Result of FASTA (omim) for pF1KB3482
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3482, 733 aa
  1>>>pF1KB3482 733 - 733 aa - 733 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.7753+/-0.000399; mu= 0.3329+/- 0.025
 mean_var=199.3515+/-39.984, 0's: 0 Z-trim(118.8): 21  B-trim: 17 in 1/55
 Lambda= 0.090837
 statistics sampled from 32005 (32026) to 32005 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.693), E-opt: 0.2 (0.375), width:  16
 Scan time:  9.470

The best scores are:                                      opt bits E(85289)
NP_005522 (OMIM: 147586) gamma-interferon-inducibl ( 729) 4720 631.3  4e-180
XP_016856639 (OMIM: 147586) PREDICTED: gamma-inter ( 520) 3254 439.2  2e-122
XP_005245184 (OMIM: 147586) PREDICTED: gamma-inter ( 789) 3254 439.2 2.9e-122
XP_016856638 (OMIM: 147586) PREDICTED: gamma-inter ( 677) 2868 388.6 4.3e-107
XP_006711353 (OMIM: 147586) PREDICTED: gamma-inter ( 677) 2868 388.6 4.3e-107
NP_001193496 (OMIM: 147586) gamma-interferon-induc ( 729) 2777 376.7 1.8e-103
NP_945146 (OMIM: 612677) pyrin and HIN domain-cont ( 483) 1981 272.3 3.2e-72
NP_945148 (OMIM: 612677) pyrin and HIN domain-cont ( 452) 1966 270.4 1.2e-71
NP_689714 (OMIM: 612677) pyrin and HIN domain-cont ( 492) 1530 213.2   2e-54
XP_011507544 (OMIM: 612677) PREDICTED: pyrin and H ( 492) 1530 213.2   2e-54
NP_945147 (OMIM: 612677) pyrin and HIN domain-cont ( 461) 1515 211.3 7.3e-54
XP_011507545 (OMIM: 612677) PREDICTED: pyrin and H ( 457) 1510 210.6 1.1e-53
XP_016855952 (OMIM: 612677) PREDICTED: pyrin and H ( 462) 1510 210.6 1.2e-53
NP_002423 (OMIM: 159553) myeloid cell nuclear diff ( 407) 1285 181.1 7.8e-45
XP_005244987 (OMIM: 612677) PREDICTED: pyrin and H ( 245)  537 83.0 1.6e-15
XP_016858337 (OMIM: 604578) PREDICTED: interferon- ( 343)  529 82.0 4.5e-15
NP_004824 (OMIM: 604578) interferon-inducible prot ( 343)  529 82.0 4.5e-15
XP_005245673 (OMIM: 604578) PREDICTED: interferon- ( 238)  516 80.2 1.1e-14


>>NP_005522 (OMIM: 147586) gamma-interferon-inducible pr  (729 aa)
 initn: 4720 init1: 4720 opt: 4720  Z-score: 3354.7  bits: 631.3 E(85289): 4e-180
Smith-Waterman score: 4720; 99.7% identity (99.7% similar) in 729 aa overlap (5-733:1-729)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005     MGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
                   10        20        30        40        50      

               70        80        90       100       110       120
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
         60        70        80        90       100       110      

              130       140       150       160       170       180
pF1KB3 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
        120       130       140       150       160       170      

              190       200       210       220       230       240
pF1KB3 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
        180       190       200       210       220       230      

              250       260       270       280       290       300
pF1KB3 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
        240       250       260       270       280       290      

              310       320       330       340       350       360
pF1KB3 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
        300       310       320       330       340       350      

              370       380       390       400       410       420
pF1KB3 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPSE
       :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: :::
NP_005 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSE
        360       370       380       390       400       410      

              430       440       450       460       470       480
pF1KB3 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
        420       430       440       450       460       470      

              490       500       510       520       530       540
pF1KB3 PAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
        480       490       500       510       520       530      

              550       560       570       580       590       600
pF1KB3 PKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVAD
        540       550       560       570       580       590      

              610       620       630       640       650       660
pF1KB3 VNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTG
        600       610       620       630       640       650      

              670       680       690       700       710       720
pF1KB3 KMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILN
        660       670       680       690       700       710      

              730   
pF1KB3 PDSSMETSPDFFF
       :::::::::::::
NP_005 PDSSMETSPDFFF
        720         

>>XP_016856639 (OMIM: 147586) PREDICTED: gamma-interfero  (520 aa)
 initn: 3254 init1: 3254 opt: 3254  Z-score: 2318.8  bits: 439.2 E(85289): 2e-122
Smith-Waterman score: 3254; 99.6% identity (99.6% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPSE
       :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: :::
XP_016 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 PAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
       :::::::::::::::::::::::                                     
XP_016 PAESHPHTPQMPPSTPSSSFLTTESFCCSESSGSKADSST                    
              490       500       510       520                    

>>XP_005245184 (OMIM: 147586) PREDICTED: gamma-interfero  (789 aa)
 initn: 3254 init1: 3254 opt: 3254  Z-score: 2315.9  bits: 439.2 E(85289): 2.9e-122
Smith-Waterman score: 4460; 92.4% identity (92.4% similar) in 765 aa overlap (1-709:1-765)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPSE
       :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: :::
XP_005 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
              430       440       450       460       470       480

              490       500                                        
pF1KB3 PAESHPHTPQMPPSTPSSSFLTT-------------------------------------
       :::::::::::::::::::::::                                     
XP_005 PAESHPHTPQMPPSTPSSSFLTTKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIGPAES
              490       500       510       520       530       540

                              510       520       530       540    
pF1KB3 -------------------LKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQ
                          :::::::::::::::::::::::::::::::::::::::::
XP_005 HPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQ
              550       560       570       580       590       600

          550       560       570       580       590       600    
pF1KB3 KKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNAD
              610       620       630       640       650       660

          610       620       630       640       650       660    
pF1KB3 RNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEV
              670       680       690       700       710       720

          670       680       690       700       710       720    
pF1KB3 VVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSS
       :::::::::::::::::::::::::::::::::::::::::::::               
XP_005 VVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSS
              730       740       750       760       770       780

          730   
pF1KB3 METSPDFFF
                
XP_005 METSPDFFF
                

>>XP_016856638 (OMIM: 147586) PREDICTED: gamma-interfero  (677 aa)
 initn: 2868 init1: 2868 opt: 2868  Z-score: 2043.6  bits: 388.6 E(85289): 4.3e-107
Smith-Waterman score: 4235; 92.1% identity (92.1% similar) in 733 aa overlap (1-733:1-677)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPSE
       :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: :::
XP_016 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
       :::::::::::::::::::::::::::                                 
XP_016 ASTTFPESHLRTPQMPPTTPSSSFFTK---------------------------------
              430       440                                        

              490       500       510       520       530       540
pF1KB3 PAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
                              :::::::::::::::::::::::::::::::::::::
XP_016 -----------------------LKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
                              450       460       470       480    

              550       560       570       580       590       600
pF1KB3 PKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVAD
          490       500       510       520       530       540    

              610       620       630       640       650       660
pF1KB3 VNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTG
          550       560       570       580       590       600    

              670       680       690       700       710       720
pF1KB3 KMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILN
          610       620       630       640       650       660    

              730   
pF1KB3 PDSSMETSPDFFF
       :::::::::::::
XP_016 PDSSMETSPDFFF
          670       

>>XP_006711353 (OMIM: 147586) PREDICTED: gamma-interfero  (677 aa)
 initn: 2868 init1: 2868 opt: 2868  Z-score: 2043.6  bits: 388.6 E(85289): 4.3e-107
Smith-Waterman score: 4235; 92.1% identity (92.1% similar) in 733 aa overlap (1-733:1-677)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPSE
       :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: :::
XP_006 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
       :::::::::::::::::::::::::::                                 
XP_006 ASTTFPESHLRTPQMPPTTPSSSFFTK---------------------------------
              430       440                                        

              490       500       510       520       530       540
pF1KB3 PAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
                              :::::::::::::::::::::::::::::::::::::
XP_006 -----------------------LKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYE
                              450       460       470       480    

              550       560       570       580       590       600
pF1KB3 PKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVAD
          490       500       510       520       530       540    

              610       620       630       640       650       660
pF1KB3 VNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTG
          550       560       570       580       590       600    

              670       680       690       700       710       720
pF1KB3 KMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILN
          610       620       630       640       650       660    

              730   
pF1KB3 PDSSMETSPDFFF
       :::::::::::::
XP_006 PDSSMETSPDFFF
          670       

>>NP_001193496 (OMIM: 147586) gamma-interferon-inducible  (729 aa)
 initn: 2598 init1: 2598 opt: 2777  Z-score: 1978.6  bits: 376.7 E(85289): 1.8e-103
Smith-Waterman score: 4115; 85.5% identity (85.5% similar) in 785 aa overlap (5-733:1-729)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001     MGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
                   10        20        30        40        50      

               70        80        90       100       110       120
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVK
         60        70        80        90       100       110      

              130       140       150       160       170       180
pF1KB3 TEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAP
       :::::::::::                                                 
NP_001 TEGAEATPGAQ-------------------------------------------------
        120                                                        

              190       200       210       220       230       240
pF1KB3 PNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
              :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------NPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQ
              130       140       150       160       170       180

              250       260       270       280       290       300
pF1KB3 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIIN
              190       200       210       220       230       240

              310       320       330       340       350       360
pF1KB3 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPC
              250       260       270       280       290       300

              370       380       390       400       410       420
pF1KB3 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPSE
       :::::::::::::::::::::::::::::::::::::::::::::::::::: ::: :::
NP_001 EEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSE
              310       320       330       340       350       360

              430       440       450       460       470       480
pF1KB3 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIG
              370       380       390       400       410       420

              490       500                                        
pF1KB3 PAESHPHTPQMPPSTPSSSFLTT-------------------------------------
       :::::::::::::::::::::::                                     
NP_001 PAESHPHTPQMPPSTPSSSFLTTKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIGPAES
              430       440       450       460       470       480

                              510       520       530       540    
pF1KB3 -------------------LKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQ
                          :::::::::::::::::::::::::::::::::::::::::
NP_001 HPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQ
              490       500       510       520       530       540

          550       560       570       580       590       600    
pF1KB3 KKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNAD
              550       560       570       580       590       600

          610       620       630       640       650       660    
pF1KB3 RNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEV
              610       620       630       640       650       660

          670       680       690       700       710       720    
pF1KB3 VVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSS
              670       680       690       700       710       720

          730   
pF1KB3 METSPDFFF
       :::::::::
NP_001 METSPDFFF
                

>>NP_945146 (OMIM: 612677) pyrin and HIN domain-containi  (483 aa)
 initn: 1495 init1: 1495 opt: 1981  Z-score: 1417.7  bits: 272.3 E(85289): 3.2e-72
Smith-Waterman score: 1981; 65.2% identity (83.7% similar) in 486 aa overlap (5-489:1-483)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
           :...::.::::::::::::::::.:::::::::::: ::.::::::::::::::::
NP_945     MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKF
                   10        20        30        40        50      

               70        80        90       100        110         
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRK-KEVDATSPAPSTSSTV
        :::::::::..:..:::: :::::::.:::::::   :.: : :::  ..:: . :. .
NP_945 PGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVKGIIPSKKTKQKEVYPATPACTPSNRL
         60        70        80        90       100       110      

     120       130       140       150       160       170         
pF1KB3 KTEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSA
        ..::: : : ::::: ..:..: : ::.:.:::.:   :::. :::::::: :.:: ::
NP_945 TAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSA
        120       130       140       150       160       170      

     180       190       200       210       220       230         
pF1KB3 PPNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVAT
       :::.::::. : .:. ..:  .:.... :.:. ::..:: :.::. : :.. ::::::::
NP_945 PPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVAT
        180       190       200       210       220       230      

     240       250       260       270       280       290         
pF1KB3 QTQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKII
       ::::::::::: .::.::  :.:::::.: . .::::::: :.::::::.::::::. ::
NP_945 QTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDII
        240       250       260       270       280       290      

     300       310       320       330       340       350         
pF1KB3 NRAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIP
        :::.  ::.:::::.:: ::::.:::: : ::.:::::::::  :.: ::: :.:::::
NP_945 RRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIP
        300       310       320       330       340       350      

     360       370       380       390       400       410         
pF1KB3 CEEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPS
       ::.::::.::::::::...::::.:::::::::.:.:: :..: .:: ::::::: :.::
NP_945 CEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPS
        360       370       380       390       400       410      

     420       430       440       450       460       470         
pF1KB3 EASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSI
       :::::.:::::.:::::::::::: ::::.:   . ...   ..:    :   .: ..: 
NP_945 EASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRIT---SPTVAPPLSSD
        420       430       440       450       460          470   

     480       490       500       510       520       530         
pF1KB3 GPAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVY
         .. :: .:                                                  
NP_945 TSTNRHPAVP                                                  
           480                                                     

>>NP_945148 (OMIM: 612677) pyrin and HIN domain-containi  (452 aa)
 initn: 1987 init1: 1484 opt: 1966  Z-score: 1407.5  bits: 270.4 E(85289): 1.2e-71
Smith-Waterman score: 1966; 69.0% identity (86.6% similar) in 448 aa overlap (5-451:1-448)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
           :...::.::::::::::::::::.:::::::::::: ::.::::::::::::::::
NP_945     MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKF
                   10        20        30        40        50      

               70        80        90       100        110         
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRK-KEVDATSPAPSTSSTV
        :::::::::..:..:::: :::::::.:::::::   :.: : :::  ..:: . :. .
NP_945 PGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVKGIIPSKKTKQKEVYPATPACTPSNRL
         60        70        80        90       100       110      

     120       130       140       150       160       170         
pF1KB3 KTEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSA
        ..::: : : ::::: ..:..: : ::.:.:::.:   :::. :::::::: :.:: ::
NP_945 TAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSA
        120       130       140       150       160       170      

     180       190       200       210       220       230         
pF1KB3 PPNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVAT
       :::.::::. : .:. ..:  .:.... :.:. ::..:: :.::. : :.. ::::::::
NP_945 PPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVAT
        180       190       200       210       220       230      

     240       250       260       270       280       290         
pF1KB3 QTQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKII
       ::::::::::: .::.::  :.:::::.: . .::::::: :.::::::.::::::. ::
NP_945 QTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDII
        240       250       260       270       280       290      

     300       310       320       330       340       350         
pF1KB3 NRAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIP
        :::.  ::.:::::.:: ::::.:::: : ::.:::::::::  :.: ::: :.:::::
NP_945 RRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIP
        300       310       320       330       340       350      

     360       370       380       390       400       410         
pF1KB3 CEEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQSQLPNPS
       ::.::::.::::::::...::::.:::::::::.:.:: :..: .:: ::::::: :.::
NP_945 CEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPS
        360       370       380       390       400       410      

     420       430       440       450       460       470         
pF1KB3 EASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSI
       :::::.:::::.:::::::::::: ::: ..:                            
NP_945 EASTTLPESHLKTPQMPPTTPSSSSFTKVTKDKDIK                        
        420       430       440       450                          

     480       490       500       510       520       530         
pF1KB3 GPAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVY

>>NP_689714 (OMIM: 612677) pyrin and HIN domain-containi  (492 aa)
 initn: 1950 init1: 1495 opt: 1530  Z-score: 1098.1  bits: 213.2 E(85289): 2e-54
Smith-Waterman score: 1953; 64.0% identity (82.2% similar) in 495 aa overlap (5-489:1-492)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
           :...::.::::::::::::::::.:::::::::::: ::.::::::::::::::::
NP_689     MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKF
                   10        20        30        40        50      

               70        80        90                100        110
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKV---------KGPALSRKRK-KEVDATS
        :::::::::..:..:::: :::::::.:::::         ::   :.: : :::  ..
NP_689 PGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPAT
         60        70        80        90       100       110      

              120       130       140       150       160       170
pF1KB3 PAPSTSSTVKTEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRS
       :: . :. . ..::: : : ::::: ..:..: : ::.:.:::.:   :::. :::::::
NP_689 PACTPSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRS
        120       130       140       150       160       170      

              180       190       200       210       220       230
pF1KB3 PSPKTSLSAPPNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKK
       : :.:: :::::.::::. : .:. ..:  .:.... :.:. ::..:: :.::. : :..
NP_689 PPPQTSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQR
        180       190       200       210       220       230      

              240       250       260       270       280       290
pF1KB3 IMFHATVATQTQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQ
        ::::::::::::::::::: .::.::  :.:::::.: . .::::::: :.::::::.:
NP_689 RMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQ
        240       250       260       270       280       290      

              300       310       320       330       340       350
pF1KB3 TFEVPNKIINRAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVV
       :::::. :: :::.  ::.:::::.:: ::::.:::: : ::.:::::::::  :.: ::
NP_689 TFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVV
        300       310       320       330       340       350      

              360       370       380       390       400       410
pF1KB3 GTGQCHNIPCEEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQ
       : :.:::::::.::::.::::::::...::::.:::::::::.:.:: :..: .:: :::
NP_689 GKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQ
        360       370       380       390       400       410      

              420       430       440       450       460       470
pF1KB3 EQSQLPNPSEASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSH
       :::: :.:::::::.:::::.:::::::::::: ::::.:   . ...   ..:    : 
NP_689 EQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRIT---SP
        420       430       440       450       460       470      

              480       490       500       510       520       530
pF1KB3 FPGPFMTSIGPAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMV
         .: ..:   .. :: .:                                         
NP_689 TVAPPLSSDTSTNRHPAVP                                         
           480       490                                           

>>XP_011507544 (OMIM: 612677) PREDICTED: pyrin and HIN d  (492 aa)
 initn: 1950 init1: 1495 opt: 1530  Z-score: 1098.1  bits: 213.2 E(85289): 2e-54
Smith-Waterman score: 1953; 64.0% identity (82.2% similar) in 495 aa overlap (5-489:1-492)

               10        20        30        40        50        60
pF1KB3 MSVKMGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKF
           :...::.::::::::::::::::.:::::::::::: ::.::::::::::::::::
XP_011     MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKF
                   10        20        30        40        50      

               70        80        90                100        110
pF1KB3 RGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKV---------KGPALSRKRK-KEVDATS
        :::::::::..:..:::: :::::::.:::::         ::   :.: : :::  ..
XP_011 PGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPAT
         60        70        80        90       100       110      

              120       130       140       150       160       170
pF1KB3 PAPSTSSTVKTEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRS
       :: . :. . ..::: : : ::::: ..:..: : ::.:.:::.:   :::. :::::::
XP_011 PACTPSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRS
        120       130       140       150       160       170      

              180       190       200       210       220       230
pF1KB3 PSPKTSLSAPPNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKK
       : :.:: :::::.::::. : .:. ..:  .:.... :.:. ::..:: :.::. : :..
XP_011 PPPQTSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQR
        180       190       200       210       220       230      

              240       250       260       270       280       290
pF1KB3 IMFHATVATQTQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQ
        ::::::::::::::::::: .::.::  :.:::::.: . .::::::: :.::::::.:
XP_011 RMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQ
        240       250       260       270       280       290      

              300       310       320       330       340       350
pF1KB3 TFEVPNKIINRAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVV
       :::::. :: :::.  ::.:::::.:: ::::.:::: : ::.:::::::::  :.: ::
XP_011 TFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVV
        300       310       320       330       340       350      

              360       370       380       390       400       410
pF1KB3 GTGQCHNIPCEEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQ
       : :.:::::::.::::.::::::::...::::.:::::::::.:.:: :..: .:: :::
XP_011 GKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQ
        360       370       380       390       400       410      

              420       430       440       450       460       470
pF1KB3 EQSQLPNPSEASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSH
       :::: :.:::::::.:::::.:::::::::::: ::::.:   . ...   ..:    : 
XP_011 EQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRIT---SP
        420       430       440       450       460       470      

              480       490       500       510       520       530
pF1KB3 FPGPFMTSIGPAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMV
         .: ..:   .. :: .:                                         
XP_011 TVAPPLSSDTSTNRHPAVP                                         
           480       490                                           




733 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 21:01:00 2016 done: Thu Nov  3 21:01:02 2016
 Total Scan time:  9.470 Total Display time:  0.120

Function used was FASTA [36.3.4 Apr, 2011]
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