FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3435, 406 aa 1>>>pF1KB3435 406 - 406 aa - 406 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3263+/-0.000511; mu= 17.2142+/- 0.031 mean_var=75.6987+/-15.406, 0's: 0 Z-trim(107.6): 190 B-trim: 164 in 1/51 Lambda= 0.147411 statistics sampled from 15446 (15643) to 15446 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.537), E-opt: 0.2 (0.183), width: 16 Scan time: 7.180 The best scores are: opt bits E(85289) NP_001407 (OMIM: 602641) eukaryotic initiation fac ( 406) 2629 569.3 6.1e-162 NP_001958 (OMIM: 601102) eukaryotic initiation fac ( 407) 2426 526.1 6.1e-149 NP_001191439 (OMIM: 602641) eukaryotic initiation ( 347) 2155 468.4 1.2e-131 NP_055555 (OMIM: 268305,608546) eukaryotic initiat ( 411) 1791 391.0 2.7e-108 XP_011523824 (OMIM: 268305,608546) PREDICTED: euka ( 390) 1379 303.4 6.3e-82 NP_001244120 (OMIM: 600326) probable ATP-dependent ( 483) 943 210.7 6.1e-54 NP_004388 (OMIM: 600326) probable ATP-dependent RN ( 483) 943 210.7 6.1e-54 XP_005271474 (OMIM: 600326) PREDICTED: probable AT ( 483) 943 210.7 6.1e-54 NP_009173 (OMIM: 605812) ATP-dependent RNA helicas ( 479) 915 204.8 3.7e-52 XP_011521136 (OMIM: 605812) PREDICTED: ATP-depende ( 484) 915 204.8 3.8e-52 XP_011521134 (OMIM: 605812) PREDICTED: ATP-depende ( 539) 915 204.8 4.1e-52 XP_011541093 (OMIM: 607663) PREDICTED: ATP-depende ( 482) 893 200.1 9.6e-51 NP_037396 (OMIM: 607663) ATP-dependent RNA helicas ( 483) 893 200.1 9.6e-51 XP_011541092 (OMIM: 607663) PREDICTED: ATP-depende ( 486) 893 200.1 9.7e-51 NP_542165 (OMIM: 142560) spliceosome RNA helicase ( 428) 874 196.0 1.4e-49 NP_004631 (OMIM: 142560) spliceosome RNA helicase ( 428) 874 196.0 1.4e-49 XP_006721190 (OMIM: 605812) PREDICTED: ATP-depende ( 370) 852 191.3 3.3e-48 XP_016878379 (OMIM: 605812) PREDICTED: ATP-depende ( 370) 852 191.3 3.3e-48 NP_001244102 (OMIM: 605812) ATP-dependent RNA heli ( 370) 852 191.3 3.3e-48 NP_001244103 (OMIM: 605812) ATP-dependent RNA heli ( 370) 852 191.3 3.3e-48 NP_001014449 (OMIM: 605812) ATP-dependent RNA heli ( 370) 852 191.3 3.3e-48 NP_001317367 (OMIM: 607663) ATP-dependent RNA heli ( 369) 824 185.4 2e-46 NP_009135 (OMIM: 606168) probable ATP-dependent RN ( 824) 825 185.8 3.3e-46 NP_001014451 (OMIM: 605812) ATP-dependent RNA heli ( 448) 821 184.8 3.7e-46 NP_001244101 (OMIM: 605812) ATP-dependent RNA heli ( 453) 821 184.8 3.7e-46 XP_011521135 (OMIM: 605812) PREDICTED: ATP-depende ( 508) 821 184.8 4.1e-46 NP_001244104 (OMIM: 605812) ATP-dependent RNA heli ( 328) 737 166.8 6.9e-41 NP_060365 (OMIM: 616621) probable ATP-dependent RN ( 796) 722 163.9 1.3e-39 XP_016866492 (OMIM: 606286) PREDICTED: probable AT ( 439) 703 159.7 1.3e-38 XP_011534230 (OMIM: 606286) PREDICTED: probable AT ( 529) 703 159.7 1.5e-38 XP_011534229 (OMIM: 606286) PREDICTED: probable AT ( 529) 703 159.7 1.5e-38 XP_011534228 (OMIM: 606286) PREDICTED: probable AT ( 604) 703 159.8 1.7e-38 NP_061135 (OMIM: 606286) probable ATP-dependent RN ( 648) 703 159.8 1.8e-38 NP_057439 (OMIM: 615428) probable ATP-dependent RN ( 455) 701 159.3 1.8e-38 XP_016857920 (OMIM: 174300,615464) PREDICTED: prob ( 619) 692 157.4 8.6e-38 XP_016857921 (OMIM: 174300,615464) PREDICTED: prob ( 619) 692 157.4 8.6e-38 NP_001026895 (OMIM: 174300,615464) probable ATP-de ( 619) 692 157.4 8.6e-38 XP_011508337 (OMIM: 174300,615464) PREDICTED: prob ( 619) 692 157.4 8.6e-38 NP_004387 (OMIM: 180630) probable ATP-dependent RN ( 614) 672 153.2 1.6e-36 NP_001307525 (OMIM: 180630) probable ATP-dependent ( 614) 672 153.2 1.6e-36 NP_001307524 (OMIM: 180630) probable ATP-dependent ( 614) 672 153.2 1.6e-36 NP_001307526 (OMIM: 180630) probable ATP-dependent ( 614) 672 153.2 1.6e-36 NP_006377 (OMIM: 608469) probable ATP-dependent RN ( 729) 667 152.2 3.9e-36 NP_001091974 (OMIM: 608469) probable ATP-dependent ( 731) 667 152.2 3.9e-36 NP_076977 (OMIM: 611665) ATP-dependent RNA helicas ( 881) 664 151.6 7.1e-36 NP_001104792 (OMIM: 611665) ATP-dependent RNA heli ( 882) 664 151.6 7.1e-36 XP_011540947 (OMIM: 600326) PREDICTED: probable AT ( 434) 650 148.4 3.2e-35 XP_016879601 (OMIM: 613369) PREDICTED: ATP-depende ( 775) 621 142.4 3.6e-33 XP_006721720 (OMIM: 613369) PREDICTED: ATP-depende ( 938) 621 142.5 4.2e-33 NP_987095 (OMIM: 613369) ATP-dependent RNA helicas ( 938) 621 142.5 4.2e-33 >>NP_001407 (OMIM: 602641) eukaryotic initiation factor (406 aa) initn: 2629 init1: 2629 opt: 2629 Z-score: 3028.3 bits: 569.3 E(85289): 6.1e-162 Smith-Waterman score: 2629; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406) 10 20 30 40 50 60 pF1KB3 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 310 320 330 340 350 360 370 380 390 400 pF1KB3 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI :::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 370 380 390 400 >>NP_001958 (OMIM: 601102) eukaryotic initiation factor (407 aa) initn: 2418 init1: 2418 opt: 2426 Z-score: 2795.0 bits: 526.1 E(85289): 6.1e-149 Smith-Waterman score: 2426; 89.7% identity (98.0% similar) in 407 aa overlap (1-406:1-407) 10 20 30 40 50 pF1KB3 MSASQDSRSRDNG-PDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQ ::... . .:..: :.::.:.::::::::::::.::::::.::::::::::::::::::: NP_001 MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 QRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKV ::::.:::::::::::::::::::::::::::::.:...: ::::::::::::::::::: NP_001 QRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 VMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMF ..::::::::.::::::::::: :.:::: :::::.:::::::::::::::::::.:::: NP_001 ILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 VLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKE ::::::::::::::::::.::::::.. ::::::::::.::::::::::::::::::::: NP_001 VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 ELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTV :::::::.:::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_001 ELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTV 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 SAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHR ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHR 310 320 330 340 350 360 360 370 380 390 400 pF1KB3 IGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI :::::::::::::::.::::::: ::::::::::..::::.:::::: NP_001 IGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI 370 380 390 400 >>NP_001191439 (OMIM: 602641) eukaryotic initiation fact (347 aa) initn: 2176 init1: 2155 opt: 2155 Z-score: 2484.5 bits: 468.4 E(85289): 1.2e-131 Smith-Waterman score: 2155; 99.4% identity (100.0% similar) in 334 aa overlap (1-334:1-334) 10 20 30 40 50 60 pF1KB3 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI ::::::::::::::::::::::::::::::::.. NP_001 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLGKLYPQNRSRWTVWP 310 320 330 340 370 380 390 400 pF1KB3 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI >>NP_055555 (OMIM: 268305,608546) eukaryotic initiation (411 aa) initn: 1782 init1: 1254 opt: 1791 Z-score: 2065.1 bits: 391.0 E(85289): 2.7e-108 Smith-Waterman score: 1791; 66.7% identity (86.7% similar) in 406 aa overlap (1-406:7-411) 10 20 30 40 50 pF1KB3 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEK :..: ..:.: . : :. ... .:: :.: :.:::::::::::: NP_055 MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 PSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQ ::::::::: ::: :::::.::::::::::.::.:: ...... ::::.:::::::: NP_055 PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 QIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPK :::: ..::::::...:::::::::: ...::.. . :...:::::::::. :: : . NP_055 QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDY-GQHVVAGTPGRVFDMIRRRSLRTR 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 YIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRI :::.:::::::::..:::.::::... : :::::.:::.: ..::.:.::: ::::: NP_055 AIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 LVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHA :::..:::::::.::.. :::::::.:::::::.:::::::::: ::.::::::::::. NP_055 LVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMRE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 RDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRE .::::.::::: ::::. ::.:::::.:::::.::. :::.:: ::::.::::::.::: NP_055 ANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRE 300 310 320 330 340 350 360 370 380 390 400 pF1KB3 NYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI :::::::.::.::::::::.: ..: : ::::: .:.:.:.:::.:::::: NP_055 LYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI 360 370 380 390 400 410 >>XP_011523824 (OMIM: 268305,608546) PREDICTED: eukaryot (390 aa) initn: 1673 init1: 1254 opt: 1379 Z-score: 1591.9 bits: 303.4 E(85289): 6.3e-82 Smith-Waterman score: 1645; 63.3% identity (82.3% similar) in 406 aa overlap (1-406:7-390) 10 20 30 40 50 pF1KB3 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEK :..: ..:.: . : :. ... .:: :.: :.:::::::::::: XP_011 MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 PSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQ ::::::::: ::: :::::.::::::::::.::.:: ... :.: XP_011 PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDI-----QGL---------- 70 80 90 100 120 130 140 150 160 170 pF1KB3 QIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPK .::::::...:::::::::: ...::.. . :...:::::::::. :: : . XP_011 ------LALGDYMNVQCHACIGGTNVGEDIRKLDY-GQHVVAGTPGRVFDMIRRRSLRTR 110 120 130 140 150 180 190 200 210 220 230 pF1KB3 YIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRI :::.:::::::::..:::.::::... : :::::.:::.: ..::.:.::: ::::: XP_011 AIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRI 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB3 LVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHA :::..:::::::.::.. :::::::.:::::::.:::::::::: ::.::::::::::. XP_011 LVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMRE 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB3 RDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRE .::::.::::: ::::. ::.:::::.:::::.::. :::.:: ::::.::::::.::: XP_011 ANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRE 280 290 300 310 320 330 360 370 380 390 400 pF1KB3 NYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI :::::::.::.::::::::.: ..: : ::::: .:.:.:.:::.:::::: XP_011 LYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI 340 350 360 370 380 390 >>NP_001244120 (OMIM: 600326) probable ATP-dependent RNA (483 aa) initn: 790 init1: 446 opt: 943 Z-score: 1089.5 bits: 210.7 E(85289): 6.1e-54 Smith-Waterman score: 943; 38.7% identity (74.2% similar) in 372 aa overlap (32-402:96-464) 10 20 30 40 50 60 pF1KB3 SASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQR . :.:. :.. :: ::. .:.:::: ::.. NP_001 IKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEE 70 80 90 100 110 120 70 80 90 100 110 120 pF1KB3 AILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVM .: ..: :..:.:..::::.... : .:....: ::.:..:::::: :.... . NP_001 SIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICI 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB3 ALGDYMG-ASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV .. .:: :. : ::::.: ....:. .. :....::::..:.... . ...:.: NP_001 QVSKHMGGAKVMATTGGTNLRDDIMRLD-DTVHVVIATPGRILDLIKKGVAKVDHVQMIV 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB3 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE :::::..::. : . . ::. : .: :..: :::.: .: . .. .. : .: . :: NP_001 LDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EE 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB3 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS :::.:. :.: : :. :. : :. : :.:..:: :. ..:. :..:. .. NP_001 LTLKGVTQYYAYVT-ERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCF 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB3 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI .:. : :..:. ....::.: : :. :::..::::.: :..:::.:.: :.:.::: NP_001 YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRI 370 380 390 400 410 420 370 380 390 400 pF1KB3 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI ::.::::. :.:::..: .:. .:..:: .: :. .: :. NP_001 GRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEK 430 440 450 460 470 480 NP_001 P >>NP_004388 (OMIM: 600326) probable ATP-dependent RNA he (483 aa) initn: 790 init1: 446 opt: 943 Z-score: 1089.5 bits: 210.7 E(85289): 6.1e-54 Smith-Waterman score: 943; 38.7% identity (74.2% similar) in 372 aa overlap (32-402:96-464) 10 20 30 40 50 60 pF1KB3 SASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQR . :.:. :.. :: ::. .:.:::: ::.. NP_004 IKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEE 70 80 90 100 110 120 70 80 90 100 110 120 pF1KB3 AILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVM .: ..: :..:.:..::::.... : .:....: ::.:..:::::: :.... . NP_004 SIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICI 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB3 ALGDYMG-ASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV .. .:: :. : ::::.: ....:. .. :....::::..:.... . ...:.: NP_004 QVSKHMGGAKVMATTGGTNLRDDIMRLD-DTVHVVIATPGRILDLIKKGVAKVDHVQMIV 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB3 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE :::::..::. : . . ::. : .: :..: :::.: .: . .. .. : .: . :: NP_004 LDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EE 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB3 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS :::.:. :.: : :. :. : :. : :.:..:: :. ..:. :..:. .. NP_004 LTLKGVTQYYAYVT-ERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCF 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB3 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI .:. : :..:. ....::.: : :. :::..::::.: :..:::.:.: :.:.::: NP_004 YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRI 370 380 390 400 410 420 370 380 390 400 pF1KB3 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI ::.::::. :.:::..: .:. .:..:: .: :. .: :. NP_004 GRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEK 430 440 450 460 470 480 NP_004 P >>XP_005271474 (OMIM: 600326) PREDICTED: probable ATP-de (483 aa) initn: 790 init1: 446 opt: 943 Z-score: 1089.5 bits: 210.7 E(85289): 6.1e-54 Smith-Waterman score: 943; 38.7% identity (74.2% similar) in 372 aa overlap (32-402:96-464) 10 20 30 40 50 60 pF1KB3 SASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQR . :.:. :.. :: ::. .:.:::: ::.. XP_005 IKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEE 70 80 90 100 110 120 70 80 90 100 110 120 pF1KB3 AILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVM .: ..: :..:.:..::::.... : .:....: ::.:..:::::: :.... . XP_005 SIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICI 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB3 ALGDYMG-ASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV .. .:: :. : ::::.: ....:. .. :....::::..:.... . ...:.: XP_005 QVSKHMGGAKVMATTGGTNLRDDIMRLD-DTVHVVIATPGRILDLIKKGVAKVDHVQMIV 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB3 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE :::::..::. : . . ::. : .: :..: :::.: .: . .. .. : .: . :: XP_005 LDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EE 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB3 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS :::.:. :.: : :. :. : :. : :.:..:: :. ..:. :..:. .. XP_005 LTLKGVTQYYAYVT-ERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCF 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB3 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI .:. : :..:. ....::.: : :. :::..::::.: :..:::.:.: :.:.::: XP_005 YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRI 370 380 390 400 410 420 370 380 390 400 pF1KB3 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI ::.::::. :.:::..: .:. .:..:: .: :. .: :. XP_005 GRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEK 430 440 450 460 470 480 XP_005 P >>NP_009173 (OMIM: 605812) ATP-dependent RNA helicase DD (479 aa) initn: 644 init1: 423 opt: 915 Z-score: 1057.3 bits: 204.8 E(85289): 3.7e-52 Smith-Waterman score: 915; 40.4% identity (71.5% similar) in 389 aa overlap (31-406:91-474) 10 20 30 40 50 60 pF1KB3 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ : ::... :. .::.:.::.::..:: ::. NP_009 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE 70 80 90 100 110 120 70 80 90 100 110 pF1KB3 RAILPCIKG---YDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQ : :: . . ..:::.::::::::.:....:.:.: : : : :.:: ::: : NP_009 NA-LPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTG 130 140 150 160 170 120 130 140 150 160 170 pF1KB3 KVVMALGDYMGASCHACIGGTNVRA-EVQKLQMEAPHIIVGTPGRVFDMLNR-RYLSPKY ::. .: .. : ::. .... : . .:..:::: :.: .. ....:: NP_009 KVIEQMGKFYPELKLA----YAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB3 IKMFVLDEADEML-SRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRI ::.::::::: :. ..: .:: : . : : :..:.:::. ..: . ..: . :: : NP_009 IKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB3 LVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHA .:.:: ::. :.:.:. .. :...::.:: ..::.::.:: .::. ..::. .. NP_009 KLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSK 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB3 RDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNR- . :. . :.: ..: .....:: :. .::.::.. ::::::.:::.:::.:::... NP_009 EGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKD 360 370 380 390 400 410 360 370 380 390 400 pF1KB3 -----ENYIHRIGRGGRFGRKGVAINMV-TEEDKRTLRDIETFYNTSIEEMPLNVADLI :.:.::::: ::::..:.:.::: .... : :. .: .::.. . : : NP_009 GNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIE 420 430 440 450 460 470 NP_009 KIAN >>XP_011521136 (OMIM: 605812) PREDICTED: ATP-dependent R (484 aa) initn: 644 init1: 423 opt: 915 Z-score: 1057.3 bits: 204.8 E(85289): 3.8e-52 Smith-Waterman score: 915; 40.4% identity (71.5% similar) in 389 aa overlap (31-406:96-479) 10 20 30 40 50 60 pF1KB3 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ : ::... :. .::.:.::.::..:: ::. XP_011 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE 70 80 90 100 110 120 70 80 90 100 110 pF1KB3 RAILPCIKG---YDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQ : :: . . ..:::.::::::::.:....:.:.: : : : :.:: ::: : XP_011 NA-LPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTG 130 140 150 160 170 180 120 130 140 150 160 170 pF1KB3 KVVMALGDYMGASCHACIGGTNVRA-EVQKLQMEAPHIIVGTPGRVFDMLNR-RYLSPKY ::. .: .. : ::. .... : . .:..:::: :.: .. ....:: XP_011 KVIEQMGKFYPELKLA----YAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK 190 200 210 220 230 240 180 190 200 210 220 230 pF1KB3 IKMFVLDEADEML-SRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRI ::.::::::: :. ..: .:: : . : : :..:.:::. ..: . ..: . :: : XP_011 IKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 250 260 270 280 290 300 240 250 260 270 280 290 pF1KB3 LVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHA .:.:: ::. :.:.:. .. :...::.:: ..::.::.:: .::. ..::. .. XP_011 KLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSK 310 320 330 340 350 360 300 310 320 330 340 350 pF1KB3 RDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNR- . :. . :.: ..: .....:: :. .::.::.. ::::::.:::.:::.:::... XP_011 EGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKD 370 380 390 400 410 420 360 370 380 390 400 pF1KB3 -----ENYIHRIGRGGRFGRKGVAINMV-TEEDKRTLRDIETFYNTSIEEMPLNVADLI :.:.::::: ::::..:.:.::: .... : :. .: .::.. . : : XP_011 GNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIE 430 440 450 460 470 480 XP_011 KIAN 406 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:59:25 2016 done: Thu Nov 3 20:59:26 2016 Total Scan time: 7.180 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]