FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3474, 197 aa 1>>>pF1KB3474 197 - 197 aa - 197 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5221+/-0.000333; mu= 8.4057+/- 0.021 mean_var=104.9992+/-20.439, 0's: 0 Z-trim(118.0): 10 B-trim: 48 in 1/52 Lambda= 0.125165 statistics sampled from 30530 (30540) to 30530 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.358), width: 16 Scan time: 6.360 The best scores are: opt bits E(85289) XP_016881269 (OMIM: 159430) PREDICTED: Golli-MBP i ( 197) 1303 245.1 5.4e-65 NP_001020271 (OMIM: 159430) Golli-MBP isoform 2 [H ( 197) 1303 245.1 5.4e-65 NP_001020272 (OMIM: 159430) Golli-MBP isoform 1 [H ( 304) 1277 240.5 2e-63 XP_011524311 (OMIM: 159430) PREDICTED: Golli-MBP i ( 384) 1277 240.6 2.4e-63 XP_016881267 (OMIM: 159430) PREDICTED: Golli-MBP i ( 225) 1020 194.0 1.5e-49 NP_002376 (OMIM: 159430) myelin basic protein isof ( 186) 414 84.6 1.1e-16 NP_001020252 (OMIM: 159430) myelin basic protein i ( 197) 414 84.6 1.1e-16 NP_001020263 (OMIM: 159430) myelin basic protein i ( 160) 410 83.8 1.6e-16 NP_001020261 (OMIM: 159430) myelin basic protein i ( 171) 410 83.8 1.7e-16 >>XP_016881269 (OMIM: 159430) PREDICTED: Golli-MBP isofo (197 aa) initn: 1303 init1: 1303 opt: 1303 Z-score: 1287.8 bits: 245.1 E(85289): 5.4e-65 Smith-Waterman score: 1303; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KB3 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG 130 140 150 160 170 180 190 pF1KB3 GDRGAPKRGSGKVSSEE ::::::::::::::::: XP_016 GDRGAPKRGSGKVSSEE 190 >>NP_001020271 (OMIM: 159430) Golli-MBP isoform 2 [Homo (197 aa) initn: 1303 init1: 1303 opt: 1303 Z-score: 1287.8 bits: 245.1 E(85289): 5.4e-65 Smith-Waterman score: 1303; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KB3 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG 130 140 150 160 170 180 190 pF1KB3 GDRGAPKRGSGKVSSEE ::::::::::::::::: NP_001 GDRGAPKRGSGKVSSEE 190 >>NP_001020272 (OMIM: 159430) Golli-MBP isoform 1 [Homo (304 aa) initn: 1319 init1: 1277 opt: 1277 Z-score: 1259.6 bits: 240.5 E(85289): 2e-63 Smith-Waterman score: 1277; 99.5% identity (99.5% similar) in 194 aa overlap (1-194:1-194) 10 20 30 40 50 60 pF1KB3 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG 130 140 150 160 170 180 190 pF1KB3 GDRGAPKRGSGKVSSEE :::::::::::: : NP_001 GDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKG 190 200 210 220 230 240 >>XP_011524311 (OMIM: 159430) PREDICTED: Golli-MBP isofo (384 aa) initn: 1302 init1: 1277 opt: 1277 Z-score: 1258.2 bits: 240.6 E(85289): 2.4e-63 Smith-Waterman score: 1277; 99.5% identity (99.5% similar) in 194 aa overlap (1-194:1-194) 10 20 30 40 50 60 pF1KB3 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG 130 140 150 160 170 180 190 pF1KB3 GDRGAPKRGSGKVSSEE :::::::::::: : XP_011 GDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKG 190 200 210 220 230 240 >>XP_016881267 (OMIM: 159430) PREDICTED: Golli-MBP isofo (225 aa) initn: 1020 init1: 1020 opt: 1020 Z-score: 1010.8 bits: 194.0 E(85289): 1.5e-49 Smith-Waterman score: 1020; 99.3% identity (100.0% similar) in 152 aa overlap (46-197:74-225) 20 30 40 50 60 70 pF1KB3 STNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKN .::::::::::::::::::::::::::::: XP_016 AICLEWPLKSQSIQDGKPRRQTRIKCREGQYGEADANQNNGTSSQDTAVTDSKRTADPKN 50 60 70 80 90 100 80 90 100 110 120 130 pF1KB3 AWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMA 110 120 130 140 150 160 140 150 160 170 180 190 pF1KB3 SQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKVSS 170 180 190 200 210 220 pF1KB3 EE :: XP_016 EE >>NP_002376 (OMIM: 159430) myelin basic protein isoform (186 aa) initn: 414 init1: 414 opt: 414 Z-score: 420.6 bits: 84.6 E(85289): 1.1e-16 Smith-Waterman score: 414; 100.0% identity (100.0% similar) in 60 aa overlap (134-193:1-60) 110 120 130 140 150 160 pF1KB3 DNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFL :::::::::::::::::::::::::::::: NP_002 MASQKRPSQRHGSKYLATASTMDHARHGFL 10 20 30 170 180 190 pF1KB3 PRHRDTGILDSIGRFFGGDRGAPKRGSGKVSSEE :::::::::::::::::::::::::::::: NP_002 PRHRDTGILDSIGRFFGGDRGAPKRGSGKVPWLKPGRSPLPSHARSQPGLCNMYKDSHHP 40 50 60 70 80 90 >>NP_001020252 (OMIM: 159430) myelin basic protein isofo (197 aa) initn: 414 init1: 414 opt: 414 Z-score: 420.2 bits: 84.6 E(85289): 1.1e-16 Smith-Waterman score: 414; 100.0% identity (100.0% similar) in 60 aa overlap (134-193:1-60) 110 120 130 140 150 160 pF1KB3 DNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFL :::::::::::::::::::::::::::::: NP_001 MASQKRPSQRHGSKYLATASTMDHARHGFL 10 20 30 170 180 190 pF1KB3 PRHRDTGILDSIGRFFGGDRGAPKRGSGKVSSEE :::::::::::::::::::::::::::::: NP_001 PRHRDTGILDSIGRFFGGDRGAPKRGSGKVPWLKPGRSPLPSHARSQPGLCNMYKDSHHP 40 50 60 70 80 90 >>NP_001020263 (OMIM: 159430) myelin basic protein isofo (160 aa) initn: 426 init1: 410 opt: 410 Z-score: 417.6 bits: 83.8 E(85289): 1.6e-16 Smith-Waterman score: 410; 98.4% identity (98.4% similar) in 61 aa overlap (134-194:1-61) 110 120 130 140 150 160 pF1KB3 DNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFL :::::::::::::::::::::::::::::: NP_001 MASQKRPSQRHGSKYLATASTMDHARHGFL 10 20 30 170 180 190 pF1KB3 PRHRDTGILDSIGRFFGGDRGAPKRGSGKVSSEE ::::::::::::::::::::::::::::: : NP_001 PRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHF 40 50 60 70 80 90 NP_001 FKNIVTPRTPPPSQGKGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRD 100 110 120 130 140 150 >>NP_001020261 (OMIM: 159430) myelin basic protein isofo (171 aa) initn: 426 init1: 410 opt: 410 Z-score: 417.2 bits: 83.8 E(85289): 1.7e-16 Smith-Waterman score: 410; 98.4% identity (98.4% similar) in 61 aa overlap (134-194:1-61) 110 120 130 140 150 160 pF1KB3 DNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFL :::::::::::::::::::::::::::::: NP_001 MASQKRPSQRHGSKYLATASTMDHARHGFL 10 20 30 170 180 190 pF1KB3 PRHRDTGILDSIGRFFGGDRGAPKRGSGKVSSEE ::::::::::::::::::::::::::::: : NP_001 PRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHF 40 50 60 70 80 90 NP_001 FKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGT 100 110 120 130 140 150 197 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:30:24 2016 done: Fri Nov 4 02:30:25 2016 Total Scan time: 6.360 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]