Result of FASTA (omim) for
pF1KB3486
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3486, 368 aa
1>>>pF1KB3486 368 - 368 aa - 368 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4035+/-0.000427; mu= 3.5497+/- 0.026
mean_var=261.3981+/-54.673, 0's: 0 Z-trim(118.7): 283 B-trim: 50 in 1/55
Lambda= 0.079327
statistics sampled from 31445 (31834) to 31445 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.373), width: 16
Scan time: 8.560
The best scores are: opt bits E(85289)
NP_003016 (OMIM: 601768) endophilin-A2 isoform 1 [ ( 368) 2426 290.9 3.2e-78
XP_016882635 (OMIM: 601768) PREDICTED: endophilin- ( 358) 2342 281.2 2.5e-75
XP_011526485 (OMIM: 601768) PREDICTED: endophilin- ( 333) 2206 265.6 1.1e-70
NP_001186872 (OMIM: 601768) endophilin-A2 isoform ( 320) 1727 210.8 3.5e-54
NP_001186873 (OMIM: 601768) endophilin-A2 isoform ( 304) 1515 186.5 6.9e-47
NP_003017 (OMIM: 604465) endophilin-A1 [Homo sapie ( 352) 1390 172.3 1.5e-42
XP_011516307 (OMIM: 604465) PREDICTED: endophilin- ( 386) 1309 163.0 1e-39
NP_003018 (OMIM: 603362) endophilin-A3 isoform a [ ( 347) 1262 157.6 3.9e-38
NP_001311111 (OMIM: 603362) endophilin-A3 isoform ( 360) 1262 157.6 4e-38
NP_001288038 (OMIM: 603362) endophilin-A3 isoform ( 355) 1184 148.7 1.9e-35
NP_001311112 (OMIM: 603362) endophilin-A3 isoform ( 355) 1184 148.7 1.9e-35
XP_011520191 (OMIM: 603362) PREDICTED: endophilin- ( 355) 1184 148.7 1.9e-35
NP_001311113 (OMIM: 603362) endophilin-A3 isoform ( 312) 1082 137.0 5.8e-32
NP_001311115 (OMIM: 603362) endophilin-A3 isoform ( 312) 1082 137.0 5.8e-32
XP_011520194 (OMIM: 603362) PREDICTED: endophilin- ( 217) 975 124.5 2.2e-28
XP_011520193 (OMIM: 603362) PREDICTED: endophilin- ( 237) 973 124.4 2.7e-28
XP_016877975 (OMIM: 603362) PREDICTED: endophilin- ( 278) 926 119.1 1.3e-26
NP_001288037 (OMIM: 603362) endophilin-A3 isoform ( 278) 926 119.1 1.3e-26
NP_001311116 (OMIM: 603362) endophilin-A3 isoform ( 278) 926 119.1 1.3e-26
NP_001311114 (OMIM: 603362) endophilin-A3 isoform ( 278) 926 119.1 1.3e-26
NP_057093 (OMIM: 609287) endophilin-B1 isoform 1 [ ( 365) 422 61.5 3.5e-09
XP_011539840 (OMIM: 609287) PREDICTED: endophilin- ( 378) 340 52.1 2.4e-06
NP_001273975 (OMIM: 609288) endophilin-B2 isoform ( 395) 321 50.0 1.1e-05
NP_064530 (OMIM: 609288) endophilin-B2 isoform b [ ( 395) 321 50.0 1.1e-05
NP_001193580 (OMIM: 609287) endophilin-B1 isoform ( 394) 311 48.8 2.5e-05
NP_001193582 (OMIM: 609287) endophilin-B1 isoform ( 265) 304 47.8 3.3e-05
XP_016856899 (OMIM: 609287) PREDICTED: endophilin- ( 219) 302 47.5 3.4e-05
XP_016856898 (OMIM: 609287) PREDICTED: endophilin- ( 235) 302 47.6 3.6e-05
NP_001193581 (OMIM: 609287) endophilin-B1 isoform ( 386) 304 48.0 4.2e-05
XP_005252155 (OMIM: 609288) PREDICTED: endophilin- ( 400) 304 48.0 4.3e-05
XP_006710735 (OMIM: 609287) PREDICTED: endophilin- ( 402) 302 47.8 5.1e-05
XP_006717254 (OMIM: 609288) PREDICTED: endophilin- ( 399) 293 46.8 0.0001
NP_001273974 (OMIM: 609288) endophilin-B2 isoform ( 404) 293 46.8 0.0001
XP_005252157 (OMIM: 609288) PREDICTED: endophilin- ( 379) 279 45.2 0.0003
XP_006717252 (OMIM: 609288) PREDICTED: endophilin- ( 424) 275 44.8 0.00045
XP_006717253 (OMIM: 609288) PREDICTED: endophilin- ( 423) 271 44.3 0.00062
XP_006717251 (OMIM: 609288) PREDICTED: endophilin- ( 428) 271 44.3 0.00062
>>NP_003016 (OMIM: 601768) endophilin-A2 isoform 1 [Homo (368 aa)
initn: 2426 init1: 2426 opt: 2426 Z-score: 1525.3 bits: 290.9 E(85289): 3.2e-78
Smith-Waterman score: 2426; 100.0% identity (100.0% similar) in 368 aa overlap (1-368:1-368)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
310 320 330 340 350 360
pF1KB3 EVLVPLPQ
::::::::
NP_003 EVLVPLPQ
>>XP_016882635 (OMIM: 601768) PREDICTED: endophilin-A2 i (358 aa)
initn: 2342 init1: 2342 opt: 2342 Z-score: 1473.5 bits: 281.2 E(85289): 2.5e-75
Smith-Waterman score: 2342; 99.7% identity (100.0% similar) in 355 aa overlap (14-368:4-358)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
.::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGVTQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
300 310 320 330 340 350
pF1KB3 EVLVPLPQ
::::::::
XP_016 EVLVPLPQ
>>XP_011526485 (OMIM: 601768) PREDICTED: endophilin-A2 i (333 aa)
initn: 2206 init1: 2206 opt: 2206 Z-score: 1389.7 bits: 265.6 E(85289): 1.1e-70
Smith-Waterman score: 2206; 100.0% identity (100.0% similar) in 333 aa overlap (36-368:1-333)
10 20 30 40 50 60
pF1KB3 LKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASR
::::::::::::::::::::::::::::::
XP_011 MEKKVDVTSKAVTEVLARTIEYLQPNPASR
10 20 30
70 80 90 100 110 120
pF1KB3 AKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB3 EVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 ALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMR
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 EASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPP
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB3 LDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVP
280 290 300 310 320 330
pF1KB3 LPQ
:::
XP_011 LPQ
>>NP_001186872 (OMIM: 601768) endophilin-A2 isoform 2 [H (320 aa)
initn: 1727 init1: 1727 opt: 1727 Z-score: 1093.7 bits: 210.8 E(85289): 3.5e-54
Smith-Waterman score: 2002; 87.0% identity (87.0% similar) in 368 aa overlap (1-368:1-320)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
:: ::::::::::
NP_001 NP------------------------------------------------GDALLDAGES
70
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
80 90 100 110 120 130
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
140 150 160 170 180 190
250 260 270 280 290 300
pF1KB3 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB3 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
260 270 280 290 300 310
pF1KB3 EVLVPLPQ
::::::::
NP_001 EVLVPLPQ
320
>>NP_001186873 (OMIM: 601768) endophilin-A2 isoform 3 [H (304 aa)
initn: 1515 init1: 1515 opt: 1515 Z-score: 962.8 bits: 186.5 E(85289): 6.9e-47
Smith-Waterman score: 1860; 82.6% identity (82.6% similar) in 368 aa overlap (1-368:1-304)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
::::::::::::::::::::
NP_001 NPASRAKLTMLNTVSKIRGQ----------------------------------------
70 80
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
::::::::::::::::::::::::::::::::::::
NP_001 ------------------------NLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
90 100 110
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB3 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB3 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
240 250 260 270 280 290
pF1KB3 EVLVPLPQ
::::::::
NP_001 EVLVPLPQ
300
>>NP_003017 (OMIM: 604465) endophilin-A1 [Homo sapiens] (352 aa)
initn: 1721 init1: 1349 opt: 1390 Z-score: 884.7 bits: 172.3 E(85289): 1.5e-42
Smith-Waterman score: 1720; 71.1% identity (87.0% similar) in 370 aa overlap (1-368:1-352)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
::::::::::.::.: :::::::::::::::::::::.::::::.:: :....:::::::
NP_003 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
::::::::.:.::.:::::: :.:::::.:.::.: :.. :.::: . ::: :: ..::.
NP_003 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
:..:.::::::::::::::::::::: .:::.::::::::::::::::::::::::::::
NP_003 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::::::::::.::::.::.:: :::: ::::::::::::.:::.::.::::::.... .:
NP_003 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
190 200 210 220 230 240
250 260 270 280 290
pF1KB3 KRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT
..:.:.:::.:.:::.:::: : :. : :::. : .::
NP_003 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK----------------
250 260 270 280
300 310 320 330 340 350
pF1KB3 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS
:: . .::: :.:::::::::.:::::.:::.:::::::::::::::: :.:::::..
NP_003 PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN
290 300 310 320 330 340
360
pF1KB3 YVEVLVPLPQ
:::.:: ::.
NP_003 YVEILVALPH
350
>>XP_011516307 (OMIM: 604465) PREDICTED: endophilin-A1 i (386 aa)
initn: 1640 init1: 1268 opt: 1309 Z-score: 834.2 bits: 163.0 E(85289): 1e-39
Smith-Waterman score: 1639; 70.6% identity (86.7% similar) in 354 aa overlap (17-368:51-386)
10 20 30 40
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKA
:::::::::::::::::::::.::::::.:
XP_011 DFAFLLKGMFGNVWRHFWLPRLERCYQHLKVSEKVGGAEGTKLDDDFKEMERKVDVTSRA
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB3 VTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGG
: :....:::::::::::::::.:.::.:::::: :.:::::.:.::.: :.. :.:::
XP_011 VMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGD
90 100 110 120 130 140
110 120 130 140 150 160
pF1KB3 ESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRL
. ::: :: ..::.:..:.::::::::::::::::::::: .:::.::::::::::::::
XP_011 DCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRL
150 160 170 180 190 200
170 180 190 200 210 220
pF1KB3 DFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYH
::::::::::::::::::::::::.::::.::.:: :::: ::::::::::::.:::.::
XP_011 DFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYH
210 220 230 240 250 260
230 240 250 260 270 280
pF1KB3 RQAVQILDELAEKLKRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIA
.::::::.... .:..:.:.:::.:.:::.:::: : :. : :::. : .::
XP_011 KQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK--
270 280 290 300 310
290 300 310 320 330 340
pF1KB3 ASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWY
:: . .::: :.:::::::::.:::::.:::.::::::::::::
XP_011 --------------PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWY
320 330 340 350 360
350 360
pF1KB3 EGMLDGQSGFFPLSYVEVLVPLPQ
:::: :.:::::..:::.:: ::.
XP_011 EGMLHGHSGFFPINYVEILVALPH
370 380
>>NP_003018 (OMIM: 603362) endophilin-A3 isoform a [Homo (347 aa)
initn: 1640 init1: 1262 opt: 1262 Z-score: 805.6 bits: 157.6 E(85289): 3.9e-38
Smith-Waterman score: 1606; 66.5% identity (85.1% similar) in 370 aa overlap (1-368:1-347)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
::::::::::.::::: :::..:::::::::.: .::.:.:::.:.:.:.:..: :::::
NP_003 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
::: :::: :::::::::::::. ::::.:::::.::...::::: .:.::.::...:::
NP_003 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
:: .:::::::::.:::.:::::: : .:::::: ::::::::::::.:::::: :::::
NP_003 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::.:::.::::::::.:: :: :.::.:.::::::.....: ::::::...::.:: ::
NP_003 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL
190 200 210 220 230 240
250 260 270 280 290
pF1KB3 KRRMREASSRPKREYKPKP--REPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT
. :. ::: :.:::::.: : .: :: ....: ... . :
NP_003 QMRISAASSVPRREYKPRPVKRSSSEL------NG---------VSTTSVVKTTGSNI--
250 260 270 280
300 310 320 330 340 350
pF1KB3 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS
:.::: :..::::::::.:::::.:::.:::::::::::::::. :.:::::..
NP_003 ------PMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPIN
290 300 310 320 330
360
pF1KB3 YVEVLVPLPQ
::::.:::::
NP_003 YVEVIVPLPQ
340
>>NP_001311111 (OMIM: 603362) endophilin-A3 isoform d [H (360 aa)
initn: 1262 init1: 1262 opt: 1262 Z-score: 805.5 bits: 157.6 E(85289): 4e-38
Smith-Waterman score: 1262; 73.0% identity (91.9% similar) in 259 aa overlap (1-259:1-259)
10 20 30 40 50 60
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
::::::::::.::::: :::..:::::::::.: .::.:.:::.:.:.:.:..: :::::
NP_001 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
::: :::: :::::::::::::. ::::.:::::.::...::::: .:.::.::...:::
NP_001 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
:: .:::::::::.:::.:::::: : .:::::: ::::::::::::.:::::: :::::
NP_001 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
::.:::.::::::::.:: :: :.::.:.::::::.....: ::::::...::.:: ::
NP_001 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
. :. ::: :.:::::.:
NP_001 QMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGLRSKRKSTQGHLGRAVLAEA
250 260 270 280 290 300
>>NP_001288038 (OMIM: 603362) endophilin-A3 isoform c [H (355 aa)
initn: 1562 init1: 1184 opt: 1184 Z-score: 757.3 bits: 148.7 E(85289): 1.9e-35
Smith-Waterman score: 1528; 64.5% identity (84.6% similar) in 358 aa overlap (11-368:19-355)
10 20 30 40 50
pF1KB3 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLA
. ..:: :::..:::::::::.: .::.:.:::.:.:.:.:.
NP_001 MDGIFAGIICNQANRCLTWTSQQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 RTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGD
.: :::::::: :::: :::::::::::::. ::::.:::::.::...::::: .:.::.
NP_001 KTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 ALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKK
::...::::: .:::::::::.:::.:::::: : .:::::: ::::::::::::.::::
NP_001 ALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB3 KRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQI
:: :::::::.:::.::::::::.:: :: :.::.:.::::::.....: ::::::...:
NP_001 KRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB3 LDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSS
:.:: ::. :. ::: :.:::::.: . . :: ....: ...
NP_001 LQELQSKLQMRISAASSVPRREYKPRPVKR----SSSELNG---------VSTTSVVKTT
250 260 270 280
300 310 320 330 340 350
pF1KB3 DKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQS
. : :.::: :..::::::::.:::::.:::.:::::::::::::::. :.:
NP_001 GSNI--------PMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGES
290 300 310 320 330
360
pF1KB3 GFFPLSYVEVLVPLPQ
::::..::::.:::::
NP_001 GFFPINYVEVIVPLPQ
340 350
368 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 23:13:22 2016 done: Fri Nov 4 23:13:24 2016
Total Scan time: 8.560 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]