FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3440, 258 aa 1>>>pF1KB3440 258 - 258 aa - 258 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2565+/-0.000383; mu= 15.2321+/- 0.024 mean_var=75.8508+/-14.948, 0's: 0 Z-trim(113.4): 139 B-trim: 66 in 1/56 Lambda= 0.147263 statistics sampled from 22502 (22657) to 22502 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.266), width: 16 Scan time: 5.450 The best scores are: opt bits E(85289) NP_002112 (OMIM: 142858) HLA class II histocompati ( 258) 1717 374.1 1.4e-103 NP_001230891 (OMIM: 123400,126200,212750,604305) H ( 261) 1111 245.4 7.8e-65 NP_002115 (OMIM: 126200,142857,180300,181000) majo ( 266) 1094 241.8 9.7e-64 NP_001230890 (OMIM: 123400,126200,212750,604305) H ( 269) 1087 240.3 2.8e-63 NP_002114 (OMIM: 123400,126200,212750,604305) HLA ( 261) 1083 239.4 4.8e-63 XP_011546040 (OMIM: 126200,142857,180300,181000) P ( 266) 1068 236.2 4.5e-62 NP_001287719 (OMIM: 615161) HLA class II histocomp ( 264) 1057 233.9 2.3e-61 XP_005249108 (OMIM: 615161) PREDICTED: HLA class I ( 275) 1057 233.9 2.3e-61 XP_011512862 (OMIM: 615161) PREDICTED: HLA class I ( 256) 1047 231.8 9.6e-61 NP_002116 (OMIM: 604776) major histocompatibility ( 266) 1043 230.9 1.8e-60 XP_011512864 (OMIM: 604776) PREDICTED: major histo ( 276) 1043 230.9 1.8e-60 NP_001230894 (OMIM: 126200,142857,180300,181000) m ( 266) 1042 230.7 2.1e-60 NP_072049 (OMIM: 612735) major histocompatibility ( 266) 1032 228.6 9e-60 NP_002111 (OMIM: 600629) HLA class II histocompati ( 273) 929 206.7 3.5e-53 XP_011512863 (OMIM: 615161) PREDICTED: HLA class I ( 219) 907 202.0 7.6e-52 NP_001185787 (OMIM: 615161) HLA class II histocomp ( 227) 907 202.0 7.8e-52 NP_620576 (OMIM: 104300,176100,176200,235200,61263 ( 260) 313 75.8 8.5e-14 XP_011507765 (OMIM: 600764) PREDICTED: major histo ( 254) 308 74.8 1.7e-13 NP_001522 (OMIM: 600764) major histocompatibility ( 341) 293 71.7 2e-12 NP_002109 (OMIM: 142856) HLA class II histocompati ( 263) 283 69.5 7.1e-12 NP_002110 (OMIM: 142930) HLA class II histocompati ( 250) 273 67.3 3e-11 NP_620578 (OMIM: 104300,176100,176200,235200,61263 ( 325) 274 67.6 3.2e-11 XP_011512845 (OMIM: 104300,176100,176200,235200,61 ( 348) 274 67.6 3.3e-11 NP_000401 (OMIM: 104300,176100,176200,235200,61263 ( 348) 274 67.6 3.3e-11 NP_001229453 (OMIM: 142880) HLA class II histocomp ( 260) 271 66.9 4.1e-11 NP_001229454 (OMIM: 142880) HLA class II histocomp ( 260) 271 66.9 4.1e-11 NP_291032 (OMIM: 142880) HLA class II histocompati ( 260) 271 66.9 4.1e-11 NP_001176 (OMIM: 194460) zinc-alpha-2-glycoprotein ( 298) 266 65.9 9.6e-11 NP_001287678 (OMIM: 104300,176100,176200,235200,61 ( 337) 265 65.7 1.2e-10 NP_002107 (OMIM: 142800,608579) HLA class I histoc ( 365) 258 64.3 3.6e-10 NP_061823 (OMIM: 143110) HLA class I histocompatib ( 346) 257 64.0 4.1e-10 XP_016885777 (OMIM: 142800,608579) PREDICTED: HLA ( 362) 257 64.0 4.2e-10 XP_016866302 (OMIM: 143110) PREDICTED: HLA class I ( 388) 257 64.1 4.4e-10 XP_005275388 (OMIM: 142800,608579) PREDICTED: HLA ( 391) 257 64.1 4.5e-10 XP_016866301 (OMIM: 143110) PREDICTED: HLA class I ( 420) 257 64.1 4.7e-10 XP_016866299 (OMIM: 143110) PREDICTED: HLA class I ( 435) 257 64.1 4.8e-10 NP_001091949 (OMIM: 143110) HLA class I histocompa ( 442) 257 64.1 4.9e-10 NP_620573 (OMIM: 104300,176100,176200,235200,61263 ( 256) 253 63.1 5.8e-10 XP_016866304 (OMIM: 143110) PREDICTED: HLA class I ( 228) 252 62.8 6.1e-10 NP_005505 (OMIM: 106300,142830,608579) major histo ( 362) 254 63.4 6.5e-10 XP_016866303 (OMIM: 143110) PREDICTED: HLA class I ( 324) 252 62.9 8e-10 NP_001181928 (OMIM: 600764) major histocompatibili ( 296) 249 62.3 1.2e-09 NP_061984 (OMIM: 142860) HLA class II histocompati ( 254) 248 62.0 1.2e-09 NP_001229687 (OMIM: 142800,608579) HLA class I his ( 365) 249 62.3 1.4e-09 XP_011512866 (OMIM: 143110) PREDICTED: HLA class I ( 343) 246 61.7 2e-09 XP_016866300 (OMIM: 143110) PREDICTED: HLA class I ( 431) 246 61.8 2.4e-09 NP_005507 (OMIM: 143010) HLA class I histocompatib ( 358) 245 61.5 2.4e-09 XP_016866298 (OMIM: 143010) PREDICTED: HLA class I ( 359) 245 61.5 2.4e-09 XP_016866297 (OMIM: 143010) PREDICTED: HLA class I ( 399) 245 61.5 2.6e-09 XP_016866296 (OMIM: 143010) PREDICTED: HLA class I ( 399) 245 61.5 2.6e-09 >>NP_002112 (OMIM: 142858) HLA class II histocompatibili (258 aa) initn: 1717 init1: 1717 opt: 1717 Z-score: 1980.8 bits: 374.1 E(85289): 1.4e-103 Smith-Waterman score: 1717; 98.8% identity (99.2% similar) in 258 aa overlap (1-258:1-258) 10 20 30 40 50 60 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 REEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQR ::::.:::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_002 REEFARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 TFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLIIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLIIC 190 200 210 220 230 240 250 pF1KB3 GVGIFMHRRSKKVQRGSA :::::::::::::::::: NP_002 GVGIFMHRRSKKVQRGSA 250 >>NP_001230891 (OMIM: 123400,126200,212750,604305) HLA c (261 aa) initn: 1090 init1: 994 opt: 1111 Z-score: 1284.9 bits: 245.4 E(85289): 7.8e-65 Smith-Waterman score: 1111; 65.7% identity (85.3% similar) in 251 aa overlap (4-252:7-257) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQR--FLE :.. .. :....: .: .: : :..:: .::....: . :: :::.: .. NP_001 MSWKKALRIPGGLRAATVTLMLSMLSTPVAEGRDSPEDFVYQFKGMCYFTNGTERVRLVS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 RYIYNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGP : ::::::.:::::::::::::: :: : :::::::::::.:::. ::.:::::.: NP_001 RSIYNREEIVRFDSDVGEFRAVTLLGLPAAEYWNSQKDILERKRAAVDRVCRHNYQLELR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 MTLQRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLI ::::::.: :..:::. :.::::::: ::::::..:.:::: : :::::::::: :: NP_001 TTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTPLI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 RNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVL ::::::::::::::::::.::::::.::: ::.::.::::.:::.::.:: :.: ::::: NP_001 RNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVL 190 200 210 220 230 240 240 250 pF1KB3 GLIICGVGIFMHRRSKKVQRGSA :::. :.:...:.::.: NP_001 GLIFLGLGLIIHHRSQKGLLH 250 260 >>NP_002115 (OMIM: 126200,142857,180300,181000) major hi (266 aa) initn: 1093 init1: 1005 opt: 1094 Z-score: 1265.3 bits: 241.8 E(85289): 9.7e-64 Smith-Waterman score: 1094; 62.8% identity (83.7% similar) in 258 aa overlap (1-256:1-258) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQR--FLERYI :. :.. .. .:::. :::: . .. . : .:.: ..::. ::::.: ::.::. NP_002 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 YNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTL ::.:: :::::::::::::::::::: :::::::::::. ::. : .::::: . .:. NP_002 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 QRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNG ::::::.:.: ::: :::::::::: :. ::::::.:::::::::: ::.:::.::.:: NP_002 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 DWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLI ::::: ::::: .:..:.:::::::: :. ::.::::.:.:.::.:: :.:.:::::::. NP_002 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 240 250 pF1KB3 ICGVGIFMHRRSKKVQRGSA . :.:.:.. :..: . : NP_002 FLGAGLFIYFRNQKGHSGLQPTGFLS 250 260 >>NP_001230890 (OMIM: 123400,126200,212750,604305) HLA c (269 aa) initn: 1076 init1: 976 opt: 1087 Z-score: 1257.2 bits: 240.3 E(85289): 2.8e-63 Smith-Waterman score: 1087; 64.4% identity (85.0% similar) in 247 aa overlap (13-256:15-261) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVV-QGRATPENYLFQGRQECYAFNGTQR--FLE :: ..:....:.:.. .:: .::...:: . :: :::.: .. NP_001 MSWKKALRIPGDLRVATVTLMLAMLSSLLAEGRDSPEDFVFQFKGMCYFTNGTERVRLVT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 RYIYNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGP ::::::::..::::::: .:::: :::: :::::::..:: :: : .::::::.. NP_001 RYIYNREEYARFDSDVGVYRAVTPQGRPDAEYWNSQKEVLEGTRAELDTVCRHNYEVAFR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 MTLQRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLI :::::.: :..:::. :.::::::: :::::::.:.:::: : :::::::::: :: NP_001 GILQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVSTPLI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 RNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVL ::::::::::::::::::.::::::.::: ::.::.::::.:::.::.:: :.:.::::: NP_001 RNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGVGGFVL 190 200 210 220 230 240 240 250 pF1KB3 GLIICGVGIFMHRRSKKVQRGSA :::. :.:.....::.: .: NP_001 GLIFLGLGLIIRQRSQKGPQGPPPAGLLH 250 260 >>NP_002114 (OMIM: 123400,126200,212750,604305) HLA clas (261 aa) initn: 1076 init1: 976 opt: 1083 Z-score: 1252.8 bits: 239.4 E(85289): 4.8e-63 Smith-Waterman score: 1083; 65.0% identity (85.6% similar) in 243 aa overlap (13-252:15-257) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVV-QGRATPENYLFQGRQECYAFNGTQR--FLE :: ..:....:.:.. .:: .::...:: . :: :::.: .. NP_002 MSWKKALRIPGDLRVATVTLMLAMLSSLLAEGRDSPEDFVFQFKGMCYFTNGTERVRLVT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 RYIYNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGP ::::::::..::::::: .:::: :::: :::::::..:: :: : .::::::.. NP_002 RYIYNREEYARFDSDVGVYRAVTPQGRPDAEYWNSQKEVLEGTRAELDTVCRHNYEVAFR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 MTLQRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLI :::::.: :..:::. :.::::::: :::::::.:.:::: : :::::::::: :: NP_002 GILQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVSTPLI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 RNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVL ::::::::::::::::::.::::::.::: ::.::.::::.:::.::.:: :.:.::::: NP_002 RNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGVGGFVL 190 200 210 220 230 240 240 250 pF1KB3 GLIICGVGIFMHRRSKKVQRGSA :::. :.:.....::.: NP_002 GLIFLGLGLIIRQRSQKGLLH 250 260 >>XP_011546040 (OMIM: 126200,142857,180300,181000) PREDI (266 aa) initn: 1060 init1: 967 opt: 1068 Z-score: 1235.4 bits: 236.2 E(85289): 4.5e-62 Smith-Waterman score: 1068; 61.2% identity (82.9% similar) in 258 aa overlap (1-256:1-258) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQR--FLERYI :. :.. .. .:::. :::: . .. . : .:.::. .:. ::::.: :::: . XP_011 MVCLKLPGGSCMAALTVTLMVLSSPLALAGDTQPRFLWQGKYKCHFFNGTERVQFLERLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 YNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTL ::.::::::::::::.::::::::: : :::::::::..:. : .::::: .: .:. XP_011 YNQEEFVRFDSDVGEYRAVTELGRPVAESWNSQKDILEDRRGQVDTVCRHNYGVGESFTV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 QRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNG ::::.:.:.: :.: :::::::::: :. ::::::.:::: ::::: ::::::.::.:: XP_011 QRRVHPEVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 DWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLI ::::: ::::: .:..:.:::::::: :. ::.::::.:.:.::.:: :.:.:::::::. XP_011 DWTFQTLVMLETVPRSGEVYTCQVEHPSVMSPLTVEWRARSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 240 250 pF1KB3 ICGVGIFMHRRSKKVQRGSA . :.:.:.. :..: . : XP_011 FLGAGLFIYFRNQKGHSGLQPTGFLS 250 260 >>NP_001287719 (OMIM: 615161) HLA class II histocompatib (264 aa) initn: 836 init1: 805 opt: 1057 Z-score: 1222.8 bits: 233.9 E(85289): 2.3e-61 Smith-Waterman score: 1057; 61.5% identity (84.0% similar) in 257 aa overlap (2-256:1-256) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRF--LERYI :.::. .. ..:.:..:..: : :...: :...: : . :: :::.: . ::: NP_001 MALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFTNGTERVRGVARYI 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 YNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTL :::::. :::::::::.::::::: :. ::. ::.::..::. :..:::::: :: NP_001 YNREEYGRFDSDVGEFQAVTELGRSIED-WNNYKDFLEQERAAVDKVCRHNYEAELRTTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 QRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNG ::.:.: :..:::. :.::::::: ::::::..:.:::: : ::::::::::.::::: NP_001 QRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTSLIRNG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 DWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLI :::::::::::.:::.::.::::::: ::.::.::::.:::.::.:: :.: :::::::: NP_001 DWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLI 180 190 200 210 220 230 240 250 pF1KB3 ICGVGIFMHRRSKKVQRGSA . :.:.....:..: :: NP_001 FLGLGLIIRHRGQKGPRGPPPAGLLH 240 250 260 >>XP_005249108 (OMIM: 615161) PREDICTED: HLA class II hi (275 aa) initn: 836 init1: 805 opt: 1057 Z-score: 1222.6 bits: 233.9 E(85289): 2.3e-61 Smith-Waterman score: 1057; 61.5% identity (84.0% similar) in 257 aa overlap (2-256:1-256) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRF--LERYI :.::. .. ..:.:..:..: : :...: :...: : . :: :::.: . ::: XP_005 MALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFTNGTERVRGVARYI 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 YNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTL :::::. :::::::::.::::::: :. ::. ::.::..::. :..:::::: :: XP_005 YNREEYGRFDSDVGEFQAVTELGRSIED-WNNYKDFLEQERAAVDKVCRHNYEAELRTTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 QRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNG ::.:.: :..:::. :.::::::: ::::::..:.:::: : ::::::::::.::::: XP_005 QRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTSLIRNG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 DWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLI :::::::::::.:::.::.::::::: ::.::.::::.:::.::.:: :.: :::::::: XP_005 DWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLI 180 190 200 210 220 230 240 250 pF1KB3 ICGVGIFMHRRSKKVQRGSA . :.:.....:..: :: XP_005 FLGLGLIIRHRGQKGPRGPPPAGNISAMIQSGERAQA 240 250 260 270 >>XP_011512862 (OMIM: 615161) PREDICTED: HLA class II hi (256 aa) initn: 1009 init1: 792 opt: 1047 Z-score: 1211.5 bits: 231.8 E(85289): 9.6e-61 Smith-Waterman score: 1047; 61.7% identity (84.6% similar) in 253 aa overlap (2-252:1-252) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRF--LERYI :.::. .. ..:.:..:..: : :...: :...: : . :: :::.: . ::: XP_011 MALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFTNGTERVRGVARYI 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 YNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTL :::::. :::::::::.::::::: :. ::. ::.::..::. :..:::::: :: XP_011 YNREEYGRFDSDVGEFQAVTELGRSIED-WNNYKDFLEQERAAVDKVCRHNYEAELRTTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 QRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNG ::.:.: :..:::. :.::::::: ::::::..:.:::: : ::::::::::.::::: XP_011 QRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTSLIRNG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 DWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLI :::::::::::.:::.::.::::::: ::.::.::::.:::.::.:: :.: :::::::: XP_011 DWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLI 180 190 200 210 220 230 240 250 pF1KB3 ICGVGIFMHRRSKKVQRGSA . :.:.....:..: XP_011 FLGLGLIIRHRGQKGLLH 240 250 >>NP_002116 (OMIM: 604776) major histocompatibility comp (266 aa) initn: 1058 init1: 963 opt: 1043 Z-score: 1206.7 bits: 230.9 E(85289): 1.8e-60 Smith-Waterman score: 1043; 59.7% identity (82.2% similar) in 258 aa overlap (1-256:1-258) 10 20 30 40 50 pF1KB3 MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQR--FLERYI :. :.. .. . ::. :::: . .. . : .: : . ::. ::::.: ::.: : NP_002 MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 YNREEFVRFDSDVGEFRAVTELGRPDEEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTL ::.:: .::::::::.:::::::::: ::::::::.::..::. : .::::: .: .:. NP_002 YNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 QRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNG ::::.:.:.: :.. ::::::::: :. ::::::.:::: :.::: ::::::.::.:: NP_002 QRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 DWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLI ::::: ::::: .:..:.:::::::: :. ::.::::.:::.::.:: :.:.:::::::. NP_002 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 240 250 pF1KB3 ICGVGIFMHRRSKKVQRGSA . :.:.:.. ...: . : NP_002 FLGAGLFIYFKNQKGHSGLHPTGLVS 250 260 258 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:02:45 2016 done: Sat Nov 5 05:02:45 2016 Total Scan time: 5.450 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]