50 60 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB3 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY 610 620 630 640 650 660 670 680 690 pF1KB3 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS ::::::::::::::::::::::::::::::::::::::: NP_872 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 670 680 690 >>XP_016868051 (OMIM: 602980) PREDICTED: SRSF protein ki (780 aa) initn: 4777 init1: 4777 opt: 4777 Z-score: 2168.5 bits: 411.9 E(85289): 4.8e-114 Smith-Waterman score: 4777; 99.9% identity (100.0% similar) in 695 aa overlap (5-699:86-780) 10 20 30 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLV .::::::::::::::::::::::::::::: XP_016 EKRPREERWCETRGGAGQGRAHGAAGGATGRVLAIQARKRRPKREKHPKKPEPQQKAPLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB3 PPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHV 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB3 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB3 MVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB3 LHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGK 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB3 ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV 360 370 380 390 400 410 340 350 360 370 380 390 pF1KB3 KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKT 420 430 440 450 460 470 400 410 420 430 440 450 pF1KB3 NGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRH 480 490 500 510 520 530 460 470 480 490 500 510 pF1KB3 KIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPK 540 550 560 570 580 590 520 530 540 550 560 570 pF1KB3 AKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST 600 610 620 630 640 650 580 590 600 610 620 630 pF1KB3 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 660 670 680 690 700 710 640 650 660 670 680 690 pF1KB3 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 720 730 740 750 760 770 pF1KB3 PWLNS ::::: XP_016 PWLNS 780 >>XP_016868052 (OMIM: 602980) PREDICTED: SRSF protein ki (780 aa) initn: 4719 init1: 4719 opt: 4719 Z-score: 2142.4 bits: 407.0 E(85289): 1.4e-112 Smith-Waterman score: 4719; 98.4% identity (99.7% similar) in 695 aa overlap (5-699:86-780) 10 20 30 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLV .::::::::::::::::::::::::::::: XP_016 EKRPREERWCETRGGAGQGRAHGAAGGATGRVLAIQARKRRPKREKHPKKPEPQQKAPLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB3 PPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHV 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB3 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB3 MVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB3 LHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGK 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB3 ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV 360 370 380 390 400 410 340 350 360 370 380 390 pF1KB3 KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKT 420 430 440 450 460 470 400 410 420 430 440 450 pF1KB3 NGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRH 480 490 500 510 520 530 460 470 480 490 500 510 pF1KB3 KIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPK 540 550 560 570 580 590 520 530 540 550 560 570 pF1KB3 AKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST 600 610 620 630 640 650 580 590 600 610 620 630 pF1KB3 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF ::::::::::::::::::::::::::::::::::::: ::::::..::..:. ::::.:: XP_016 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIALIIELLGKVPRKYAMLGKYSKEF 660 670 680 690 700 710 640 650 660 670 680 690 pF1KB3 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH :.:.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 720 730 740 750 760 770 pF1KB3 PWLNS ::::: XP_016 PWLNS 780 >>NP_872633 (OMIM: 602980) SRSF protein kinase 2 isoform (688 aa) initn: 4653 init1: 4653 opt: 4653 Z-score: 2113.4 bits: 401.5 E(85289): 5.6e-111 Smith-Waterman score: 4653; 98.8% identity (99.6% similar) in 683 aa overlap (17-699:6-688) 10 20 30 40 50 60 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI .. . ..:::::::::::::::::::::::::::::::::::: NP_872 MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 10 20 30 40 70 80 90 100 110 120 pF1KB3 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB3 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB3 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB3 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB3 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB3 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY 590 600 610 620 630 640 670 680 690 pF1KB3 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS ::::::::::::::::::::::::::::::::::::::: NP_872 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 650 660 670 680 >>XP_016868055 (OMIM: 602980) PREDICTED: SRSF protein ki (688 aa) initn: 4653 init1: 4653 opt: 4653 Z-score: 2113.4 bits: 401.5 E(85289): 5.6e-111 Smith-Waterman score: 4653; 98.8% identity (99.6% similar) in 683 aa overlap (17-699:6-688) 10 20 30 40 50 60 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI .. . ..:::::::::::::::::::::::::::::::::::: XP_016 MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 10 20 30 40 70 80 90 100 110 120 pF1KB3 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB3 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB3 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB3 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB3 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB3 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY 590 600 610 620 630 640 670 680 690 pF1KB3 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS ::::::::::::::::::::::::::::::::::::::: XP_016 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 650 660 670 680 >>NP_001265202 (OMIM: 602980) SRSF protein kinase 2 isof (688 aa) initn: 4653 init1: 4653 opt: 4653 Z-score: 2113.4 bits: 401.5 E(85289): 5.6e-111 Smith-Waterman score: 4653; 98.8% identity (99.6% similar) in 683 aa overlap (17-699:6-688) 10 20 30 40 50 60 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI .. . ..:::::::::::::::::::::::::::::::::::: NP_001 MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 10 20 30 40 70 80 90 100 110 120 pF1KB3 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB3 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB3 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB3 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB3 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB3 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY 590 600 610 620 630 640 670 680 690 pF1KB3 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS ::::::::::::::::::::::::::::::::::::::: NP_001 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 650 660 670 680 >>XP_016868049 (OMIM: 602980) PREDICTED: SRSF protein ki (725 aa) initn: 4653 init1: 4653 opt: 4653 Z-score: 2113.1 bits: 401.5 E(85289): 5.8e-111 Smith-Waterman score: 4653; 98.8% identity (99.6% similar) in 683 aa overlap (17-699:43-725) 10 20 30 40 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPP .. . ..:::::::::::::::::::::: XP_016 PFRPESGGRKERNIRKKIKQKIELLMSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPP 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB3 PLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB3 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB3 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDI 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB3 KPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKK 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB3 QKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAE 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB3 AETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLE 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB3 QQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFST 440 450 460 470 480 490 470 480 490 500 510 520 pF1KB3 SLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNP 500 510 520 530 540 550 530 540 550 560 570 580 pF1KB3 LDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAF 560 570 580 590 600 610 590 600 610 620 630 640 pF1KB3 ELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITK 620 630 640 650 660 670 650 660 670 680 690 pF1KB3 LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 680 690 700 710 720 >>XP_016868050 (OMIM: 602980) PREDICTED: SRSF protein ki (688 aa) initn: 4595 init1: 4595 opt: 4595 Z-score: 2087.3 bits: 396.7 E(85289): 1.6e-109 Smith-Waterman score: 4595; 97.4% identity (99.3% similar) in 683 aa overlap (17-699:6-688) 10 20 30 40 50 60 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI .. . ..:::::::::::::::::::::::::::::::::::: XP_016 MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 10 20 30 40 70 80 90 100 110 120 pF1KB3 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB3 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB3 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB3 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB3 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB3 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB3 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB3 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB3 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB3 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY ::::::::::: ::::::..::..:. ::::.:::.:.:::::::::::::::::::::: XP_016 EDYSRDEDHIALIIELLGKVPRKYAMLGKYSKEFFTRKGELRHITKLKPWSLFDVLVEKY 590 600 610 620 630 640 670 680 690 pF1KB3 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS ::::::::::::::::::::::::::::::::::::::: XP_016 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 650 660 670 680 >>XP_005250607 (OMIM: 602980) PREDICTED: SRSF protein ki (730 aa) initn: 4504 init1: 4368 opt: 4373 Z-score: 1987.3 bits: 378.3 E(85289): 5.9e-104 Smith-Waterman score: 4732; 95.8% identity (95.8% similar) in 730 aa overlap (1-699:1-730) 10 20 30 40 50 60 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB3 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB3 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 550 560 570 580 590 600 610 620 630 pF1KB3 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRR---------------------- :::::::::::::::::::::::::::::::::::::: XP_005 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGKVPRKYAMLGK 610 620 630 640 650 660 640 650 660 670 680 pF1KB3 ---------GELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAG ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YSKEFFTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAG 670 680 690 700 710 720 690 pF1KB3 ECLRHPWLNS :::::::::: XP_005 ECLRHPWLNS 730 >>XP_005250606 (OMIM: 602980) PREDICTED: SRSF protein ki (811 aa) initn: 4583 init1: 4338 opt: 4346 Z-score: 1974.6 bits: 376.1 E(85289): 3e-103 Smith-Waterman score: 4705; 95.6% identity (95.7% similar) in 726 aa overlap (5-699:86-811) 10 20 30 pF1KB3 MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLV .::::::::::::::::::::::::::::: XP_005 EKRPREERWCETRGGAGQGRAHGAAGGATGRVLAIQARKRRPKREKHPKKPEPQQKAPLV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB3 PPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHV 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB3 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB3 MVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB3 LHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGK 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB3 ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEV 360 370 380 390 400 410 340 350 360 370 380 390 pF1KB3 KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKT 420 430 440 450 460 470 400 410 420 430 440 450 pF1KB3 NGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRH 480 490 500 510 520 530 460 470 480 490 500 510 pF1KB3 KIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPK 540 550 560 570 580 590 520 530 540 550 560 570 pF1KB3 AKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST 600 610 620 630 640 650 580 590 600 610 620 630 pF1KB3 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 660 670 680 690 700 710 640 650 660 pF1KB3 FNRR-------------------------------GELRHITKLKPWSLFDVLVEKYGWP :::: ::::::::::::::::::::::::: XP_005 FNRRDHIALIIELLGKVPRKYAMLGKYSKEFFTRKGELRHITKLKPWSLFDVLVEKYGWP 720 730 740 750 760 770 670 680 690 pF1KB3 HEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS :::::::::::::::::::::::::::::::::::: XP_005 HEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 780 790 800 810 699 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:51:42 2016 done: Sat Nov 5 01:51:44 2016 Total Scan time: 13.210 Total Display time: 0.180 Function used was FASTA [36.3.4 Apr, 2011]