FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3422, 131 aa 1>>>pF1KB3422 131 - 131 aa - 131 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8461+/-0.000332; mu= 8.9245+/- 0.021 mean_var=81.0122+/-15.644, 0's: 0 Z-trim(116.9): 26 B-trim: 190 in 1/49 Lambda= 0.142495 statistics sampled from 28471 (28497) to 28471 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.334), width: 16 Scan time: 5.090 The best scores are: opt bits E(85289) NP_059140 (OMIM: 607268) chromatin accessibility c ( 131) 819 177.2 6.9e-45 NP_001136062 (OMIM: 605344) nuclear transcription ( 301) 184 46.8 2.7e-05 NP_063949 (OMIM: 607269) DNA polymerase epsilon su ( 117) 178 45.4 2.9e-05 NP_001136059 (OMIM: 605344) nuclear transcription ( 334) 184 46.8 3e-05 XP_016856857 (OMIM: 605344) PREDICTED: nuclear tra ( 335) 184 46.8 3e-05 XP_006710725 (OMIM: 605344) PREDICTED: nuclear tra ( 335) 184 46.8 3e-05 NP_055038 (OMIM: 605344) nuclear transcription fac ( 335) 184 46.8 3e-05 XP_016856858 (OMIM: 605344) PREDICTED: nuclear tra ( 335) 184 46.8 3e-05 NP_001136060 (OMIM: 605344) nuclear transcription ( 354) 184 46.9 3.1e-05 XP_016856856 (OMIM: 605344) PREDICTED: nuclear tra ( 354) 184 46.9 3.1e-05 XP_006710723 (OMIM: 605344) PREDICTED: nuclear tra ( 354) 184 46.9 3.1e-05 XP_016856855 (OMIM: 605344) PREDICTED: nuclear tra ( 355) 184 46.9 3.1e-05 XP_011539819 (OMIM: 605344) PREDICTED: nuclear tra ( 427) 184 46.9 3.6e-05 XP_006710724 (OMIM: 605344) PREDICTED: nuclear tra ( 439) 184 46.9 3.7e-05 XP_006710721 (OMIM: 605344) PREDICTED: nuclear tra ( 439) 184 46.9 3.7e-05 NP_001295044 (OMIM: 605344) nuclear transcription ( 439) 184 46.9 3.7e-05 XP_005270951 (OMIM: 605344) PREDICTED: nuclear tra ( 458) 184 46.9 3.9e-05 NP_001295043 (OMIM: 605344) nuclear transcription ( 458) 184 46.9 3.9e-05 XP_016856854 (OMIM: 605344) PREDICTED: nuclear tra ( 458) 184 46.9 3.9e-05 XP_011539818 (OMIM: 605344) PREDICTED: nuclear tra ( 458) 184 46.9 3.9e-05 XP_005270952 (OMIM: 605344) PREDICTED: nuclear tra ( 458) 184 46.9 3.9e-05 XP_016856853 (OMIM: 605344) PREDICTED: nuclear tra ( 459) 184 46.9 3.9e-05 >>NP_059140 (OMIM: 607268) chromatin accessibility compl (131 aa) initn: 819 init1: 819 opt: 819 Z-score: 926.9 bits: 177.2 E(85289): 6.9e-45 Smith-Waterman score: 819; 100.0% identity (100.0% similar) in 131 aa overlap (1-131:1-131) 10 20 30 40 50 60 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVLTAKATELFVQCLATYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 YRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYLKMLKEEKREEDEENDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 YRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYLKMLKEEKREEDEENDN 70 80 90 100 110 120 130 pF1KB3 DNESDHDEADS ::::::::::: NP_059 DNESDHDEADS 130 >>NP_001136062 (OMIM: 605344) nuclear transcription fact (301 aa) initn: 195 init1: 177 opt: 184 Z-score: 216.0 bits: 46.8 E(85289): 2.7e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: NP_001 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. NP_001 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. NP_001 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>NP_063949 (OMIM: 607269) DNA polymerase epsilon subuni (117 aa) initn: 178 init1: 178 opt: 178 Z-score: 215.5 bits: 45.4 E(85289): 2.9e-05 Smith-Waterman score: 178; 36.2% identity (68.8% similar) in 80 aa overlap (15-94:37-116) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :: :::.:.....:..:.:. .:::. . NP_063 AGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAGQEAIFI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :.:.::::. .: .: .. ..:.: :: :. . . : :: : NP_063 LARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD 70 80 90 100 110 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS >>NP_001136059 (OMIM: 605344) nuclear transcription fact (334 aa) initn: 195 init1: 177 opt: 184 Z-score: 215.3 bits: 46.8 E(85289): 3e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: NP_001 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. NP_001 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. NP_001 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>XP_016856857 (OMIM: 605344) PREDICTED: nuclear transcr (335 aa) initn: 195 init1: 177 opt: 184 Z-score: 215.3 bits: 46.8 E(85289): 3e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: XP_016 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. XP_016 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. XP_016 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>XP_006710725 (OMIM: 605344) PREDICTED: nuclear transcr (335 aa) initn: 195 init1: 177 opt: 184 Z-score: 215.3 bits: 46.8 E(85289): 3e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: XP_006 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. XP_006 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. XP_006 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>NP_055038 (OMIM: 605344) nuclear transcription factor (335 aa) initn: 195 init1: 177 opt: 184 Z-score: 215.3 bits: 46.8 E(85289): 3e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: NP_055 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. NP_055 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. NP_055 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>XP_016856858 (OMIM: 605344) PREDICTED: nuclear transcr (335 aa) initn: 195 init1: 177 opt: 184 Z-score: 215.3 bits: 46.8 E(85289): 3e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: XP_016 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. XP_016 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. XP_016 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>NP_001136060 (OMIM: 605344) nuclear transcription fact (354 aa) initn: 195 init1: 177 opt: 184 Z-score: 214.9 bits: 46.9 E(85289): 3.1e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: NP_001 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. NP_001 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. NP_001 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 >>XP_016856856 (OMIM: 605344) PREDICTED: nuclear transcr (354 aa) initn: 195 init1: 177 opt: 184 Z-score: 214.9 bits: 46.9 E(85289): 3.1e-05 Smith-Waterman score: 184; 34.7% identity (63.4% similar) in 101 aa overlap (15-115:39-131) 10 20 30 40 pF1KB3 MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL :. :::.::. ::: . .:. :. :: :: XP_016 GTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASKYL :::...:. :. .. : .....: .:.: . . . :.:: ::.:. XP_016 FAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRD------- 70 80 90 100 110 120 110 120 130 pF1KB3 KMLKEEKREEDEENDNDNESDHDEADS :: ::.:. XP_016 -ELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 130 140 150 160 170 180 131 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:22:09 2016 done: Fri Nov 4 02:22:10 2016 Total Scan time: 5.090 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]