FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3469, 191 aa 1>>>pF1KB3469 191 - 191 aa - 191 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7633+/-0.000345; mu= 6.2670+/- 0.021 mean_var=105.5843+/-21.136, 0's: 0 Z-trim(116.5): 63 B-trim: 187 in 1/49 Lambda= 0.124817 statistics sampled from 27642 (27709) to 27642 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.325), width: 16 Scan time: 5.900 The best scores are: opt bits E(85289) NP_001120794 (OMIM: 604478) chromobox protein homo ( 191) 1266 238.1 6.8e-63 NP_036249 (OMIM: 604478) chromobox protein homolog ( 191) 1266 238.1 6.8e-63 NP_001120793 (OMIM: 604478) chromobox protein homo ( 191) 1266 238.1 6.8e-63 NP_006798 (OMIM: 604511) chromobox protein homolog ( 185) 781 150.7 1.3e-36 NP_001120700 (OMIM: 604511) chromobox protein homo ( 185) 781 150.7 1.3e-36 NP_057671 (OMIM: 604477) chromobox protein homolog ( 183) 470 94.7 9.2e-20 XP_005249668 (OMIM: 604477) PREDICTED: chromobox p ( 183) 470 94.7 9.2e-20 NP_009207 (OMIM: 604477) chromobox protein homolog ( 183) 470 94.7 9.2e-20 NP_116036 (OMIM: 602770,613080) chromobox protein ( 211) 218 49.4 4.7e-06 NP_005180 (OMIM: 602770,613080) chromobox protein ( 532) 218 49.6 1e-05 XP_011523684 (OMIM: 602770,613080) PREDICTED: chro ( 586) 218 49.6 1.1e-05 XP_011513299 (OMIM: 603778) PREDICTED: chromodomai ( 522) 217 49.4 1.2e-05 NP_004815 (OMIM: 603778) chromodomain Y-like prote ( 544) 217 49.4 1.2e-05 XP_011528327 (OMIM: 608457) PREDICTED: chromobox p ( 165) 192 44.6 9.9e-05 XP_006724241 (OMIM: 608457) PREDICTED: chromobox p ( 166) 192 44.6 0.0001 NP_059990 (OMIM: 611626) M-phase phosphoprotein 8 ( 860) 203 47.0 0.0001 NP_003646 (OMIM: 603079) E3 SUMO-protein ligase CB ( 560) 200 46.3 0.0001 XP_011533426 (OMIM: 611626) PREDICTED: M-phase pho ( 879) 203 47.0 0.0001 XP_006724239 (OMIM: 608457) PREDICTED: chromobox p ( 200) 192 44.7 0.00012 XP_006724238 (OMIM: 608457) PREDICTED: chromobox p ( 258) 192 44.7 0.00014 XP_006724237 (OMIM: 608457) PREDICTED: chromobox p ( 259) 192 44.7 0.00014 NP_001180353 (OMIM: 606503) histone-lysine N-methy ( 410) 192 44.8 0.00021 XP_011529814 (OMIM: 400016,415000) PREDICTED: test ( 470) 188 44.1 0.00039 NP_733841 (OMIM: 400016,415000) testis-specific ch ( 540) 188 44.2 0.00044 NP_004671 (OMIM: 400016,415000) testis-specific ch ( 554) 188 44.2 0.00045 XP_005261470 (OMIM: 608457) PREDICTED: chromobox p ( 158) 179 42.3 0.00048 XP_016884168 (OMIM: 608457) PREDICTED: chromobox p ( 250) 182 42.9 0.00049 NP_783640 (OMIM: 608457) chromobox protein homolog ( 251) 182 42.9 0.00049 XP_006724240 (OMIM: 608457) PREDICTED: chromobox p ( 192) 179 42.3 0.00057 NP_004816 (OMIM: 400018,415000) testis-specific ch ( 541) 183 43.3 0.00083 NP_001180355 (OMIM: 606503) histone-lysine N-methy ( 230) 174 41.5 0.0012 >>NP_001120794 (OMIM: 604478) chromobox protein homolog (191 aa) initn: 1266 init1: 1266 opt: 1266 Z-score: 1250.2 bits: 238.1 E(85289): 6.8e-63 Smith-Waterman score: 1266; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED 130 140 150 160 170 180 190 pF1KB3 AENKEKETAKS ::::::::::: NP_001 AENKEKETAKS 190 >>NP_036249 (OMIM: 604478) chromobox protein homolog 5 [ (191 aa) initn: 1266 init1: 1266 opt: 1266 Z-score: 1250.2 bits: 238.1 E(85289): 6.8e-63 Smith-Waterman score: 1266; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED 130 140 150 160 170 180 190 pF1KB3 AENKEKETAKS ::::::::::: NP_036 AENKEKETAKS 190 >>NP_001120793 (OMIM: 604478) chromobox protein homolog (191 aa) initn: 1266 init1: 1266 opt: 1266 Z-score: 1250.2 bits: 238.1 E(85289): 6.8e-63 Smith-Waterman score: 1266; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED 130 140 150 160 170 180 190 pF1KB3 AENKEKETAKS ::::::::::: NP_001 AENKEKETAKS 190 >>NP_006798 (OMIM: 604511) chromobox protein homolog 1 [ (185 aa) initn: 808 init1: 414 opt: 781 Z-score: 778.4 bits: 150.7 E(85289): 1.3e-36 Smith-Waterman score: 781; 63.9% identity (82.7% similar) in 191 aa overlap (1-187:1-183) 10 20 30 40 50 pF1KB3 MGKK-TKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDC :::: .:. .. :.:::::::::::::::::.:::::::::::.: ::::::.:::: NP_006 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 PELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSAD---DIKSKKKREQSNDIARG :.::.::... : .: .:::..:::.. :.: : . : :::.:.: . :: NP_006 PDLIAEFLQSQKTAHE------TDKSEGGKRKAD-SDSEDKGEESKPKKKKEES-EKPRG 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 FERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHA : ::::::.::::::: :.::::::::..:::::: ::::::::::.::.:::::::::. NP_006 FARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHS 120 130 140 150 160 170 180 190 pF1KB3 YPEDAENKEKETAKS :: . ..:. . NP_006 YPSEDDDKKDDKN 180 >>NP_001120700 (OMIM: 604511) chromobox protein homolog (185 aa) initn: 808 init1: 414 opt: 781 Z-score: 778.4 bits: 150.7 E(85289): 1.3e-36 Smith-Waterman score: 781; 63.9% identity (82.7% similar) in 191 aa overlap (1-187:1-183) 10 20 30 40 50 pF1KB3 MGKK-TKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDC :::: .:. .. :.:::::::::::::::::.:::::::::::.: ::::::.:::: NP_001 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 PELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSAD---DIKSKKKREQSNDIARG :.::.::... : .: .:::..:::.. :.: : . : :::.:.: . :: NP_001 PDLIAEFLQSQKTAHE------TDKSEGGKRKAD-SDSEDKGEESKPKKKKEES-EKPRG 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 FERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHA : ::::::.::::::: :.::::::::..:::::: ::::::::::.::.:::::::::. NP_001 FARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHS 120 130 140 150 160 170 180 190 pF1KB3 YPEDAENKEKETAKS :: . ..:. . NP_001 YPSEDDDKKDDKN 180 >>NP_057671 (OMIM: 604477) chromobox protein homolog 3 [ (183 aa) initn: 449 init1: 449 opt: 470 Z-score: 475.8 bits: 94.7 E(85289): 9.2e-20 Smith-Waterman score: 746; 63.9% identity (80.0% similar) in 180 aa overlap (1-180:11-180) 10 20 30 40 50 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNT :::: . . . . ::.:::::::::::.:.:::.::::::.. :: NP_057 MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 WEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQS ::::.:::::::: :... : :: ....:::: .. .:: ::::::. . NP_057 WEPEENLDCPELIEAFLNSQKAGKE---------KDGTKRKSLSDSESDDSKSKKKRD-A 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 NDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEE : ::: :::.::.::::::: :.:::::::::.::::::::::::.:::::::::::: NP_057 ADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEE 120 130 140 150 160 170 180 190 pF1KB3 RLTWHAYPEDAENKEKETAKS :::::. ::: NP_057 RLTWHSCPEDEAQ 180 >>XP_005249668 (OMIM: 604477) PREDICTED: chromobox prote (183 aa) initn: 449 init1: 449 opt: 470 Z-score: 475.8 bits: 94.7 E(85289): 9.2e-20 Smith-Waterman score: 746; 63.9% identity (80.0% similar) in 180 aa overlap (1-180:11-180) 10 20 30 40 50 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNT :::: . . . . ::.:::::::::::.:.:::.::::::.. :: XP_005 MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 WEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQS ::::.:::::::: :... : :: ....:::: .. .:: ::::::. . XP_005 WEPEENLDCPELIEAFLNSQKAGKE---------KDGTKRKSLSDSESDDSKSKKKRD-A 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 NDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEE : ::: :::.::.::::::: :.:::::::::.::::::::::::.:::::::::::: XP_005 ADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEE 120 130 140 150 160 170 180 190 pF1KB3 RLTWHAYPEDAENKEKETAKS :::::. ::: XP_005 RLTWHSCPEDEAQ 180 >>NP_009207 (OMIM: 604477) chromobox protein homolog 3 [ (183 aa) initn: 449 init1: 449 opt: 470 Z-score: 475.8 bits: 94.7 E(85289): 9.2e-20 Smith-Waterman score: 746; 63.9% identity (80.0% similar) in 180 aa overlap (1-180:11-180) 10 20 30 40 50 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNT :::: . . . . ::.:::::::::::.:.:::.::::::.. :: NP_009 MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB3 WEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQS ::::.:::::::: :... : :: ....:::: .. .:: ::::::. . NP_009 WEPEENLDCPELIEAFLNSQKAGKE---------KDGTKRKSLSDSESDDSKSKKKRD-A 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 NDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEE : ::: :::.::.::::::: :.:::::::::.::::::::::::.:::::::::::: NP_009 ADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEE 120 130 140 150 160 170 180 190 pF1KB3 RLTWHAYPEDAENKEKETAKS :::::. ::: NP_009 RLTWHSCPEDEAQ 180 >>NP_116036 (OMIM: 602770,613080) chromobox protein homo (211 aa) initn: 201 init1: 201 opt: 218 Z-score: 229.6 bits: 49.4 E(85289): 4.7e-06 Smith-Waterman score: 218; 41.8% identity (75.9% similar) in 79 aa overlap (13-91:5-82) 10 20 30 40 50 60 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP :: :. ...: .:..:. ::..:::.::.:.: .::.::::.:. : NP_116 MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDP 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG .:. :.:: .. :: .: : .. .. :: NP_116 RLLLAFQKK-EHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKVGGCAGYADPTSQHP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED NP_116 LGVGGRQREGLGPSGRGWHFCQQSVPLLGKQEPPFFLSLSFCCQGPQPAESSSPPLPGAS 120 130 140 150 160 170 >>NP_005180 (OMIM: 602770,613080) chromobox protein homo (532 aa) initn: 221 init1: 202 opt: 218 Z-score: 223.5 bits: 49.6 E(85289): 1e-05 Smith-Waterman score: 218; 41.8% identity (75.9% similar) in 79 aa overlap (13-91:5-82) 10 20 30 40 50 60 pF1KB3 MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP :: :. ...: .:..:. ::..:::.::.:.: .::.::::.:. : NP_005 MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDP 10 20 30 40 50 70 80 90 100 110 120 pF1KB3 ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG .:. :.:: .. :: .: : .. .. :: NP_005 RLLLAFQKK-EHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSSS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB3 LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED NP_005 SSTSSSSSSDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPP 120 130 140 150 160 170 191 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:02:50 2016 done: Fri Nov 4 21:02:51 2016 Total Scan time: 5.900 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]