FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3490, 337 aa 1>>>pF1KB3490 337 - 337 aa - 337 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0397+/-0.000956; mu= 11.7169+/- 0.057 mean_var=70.6258+/-14.170, 0's: 0 Z-trim(104.7): 50 B-trim: 14 in 1/50 Lambda= 0.152613 statistics sampled from 8025 (8060) to 8025 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.623), E-opt: 0.2 (0.248), width: 16 Scan time: 2.530 The best scores are: opt bits E(32554) CCDS9185.1 RFC5 gene_id:5985|Hs108|chr12 ( 340) 2147 482.0 2.9e-136 CCDS41843.2 RFC5 gene_id:5985|Hs108|chr12 ( 319) 2001 449.9 1.3e-126 CCDS3283.1 RFC4 gene_id:5984|Hs108|chr3 ( 363) 741 172.5 4.8e-43 CCDS5568.1 RFC2 gene_id:5982|Hs108|chr7 ( 354) 735 171.2 1.2e-42 CCDS75618.1 RFC2 gene_id:5982|Hs108|chr7 ( 251) 493 117.8 9.3e-27 CCDS5567.1 RFC2 gene_id:5982|Hs108|chr7 ( 320) 396 96.5 3.1e-20 >>CCDS9185.1 RFC5 gene_id:5985|Hs108|chr12 (340 aa) initn: 1737 init1: 1737 opt: 2147 Z-score: 2559.8 bits: 482.0 E(32554): 2.9e-136 Smith-Waterman score: 2147; 98.8% identity (99.1% similar) in 340 aa overlap (1-337:1-340) 10 20 30 40 50 60 pF1KB3 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 PPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 PPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 LVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 LMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTG 190 200 210 220 230 240 250 260 270 280 290 pF1KB3 HPLKSDIANILDWMLNQDFTTAYR---KLKTLKGLALHDILTEIHLFVHRVDFPSSVRIH :::::::::::::::::::::::: .:::::::::::::::::::::::::::::::: CCDS91 HPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIH 250 260 270 280 290 300 300 310 320 330 pF1KB3 LLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA :::::::::::::::::::::::::::::::::::::::: CCDS91 LLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA 310 320 330 340 >>CCDS41843.2 RFC5 gene_id:5985|Hs108|chr12 (319 aa) initn: 1591 init1: 1591 opt: 2001 Z-score: 2386.5 bits: 449.9 E(32554): 1.3e-126 Smith-Waterman score: 2001; 98.7% identity (99.1% similar) in 318 aa overlap (23-337:2-319) 10 20 30 40 50 60 pF1KB3 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYG :::::::::::::::::::::::::::::::::::::: CCDS41 MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYG 10 20 30 70 80 90 100 110 120 pF1KB3 PPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 PPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFK 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB3 LVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB3 LMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTG 160 170 180 190 200 210 250 260 270 280 290 pF1KB3 HPLKSDIANILDWMLNQDFTTAYR---KLKTLKGLALHDILTEIHLFVHRVDFPSSVRIH :::::::::::::::::::::::: .:::::::::::::::::::::::::::::::: CCDS41 HPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIH 220 230 240 250 260 270 300 310 320 330 pF1KB3 LLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA :::::::::::::::::::::::::::::::::::::::: CCDS41 LLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA 280 290 300 310 >>CCDS3283.1 RFC4 gene_id:5984|Hs108|chr3 (363 aa) initn: 714 init1: 388 opt: 741 Z-score: 886.3 bits: 172.5 E(32554): 4.8e-43 Smith-Waterman score: 741; 40.0% identity (70.9% similar) in 320 aa overlap (16-324:34-353) 10 20 30 40 pF1KB3 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQ : . .::::::::. .... ......... CCDS32 FLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEVVAVLK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 KFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPI : .. ::.::.:::::::::::::: :..:. . : ::::::::.:::...: . CCDS32 KSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKV 70 80 90 100 110 120 110 120 130 140 150 pF1KB3 LSFAS-----TRTIFKK--GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYL .::. .:. : ::.:::::::.::. :: ::::..:: ...:::::::::. CCDS32 KNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB3 SKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALN :.:: : :::..::: ::. ... :: ....:.: ::..:. :: .: ::.:.:.. CCDS32 SRIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSEGDLRKAIT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB3 ILQS-TNMAFGK-VTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRKLKTL--KGLAL .::: : .. :: .::... .: : ... . .: .: : .: : CCDS32 FLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAA 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB3 HDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIV ......: : . .. .. . . :.:... :. :..:..:: :: : CCDS32 TQLVNQLHDVVVENNLSDKQKSIITEKLAEVDKCLADGADEHLQLISLCATVMQQLSQNC 310 320 330 340 350 360 pF1KB3 AEA >>CCDS5568.1 RFC2 gene_id:5982|Hs108|chr7 (354 aa) initn: 673 init1: 573 opt: 735 Z-score: 879.4 bits: 171.2 E(32554): 1.2e-42 Smith-Waterman score: 735; 37.0% identity (70.3% similar) in 316 aa overlap (12-324:28-342) 10 20 30 40 pF1KB3 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTI :... .::::::::: ::......: .: . CCDS55 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 QKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGP . : : .:.... ::::::::..:: :. : . . .::::::.:::::..:. CCDS55 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALL-GPALKDAMLELNASNDRGIDVVRNK 70 80 90 100 110 110 120 130 140 150 160 pF1KB3 ILSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIP : ::. .. . :: :..::::::.::. ::.::::..: ....::: : :: .::: CCDS55 IKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB3 ALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQST .::::. .:. :: .. :: .:.:.:.: ..::..:.. ..::::.::: :::: CCDS55 PIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQST 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB3 NMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRKLKTLK--GLALHDILTEI .:: .. :.:. .: . .... .: .. ::. : : : . .::. .: CCDS55 FSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNI 240 250 260 270 280 290 290 300 310 320 330 pF1KB3 HLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA . .. ...... ... ..... :.: .:...:.: CCDS55 FRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS 300 310 320 330 340 350 >>CCDS75618.1 RFC2 gene_id:5982|Hs108|chr7 (251 aa) initn: 441 init1: 384 opt: 493 Z-score: 593.9 bits: 117.8 E(32554): 9.3e-27 Smith-Waterman score: 493; 34.9% identity (69.4% similar) in 235 aa overlap (93-324:5-239) 70 80 90 100 110 120 pF1KB3 GTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKG-FKL :. ::::..:. : ::. .. . :: :. CCDS75 MCPTSSLRGIDVVRNKIKMFAQQKVTLPKGRHKI 10 20 30 130 140 150 160 170 180 pF1KB3 VILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPEL .::::::.::. ::.::::..: ....::: : :: .::: .::::. .:. :: CCDS75 IILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQ 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB3 MVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGH .. :: .:.:.:.: ..::..:.. ..::::.::: :::: .:: .. :.:. . CCDS75 ILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDE 100 110 120 130 140 150 250 260 270 280 290 pF1KB3 PLKSDIANILDWMLNQDFTTAYRKLKTLK--GLALHDILTEIHLFVHRVDFPSSVRIHLL : . .... .: .. ::. : : : . .::. .: . .. ...... CCDS75 PHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFI 160 170 180 190 200 210 300 310 320 330 pF1KB3 TKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA ... ..... :.: .:...:.: CCDS75 KEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS 220 230 240 250 >>CCDS5567.1 RFC2 gene_id:5982|Hs108|chr7 (320 aa) initn: 574 init1: 346 opt: 396 Z-score: 476.7 bits: 96.5 E(32554): 3.1e-20 Smith-Waterman score: 553; 31.7% identity (62.2% similar) in 315 aa overlap (12-324:28-308) 10 20 30 40 pF1KB3 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTI :... .::::::::: ::......: .: . CCDS55 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB3 QKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGP . : : .:.... ::::::::..:: :. : . . .::::::.: CCDS55 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALL-GPALKDAMLELNASND--------- 70 80 90 100 110 110 120 130 140 150 160 pF1KB3 ILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA .::. ::.::::..: ....::: : :: .::: CCDS55 ------------------------SMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 120 130 140 170 180 190 200 210 220 pF1KB3 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTN .::::. .:. :: .. :: .:.:.:.: ..::..:.. ..::::.::: :::: CCDS55 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTF 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB3 MAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRKLKTLK--GLALHDILTEIH .:: .. :.:. .: . .... .: .. ::. : : : . .::. .: CCDS55 SGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIF 210 220 230 240 250 260 290 300 310 320 330 pF1KB3 LFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA . .. ...... ... ..... :.: .:...:.: CCDS55 RVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS 270 280 290 300 310 320 337 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:31:53 2016 done: Fri Nov 4 02:31:53 2016 Total Scan time: 2.530 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]