FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3473, 497 aa 1>>>pF1KB3473 497 - 497 aa - 497 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.0710+/-0.00106; mu= -10.8146+/- 0.064 mean_var=385.3125+/-76.786, 0's: 0 Z-trim(116.1): 33 B-trim: 0 in 0/54 Lambda= 0.065338 statistics sampled from 16690 (16712) to 16690 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.513), width: 16 Scan time: 4.010 The best scores are: opt bits E(32554) CCDS53978.1 MEF2A gene_id:4205|Hs108|chr15 ( 497) 3341 328.6 9.7e-90 CCDS81920.1 MEF2A gene_id:4205|Hs108|chr15 ( 505) 3315 326.2 5.4e-89 CCDS45362.1 MEF2A gene_id:4205|Hs108|chr15 ( 499) 3129 308.6 1e-83 CCDS58401.1 MEF2A gene_id:4205|Hs108|chr15 ( 429) 2790 276.6 3.7e-74 CCDS45363.1 MEF2A gene_id:4205|Hs108|chr15 ( 437) 2764 274.2 2.1e-73 CCDS60304.1 MEF2D gene_id:4209|Hs108|chr1 ( 514) 1506 155.6 1.2e-37 CCDS1143.1 MEF2D gene_id:4209|Hs108|chr1 ( 521) 1492 154.3 3e-37 CCDS54878.1 MEF2C gene_id:4208|Hs108|chr5 ( 483) 1286 134.9 2e-31 CCDS47245.1 MEF2C gene_id:4208|Hs108|chr5 ( 473) 1255 131.9 1.5e-30 CCDS78034.1 MEF2C gene_id:4208|Hs108|chr5 ( 465) 955 103.7 4.7e-22 CCDS47244.1 MEF2C gene_id:4208|Hs108|chr5 ( 463) 858 94.5 2.6e-19 CCDS46024.1 MEF2B gene_id:100271849|Hs108|chr19 ( 368) 658 75.6 1e-13 CCDS12394.1 MEF2B gene_id:4207|Hs108|chr19 ( 365) 640 73.9 3.4e-13 CCDS78030.1 MEF2C gene_id:4208|Hs108|chr5 ( 393) 593 69.5 7.7e-12 CCDS54877.1 MEF2C gene_id:4208|Hs108|chr5 ( 417) 587 68.9 1.2e-11 >>CCDS53978.1 MEF2A gene_id:4205|Hs108|chr15 (497 aa) initn: 3341 init1: 3341 opt: 3341 Z-score: 1724.6 bits: 328.6 E(32554): 9.7e-90 Smith-Waterman score: 3341; 100.0% identity (100.0% similar) in 497 aa overlap (1-497:1-497) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGAT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 GANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 GANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB3 ATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 ATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB3 HLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 HLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB3 PPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNTE 430 440 450 460 470 480 490 pF1KB3 DRESPSVKRMRMDAWVT ::::::::::::::::: CCDS53 DRESPSVKRMRMDAWVT 490 >>CCDS81920.1 MEF2A gene_id:4205|Hs108|chr15 (505 aa) initn: 2401 init1: 1908 opt: 3315 Z-score: 1711.2 bits: 326.2 E(32554): 5.4e-89 Smith-Waterman score: 3315; 98.4% identity (98.4% similar) in 505 aa overlap (1-497:1-505) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 DSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 PQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGAT 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 GANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPL--------NTQRIS :::::::::::::::::::::::::::::::::::::::::::::: :::::: CCDS81 GANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQRIS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 SSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 SSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 QVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 QQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIV 430 440 450 460 470 480 480 490 pF1KB3 LGRPPNTEDRESPSVKRMRMDAWVT ::::::::::::::::::::::::: CCDS81 LGRPPNTEDRESPSVKRMRMDAWVT 490 500 >>CCDS45362.1 MEF2A gene_id:4205|Hs108|chr15 (499 aa) initn: 3131 init1: 2480 opt: 3129 Z-score: 1616.5 bits: 308.6 E(32554): 1e-83 Smith-Waterman score: 3129; 93.8% identity (96.8% similar) in 499 aa overlap (1-497:1-499) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRFSKLNE ::::::::::::::::::::::::::.: :: ::.::: : . .: .:....:.:: CCDS45 DMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINE 70 80 90 100 110 120 130 140 150 160 170 pF1KB3 DSDFIFK--RGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSML . : ... . :::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSML 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB3 SPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB3 ATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB3 PLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQ 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB3 QHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB3 QQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPN 430 440 450 460 470 480 480 490 pF1KB3 TEDRESPSVKRMRMDAWVT ::::::::::::::::::: CCDS45 TEDRESPSVKRMRMDAWVT 490 >>CCDS58401.1 MEF2A gene_id:4205|Hs108|chr15 (429 aa) initn: 2790 init1: 2790 opt: 2790 Z-score: 1444.8 bits: 276.6 E(32554): 3.7e-74 Smith-Waterman score: 2790; 99.8% identity (100.0% similar) in 412 aa overlap (86-497:18-429) 60 70 80 90 100 110 pF1KB3 QYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRF .::::::::::::::::::::::::::::: CCDS58 MGRKKIQITRIMDERNRQTLRKKGLNGCESPDADDYFEHSPLSEDRF 10 20 30 40 120 130 140 150 160 170 pF1KB3 SKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDS 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB3 SMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPN 110 120 130 140 150 160 240 250 260 270 280 290 pF1KB3 LIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 LIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQ 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB3 ATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVS 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB3 AWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 AWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQ 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB3 QQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 QQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGR 350 360 370 380 390 400 480 490 pF1KB3 PPNTEDRESPSVKRMRMDAWVT :::::::::::::::::::::: CCDS58 PPNTEDRESPSVKRMRMDAWVT 410 420 >>CCDS45363.1 MEF2A gene_id:4205|Hs108|chr15 (437 aa) initn: 1759 init1: 1460 opt: 2764 Z-score: 1431.4 bits: 274.2 E(32554): 2.1e-73 Smith-Waterman score: 2764; 97.9% identity (98.1% similar) in 420 aa overlap (86-497:18-437) 60 70 80 90 100 110 pF1KB3 QYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDADDYFEHSPLSEDRF .::::::::::::::::::::::::::::: CCDS45 MGRKKIQITRIMDERNRQTLRKKGLNGCESPDADDYFEHSPLSEDRF 10 20 30 40 120 130 140 150 160 170 pF1KB3 SKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDS 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB3 SMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 SMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPN 110 120 130 140 150 160 240 250 260 270 280 pF1KB3 LIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPL--------N ::::::::::::::::::::::::::::::::::::::::::::::::::: : CCDS45 LIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELN 170 180 190 200 210 220 290 300 310 320 330 340 pF1KB3 TQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPG 230 240 250 260 270 280 350 360 370 380 390 400 pF1KB3 MLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPS 290 300 310 320 330 340 410 420 430 440 450 460 pF1KB3 GFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 GFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDF 350 360 370 380 390 400 470 480 490 pF1KB3 HSPIVLGRPPNTEDRESPSVKRMRMDAWVT :::::::::::::::::::::::::::::: CCDS45 HSPIVLGRPPNTEDRESPSVKRMRMDAWVT 410 420 430 >>CCDS60304.1 MEF2D gene_id:4209|Hs108|chr1 (514 aa) initn: 1292 init1: 791 opt: 1506 Z-score: 789.5 bits: 155.6 E(32554): 1.2e-37 Smith-Waterman score: 1684; 54.4% identity (73.0% similar) in 540 aa overlap (1-495:1-511) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST :::::::: :: ::::::::::::::::::::::::::::::::::::: :::::::::: CCDS60 MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESP--DADDYFEHSPLSEDRFSKL :::::::::::::::::::::.::.:::::::.:::.:: :..: .:.::: ::.. . CCDS60 DMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 NEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSML .:. : .:.: .: ::.: :::::.. ..:...::..:::.:::..:: ::: .: CCDS60 SEELDGLFRRYGSTVPAPNFAMPVTVPVSNQSSLQFSNPSGSLVTPSLVTSS-LTDPRLL 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 SPPQTTLHRN-VSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLI :: : .:.:: :::: :::: : ::.::. ::. ::: ::::::.:..::::.:. CCDS60 SPQQPALQRNSVSPGLPQRPAS---AGAMLGG-DLNSANGACPSPVGNGYVSARASPGLL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 GATGANSLGKVMPTKSPPPPGGGN-LGMNSRKPDLRVVIPPSSKGMMPPLNT-QRISSSQ ....:::.::.:.:::::: .. :: ::::::::. ..::.: ::. ::.. :: CCDS60 PVANGNSLNKVIPAKSPPPPTHSTQLGAPSRKPDLRVITSQAGKGLMHHLNNAQRLGVSQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 ATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVS .:. :.::::::.:::: ::: .:.:::::::::.::::.::.: .:.::: ::::.:. CCDS60 STHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLTSAELSSLPAFSSPGGLSLGNVT 300 310 320 330 340 350 360 370 pF1KB3 AWQQ--------------------------------------HHLGQAALSSLVAGGQLS :::: :: ..::.:. :. : CCDS60 AWQQPQQPQQPQQPQPPQQQPPQPQQPQPQQPQQPQQPPQQQSHLVPVSLSNLIPGSPLP 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB3 Q-GSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQP . :. :...:. .:::::::.:: :.: .:. :::: : .:.: CCDS60 HVGAALTVTTHPHISIKSEPVSPSRER-SPA--------------PPPPAVFPAA-RPEP 420 430 440 450 440 450 460 470 480 490 pF1KB3 RQEMGRSPVDSLSS-SSSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRMDAW : :.::: ...::. .::.: :::: . : :: . :. .:::::.:.: CCDS60 ----G----DGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRLDTW 460 470 480 490 500 510 pF1KB3 VT CCDS60 TLK >>CCDS1143.1 MEF2D gene_id:4209|Hs108|chr1 (521 aa) initn: 1894 init1: 620 opt: 1492 Z-score: 782.3 bits: 154.3 E(32554): 3e-37 Smith-Waterman score: 1670; 53.7% identity (72.0% similar) in 547 aa overlap (1-495:1-518) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST :::::::: :: ::::::::::::::::::::::::::::::::::::: :::::::::: CCDS11 MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESP--DADDYFEHSPLSEDRFSKL :::::::::::::::::::::.::.:::::::.:::.:: :..: .:.::: ::.. . CCDS11 DMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 NEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSML .:. : .:.: .: ::.: :::::.. ..:...::..:::.:::..:: ::: .: CCDS11 SEELDGLFRRYGSTVPAPNFAMPVTVPVSNQSSLQFSNPSGSLVTPSLVTSS-LTDPRLL 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 SPPQTTLHRN-VSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLI :: : .:.:: :::: :::: : ::.::. ::. ::: ::::::.:..::::.:. CCDS11 SPQQPALQRNSVSPGLPQRPAS---AGAMLGG-DLNSANGACPSPVGNGYVSARASPGLL 180 190 200 210 220 230 240 250 260 270 280 pF1KB3 GATGANSLGKVMPTKSPPPPGGGN-LGMNSRKPDLRVVIPPSSKGMMPPL--------NT ....:::.::.:.:::::: .. :: ::::::::. ..::.: : :. CCDS11 PVANGNSLNKVIPAKSPPPPTHSTQLGAPSRKPDLRVITSQAGKGLMHHLTEDHLDLNNA 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB3 QRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGM ::.. ::.:. :.::::::.:::: ::: .:.:::::::::.::::.::.: .:.::: CCDS11 QRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLTSAELSSLPAFSSPGG 300 310 320 330 340 350 350 360 370 pF1KB3 LSLGQVSAWQQ--------------------------------------HHLGQAALSSL ::::.:.:::: :: ..::.: CCDS11 LSLGNVTAWQQPQQPQQPQQPQPPQQQPPQPQQPQPQQPQQPQQPPQQQSHLVPVSLSNL 360 370 380 390 400 410 380 390 400 410 420 pF1KB3 VAGGQLSQ-GSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQP . :. : . :. :...:. .:::::::.:: :.: .:. :::: : CCDS11 IPGSPLPHVGAALTVTTHPHISIKSEPVSPSRER-SPA--------------PPPPAVFP 420 430 440 450 460 430 440 450 460 470 480 pF1KB3 QPPQPQPRQEMGRSPVDSLSS-SSSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVK .:.: : :.::: ...::. .::.: :::: . : :: . :. .:: CCDS11 AA-RPEP----G----DGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVK 470 480 490 500 510 490 pF1KB3 RMRMDAWVT :::.:.: CCDS11 RMRLDTWTLK 520 >>CCDS54878.1 MEF2C gene_id:4208|Hs108|chr5 (483 aa) initn: 1668 init1: 652 opt: 1286 Z-score: 677.8 bits: 134.9 E(32554): 2e-31 Smith-Waterman score: 1740; 58.1% identity (75.7% similar) in 527 aa overlap (1-497:1-483) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS54 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 10 20 30 40 50 60 70 80 90 100 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPD--ADDY-------------- ::::::::::::::::::::::::::::::::::::.::: ::: CCDS54 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGCESPD 70 80 90 100 110 120 110 120 130 140 150 pF1KB3 ----FEHSPLSEDRFSKLNEDSDFIFKRGP-PGLPPQNFSMSVTVPVTSPNALSYTNPGS . .: .:....:.::. : ..: :..:: :: : :..::.: :.: :.:: : CCDS54 PDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHNSLVYSNPVS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB3 SLVSPSLAASSTLTDSSMLSPPQTTLHRN-VSPGAPQRPPSTGNAGGMLSTTDLTVPNGA :: .:.: :. : .:.:: .:::. .::::.::.::... ::: .:: CCDS54 SLGNPNLLP---------LAHP--SLQRNSMSPGVTHRPPSAGNTGGLMGG-DLT--SGA 190 200 210 220 220 230 240 250 260 270 pF1KB3 GSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPS :.: .:::. : : ::.:. . : .:.: : .::::: :::::.:::::::.:::. CCDS54 GTS-AGNGYGNPRNSPGLLVSPG--NLNKNMQAKSPPP---MNLGMNNRKPDLRVLIPPG 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB3 SKGMMPPLNTQRISSSQATQPLATPVVSVTTPSLPPQGL--VYSAMPTAYNTDYSLTSAD ::. :: .: :::..::..: ::::::::.::.:: ::. ::. :.:.:.:::.::: CCDS54 SKNTMPSVN-QRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSAD 290 300 310 320 330 340 350 360 370 380 390 pF1KB3 LSALQGFNSPGMLSLGQVSAWQQHHLGQ---AALSSLVA--GGQLSQGSNLSINTNQNIS ::.:.:::. . : ::.:..:::.:: . .:::.: : . .:::.::::. ..:... CCDS54 LSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLN 340 350 360 370 380 390 400 410 420 430 440 450 pF1KB3 IKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSS :::::.:::::: : :. :: . :.: :::::::::: CCDS54 IKSEPVSPPRDRTTT------------------PSRYPQ----HTRHEAGRSPVDSLSSC 400 410 420 430 460 470 480 490 pF1KB3 SSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRM-DAWVT ::::::::::: :..::::: : :: . ..::::::::::. ..:.: CCDS54 SSSYDGSDREDHRNEFHSPIGLTRP-SPDERESPSVKRMRLSEGWAT 440 450 460 470 480 >>CCDS47245.1 MEF2C gene_id:4208|Hs108|chr5 (473 aa) initn: 1417 init1: 652 opt: 1255 Z-score: 662.2 bits: 131.9 E(32554): 1.5e-30 Smith-Waterman score: 1782; 59.9% identity (77.5% similar) in 516 aa overlap (1-497:1-473) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS47 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPD--ADDYFEHSPLSEDRFSKL ::::::::::::::::::::::::::::::::::::.::: ::: ::: :::.. :. CCDS47 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 NEDSDFIFKRGPP-GLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSM ::: :....: ..:: :: : :..::.: :.: :.:: ::: .:.: CCDS47 NEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLP--------- 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 LSPPQTTLHRN-VSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNL :. : .:.:: .:::. .::::.::.::... ::: .:::.: .:::. : : ::.: CCDS47 LAHP--SLQRNSMSPGVTHRPPSAGNTGGLMGG-DLT--SGAGTS-AGNGYGNPRNSPGL 180 190 200 210 220 240 250 260 270 280 pF1KB3 IGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLN-------TQ . . : .:.: : .::::: :::::.:::::::.:::.::. :: .. .: CCDS47 LVSPG--NLNKNMQAKSPPP---MNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQ 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB3 RISSSQATQPLATPVVSVTTPSLPPQGL--VYSAMPTAYNTDYSLTSADLSALQGFNSPG ::..::..: ::::::::.::.:: ::. ::. :.:.:.:::.:::::.:.:::. . CCDS47 RINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTAS 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB3 MLSLGQVSAWQQHHLGQ---AALSSLVA--GGQLSQGSNLSINTNQNISIKSEPISPPRD : ::.:..:::.:: . .:::.: : . .:::.::::. ..:...:::::.::::: CCDS47 ALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRD 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB3 RMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDRED : : :. :: . :.: :::::::::: ::::::::::: CCDS47 RTTT------------------PSRYPQ----HTRHEAGRSPVDSLSSCSSSYDGSDRED 410 420 430 470 480 490 pF1KB3 PRGDFHSPIVLGRPPNTEDRESPSVKRMRM-DAWVT :..::::: : :: . ..::::::::::. ..:.: CCDS47 HRNEFHSPIGLTRP-SPDERESPSVKRMRLSEGWAT 440 450 460 470 >>CCDS78034.1 MEF2C gene_id:4208|Hs108|chr5 (465 aa) initn: 1668 init1: 652 opt: 955 Z-score: 509.5 bits: 103.7 E(32554): 4.7e-22 Smith-Waterman score: 1800; 60.9% identity (78.4% similar) in 509 aa overlap (1-497:1-465) 10 20 30 40 50 60 pF1KB3 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS78 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYAST 10 20 30 40 50 60 70 80 90 100 110 pF1KB3 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPD--ADDYFEHSPLSEDRFSKL ::::::::::::::::::::::::::::::::::::.::: ::: ::: :::.. :. CCDS78 DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB3 NEDSDFIFKRGPP-GLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSM ::: :....: ..:: :: : :..::.: :.: :.:: ::: .:.: CCDS78 NEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLP--------- 130 140 150 160 170 180 190 200 210 220 230 pF1KB3 LSPPQTTLHRN-VSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNL :. : .:.:: .:::. .::::.::.::... ::: .:::.: .:::. : : ::.: CCDS78 LAHP--SLQRNSMSPGVTHRPPSAGNTGGLMGG-DLT--SGAGTS-AGNGYGNPRNSPGL 180 190 200 210 220 240 250 260 270 280 290 pF1KB3 IGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQA . . : .:.: : .::::: :::::.:::::::.:::.::. :: .: :::..::. CCDS78 LVSPG--NLNKNMQAKSPPP---MNLGMNNRKPDLRVLIPPGSKNTMPSVN-QRINNSQS 230 240 250 260 270 300 310 320 330 340 350 pF1KB3 TQPLATPVVSVTTPSLPPQGL--VYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQV .: ::::::::.::.:: ::. ::. :.:.:.:::.:::::.:.:::. . : ::.: CCDS78 AQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSV 280 290 300 310 320 330 360 370 380 390 400 pF1KB3 SAWQQHHLGQ---AALSSLVA--GGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGF ..:::.:: . .:::.: : . .:::.::::. ..:...:::::.:::::: : CCDS78 TGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTT--- 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB3 QQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHS :. :: . :.: :::::::::: ::::::::::: :..::: CCDS78 ---------------PSRYPQ----HTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHS 400 410 420 430 470 480 490 pF1KB3 PIVLGRPPNTEDRESPSVKRMRM-DAWVT :: : :: . ..::::::::::. ..:.: CCDS78 PIGLTRP-SPDERESPSVKRMRLSEGWAT 440 450 460 497 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:21:22 2016 done: Thu Nov 3 13:21:23 2016 Total Scan time: 4.010 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]